[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hip-arthroplasty\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hip-arthroplasty":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,48,83,111,136,168,195,219,255],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":4},"100641802","patient-controlled-remimazolam-sedation-under-spinal-anesthesia-100641802",false,"NCT07661810","Patient-controlled Remimazolam Sedation Under Spinal Anesthesia","Patient-controlled Remimazolam Sedation During Primary Hip Arthroplasty Under Spinal Anesthesia: an Open-Label Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 19 to 70 years with an ASA (American Society of Anesthesiologists) physical status of I or II who are undergoing primary hip arthroplasty under spinal anesthesia.\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Patients with contraindications to spinal anesthesia\n* Patients who do not consent to intraoperative sedation\n* Patients with contraindications to remimazolam\n* Patients with a history of allergy or hypersensitivity to remimazolam\n* Patients with a baseline MOAA\u002FS (Modified Observer's Assessment of Alertness\u002FSedation) score of 4 or lower\n* Pregnant women","ALL","19 Years","70 Years",{"count":20,"type":21},104,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to compare the efficacy of patient-controlled sedation (PCS) versus clinician-controlled sedation (CCS) using remimazolam in adult patients undergoing primary hip arthroplasty under spinal anesthesia.\n\nThe main questions it aims to answer are:\n\n* Does patient-controlled sedation significantly reduce the total consumption of remimazolam compared to clinician-controlled sedation?\n* Are there differences in secondary outcomes, such as sedation depth , sedation-related adverse events, frequency of airway interventions, and patient\u002Fsurgeon satisfaction?\n\nResearchers will compare the PCS group to the CCS group to see if the patient-controlled method leads to a reduction in total remimazolam consumption while maintaining effective sedation.\n\nParticipants will:\n\n* Be randomly assigned to either the PCS group or the CCS group.\n* In the PCS group: Receive an initial 0.05 mg\u002Fkg remimazolam dose over 1 minute. If deeper sedation is desired, the patient can self-administer a 1 mg bolus of remimazolam via a button press, which has a 1-minute lockout interval.\n* In the CCS group: Receive an initial 0.05 mg\u002Fkg remimazolam dose over 1 minute, followed by a continuous infusion starting at 0.3 mg\u002Fkg\u002Fh. The clinician will assess the MOAA\u002FS score every 10 minutes and adjust the infusion rate to maintain a target MOAA\u002FS score of 3.",[27,28,29,30],"Hip Arthroplasty","Spinal Anesthesia","Remimazolam","Patient-controlled Sedation",[32,33,34,35],"patient-controlled sedation","remimazolam","spinal anesthesia","hip arthroplasty","NOT_YET_RECRUITING","2026-06-16",{"date":39,"type":40},"2026-06-22","ACTUAL",{"date":42,"type":21},"2026-07-01",{"date":44,"type":21},"2027-05-31",{"name":46,"class":47},"Seoul National University Hospital","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":58,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":79,"locationsCount":82},"100642976","the-relationship-between-preoperative-anxiety-level-and-frailty-score-in-elderly-patients-scheduled-for-elective-hip-arthroplasty-a-prospective-observational-study-100642976","NCT07633483","The Relationship Between Preoperative Anxiety Level and Frailty Score in Elderly Patients Scheduled for Elective Hip Arthroplasty: A Prospective Observational Study","Assessment of the Relationship Between Preoperative Anxiety Level Measured by the Hamilton Anxiety Rating Scale and Frailty Score Assessed by the FRAIL Scale in Elderly Patients Aged 65 Years and Older Scheduled for Elective Hip Arthroplasty: A Prospective Observational Single-Center Study","Inclusion Criteria:\n\n* Patients of both sexes aged 65 years and older\n* Patients with ASA physical status classification I, II, or III scheduled for elective hip arthroplasty\n* Patients who voluntarily agree to participate in the study\n* Patients with intact orientation and sufficient cooperation for assessment\n\nExclusion Criteria:\n\n* Patients with ASA physical status classification IV or V\n* Patients who refuse to participate in the study\n* Patients with impaired orientation or insufficient cooperation for assessment\n* Patients scheduled for emergency surgery\n* Patients to be operated during an active intensive care unit admission","65 Years",{"count":57,"type":21},142,"1 Week","OBSERVATIONAL","Frailty is a state of vulnerability resulting from decreased physiological reserve across multiple organ systems, impairing an individual's ability to withstand stressors. As the elderly population grows worldwide, the proportion of older adults undergoing surgical procedures continues to rise, and frailty is expected to become increasingly prevalent among surgical candidates.\n\nAnxiety is one of the most common psychiatric conditions, affecting approximately one in three individuals globally. Preoperative anxiety may negatively influence surgical outcomes, particularly in older and more vulnerable patients.\n\nThis prospective observational study aims to evaluate the relationship between preoperative anxiety level and frailty score in elderly patients aged 65 years and older scheduled for elective hip arthroplasty. Frailty will be assessed using the FRAIL Scale (Fatigue, Resistance, Ambulation, Illness, Loss of Weight), and anxiety will be measured using the Hamilton Anxiety Rating Scale (HAM-A). Secondary outcomes include the prevalence of frailty and anxiety, the effect of frailty on length of hospital stay, postoperative intensive care unit admission rates, and the relationship between frailty and preoperative laboratory and hemodynamic parameters.",[62,63,27],"Fraility","Anxiety, Preoperative",[62,65,66,67,27,68,69,70,71],"FRAIL Scale","Preoperative Anxiety","Hamilton Anxiety Rating Scale","Elderly","Geriatric","Observational Study","Anesthesiology","RECRUITING","2026-06-04",{"date":75,"type":40},"2026-06-08",{"date":77,"type":40},"2024-12-01",{"date":42,"type":21},{"name":80,"class":81},"Başakşehir Çam & Sakura City Hospital","OTHER_GOV",1,{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":110},"100637466","the-quadro-iliac-plane-qip-block-in-hip-arthroplasty-100637466","NCT07591311","The Quadro-Iliac Plane (QIP) Block in Hip Arthroplasty","The Effectiveness of the \"Quadro-Iliac Plane Block\" in Hip Arthroplasty: A Prospective Observational Clinical Study","QIP in hip","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients undergoing hip arthroplasty surgery, either elective or for a proximal femoral fracture\n* Expected postoperative hospital stay ≥ 24 hours\n* ASA physical status I-III\n* Neuraxial and\u002For locoregional anesthesia according to standard clinical practice\n* Provision of informed consent to participate in the study\n\nExclusion Criteria:\n\n* Absence of informed consent\n* Contraindications to locoregional and\u002For spinal anesthesia\n* Allergy to local anesthetic agents\n* Cognitive impairment preventing reliable assessment of outcomes\n* Coagulation disorders and\u002For platelet abnormalities\n* Antiplatelet or anticoagulant therapy that contraindicates spinal anesthesia\n* Presence of localized infection or sepsis at the sites to be treated",{"count":92,"type":21},80,"The goal of this observational study is to learn about the effectiveness of different locoregional anesthesia techniques, particularly the Quadro-Iliac Plane (QIP) block, in patients undergoing total hip arthroplasty. The main question it aims to answer is:\n\nDoes the QIP block improve postoperative recovery and pain control compared to other routinely used locoregional anesthesia techniques in patients undergoing hip replacement surgery?\n\nParticipants undergoing hip arthroplasty as part of their standard clinical care will receive one of the locoregional anesthesia techniques already in use at the hospital (including QIP block, fascia iliaca block, PENG block, or others, according to anesthesiologist choice). Postoperative outcomes will be collected prospectively, including quality of recovery (QoR-15 at 24 hours), pain scores at rest and during movement at predefined time points up to 48 hours, analgesic consumption, time to first analgesic request, time to mobilization, and occurrence of complications.",[95,27],"Hip Surgery",[97,98,99,100],"regional anesthesia","hip","hip fracture","QIP","2026-05-18",{"date":103,"type":40},"2026-05-22",{"date":105,"type":21},"2026-05",{"date":107,"type":21},"2027-11",{"name":109,"class":47},"San Giovanni di Dio Hospital",2,{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":16,"minAge":118,"maxAge":119,"enrollmentInfo":120,"targetDuration":4,"studyType":22,"phases":122,"briefSummary":123,"conditions":124,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":4},"100385667","fab-block-vs-placebo-for-hip-arthroplasty-patients-100385667","NCT04301687","FAB Block vs. Placebo for Hip Arthroplasty Patients","The Analgesic Efficacy of the Ultrasound-Guided Femoral Articular Branch Block for Ambulatory Hip Arthroplasty: A Randomized-Controlled Trial Secondary IDs:","Inclusion Criteria:\n\n* ASA I-III patients\n* Ages 18-60yrs\n* BMI ≤ 35 kg\u002Fm2\n\nExclusion Criteria:\n\n* Preexisting neurological deficits or peripheral neuropathy in the distribution of femoral, obturator, or lateral cutaneous nerves\n* Local infection\n* Contra-indication to regional anesthesia e.g. bleeding diathesis, coagulopathy\n* Chronic pain disorders\n* History of use of over 30mg oxycodone or equivalent per day\n* Contraindication to a component of multi-modal analgesia\n* Allergy to local anesthetics\n* History of significant psychiatric conditions that may affect patient assessment\n* Pregnancy\n* Inability to provide informed consent\n* Patient refusal of FAB\n* Revision arthroscopy surgeries","18 Years","85 Years",{"count":121,"type":21},95,[24],"Hip arthroplasty surgery can be associated with significant pain. A regional anesthesia technique, the femoral articular branch block (FAB), has recently been proposed to collectively block terminal femoral and accessory obturator nerve branches to the hip joint with a single injection, theoretically blocking most of the innervation relevant to hip arthroscopy while sparing the main femoral nerve branches to the quadriceps muscles. The investigators aim to demonstrate the analgesic benefits of FAB. The investigators hypothesize that FAB will reduce opioid consumption and improve postoperative quality of recovery in patients having hip arthroplasty. This is a randomized, controlled, double-blind study and half the patients will be randomized to receive the femoral articular branch block and the other half of patients will be randomized to receive a placebo block. A comparison of pain will be made between both groups.",[27,125,126],"Anesthesia, Regional","Femoral Articular Branch Block","2026-04-21",{"date":129,"type":40},"2026-04-27",{"date":131,"type":21},"2026-12",{"date":133,"type":21},"2028-12",{"name":135,"class":47},"Women's College Hospital",{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":144,"sex":16,"minAge":118,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":22,"phases":147,"briefSummary":148,"conditions":149,"keywords":153,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":82},"100609293","development-of-an-outcome-score-for-patients-with-knee-osteoarthritis-and-knee-joint-endoprosthesis-using-an-app-100609293","NCT07212699","Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App","Pilot Study: Development of an Outcome Score for Patients With Knee Osteoarthritis and\u002For Knee Joint Endoprosthesis Using an App Developed at the Clinic for Orthopedics","KneeApp","Inclusion criteria:\n\n* aged 18 years or older\n* german speaking\n* signed informed consent\n* using own smartphone\n\nExclusion criteria:\n\n* age below 18 years.\n* Lack of informed consent\n* no smartphone\n* non-German-speaking",true,{"count":146,"type":21},1250,[24],"Total knee arthroplasty (TKA) and total hip arthroplasty (THA) is one of the most frequent orthopedic procedures. Over 50% of patients report higher expectations than their surgeons, and 10-50% remain dissatisfied postoperatively. Persistent pain, functional limitations, and unmet expectations are key drivers. Identifying risks pre- and early postoperatively is essential, alongside empowering patients through self-management.\n\nExisting scoring systems integrate PROMs, demographics, and sometimes imaging but within limited timeframes. They rarely capture functional deficits or long-term trajectories. Digital health solutions for TKA (pre-)rehabilitation exist, yet most focus on physiotherapy and education rather than predictive outcome modeling.\n\nTo address this gap, the study team has developed a novel mobile application that enables the documentation and analysis of movement data up to 10 years before surgery and throughout long-term follow-up. These data are combined with PROMs and functional test results, providing a unique basis for outcome prediction and risk stratification in TKA\u002FTHA.\n\nPrimary Objective The aim of this pilot study is to develop a composite outcome score for TKA\u002FTHA patients. This score will integrate demographic variables, PROMs, and objective functional measures (knee joint angles, gait parameters, walk tests) to identify risk factors for dissatisfaction and support predictive modeling. A machine learning algorithm will be trained using the collected dataset to predict patient satisfaction after TKA\u002FTHA.\n\nEndpoints Primary endpoint: Overall patient satisfaction Secondary endpoints: Age, height, weight, step count, step length, gait asymmetry, gait speed, double support phase, knee joint ROM, walk test, KOOS, SF-36, EQ5d, satisfaction with the app, and satisfaction with app use.\n\nStudy Population App-Group: Inclusion criteria are patients ≥18 years before or after TKA\u002FTHA. Exclusion criteria include missing consent, ineligible diagnosis, lack of smartphone, age \\\u003C18 years, or insufficient German language skills (as no English version of the app is currently available). Planned enrollment: 450 patients.\n\nNon-App-Group: Inclusion criteria are patients ≥18 years before or after TKA\u002FTHA. Exclusion criteria include missing consent, ineligible diagnosis, age \\\u003C18 years, or insufficient German language skills (as no English version of the app is currently available). Planned enrollment: 450 patients.\n\nHealthy-group: Inclusion criteria are healthy proband ≥18 years with no lower limb conditions. The overall procedure is identical to that of the AppGroup. Exclusion criteria include missing consent, ineligible diagnosis, no smartphone, age \\\u003C18 years, or insufficient German language skills (as no English version of the app is currently available). Planned enrollment: 450 patients.\n\nMethods Design: Single-center, prospective pilot study. The app collects patient-authorized movement data already stored on smartphones as well as future data. Participants choose which data to share. In addition, they are prompted to complete gait tests and knee function tests. PROMs (KOOS, SF-36, satisfaction) are administered at regular intervals.",[150,151,152,27],"Knee Osteoarthritis","Knee Arthroplasty","Hip Osteoarthritis",[154,155,156,157,158,98],"knee","app","arthroplasty","detection","risk score","2026-03-31",{"date":161,"type":40},"2026-04-06",{"date":163,"type":40},"2025-10-01",{"date":165,"type":21},"2028-08-31",{"name":167,"class":47},"Technical University of Munich",{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":16,"minAge":118,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":22,"phases":177,"briefSummary":178,"conditions":179,"keywords":183,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":110},"100627706","dipb-vs-sifib-for-postoperative-analgesia-after-hip-surgery-100627706","NCT07452120","DIPB vs. SIFIB for Postoperative Analgesia After Hip Surgery","Comparison of the Effects of Deep Iliacus Plane Block (DIPB) and Suprainguinal Fascia Iliaca Block (SIFIB) on Postoperative Analgesia in Patients Undergoing Hip Surgery: A Randomized Controlled Study","Inclusion Criteria:\n\n* Patients aged ≥18 years\n* ASA physical status I-III\n* Scheduled for elective primary total hip arthroplasty under spinal anesthesia\n* Ability to understand the study procedures and provide informed consent\n\nExclusion Criteria:\n\n* Coagulation disorders or anticoagulant therapy contraindicating regional anesthesia\n* Infection at the block application site\n* Hemodynamic instability\n* Known allergy to local anesthetics\n* Pre-existing significant neurological or motor deficits in the lower extremities\n* Cognitive impairment preventing pain assessment\n* Refusal to participate or inability to provide informed consent",{"count":176,"type":21},70,[24],"This randomized, double-blind clinical trial aims to compare the effectiveness of the Deep Iliacus Plane Block (DIPB) and the Suprainguinal Fascia Iliaca Block (SIFIB) for postoperative pain control in patients undergoing primary total hip arthroplasty. Effective analgesia after hip surgery is essential for early mobilization, reduction of complications, and improved recovery outcomes.\n\nSeventy patients scheduled for elective hip arthroplasty under spinal anesthesia will be randomly assigned to receive either DIPB or SIFIB at the end of surgery. Postoperative pain scores, opioid consumption, motor block, and block-related complications will be evaluated over a 48-hour period.\n\nThe study aims to determine whether DIPB provides superior or comparable analgesia with reduced motor blockade compared to SIFIB, thereby contributing to safer and more comprehensive postoperative pain management in hip surgery patients.",[27,180,181,182],"Postoperative Pain","Regional Anesthesia","Acute Postoperative Pain",[184,185,27,180,181],"Deep Iliacus Plane Block","Suprainguinal Fascia Iliaca Block","2026-03-28",{"date":188,"type":40},"2026-04-02",{"date":190,"type":40},"2026-03-27",{"date":192,"type":21},"2026-11-01",{"name":194,"class":81},"Sivas Numune Hospital",{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":200,"acronym":4,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":16,"minAge":202,"maxAge":203,"enrollmentInfo":204,"targetDuration":4,"studyType":22,"phases":205,"briefSummary":206,"conditions":207,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":217,"locationsCount":82},"100626983","sacral-espb-vs-peng-block-for-hip-hemiarthroplasty-analgesia-100626983","NCT07442721","Sacral ESPB vs. PENG Block for Hip Hemiarthroplasty Analgesia","Sacral Erector Spinae Plane Block Versus Pericapsular Nerve Group Block For Analgesia In Hip Hemi Arthroplasty: A Randomized Comparative Study","Inclusion Criteria:\n\n* Patients with ages from 50 to 90 years of either gender, with diagnosis of intracapsular neck of femur fracture scheduled for elective hip hemiarthroplasty • Patients with an American Society of Anesthesiologists (ASA) physical status I to III.\n\nExclusion Criteria:\n\n* • Patient refusal.\n\n  * Allergy to local anesthetics and patient with infection at the injection site of block\n  * Patient with contraindication to spinal anesthesia.\n  * Coagulopathy as INR≥1.5 or platelets ≤80\\*103 \u002F microliter)\n  * Patients with body mass index\\>35 kg \u002F m2\n  * Patients with peripheral neuropathy or diabetic neuropathy\n  * Patients receiving opioids for chronic analgesic therapy (cancer, addiction).\n  * Cognitive impairment preventing pain scoring.\n  * Chronic renal failure requiring dose modification.\n  * Bilateral hip fracture or previous ipsilateral hip surgery","50 Years","90 Years",{"count":92,"type":21},[24],"Sacral erector spinae plane block(S-ESPB) has been recently described. Case reports are showing that it is useful in various types of surgery. In case presentations, it has been reported as effective in providing analgesia in the posterior branches of the sacral nerves in pilonidal sinus surgery, in the treatment of radicular pain at the L5 - S1 level, after a sex reassignment operation and hypospadias surgery, and its use in combination with lumbar ESPB for analgesia was reported after hip prosthesis surgery . Described in 2018, pericapsular nerve group (PENG) block selectively targets the articular branches of the femoral and accessory obturator nerves thereby providing potential motorsparing analgesia for hip surgery\n\n. Recent studies found that PENG block targets the articular branches of the femoral and accessory obturator nerves, only anesthetizes the anterior hip joint sparing posterior part , as well as there was a motor impairment after block which is from local anesthetic (LA) diffusion to the femoral nerve\n\n. Motor-sparing regional anesthesia techniques have emerged as a safer alternative, balancing effective pain relief with the preservation of quadriceps function . These techniques align with Enhanced Recovery After Surgery (ERAS) protocols, which emphasize multimodal pain control, opioid minimization, and early mobility to reduce complications such as venous thromboembolism (VTE) and postoperative pneumonia\n\n.",[27,208,209,180],"Hip Fracture Surgeries","Femoral Neck Fractures","2026-02-28",{"date":212,"type":40},"2026-03-03",{"date":214,"type":40},"2026-02-01",{"date":216,"type":21},"2027-08-01",{"name":218,"class":47},"Fayoum University Hospital",{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":225,"eligibilityCriteria":226,"healthyVolunteers":144,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":229,"conditions":230,"keywords":235,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":254},"100626159","orthopedic-procedures-and-postoperative-delirium-in-older-adults-in-the-czech-republic-100626159","NCT07432009","Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic","Orthopedic Procedures and Postoperative Delirium in the Czech Republic","ORTOPODCZ","Inclusion Criteria:\n\n* Age ≥ 65 years\n* Elective total hip arthroplasty in general or regional anesthesia\n* ASA physical status I-III\n* Ability to understand and cooperate during testing; no severe sensory impairment (compensatory aids allowed)\n* Expected postoperative hospitalization in ICU, PACU, or standard ward\n\nExclusion Criteria:\n\n* Glasgow Coma Scale ≤ 14\n* Limited legal capacity\n* Active psychiatric disorder (e.g., psychotic disorder, bipolar disorder)\n* Active oncological disease\n* Chronic use of strong opioids\n* Premedication with anxiolytics or antipsychotics during preanesthetic evaluation\n* Acute reoperation within 3 months of primary surgery\n* Refusal to participate or withdrawal of consent",{"count":228,"type":21},400,"This multicenter, prospective, non-interventional observational study (ORTOPODCZ) investigates the association between preoperative cognitive impairment and postoperative delirium (POD) in older adults undergoing elective total hip arthroplasty in the Czech Republic. Postoperative delirium is a frequent and serious neurocognitive complication in senior surgical patients and is associated with increased morbidity, mortality, prolonged hospitalization, and impaired functional and cognitive outcomes. Despite international recommendations, routine preoperative cognitive screening remains insufficiently implemented.\n\nThe study evaluates the predictive value of the ALBA test, a brief cognitive screening tool, performed during the pre-anesthetic assessment. Postoperative delirium will be assessed using the validated CAM-ICU instrument for up to 72 hours after surgery. Secondary objectives include assessing the relationship between POD and frailty, polypharmacy, comorbidities, type of anesthesia, intraoperative hemodynamics, blood loss, vasoactive support, and postoperative complications.\n\nApproximately 300-400 participants aged ≥65 years will be enrolled across seven centers. No additional procedures, biological sampling, or deviations from standard clinical care are required. Data will be collected in REDCap and analyzed according to a predefined statistical analysis plan. The study aims to provide robust evidence supporting the integration of cognitive screening into routine preoperative evaluation and to describe feasibility and implementation requirements for the ALBA test in clinical practice.",[231,232,233,27,234],"Frailty","Cognitive Impairment","Older Adults","Postoperative Delirium",[236,237,238,239,240,241,242,243,70,244],"ALBA test","CAM-ICU","Cognitive Screening","Geriatric Patients","Perioperative Neurocognitive Disorders","Polypharmacy","Clinical Frailty Scale","Total Hip Replacement","Prospective Cohort","2026-02-24",{"date":247,"type":40},"2026-02-25",{"date":249,"type":21},"2026-04-01",{"date":251,"type":21},"2030-03-31",{"name":253,"class":47},"Tomas Bata Hospital, Czech Republic",7,{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":260,"acronym":4,"eligibilityCriteria":261,"healthyVolunteers":11,"sex":16,"minAge":118,"maxAge":119,"enrollmentInfo":262,"targetDuration":4,"studyType":22,"phases":264,"briefSummary":265,"conditions":266,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":82},"100594265","opposed-anterior-hip-arthroplasty-regional-anesthesia-study-study-100594265","NCT07017192","OPPOSED (anteriOr hiP arthroPlasty regiOnal aneSthEsia stuDy) Study","OPPOSED (anteriOr hiP arthroPlasty regiOnal aneSthEsia stuDy) Study. Regional Anesthesia Techniques for Anterior Approach Hip Arthroplasty Analgesia: SIFI Block Versus Lumbar ESP Block","Inclusion Criteria:\n\n* Age \\>=18 years and =\\\u003C85 years\n* patients undergoing elective unilateral THA with direct anterior approach\n* patients able to understand the purposes of the study and provide signed informed consent\n\nExclusion Criteria:\n\n* pregnancy\n* Age \\\u003C18 years or \\>85 years\n* revision or bilateral surgeries\n* psychiatric pathology or cognitive deficits, mental retardation, inability to provide valid informed consent\n* History of illicit drugs and\u002For alcohol abuse\n* urgent\u002Femergent surgery with admission to Intensive Care under sedation and mechanical ventilation or complications that do not allow evaluation\n* known allergy to the drugs used in the study\n* refusal to provide informed consent",{"count":263,"type":21},50,[24],"Main indications for total hip arthroplasty (THA) are degenerative osteoarthritis of the coxofemoral joint, osteonecrosis of the hip, congenital disorders such as dysplasia and inflammatory arthritis. More recently, surgery using the direct anterior approach is getting popularity: this method, in fact, granting a significant sparing of the hip muscles, is associated with favorable results compared to other techniques, such as a lower risk of dislocation, limitated damage to soft tissues with better recovery and early discharge.\n\nPatients undergoing this procedure may although experience moderate to severe postoperative pain in the first few hours (with peaks observed in the first 12 hours), as well as potential complications such as nausea and vomiting related to opioids use.\n\nIt has been shown that adequate pain control influences early mobilization and rehabilitation, ensuring a quicker recovery. The role of regional anesthesia techniques has been established in almost all areas of orthopedic surgery, and in particularly in the management of postoperative pain following hip replacement surgery, but definitive data are missing with regard to direct anterior approach.\n\nRegional anesthesia consists of infiltrating local anesthetics in sites (fascial planes or nerves), in order to limit or even eliminate the use of traditional painkillers, with a significant reduction in the side effects.\n\nThe aim of this study is to compare the impact of two techniques, the Suprainguinal Fascia Iliaca (SIFI) block and the lumbar Erector Spinae Plane (ESP) block, in managing postoperative pain in subjects undergoing total hip replacement surgery performed by direct anterior approach.\n\nThe primary objective of the study is the incidence of residual femoral and obturator nerves block (knee extension and hip adduction according to ASIA score) 8 hours after surgery in the two treatment groups.\n\nSecondary objectives include: • Time elapsed between the end of surgery and the recovery of lower limb motility enough to allow the patient to mobilize independently; • Total opioid consumption (calculated as morphine equivalents) at 8, 24 and 48 hours after surgery; • Pain according to NRS (numerica rating scale) at 8, 24 and 48 hours after surgery; • Extent of sensory block of the three branches of the lumbar plexus (femoral, obturator, lateral femorocutaneuous nerves) at 8, 24 and 48 hours after surgery; • Timing of hospital discharge; • Incidence of chronic or persistent postoperative pain (at 30 and 90 days after surgery); • Any postoperative complication",[267,268,269,27,270,95,271,272],"Hip Replacement Surgery","Hip Replacement, Total","Hip Pain","Hip Replacement Postoperative","Pain,Postoperative","Mobility and Independence","2025-06-27",{"date":275,"type":40},"2025-06-29",{"date":277,"type":40},"2025-06-23",{"date":279,"type":21},"2026-09-23",{"name":281,"class":47},"A.O.U. Città della Salute e della Scienza"]