[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hip-fracture-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hip-fracture-surgery":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,80,116],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100642566","phase-4-fascia-iliaca-block-using-liposomal-bupivacaine-for-analgesia-after-hip-fracture-surgery-100642566",false,"NCT07643792","Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Fracture Surgery","Fascia Iliaca Block Using Liposomal Bupivacaine for Analgesia After Hip Fracture Surgery: a Randomized Trial","Inclusion Criteria:\n\n* Aged ≥ 55 years.\n* Diagnosed as hip fracture and scheduled to undergo hip replacement surgery.\n* Agree to receive regional nerve block and postoperative patient-controlled intravenous analgesia (PCIA).\n\nExclusion Criteria:\n\n* Inability to communicate due to visual, auditory, language, or other reasons before surgery.\n* Chronic opioid dependence and long-term use of various types of analgesics (for more than 3 months).\n* Severe coagulation abnormalities (International Normalized Ratio \\> 1.7, activated partial thromboplastin time exceeding the normal value by more than 4 seconds, platelet count \\\u003C 80 × 10⁹\u002FL), trauma or infection at the intended puncture site, or severe low back pain.\n* Preoperative severe renal insufficiency (serum creatinine \\> 442 μmol\u002FL or requiring renal replacement therapy), hepatic insufficiency (Child-Pugh class C), or ASA physical status \\> IV.\n* Known allergy to local anesthetics.\n* Any other condition that the investigator or attending physician deems unsuitable for participation in the study.","ALL","55 Years",{"count":19,"type":20},148,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","Older patients with hip fractures often suffer from severe pain. Inadequate analgesia increases the risk of postoperative delirium, myocardial injury, and other complications. Peripheral nerve block is an important component of multimodal analgesia, but conventional local anesthetics (such as plain bupivacaine) provide only approximately 12 hours of analgesic duration, which is far from covering the most painful 72 hours after surgery. Liposomal bupivacaine has a slow-release property, prolonging the analgesic duration up to 72 hours after a single injection. However, its clinical advantages in hip fracture surgery remain controversial. The investigators suppose that, compared with plain bupivacaine alone, preoperative supra-inguinal fascia iliaca block using liposomal bupivacaine combined with plain bupivacaine can further improve analgesia, decrease opioid consumption, and improve postoperative recovery quality within 72 hours in older patients after hip fracture surgery.",[26,27,28,29,30],"Older Adults","Hip Fracture Surgery","Fascia Iliaca Block","Liposomal Bupivacaine","Postoperative Pain",[26,32,28,29,30],"Hip fracture surgery","NOT_YET_RECRUITING","2026-06-11",{"date":36,"type":37},"2026-06-15","ACTUAL",{"date":39,"type":20},"2026-07",{"date":41,"type":20},"2028-08",{"name":43,"class":44},"Peking University First Hospital","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":45},"100636090","feasibility-of-a-co-designed-mobility-intervention-after-hip-fracture-surgery-100636090","NCT07561164","Feasibility of a Co-designed Mobility Intervention After Hip Fracture Surgery","Feasibility, Fidelity, and Acceptability of a Co-designed Intervention to Promote Mobility in Patients After Hip Fracture Surgery","HIP-ME-UP","Inclusion Criteria:\n\n* Age ≥ 60 years.\n* Admitted to one of the two acute orthopedic wards at Copenhagen University Hospital Hvidovre (CUHH) following hip fracture surgery.\n* Pre-fracture Cumulated Ambulation Score (CAS) (by recall) ≥ 3 points, indicating independence or assisted independence in basic mobility activities such as bed transfer, chair transfer, and indoor walking.\n* Participants may be included if they are able to provide informed consent independently or if informed consent is obtained from a legally authorized proxy (e.g., caregiver or close relative) in cases of cognitive impairment. This applies to both Danish- and non-Danish speaking patients. Non-Danish speakers may be included with support from translated study materials and assistance from relatives or interpreters, where appropriate.\n* Inclusion the latest on postoperative day three.\n\nExclusion Criteria:\n\n* Non-ambulatory before the fracture, e.g. permanently bedbound or wheelchair-dependent.\n* Terminal illness with limited expected survival.\n* Post-operative weight-bearing restrictions precluding mobility activities.\n* Multiple fractures or suspected pathological fractures (e.g. related to malignancy).\n* Clinically unstable or presenting conditions in which early mobilization is contraindicated.\n* Patients who previously participated in HIP-ME-UP Study 4, ensuring that recipients in Study 6 have not been prior HIP-ME-UP study participants or patient partners.","60 Years",{"count":56,"type":20},25,[58],"NA","This clinical study examines whether a co-designed mobility intervention can be delivered in routine hospital care after hip fracture surgery.\n\nHip fracture is a common and serious condition among older adults and is associated with loss of independence, complications, and increased mortality. During hospitalization, many patients remain inactive, even though early and frequent mobility is considered important for recovery.\n\nThe HIP-ME-UP intervention was developed in collaboration with healthcare professionals, patients, caregivers, and hospital management. It aims to support early mobilization, independence in basic mobility activities such as getting in and out of bed and increased physical activity during hospitalization.\n\nThe study will investigate whether the intervention is feasible to deliver in routine clinical practice, whether it is delivered as intended, and whether it is acceptable to patients and healthcare professionals.\n\nParticipants admitted after a hip fracture surgery will receive the intervention during hospitalization. Researchers will collect information on recruitment, retention, fidelity, acceptability, and mobility-related outcomes. Approximately 25 participants will be included.\n\nThe results will help determine whether a larger effectiveness study should be conducted.",[27,61,62],"Mobility Limitation","Postoperative Rehabilitation",[64,65,66,67,68,69],"Early mobility","Physical activity","Feasibility study","Frequent mobility","hospitalization","Fidelity","RECRUITING","2026-05-27",{"date":73,"type":37},"2026-05-29",{"date":75,"type":37},"2026-05-11",{"date":77,"type":20},"2027-06-30",{"name":79,"class":44},"Hvidovre University Hospital",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":16,"minAge":87,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":21,"phases":90,"briefSummary":91,"conditions":92,"keywords":95,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":115},"100631818","ai-based-rehabilitation-for-hip-and-knee-surgery-patients-100631818","NCT07505628","AI-based Rehabilitation for Hip and Knee Surgery Patients","Evaluation of the Efficacy and Safety of AI-based Rehabilitation Exercise After Hip and Knee Arthroplasty","Inclusion Criteria:\n\n* Adult patients aged 19 years or older.\n* Patients scheduled to undergo hip or knee arthroplasty at Gangnam Severance Hospital or affiliated hospitals of Chung-Ang University Medical Center (Chung-Ang University Hospital, Gwangmyeong Hospital, Hyundai Hospital).\n* Patients with a preoperative Functional Ambulatory Category (FAC) stage of 4 or 5 (For hip fracture cases, pre-fracture FAC stage will be considered).\n* Patients capable of downloading and using mobile applications on smart devices (smartphones or tablets) independently without researcher assistance.\n* Patients who fully understand the study's purpose and procedures and have voluntarily signed the informed consent form.\n\nExclusion Criteria:\n\n* Individuals unable to perform exercises due to severe musculoskeletal pain.\n* Individuals with severe dizziness or poor vision that prevents them from following exercise videos provided by the digital treatment.\n* Individuals with visual impairment that causes difficulty in recognizing the monitor\u002Fdevice screen.\n* Individuals requiring long-term inpatient treatment due to unstable vital signs.\n* Individuals with partial or total lower-limb amputation due to trauma, disease, or congenital defects.\n* Individuals classified as vulnerable subjects (as defined by clinical research ethics guidelines).\n* Any other individuals deemed ineligible for participation at the discretion of the principal investigator.","19 Years",{"count":89,"type":20},106,[58],"This study aims to evaluate the efficacy and safety of an AI-based home rehabilitation application (\"Exersite Rehab\") for patients who have undergone hip or knee arthroplasty(Total Knee Arthroplasty (TKA), Total Hip Arthroplasty (THA) or hip fracture surgery). Following surgery, effective rehabilitation is crucial for functional recovery; however, many patients face barriers to consistent in-hospital exercise. This interventional study divides participants into two groups to compare outcomes. The experimental group will perform a 12-week home-based rehabilitation program guided by an AI application that provides real-time posture correction and monitoring. In contrast, the control group will perform the same exercise protocol using traditional printed educational brochures.The primary objective is to determine if the AI-based digital healthcare solution significantly improves physical function, measured by the Functional Ambulatory Category(FAC), compared to conventional methods. Secondary outcomes including pain levels(Visual Analog Scale (VAS)) and joint-specific functional scores (Knee Society Score (KSS), Harris Hip Score (HHS)) will also be assessed over the 12-week period.",[93,94,27],"Total Knee Arthroplasty","Total Hip Arthroplasty (THA)",[96,97,98,99,100,101,102,103,104,105],"Arthroplasty","TKA","THA","Hip Fracture","Digital Therapeutics","AI Rehabilitation","Mobile Application","Home-based Exercise","Remote Monitoring","Physical Function","2026-03-26",{"date":108,"type":37},"2026-04-01",{"date":110,"type":20},"2026-03-09",{"date":112,"type":20},"2028-12-31",{"name":114,"class":44},"Gangnam Severance Hospital",2,{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":124,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":21,"phases":127,"briefSummary":129,"conditions":130,"keywords":133,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":149},"100610521","phase-3-hip-fracture-surgery-arterial-and-venous-thrombotic-events-prevention-100610521","NCT07228663","Hip Fracture Surgery Arterial and Venous Thrombotic Events Prevention","Rivaroxaban Plus Acetylsalicylic Acid Versus Standard of Care for Arterial and Venous Cardiovascular Prevention After Hip Fracture Surgery in Patients With Myocardial Injury: a Pilot Randomized Trial","HIPSTER-Pilot","Inclusion Criteria:\n\n* Age ≥45 years, received surgery for a hip fracture due to a low-energy mechanism, and myocardial injury (i.e., an elevated troponin measurement).\n\nExclusion Criteria:\n\n* Centers in which standard of care for VTE prophylaxis after hip fractures is ASA, alone or in combination with other drugs; patients with GFR \\\u003C15mL\u002Fmin; patients with drug interactions and conditions that prevent the use of the standard of care or intervention \\[Known allergy to the study drugs; pregnancy; an indication for anticoagulation, for dual antiplatelet therapy, for a P2Y12 inhibitor; already on rivaroxaban 2.5 mg twice daily + ASA before the fracture; bleeding diathesis that in the judgment of the investigator precludes the use of anticoagulant prophylaxis; history of significant hepatic disease (Child-Pugh B or C, see supplementary material) or any other condition that, in the judgment of the investigator, precludes the use of rivaroxaban; concomitant use of drugs that are strong inhibitors or strong inducers of P-glycoprotein (P-gp, e.g., systemic azole antimycotics, such as ketoconazole, and human immunodeficiency virus \\[HIV\\]-protease inhibitors, such as ritonavir) and\u002For Cytochrome P450 3A4 (CYP3A4)\\]; expected requirement for major surgery post-arthroplasty within 90 days; women Persons of childbearing potential who are not abstinent or do not use appropriate contraception or are breast-feeding; unable or unwilling to provide consent; previous participation in the HIPSTER trial; participation in another anticoagulant or antiplatelet study.","45 Years",{"count":126,"type":20},100,[128],"PHASE3","A third of patients undergoing surgery for a hip fracture develop a myocardial injury (i.e., an elevated troponin measurement), and these patients are at substantial risk of death and morbidity. Current prophylaxis strategies focus on preventing venous thromboembolism (VTE); however, arterial events are more common and carry a poor prognosis. The association of acetylsalicylic acid (ASA) 75-100 mg once daily and rivaroxaban 2.5 mg twice a day (the regimen used in the COMPASS trial) might prevent both VTE and arterial cardiovascular events. Among patients who have undergone hip fracture surgery and have evidence of myocardial injury, to explore the feasibility of a randomized controlled trial (RCT) comparing rivaroxaban 2.5 mg twice daily + low-dose ASA (75-100 mg) for 90 days, with standard VTE thromboprophylaxis for 30 days, for prevention of major cardiovascular events. The HIPSTER-Pilot is a multicenter, international, open-label, pilot RCT with blinded outcome adjudication. A total of 100 participants aged ≥45 years who received hip fracture surgery and experienced a myocardial injury will be randomized to receive either rivaroxaban 2.5 mg twice daily plus ASA 75-100 mg daily for 90 days or standard VTE prophylaxis with an anticoagulant for 30 days. The primary feasibility outcome will be the recruitment rate. Other feasibility measures include completeness of follow-up and adherence to the treatment. Exploratory clinical outcomes will be assessed. This pilot trial will provide information on the feasibility of conducting a larger RCT to evaluate the efficacy and safety of the COMPASS regimen for preventing arterial and venous thrombotic events after hip fracture surgery in patients who have had myocardial injury. The results of this feasibility study will inform the design of the full-scale trial.",[27,131,132],"Cardiovascular Prevention","Venous Thromboembolism (VTE)",[134,135,136,137,138,139],"rivaroxaban","acetylsalicylic acid","cardiovascular prevention","hip fracture surgery","myocardial injury","venous thromboembolism (VTE)","2025-11-13",{"date":142,"type":37},"2025-11-14",{"date":144,"type":20},"2025-12-01",{"date":146,"type":20},"2027-12-01",{"name":148,"class":44},"McMaster University",3]