[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hip-fracture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hip-fracture":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,21,0,[8,51,88,118,145,171,193,218,249,281,312,341,373,400,423,452,478,504,532,554,578],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100644958","comparison-of-three-analgesic-strategies-for-hip-fracture-surgery-100644958",false,"NCT07676734","Comparison of Three Analgesic Strategies for Hip Fracture Surgery","Comparison of the Postoperative Analgesic Efficacy of Quadro-Iliac Plane Block, Suprainguinal Fascia Iliaca Block, and Standard Analgesia Protocol in Patients Undergoing Hip Fracture Surgery Under Spinal Anesthesia: A Prospective, Randomized, Double-Blind, Controlled Trial","HIP-3B","Inclusion Criteria:\n\n* Adult patients aged 18 years or older\n* Patients scheduled for hip fracture surgery under spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate\n* Contraindications to spinal anesthesia\n* Contraindications to regional anesthesia\n* Allergy to local anesthetics or study medications\n* Infection at the injection site\n* Coagulopathy or anticoagulant therapy precluding regional block\n* Cognitive impairment preventing pain assessment\n* Chronic opioid use\n* Revision surgery","ALL","18 Years","85 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"NA","Hip fracture surgery is associated with significant postoperative pain and increased opioid requirements. Regional anesthesia techniques may improve analgesia and reduce opioid consumption. This prospective, randomized, double-blind, controlled trial aims to compare the postoperative analgesic efficacy of Quadro-Iliac Plane Block (QIPB), Suprainguinal Fascia Iliaca Block (SIFIB), and standard analgesia in patients undergoing hip fracture surgery under spinal anesthesia. The primary outcome is cumulative tramadol consumption during the first 24 postoperative hours. Secondary outcome measures include postoperative pain intensity, rescue analgesic requirement, incidence of postoperative nausea and vomiting, Quality of Recovery-15 (QoR-15) score, and patient satisfaction score.",[28],"Hip Fracture",[30,31,32,33,34,35,36,37],"Quadro-Iliac Plane Block","Suprainguinal Fascia Iliaca Block","Regional Anesthesia","Postoperative Analgesia","Spinal Anesthesia","Tramadol Consumption","QoR-15","Hip Fracture Surgery","NOT_YET_RECRUITING","2026-06-27",{"date":41,"type":42},"2026-06-30","ACTUAL",{"date":44,"type":22},"2026-07-15",{"date":46,"type":22},"2027-02",{"name":48,"class":49},"Başakşehir Çam & Sakura City Hospital","OTHER_GOV",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":63,"conditions":64,"keywords":68,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":87},"100642134","phase-4-ironcare-iron-treatment-in-older-patients-with-hip-fractures-100642134","NCT07659184","IRONCARE: Iron Treatment in Older Patients With Hip Fractures","IRONCARE: Iron Treatment in Older Patients With Hip Fractures - A Double-blinded Placebo-controlled Randomized Trial","Inclusion Criteria:\n\n* Hip fracture (ICD-10 codes: DS720, DS721 and DS722)\n* Low energy trauma\n* Age ≥ 75 years\n* Hemoglobin ≤7.0 mmol\u002FL (11 g\u002FdL) during hospital admission\n\nExclusion Criteria:\n\n* Pathological fracture\n* Periprosthetic fracture\n* Inability to understand or speak Danish\n* Dysphagia and thus inability to swallow study medication\n* Signs of iron overload, hemochromatosis, or hemosiderosis\n* Liver disease (cirrhosis or hepatitis) and transaminase levels \\>3 times upper limit of normal\n* Known allergy to iron formulations\n* Severe asthma\n* Severe hypophosphatemia: \\\u003C0.35 mmol\u002FL\n* Patients already receiving iron supplementation that cannot be paused for the study period\n* Cognitive impairment that results in either memantine-treatment or a Short Portable Mental Status Questionnaire (SPMSQ) score \\> 4","75 Years",{"count":60,"type":22},528,[62],"PHASE4","The aim of this study is to investigate the effects of intravenous (IV) iron therapy compared to alternate-day oral iron treatment and no supplementation in older patients with hip fractures. This study will examine the impact of iron treatment on fatigue, functional decline, fear of falling, cognitive impairment, and quality of life, as well as its effects on iron stores and hemoglobin levels, with the overall goal of improving postoperative rehabilitation.\n\nThe trial will be conducted on five different hospitals in the Central Region of Denmark (Region Midtjylland).",[28,65,66,67],"Anemia","Iron","Placebo - Control",[69,65,70,71,72,73,74,75,76],"Hip fracture","iron","Intravenous iron","mobility","fatigue","hemoglobin","RCT","Placebo","2026-06-19",{"date":79,"type":42},"2026-06-24",{"date":81,"type":22},"2026-10-01",{"date":83,"type":22},"2028-09-30",{"name":85,"class":86},"University of Aarhus","OTHER",5,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":17,"minAge":96,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":23,"phases":99,"briefSummary":100,"conditions":101,"keywords":102,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":117},"100585165","phase-4-the-effects-of-intravenous-iron-on-mobility-in-elderly-patients-following-hip-fracture-surgery-100585165","NCT06898814","The Effects of Intravenous Iron on Mobility in Elderly Patients Following Hip Fracture Surgery","The Effects of Intravenous Iron on Mobility in Elderly Patients Following Hip Fracture Surgery: a Multicentre, Parallel Group, Randomised Controlled Trial","IronHip","Inclusion Criteria:\n\n1. 65 years of age or older\n2. Acute proximal femur fracture surgery\n3. A hemoglobin measurement ≤6.5 mmol\u002FL (10.5 g\u002FdL) on day 1 to 5 postoperatively\n4. Independent prefracture indoor walking ability, indoor NMS ≥ 2\n5. Ability to speak and understand Danish\n6. Able to provide informed consent on the participants own behalf\n\nExclusion Criteria:\n\n1. Known allergy to intravenous iron\n2. Residing permanently at a nursing home\n3. Hematological conditions with a risk of iron overload e.g. haemochromatosis, hemosiderosis, or where alternative treatments are necessary e.g. haematological malignancies\n4. Other contraindication to iron treatment, e.g. severe liver cirrhosis and hepatitis\n5. Severe uncontrolled infection as assessed by the responsible clinician (e.g. bacteraemia or sepsis)\n6. Plasma sodium levels below 125 or above 150 mmol\u002FL on the day of inclusion\n7. Renal replacement therapy\n8. Severe dementia assessed by physician\n9. Recent intravenous iron injection, 4 weeks prior to surgery\n10. Patient declared terminally ill\n11. Pathologic Fracture","65 Years",{"count":98,"type":22},210,[62],"The primary aim of this clinical trial is to investigate the effects of intravenous iron on recovery in mobility compared to the pre-fracture level in patients with a hip fracture\n\nThe main questions it aims to answer are:\n\nIt is hypothesize that intravenous iron will enhance gains in mobility and hereby recovery of mobility, increase hemoglobin (Hgb), lower fatigue, have a positive effect on skeletal muscles in the weeks and months after administration.\n\nThe primary objective is to compare the effect of a single dose of ferric derisomaltose (FDI) (20 mg\u002Fkg body weight) relative to placebo on patients' recovery of functional mobility, measured as the change from baseline in the New Mobility Score.\n\nParticipants will:\n\n\\- Receive either a single dose of intravenous FDI (20 mg\u002Fkg body weight) (and saline) or placebo (saline) at 1-5 days after surgery.\n\nThis trial will be conducted at three hospitals in Denmark, involving an anticipated 210 participants.",[28,65],[69,65,103,104,105,106],"IV Iron","Mobility","Perioperative optimisation","Randomized Controlled Trial","RECRUITING","2026-05-29",{"date":110,"type":42},"2026-06-01",{"date":112,"type":42},"2025-06-09",{"date":114,"type":22},"2027-09-14",{"name":116,"class":86},"Soren Overgaard",3,{"id":119,"slug":120,"hasResults":11,"nctId":121,"briefTitle":122,"officialTitle":123,"acronym":124,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":126,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":129,"conditions":130,"keywords":132,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":50},"100639461","comparison-of-meta-peng-and-suprainguinal-fascia-iliaca-plane-block-in-hip-fractures-100639461","NCT07612761","Comparison of Meta-PENG and Suprainguinal Fascia Iliaca Plane Block in Hip Fractures","Comparison of the Effects of Ultrasound-Guided Meta-PENG Block and Suprainguinal Fascia Iliaca Plane Block in Patients Undergoing Hip Fracture Surgery Under Spinal Anesthesia","META-SIFI","Inclusion Criteria:\n\n* Age greater than 18 years\n* ASA physical status I-III\n* Scheduled to undergo hip fracture surgery under spinal anesthesia\n* Written informed consent obtained from the patient or the patient's legal representative\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* ASA physical status IV-V\n* Presence of central or autonomic nervous system disease\n* Known allergy to the drugs used in the study",{"count":127,"type":22},80,"OBSERVATIONAL","This prospective observational single-center study will compare the effects of ultrasound-guided meta-PENG block and suprainguinal fascia iliaca plane block in patients undergoing hip fracture surgery under spinal anesthesia.\n\nHip fracture surgery can cause significant pain before, during, and after the operation. Regional anesthesia techniques may help reduce pain, improve positioning for spinal anesthesia, decrease the need for additional analgesics, and support earlier mobilization.\n\nPatients included in the study will be adults scheduled for hip fracture surgery under spinal anesthesia. According to routine clinical practice and the anesthesiologist's decision, patients will receive either ultrasound-guided meta-PENG block or ultrasound-guided suprainguinal fascia iliaca plane block. The study will not assign patients to a treatment group by randomization.\n\nThe main outcome will be pain during positioning for spinal anesthesia, measured using the Numeric Rating Scale. Additional outcomes will include postoperative pain at rest and during activity, additional analgesic consumption, patient satisfaction, mobilization time, and length of hospital stay.",[28,131,32],"Postoperative Pain",[69,133,134,135,136],"Meta-PENG block","Suprainguinal fascia iliaca plane block","Postoperative analgesia","Regional anesthesia","2026-05-23",{"date":108,"type":42},{"date":140,"type":42},"2026-05-14",{"date":142,"type":22},"2026-12-31",{"name":144,"class":86},"Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital",{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":11,"sex":17,"minAge":58,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":23,"phases":154,"briefSummary":155,"conditions":156,"keywords":159,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":162,"lastUpdatePostDateStruct":163,"startDateStruct":165,"completionDateStruct":167,"leadSponsor":169,"locationsCount":170},"100588237","how-bleeding-affects-delirium-in-older-patients-with-hip-fractures-the-improve-hip-study-100588237","NCT06938789","How Bleeding Affects Delirium in Older Patients With Hip Fractures: The IMPROVE-HIP Study","The Impact of Bleeding on Delirium Outcomes in Older Patients With Hip Fractures: A Single-Blind, Randomized Controlled Trial - The IMPROVE-HIP Study","Inclusion Criteria:\n\n* Hip fracture\n\nExclusion Criteria:\n\n* Pathological hip fracture\n* Periprosthtic fracture\n* Unable to speak or understand Danish\n* Does not wish to recieve blood transfusion\n* If the investigator finds the patient unable to cooperate to the study (e.g. in case of severe dementia and externalizing behaviour)",{"count":153,"type":22},198,[25],"The goal of this clinical trial is to investigate whether early detection of bleeding and prompt blood transfusions can help prevent delirium in patients aged 75 and older who are admitted to the hospital with hip fractures. The main question the trial aims to answer is:\n\nDo patients aged 75 and older with hip fractures benefit from earlier treatment of anemia (low blood count) to reduce the risk of delirium?\n\nResearchers will compare early diagnosis and treatment of bleeding with standard care to determine if it helps lower the risk of developing delirium.\n\nParticipants will:\n\nUndergo blood tests, have their vital signs monitored, and be screened for delirium three times a day for the first 48 hours after surgery.\n\nReceive blood transfusions promptly if their hemoglobin levels fall below a specified threshold.\n\nAttend a follow-up visit at 30 days to assess cognitive function and overall quality of life.\n\nAttend another follow-up at 90 days to evaluate hospital readmissions and survival.",[157,28,158],"Bleeding","Delirium - Postoperative",[69,160,161],"Delirium","Blood transfusion","2026-05-19",{"date":164,"type":42},"2026-05-22",{"date":166,"type":42},"2025-04-24",{"date":168,"type":22},"2027-06-01",{"name":85,"class":86},2,{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":17,"minAge":96,"maxAge":4,"enrollmentInfo":178,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":180,"conditions":181,"keywords":4,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":170},"100563308","frailty-hip-fractures-and-inflammatory-biomarkers-100563308","NCT06614478","Frailty, Hip Fractures and Inflammatory Biomarkers","Frailty in Hip Fracture Patients Treated With Surgery; the Role of Simple Inflammatory Biomarkers. An Observational Study","Inclusion Criteria:\n\n* age \\>65 years, ASA PS I-III, non- institutionalized, able to communicate patients\n\nExclusion Criteria:\n\n* Patients with severe cognitive dysfunction, those treated conservatively, those with pathological fractures and patients who refused to participate",{"count":179,"type":22},200,"We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.",[182,28,183],"Frailty","Inflammatory Biomarkers","2026-05-03",{"date":186,"type":42},"2026-05-05",{"date":188,"type":42},"2023-04-01",{"date":190,"type":22},"2027-04-12",{"name":192,"class":86},"University of Thessaly",{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":11,"sex":17,"minAge":200,"maxAge":4,"enrollmentInfo":201,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":202,"conditions":203,"keywords":205,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":209,"lastUpdatePostDateStruct":210,"startDateStruct":212,"completionDateStruct":214,"leadSponsor":216,"locationsCount":50},"100629939","frailty-and-nottingham-hip-fracture-score-for-predicting-90-day-mortality-after-hip-fracture-surgery-100629939","NCT07481188","Frailty and Nottingham Hip Fracture Score for Predicting 90-Day Mortality After Hip Fracture Surgery","Incremental Prognostic Value of Frailty Beyond the Nottingham Hip Fracture Score for Predicting 90-Day Mortality After Hip Fracture Surgery: A Prospective Cohort Study","Inclusion Criteria:\n\n* Age 60 years or older\n* Admission for acute proximal femoral fracture (femoral neck, intertrochanteric, or subtrochanteric fracture)\n* Surgical treatment for hip fracture\n* Ability to obtain clinical data required for NHFS and frailty assessment\n\nExclusion Criteria:\n\n* Pathological fractures\n* Periprosthetic fractures\n* Hip fractures resulting from high-energy trauma or polytrauma\n* Non-operative treatment\n* Second hip fracture occurring in the same patient during the study period","60 Years",{"count":179,"type":22},"Hip fractures are serious injuries that occur mostly in older adults. Many people experience health problems or may die in the months after surgery. Doctors try to identify patients who have a higher risk of poor outcomes as early as possible.\n\nDoctors often use the Nottingham Hip Fracture Score (NHFS) to estimate the risk of death after hip fracture surgery. This score uses information such as age and other health conditions. However, it does not fully reflect how physically vulnerable a person may be.\n\nAnother important concept is frailty. Frailty describes how strong or weak a person's overall health and physical reserve are. In this study, frailty will be measured using the Clinical Frailty Scale (CFS). This scale evaluates a person's level of independence and physical function before the fracture.\n\nThe purpose of this study is to determine whether measuring frailty can improve the prediction of death after hip fracture surgery.\n\nOlder adults with hip fractures who undergo surgery will be invited to participate in the study. Researchers plan to include about 200 participants or all eligible patients enrolled within one year, whichever occurs first. Health information that is already collected during routine hospital care will be recorded. Frailty will be assessed when participants are admitted to the hospital.\n\nParticipants will be followed for 30 days and 90 days after surgery to determine survival status. Researchers will review hospital records and may contact participants or their relatives by phone if needed.\n\nThe results of this study may help doctors better identify patients at higher risk and improve care planning after hip fracture surgery.",[28,204,182],"Proximal Femur Fracture",[69,206,182,207,208],"Proximal femur fracture","Geriatric fracture","Mortality prediction","2026-03-25",{"date":211,"type":42},"2026-03-31",{"date":213,"type":42},"2026-03-15",{"date":215,"type":22},"2027-03-15",{"name":217,"class":86},"Trakya University",{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":223,"acronym":224,"eligibilityCriteria":225,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":226,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":227,"conditions":228,"keywords":236,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":4},"100625102","communication-for-early-mobilisation-of-people-living-with-dementia-following-surgery-for-hip-fracture-100625102","NCT07418268","Communication for Early Mobilisation of People Living With Dementia Following Surgery for Hip Fracture","Communication Practices to Achieve Early Mobilisation of People Living With Dementia Following Surgery for Hip Fracture: a Conversation Analytical Study ('VideOing to Improve Communication Through Education - Hip Fracture', VOICE-HF)","VOICE-HF","Inclusion Criteria:\n\nPatient participants will:\n\n* have a documented diagnosis of dementia\n* be either waiting for hip fracture surgery or have had hip fracture surgery within the previous 7 days\n* have someone who can act as their personal consultee, in case they are assessed as lacking capacity during the study.\n\nHCP participants will:\n\n* be registered, student or assistant healthcare practitioners\n* be involved in assessing, supporting or encouraging PLWD to mobilise post-hip fracture surgery\n* work on the relevant wards\n\nRelative and friend participants will:\n\n* Be visiting a consented patient at a time when an appropriate recording with consented HCPs will take place\n* Be a relative or friend of the consented patient who might normally be present during attempts to mobilise the patient after surgery\n\nExclusion Criteria:\n\n* Patients will be excluded if we are unable to gain informed consent or consultee agreement, or if they are expected to die within 7 days.",{"count":179,"type":22},"This goal of this study is to identify ways that healthcare professionals communicate that are effective in helping a person living with dementia to stand or walk after surgery for a broken hip (hip fracture). We aim to identify 'what works' in successfully helping people with dementia to mobilise early, and share this in practice. The main question the research aims to answer is:\n\nWhat healthcare professional communication practices are effective in achieving early and continued mobilisation among people living with dementia following hip fracture surgery?\n\nWe will use a research method called 'Conversation Analysis', to look at the fine detail of the language healthcare professionals use and responses to it. We will make video recordings of real-life ward care, when healthcare staff are trying to help a person with dementia get up early after hip fracture surgery. We will involve people with dementia in decisions to take part and get agreement from their families before we record anything. We have done this successfully in two previous studies. We will record up to 50 episodes of care on three trauma orthopaedic wards. We will identify specific, practical recommendations and 'teachable' approaches: ways of speaking, or sequences of requests or instructions. We will work with people with dementia, family carers, educators and clinicians to do this. We will use clips of videos in future communication training.",[229,28,230,231,232,233,234,235],"Dementia","Early Mobilisation","Communication Research","Communication","Communication Skills","Rehabilitation Frail Elderly Subjects","Rehabilitation Strategies for Elderly Post-operative Patients",[229,69,237,238,232,239],"Early mobilisation","Conversation analysis","Surgery","2026-02-10",{"date":242,"type":42},"2026-02-18",{"date":244,"type":22},"2026-02",{"date":246,"type":22},"2026-09",{"name":248,"class":86},"University of Nottingham",{"id":250,"slug":251,"hasResults":11,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":4,"eligibilityCriteria":255,"healthyVolunteers":11,"sex":17,"minAge":200,"maxAge":4,"enrollmentInfo":256,"targetDuration":4,"studyType":23,"phases":258,"briefSummary":259,"conditions":260,"keywords":265,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":275,"completionDateStruct":277,"leadSponsor":279,"locationsCount":50},"100623756","hope-theory-based-nursing-intervention-after-hip-fracture-surgery-100623756","NCT07400770","Hope Theory-Based Nursing Intervention After Hip Fracture Surgery","Effect of a Snyder Hope Theory-Based Nursing Intervention on Psychological Status, Pain, and Functional Recovery in Elderly Patients After Hip Fracture Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 60 years.\n* Patients with hip fracture requiring surgical intervention.\n* Patients who have undergone hip fracture surgery within the past 2 weeks.\n* Patients who are able to communicate and provide informed consent.\n* Patients and\u002For their family members who are willing to participate in the study.\n\nExclusion Criteria:\n\n* Patients with other lower limb fractures or history of lower limb thrombosis.\n* Patients with multiple fractures.\n* Patients with severe damage to major organs (heart, lungs, brain) or malignant tumors.\n* Patients who have undergone hip replacement surgery in the past.\n* Patients with infectious diseases or immune system disorders.\n* Patients with chronic diseases or neurological disorders.",{"count":257,"type":22},112,[25],"This is a randomized controlled trial to evaluate the effectiveness of a Snyder Hope Theory-based nursing intervention on elderly patients following hip fracture surgery. The study aims to improve the patient's psychological well-being, reduce pain, and enhance their functional recovery. Participants will be randomly assigned to either the intervention group or the control group. The intervention involves individualized counseling, goal setting, and rehabilitation training based on the Snyder Hope Theory. The trial will assess changes in hope levels, anxiety, pain, hip joint function, and quality of life before and after the intervention.",[28,261,262,263,264],"Elderly Patients","Postoperative Recovery","Nursing Interventions","Snyder Hope Theory",[266,267,268,269,270,271,272],"Hope Theory","Elderly Hip Fracture Surgery","Postoperative Nursing","Psychological Counseling","Rehabilitation Training","Pain Management, Anxiety","Quality of Life","2026-02-03",{"date":240,"type":42},{"date":276,"type":42},"2024-05-01",{"date":278,"type":22},"2026-11-30",{"name":280,"class":49},"Institute of Orthopaedic Surgery, Taizhou No.3 People's Hospital",{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":287,"eligibilityCriteria":288,"healthyVolunteers":11,"sex":17,"minAge":96,"maxAge":4,"enrollmentInfo":289,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":291,"conditions":292,"keywords":295,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":50},"100619912","prediction-of-mortality-and-morbidity-after-hip-fracture-using-monocyte-distribution-width-mdw-100619912","NCT07350785","Prediction of Mortality and Morbidity After Hip Fracture Using Monocyte Distribution Width (MDW)","The Role of Monocyte Distribution Width (MDW) and Other Inflammatory Biomarkers in the Prediction of Mortality and Morbidity in Patients With Hip Fracture","MDW","Inclusion Criteria:\n\n* Patients aged ≥65 years\n* Admission with low-energy hip fracture (femoral neck, intertrochanteric, or subtrochanteric fracture)\n* Admission to General Hospital of Attica KAT\n* Availability of baseline laboratory measurements, including complete blood count with monocyte distribution width (MDW) and inflammatory biomarkers\n\nExclusion Criteria:\n\n* Age \\\u003C65 years\n* High-energy trauma-related hip fractures\n* Pathological fractures",{"count":290,"type":22},100,"Hip fracture is a common injury in older adults and is often associated with serious complications, longer hospital stays, and increased risk of death. One of the most important causes of poor outcomes after hip fracture surgery is infection, including severe infections such as sepsis. Early identification of patients at higher risk for complications could help improve treatment and survival.\n\nThis study aims to examine whether a blood test parameter called Monocyte Distribution Width (MDW), along with other commonly used inflammatory markers, can help predict complications and survival in elderly patients with hip fracture. MDW is measured as part of a routine complete blood count and has shown promise in the early detection of infection and systemic inflammation.\n\nApproximately 100 patients aged 65 years or older who are admitted to the hospital with a low-energy hip fracture will be included in this study. Blood tests will be performed at hospital admission, after surgery, and at other time points as part of standard clinical care. These tests include routine blood counts and inflammatory markers such as C-reactive protein (CRP), procalcitonin (PCT), antithrombin III, and MDW. No additional invasive procedures are required beyond standard medical care.\n\nResearchers will collect information about each patient's medical history, overall health status, and daily activity level before the fracture. Patients will be followed after surgery to assess complications, length of hospital stay, and survival at 1 month, 3 months, and 1 year.\n\nThe results of this study may help determine whether MDW can be used as a simple and reliable marker to identify patients at higher risk of complications or death after hip fracture. This could support earlier intervention, closer monitoring, and improved care for elderly patients with hip fractures in the future.",[293,294,28],"Sepsis","Osteoporotic Hip Fracture",[296,297,183,298,299,300,301,302,28],"Monocyte Distribution Width (MDW)","Geriatric Patients","Postoperative Mortality","Postoperative Morbidity","C-reactive Protein","Procalcitonin","Antithrombin III","2026-01-10",{"date":305,"type":42},"2026-01-20",{"date":307,"type":42},"2024-12-01",{"date":309,"type":22},"2026-03-01",{"name":311,"class":86},"National and Kapodistrian University of Athens",{"id":313,"slug":314,"hasResults":11,"nctId":315,"briefTitle":316,"officialTitle":316,"acronym":317,"eligibilityCriteria":318,"healthyVolunteers":11,"sex":17,"minAge":96,"maxAge":4,"enrollmentInfo":319,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":321,"conditions":322,"keywords":326,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":50},"100616743","regional-versus-general-anesthesia-for-hip-fracture-and-postoperative-oxygenation-100616743","NCT07309575","Regional Versus General Anesthesia for Hip Fracture and Postoperative Oxygenation","REGENERATION","Inclusion Criteria:\n\n* hospital admission for hip fracture;\n* scheduled for hip fracture surgery;\n* age above 65 years, both genders;\n* capable of consent or consent by responsible person;\n\nExclusion Criteria:\n\n* hip fracture during hospitalization (not present upon admission)\n* patient refusal to participate",{"count":320,"type":22},102,"With this study, the investigators intend to measure oxygen saturation before and after hip surgery in the context of proximal femur fracture, comparing two types of anesthesia (general or spinal). The investigators also intend to study the effects of the two anesthetic techniques on sleep apnea, delirium, respiratory complications, and length of hospital stay.\n\nThis is an observational study, in which oxygen is measured at the fingertip with a sensor and a bracelet, without any intervention, inconvenience, or discomfort for the participant. Data will be collected on: respiratory complications, sleep apnea, delirium, length of hospital stay, and survival.\n\nData will be collected in the operating room and wards of Santa Maria Hospital, Lisbon, Portugal over a period of approximately 24 hours after the participant's operation. Information about participant's health and co-morbidities will be recorded.\n\nThere will be no implication for the participants' clinical care, since the study measurements will not be sent to the health professionals in charge. The operation, recovery, and treatments will not be influenced at any time by participation in the study.",[323,324,325],"Hip-fracture","General Anaesthesia","Regional Anaesthesia",[327,328,329,330,331],"anaesthesia","hip femur fracture","postoperative pulmonary complications","oxygenation","sleep apnea","2025-12-19",{"date":334,"type":42},"2025-12-30",{"date":336,"type":42},"2025-11-27",{"date":338,"type":22},"2026-12",{"name":340,"class":86},"University of Lisbon",{"id":342,"slug":343,"hasResults":11,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":347,"eligibilityCriteria":348,"healthyVolunteers":11,"sex":17,"minAge":96,"maxAge":4,"enrollmentInfo":349,"targetDuration":4,"studyType":23,"phases":351,"briefSummary":353,"conditions":354,"keywords":358,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":369,"leadSponsor":371,"locationsCount":50},"100601668","phase-3-remimazolam-vs-midazolam-for-sedation-and-cognitive-outcomes-in-orthopedic-surgery-100601668","NCT07113483","Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery","Randomized, Double-Blind, 2x2 Factorial Trial of Remimazolam vs. Midazolam on Sedation and Early Cognitive Outcomes in Patients Undergoing Traumatic or Non-Traumatic Orthopedic Surgery With Regional Anesthesia","REMIND-ORTHO","Inclusion Criteria:\n\n* Adults aged 65 years or older.\n* Scheduled for traumatic or non-traumatic orthopedic surgery under regional anesthesia.\n* Able to provide informed consent or have a legally authorized representative provide consent.\n\nExclusion Criteria:\n\n* Patient refusal to participate.\n* Mini-Cog score less than 3 (indicative of significant cognitive impairment).\n* Severe hepatic or renal failure.\n* Known allergy to benzodiazepines or propofol.\n* History of benzodiazepine dependence.",{"count":350,"type":22},120,[352],"PHASE3","This study aims to compare two medications, Remimazolam and Midazolam, used for sedation during orthopedic surgeries performed under regional anesthesia. We want to find out which medication provides better sedation during the procedure and which one affects early recovery of brain function after surgery.\n\nOlder adults (65 years and above) undergoing surgery for bone injuries or conditions will participate. We will monitor their sedation levels, blood pressure, heart rate, side effects, and how quickly they recover after surgery. We also want to see if either medication causes fewer problems with thinking and memory shortly after surgery.\n\nThe study is designed so neither the patients nor the medical staff know which medication is being given, to ensure unbiased results. Participants will be randomly assigned to receive either Remimazolam or Midazolam.\n\nThe information gathered will help doctors choose the safest and most effective sedative for older patients undergoing orthopedic surgeries, potentially improving patient comfort and recovery.",[355,356,357,28],"Postoperative Cognitive Dysfunction","Orthopedic Procedures","Postoperative Pain Management",[359,360,32,361,362,363,364],"Remimazolam","Midazolam","Sedation","Cognitive dysfunction","Elderly patients","Trauma","2025-09-26",{"date":367,"type":42},"2025-10-01",{"date":367,"type":22},{"date":370,"type":22},"2026-02-15",{"name":372,"class":86},"Romanian Society for Enteral and Parenteral Nutrition",{"id":374,"slug":375,"hasResults":11,"nctId":376,"briefTitle":377,"officialTitle":378,"acronym":379,"eligibilityCriteria":380,"healthyVolunteers":11,"sex":17,"minAge":96,"maxAge":4,"enrollmentInfo":381,"targetDuration":4,"studyType":23,"phases":383,"briefSummary":384,"conditions":385,"keywords":386,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":393,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":50},"100608488","effectiveness-of-the-delirium-zero-protocol-to-prevent-the-onset-of-delirium-in-patients-undergoing-hip-fracture-surgery-100608488","NCT07202208","Effectiveness of the Delirium Zero Protocol to Prevent the Onset of Delirium in Patients Undergoing Hip Fracture Surgery","Effectiveness of the Delirium Zero Protocol to Prevent the Onset of Delirium in Patients Undergoing Hip Fracture Surgery: Randomized Clinical Trial","DZ","Inclusion Criteria:\n\n* The participants will be patients over 65 years old\n* Admitted to the orthopedic hospitalization units of the La Fe University and Polytechnic Hospital (La Fe health department, Valencia, Spain).\n* Who are undergoing surgery for hip fracture\n* Accompanied by a family member\u002Fcaregiver who understands Spanish and knows how to read and write it.\n\nExclusion Criteria:\n\n* Have previously been diagnosed with severe cognitive impairment according to the Pfeiffer scale, which corresponds to a score of 8-10 points.\n* Have previously been diagnosed with any serious mental disorder (schizophrenic disorders, schizotypal disorders, persistent delusional disorders, substance-induced delusional disorders, schizoaffective disorders, other non-organic psychotic disorders, bipolar disorder, serious depressive episode with psychotic symptoms, and severe recurrent depressive disorders). - that they have delirium at the time of admission to the trauma room.\n* That they have a language barrier, deep aphasia, coma, or terminal illness.\n* That they have been previously enrolled in this study.\n* That before the surgery they were admitted to a different hospital unit than those participating in the study, although they may then be transferred to one of these trauma units.\n* That before entering the trauma hospitalization unit, they have been in the emergency room for more than 36 hours.\n* That they present brain alterations (tumors, occupying lesions).",{"count":382,"type":22},140,[25],"The main objective of this research will be to investigate whether the control of care provided by the family\u002Fcaregiver can prevent the onset of delirium in individuals undergoing surgical intervention for hip fracture.\n\nThe research will be a randomized, single-blind, parallel, two-arm clinical trial that compares two conditions: intervention group, hereafter IG (Delirium Zero protocol based on a space-temporal orientation poster for the patient, a clock hung on the wall next to the orientation poster, and a checklist for the preventive measures taken by the caregiver\u002Ffamily), and control group, hereafter CG (standard of care).\n\nThe participants will be patients over 65 years old, admitted to the trauma hospitalization units of the La Fe University and Polytechnic Hospital (La Fe Health Department, Valencia, Spain), operated on for hip fracture and accompanied by a relative\u002Fcaregiver.\n\nThe research will be carried out at the La Fe University and Polytechnic Hospital (La Fe Health Department, Valencia, Spain) because it is the reference hospital for the Valencian Community, and because the rooms in this center are private, which allows for no interference between the intervention under study (in GI) or the standard care (GC).",[28,158],[387,388,389,390,160,391],"hip fracture","Family","Care","Care Protocol","Caregiver","2025-09-23",{"date":367,"type":42},{"date":395,"type":42},"2025-01-15",{"date":397,"type":22},"2028-07-31",{"name":399,"class":86},"Cardenal Herrera University",{"id":401,"slug":402,"hasResults":11,"nctId":403,"briefTitle":404,"officialTitle":404,"acronym":405,"eligibilityCriteria":406,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":407,"targetDuration":4,"studyType":23,"phases":409,"briefSummary":410,"conditions":411,"keywords":412,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":50},"100606629","remote-ischaemic-conditioning-for-post-surgical-complications-in-hip-fracture-ric-fracture-100606629","NCT07178041","Remote Ischaemic Conditioning for Post-surgical Complications in Hip Fracture (RIC-FRACTURE)","RIC-FRACTURE","Inclusion Criteria:\n\n* Adults (aged \\> 18 years)\n* Participant has had a hip fracture identified on X-ray or computed tomography (CT) scan.\n* Qualifying hip fracture has not occurred more than 7 days prior to enrollment.\n* Able to give written informed consent.\n* In the opinion of the treating physician would be able to conform to the study protocol and procedures.\n\nExclusion Criteria:\n\n* History or presence of significant peripheral vascular disease in the limb conditioned.\n* History or presence of complex neuropathic pains or peripheral neuropathy in the limb conditioned.\n* Presence of lymphoedema in the limb conditioned.\n* Presence of skin ulceration to the limb conditioned.\n* Uncontrolled arrhythmia, hypertension, diabetes or angina.\n* Third degree heart block or progressive heart failure.\n* Acute aortic dissection, myocarditis, or pericarditis.\n* Acute deep vein thrombosis, pulmonary embolism.\n* Suspected or known dissecting aneurysm.\n* Stroke or TIA myocardial infarction in the last 4 weeks.",{"count":408,"type":22},12,[25],"Background Hip fracture affects 70,000 people in the United Kingdom (UK) and costs an estimated £1.1 billion per year to the National Health Service (NHS). Key clinical indicators, such as early surgical repair, have been shown to improve patient outcomes, however morbidity and mortality remain extremely high, reflecting the urgent need for novel therapies to enhance outcomes. Common complications include infection, cardiovascular events, falls and venous thromboembolism. Remote Ischaemic Conditioning (RIC) is a treatment whereby a blood pressure cuff is inflated around an arm or leg to above systolic pressures to occlude blood flow to the limb for short periods of time, that do not result in harm, but trigger innate mechanisms that reduce inflammation, improve organ blood flow and improve bone healing. These may be beneficial effects after hip fracture.\n\nMethods This is a single centre, feasibility study; the participants will receive RIC daily for 40 minutes for 10 days during their inpatient stay. Outcome measures relating primarily to safety, tolerability and feasibility will be collected along with compliance with the intervention. Study feasibility will be determined by success criteria based on recruitment, outcome measure assessment compliance with intervention and follow up.\n\nSecondary outcomes including inpatient mortality, inpatient complications, length of inpatient stay, blood pressure, serum inflammatory and stress markers and functional recovery will also be collected at discharge and 3 month follow up.\n\nResults Data collected on safety, tolerability, and feasibility will be presented descriptively and simple analysis of variance will be undertaken on quantitative data such as blood pressure and serum inflammatory and stress markers between baseline and follow up time points. The study will hopefully establish whether this therapy is feasible to deliver after acute hip fracture.",[28],[28,413],"Remote ischaemic conditioning","2025-09-16",{"date":416,"type":42},"2025-09-17",{"date":418,"type":42},"2024-08-02",{"date":420,"type":22},"2025-12-31",{"name":422,"class":86},"Sheffield Teaching Hospitals NHS Foundation Trust",{"id":424,"slug":425,"hasResults":11,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":4,"eligibilityCriteria":429,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":430,"targetDuration":4,"studyType":23,"phases":432,"briefSummary":433,"conditions":434,"keywords":436,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":444,"startDateStruct":446,"completionDateStruct":448,"leadSponsor":450,"locationsCount":50},"100596483","peng-block-continuous-infusion-vs-programmed-intermittent-bolus-in-neck-of-femur-fracture-100596483","NCT07046052","PENG Block: Continuous Infusion vs. Programmed Intermittent Bolus in Neck of Femur Fracture","A Double Blind Randomised Controlled Trial Comparing Continuous Infusion vs. Programmed Intermittent Bolus Via a Pericapsular Nerve Group (PENG) Catheter for Post Operative Fractured Neck of Femur Analgesia","Inclusion Criteria:\n\n* English-speaking\n* over the age of 18 years\n* hemiarthroplasty for fractured neck of femur\n* able to provide written consent.\n\nExclusion Criteria:\n\n* under 50kg body weight.\n* unable to provide consent due to incapacity\n* pregnant women\n* vulnerable adults under state guardianship\n* Patients with pre-existing chronic pain disorders or with a history of long-term opioid use\n* those with contraindications to a peripheral nerve block such as local site infection, allergy to local anaesthetic or those who are coagulopathic",{"count":431,"type":22},150,[25],"Pericapsular Nerve Group Block (PENG) is an effective regional anaesthesia modality in providing analgesia following neck of femur fracture. Continuous PENG techniques, using indwelling catheters and infusions of local anaesthetic, facilitate the continuation of analgesia for a number of days following hip fracture surgery. It is unclear from the published literature whether an optimal strategy of local anaesthetic delivery has been characterized.\n\nSimilar doses of local anaesthetic agents can be administered by either continuous infusion or timed intermittent bolus. It is unclear whether one dosing strategy is superior to the other in the context of hip fracture analgesia. The study aims to evaluate the clinical efficacy of both dosing strategies in patients undergoing hip fracture surgery.",[28,435],"Analgesia Post Fracture",[387,437,438,439,440,441,442],"regional anaesthesia","analgesia","peng block","continuous infusion","programmed intermittent bolus","randomised controlled trial","2025-06-22",{"date":445,"type":42},"2025-07-01",{"date":447,"type":42},"2024-03-28",{"date":449,"type":22},"2026-01-07",{"name":451,"class":86},"University College Cork",{"id":453,"slug":454,"hasResults":11,"nctId":455,"briefTitle":456,"officialTitle":457,"acronym":458,"eligibilityCriteria":459,"healthyVolunteers":11,"sex":17,"minAge":200,"maxAge":4,"enrollmentInfo":460,"targetDuration":4,"studyType":23,"phases":462,"briefSummary":463,"conditions":464,"keywords":465,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":471,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":476,"locationsCount":50},"100471936","phase-4-intravenous-vs-oral-acetaminophen-in-postoperative-hip-fracture-adult-patients-100471936","NCT05425355","Intravenous vs Oral Acetaminophen in Postoperative Hip Fracture Adult Patients","INTACT-HIP: INTravenous Acetaminophen vs. Oral Randomized Controlled Trial in HIP Fracture Patients - a Feasibility Trial","INTACT-HIP","Inclusion Criteria:\n\n* 60 years of age and older\n* Patients who were ambulating without human assistance before fracture, with any type of non-neoplastic hip fracture\n* Patients undergoing surgical treatment as an inpatient\n\nExclusion Criteria:\n\n* Patients with neoplastic hip fracture\n* Severe cognitive impairment (Montreal Cognitive Assessment (MoCA) \\\u003C10)\n* Pre-existing delirium\n* Known hypersensitivity or allergy to acetaminophen\n* Severe or chronic liver or kidney dysfunction\n* Planned postoperative ventilation\n* Swallowing issues and\u002For dysphagia\n* English language limitation\n* Weight \\\u003C50kg",{"count":461,"type":22},42,[62],"The INTACT-HIP trial study will evaluate feasibility of conducting a randomized, double-blinded controlled trial comparing postoperative treatment with intravenous (IV) acetaminophen versus oral acetaminophen, in older adults undergoing hip fracture surgery.\n\nThe results of this feasibility trial will be used to inform designing a larger, multi-center, randomized controlled trial to assess the efficacy of IV acetaminophen compared to oral acetaminophen to reduce delirium and improve other clinical and patient-centered outcomes after hip fracture surgery. It will randomize 42 older adults to receive either oral or IV acetaminophen after hip fracture surgery.",[323,239],[466,467,468,469],"elderly","acetaminophen","oral vs intravenous","hip fracture surgery","2025-05-23",{"date":472,"type":42},"2025-05-30",{"date":474,"type":42},"2023-01-23",{"date":41,"type":22},{"name":477,"class":86},"University Health Network, Toronto",{"id":479,"slug":480,"hasResults":11,"nctId":481,"briefTitle":482,"officialTitle":483,"acronym":4,"eligibilityCriteria":484,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":485,"targetDuration":4,"studyType":23,"phases":487,"briefSummary":488,"conditions":489,"keywords":491,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":496,"lastUpdatePostDateStruct":497,"startDateStruct":499,"completionDateStruct":500,"leadSponsor":502,"locationsCount":4},"100592101","ultrasound-guided-peng-block-vs-femoral-nerve-block-for-analgesia-before-spinal-anesthesia-in-hip-fracture-surgery-100592101","NCT06989047","Ultrasound-Guided PENG Block vs Femoral Nerve Block for Analgesia Before Spinal Anesthesia in Hip Fracture Surgery","Comparative Study of Preoperative Ultrasound-Guided Pericapsular Nerve Group Block and Femoral Nerve Block for Analgesia Before Spinal Anesthesia in Proximal Femur Fracture Fixation","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Scheduled for proximal femur fracture fixation under spinal anesthesia\n* Classified as American Society of Anesthesiologists (ASA) physical status I, II, or III\n* Ability to understand and use the Visual Analog Scale (VAS)\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Coagulopathy\n* Local infection at the injection site\n* Known allergy to local anesthetics or magnesium sulfate\n* Severe cardiopulmonary disease \\[American Society of Anesthesiologists (ASA) ≥ IV\\]\n* Preexisting diabetic or other neuropathies\n* Chronic opioid use\n* Contraindication to spinal anesthesia\n* Cognitive impairment or inability to comprehend Visual Analog Scale (VAS)",{"count":486,"type":22},60,[25],"This study will compare two types of ultrasound-guided nerve blocks-Pericapsular Nerve Group (PENG) block and Femoral Nerve Block (FNB)-to evaluate their effectiveness in reducing pain before spinal anesthesia in patients who will undergo surgery for proximal femur fractures. Proximal femur fractures will continue to be common, especially in older adults, and often will cause severe pain that will make it difficult to position patients for spinal anesthesia. Both nerve blocks will aim to reduce pain, improve comfort during spinal anesthesia, and decrease the need for postoperative pain medication.\n\nA total of 60 adult patients who will undergo proximal femur fracture fixation under spinal anesthesia will be enrolled and randomly assigned to receive either a Pericapsular Nerve Group (PENG) block or a femoral nerve block before the procedure. The study will monitor patients' pain scores using the Visual Analog Scale (VAS) at multiple time points, including during positioning and throughout the first 24 hours after surgery. It also will evaluate how long it will take before the patients require rescue pain medication, and how much total pain medication will be needed.",[204,28,490,34],"Pain Management",[492,493,494,34,495,32],"Pericapsular Nerve Group Block (PENG)","Femoral Nerve Block (FNB)","Ultrasound-Guided Nerve Block","Hip Surgery","2025-05-16",{"date":498,"type":42},"2025-05-25",{"date":472,"type":22},{"date":501,"type":22},"2026-05-30",{"name":503,"class":86},"Ain Shams University",{"id":505,"slug":506,"hasResults":11,"nctId":507,"briefTitle":508,"officialTitle":509,"acronym":4,"eligibilityCriteria":510,"healthyVolunteers":11,"sex":17,"minAge":511,"maxAge":512,"enrollmentInfo":513,"targetDuration":4,"studyType":23,"phases":514,"briefSummary":515,"conditions":516,"keywords":519,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":523,"lastUpdatePostDateStruct":524,"startDateStruct":526,"completionDateStruct":528,"leadSponsor":530,"locationsCount":4},"100583641","comparison-of-peng-block-and-sificb-in-hip-fracture-surgeries-100583641","NCT06878963","COmparison of PENG Block and SIFICB in Hip Fracture Surgeries","Comparison of the Effects of Pericapsular Nerve Group Block and Suprainguinal Fascia Iliaca Compartment Block on Neuraxial Anesthesia Positioning and Postoperative Analgesia in Hip Fracture Surgeries","Inclusion Criteria:\n\n* Hip fractures\n* 40-80 years\n\nExclusion Criteria:\n\n* Contraindicated to spinal anesthesia\n* allergy to local anesthetics\n* severe peripheral neuropathy\n* mental disorders","40 Years","80 Years",{"count":431,"type":22},[25],"The aim of this study is to compare the effectiveness of the PENG block and SIFIB in facilitating the positioning for neuroaxial anesthesia and their impact on the quality of postoperative analgesia.",[28,517,518],"Pericapsular Nerve Group Block (PENG Block)","Suprainguinal Fasya Iliaca Block",[69,520,521,522],"Pericapsular nerve group block","Suprainguinal fasya iliaca block","Patient positioning","2025-03-11",{"date":525,"type":42},"2025-03-17",{"date":527,"type":22},"2025-04-01",{"date":529,"type":22},"2025-10-15",{"name":531,"class":86},"Adiyaman University Research Hospital",{"id":533,"slug":534,"hasResults":11,"nctId":535,"briefTitle":536,"officialTitle":536,"acronym":4,"eligibilityCriteria":537,"healthyVolunteers":538,"sex":17,"minAge":96,"maxAge":4,"enrollmentInfo":539,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":540,"conditions":541,"keywords":4,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":546,"lastUpdatePostDateStruct":547,"startDateStruct":549,"completionDateStruct":551,"leadSponsor":552,"locationsCount":50},"100578985","is-the-crp-albumin-lymphocyte-cally-index-effective-in-predicting-postoperative-delirium-in-geriatric-patients-undergoing-hip-fracture-surgery-100578985","NCT06818409","Is the CRP-Albumin-Lymphocyte (CALLY) Index Effective in Predicting Postoperative Delirium in Geriatric Patients Undergoing Hip Fracture Surgery","Inclusion Criteria:\n\n* Patients aged 65 years and older who undergo surgery for femoral neck or intertrochanteric fractures\n\nExclusion Criteria:\n\n* Patients with preoperative delirium\n* Patients with preoperative dementia\n* Patients with pathological fractures\n* Patients with open fractures\n* Patients with systemic or localized infections in the fracture region during the preoperative period\n* Patients with multiple trauma\n* Patients with a BMI \\\u003C18.5 or ≥35\n* Patients with chronic organ failure\n* Patients with advanced-stage cancer",true,{"count":290,"type":22},"Introduction: Postoperative delirium (POD) is a common complication in elderly surgical patients and is significantly associated with prolonged hospital stays, cognitive impairment, functional decline, and increased mortality rates within 6 to 12 months. Its incidence has been reported to range between 10% and 70%, depending on the diagnostic criteria used, the population studied, and the type of surgical procedure performed. The incidence is particularly higher following vascular, cardiac, and hip fracture surgeries.\n\nAccording to the 2024 updated guidelines by the European Society of Anaesthesiology and Intensive Care (ESAIC), POD should be screened at least once daily for a minimum of three days, beginning in the post-anesthesia recovery unit, based on the DSM-5 criteria. POD is a complex syndrome associated with various phenotypes and is likely the result of a combination of neuroinflammatory and oxidative stress processes.\n\nCandidate biomarkers for POD include inflammatory parameters (such as interleukins, C-reactive protein \\[CRP\\], erythrocyte sedimentation rate, and CD68), dopamine receptors, norepinephrine levels, cortisol levels, genetic biomarkers (e.g., apolipoprotein E4), acetylcholinesterase levels, and albumin levels. However, systemic stress can lead to nonspecific activation of the immune system, resulting in a decrease in lymphocyte count.\n\nAlthough the relationships between CRP, albumin, and lymphocyte count with POD have been individually investigated in the literature, no study has examined the combined effect of these three parameters. Based on this, we aimed to investigate whether the CRP-Albumin-Lymphocyte (CALLY) Index, a novel index not previously reported in the literature, is effective in predicting POD in geriatric patients with hip fractures. The CALLY Index is calculated using the formula: (Albumin × Lymphocyte) \u002F (CRP × 10⁴).\n\nAim\u002FHypothesis:\n\nH₀: The CALLY Index cannot predict the risk of postoperative delirium in geriatric patients undergoing hip fracture surgery.\n\nH₁: The CALLY Index can predict the risk of postoperative delirium in geriatric patients undergoing hip fracture surgery.\n\nMaterial-Methods:\n\nThe following data will be recorded for each patient:\n\n* Demographic variables: age, sex, height, weight, and body mass index (BMI)\n* American Society of Anesthesiologists (ASA) physical status classification\n* Comorbidities and medication use\n* Smoking and alcohol consumption history\n* Preoperative laboratory parameters: obtained from the hospital information system for CALLY Index calculation\n* Perioperative variables: type and duration of anesthesia, duration of surgery, type of surgical procedure, estimated blood loss, blood product transfusion status, and occurrence of intraoperative adverse events\n* Postoperative data:\n* Ward of admission after surgery (orthopedic ward\u002Fintensive care unit)\n* Presence of delirium, assessed twice daily (morning and evening) for three days using DSM-5 criteria, starting in the post-anesthesia recovery unit\n* Occurrence of postoperative complications\n* Length of stay in the intensive care unit\n* Total hospital length of stay\n* Mortality status\n\nPatients aged 65 years and older who undergo surgery for femoral neck or intertrochanteric fractures will be included in the study. Patients with preoperative delirium, preoperative dementia, pathological or open fractures, systemic or localized infections in the fracture region during the preoperative period, or multiple trauma will be excluded. Additionally, those with a BMI \\\u003C18.5 or ≥35 chronic organ failure, or advanced-stage cancer will be excluded from the study.",[542,28,543,544,545],"Postoperative Delirium (POD)","CRP","Albumin","Lymphocyte","2025-02-12",{"date":548,"type":42},"2025-02-14",{"date":550,"type":42},"2025-02-06",{"date":420,"type":22},{"name":553,"class":49},"Ankara Ataturk Sanatorium Training and Research Hospital",{"id":555,"slug":556,"hasResults":11,"nctId":557,"briefTitle":558,"officialTitle":559,"acronym":4,"eligibilityCriteria":560,"healthyVolunteers":11,"sex":17,"minAge":96,"maxAge":4,"enrollmentInfo":561,"targetDuration":4,"studyType":128,"phases":4,"briefSummary":563,"conditions":564,"keywords":567,"overallStatus":107,"whyStopped":4,"lastUpdateSubmitDate":573,"lastUpdatePostDateStruct":574,"startDateStruct":575,"completionDateStruct":576,"leadSponsor":577,"locationsCount":50},"100576345","relationship-between-fracture-type-and-preoperative-nutritional-status-with-postoperative-pain-100576345","NCT06784089","Relationship Between Fracture Type and Preoperative Nutritional Status with Postoperative Pain","Relationship Between Fracture Type and Preoperative Nutritional Status with Postoperative Pain and Prognosis in Geriatric Hip Surgery","Inclusion Criteria:\n\n* Patients undergoing hip surgery\n* Patients with informed consent\n* Patients over the age of 65\n* Patients undergoing surgery with spinal anesthesia\n* Patients evaluated in the ASA (American Society of Anesthesiologist) 1-2-3 category\n* Those with a body mass index (BMI) between 18-35\n\nExclusion Criteria:\n\n* Patients with ASA 4 and above\n* Patients under the age of 65\n* Those with a BMI below 18 and above 35,\n* Patients with systemic inflammatory diseases,\n* Patients using continuous anti-inflammatory\u002Fanalgesic drugs,\n* Patients with chronic pain before surgery,\n* Those with pathological fractures,\n* Multiple traumas\n* Those with end-stage disease (malignancy),\n* Severe renal failure, gastrointestinal ulceration or severe asthma that prevents the use of standard analgesia protocol\n* Patients who have previously had hip surgery on the same side\n* Patients who want to have surgery with general anesthesia\n* Patients who need general anesthesia in addition to spinal anesthesia\n* Those with a history of Pulmonary Thromboembolism",{"count":562,"type":22},95,"The geriatric patient group is a population that should be considered differently than other age groups due to physiological characteristics that change with age. When literature data is examined, it is seen that patients over the age of 65 are evaluated differently in studies. The rapid aging of the general population causes more elderly patients to need surgery. However, malnutrition is a common comorbidity in surgical patients . In addition, chronic diseases, multiple drug addiction, low nutritional intake, decreased appetite and psychological conditions seen in geriatric patients are risk factors for the development of nutritional deficiencies . Therefore, it is important to specifically consider geriatric patients, who frequently have these risk factors, in terms of malnutrition and to evaluate the nutritional status of these patients before surgery. It is estimated that the prevalence of malnutrition in hospitalized geriatric patients varies between 30% and 60%, depending on the population studied and the assessment tools applied . Despite these high malnutrition rates, this issue has not received sufficient clinical attention. Furthermore, malnutrition is highly associated with the prognosis of elderly perioperative patients, which may lead to poor clinical outcomes, increased morbidity and mortality, complication rates, decreased quality of life, prolonged hospital stay, and increased hospital and healthcare costs. A number of different screening tools are currently available to assess nutritional status in the elderly. However, there is currently no gold standard. The Nutrition Risk Score 2002 (NRS2002) is a nutritional screening tool for adult inpatients, launched in 2002 by the European Society of Clinical Nutrition and Metabolism (ESPEN). The Mini Nutritional Assessment - Short Form (MNA-SF), recommended by the European Union, and the Geriatric Nutrition Risk Index (GNRI), which has recently been evaluated as a new screening tool, has been validated for the diagnosis of malnutrition and the prediction of clinical outcomes, and is based on objective measurements that do not require patient cooperation, and whose validity has been demonstrated in other studies for the prediction of short- and long-term outcomes. In addition, the Prognostic Nutrition Index (PNI) is an indicator used to assess the nutritional status of surgical patients, estimate the risk of surgery, and make prognostic judgments. Although it has been stated that all four nutritional screening tools mentioned above can be used as prognostic indicators in geriatric surgical patients, the relationship between these screening tools and postoperative pain, complications, and hospital stay in geriatric patients undergoing orthopedic hip surgery has not yet been evaluated.\n\nHip fracture is a painful event that is frequently seen in older adults. Hip fractures are generally classified as femoral head fracture, femoral neck fracture, intertrochanteric fracture, and subtrochanteric fracture. Hip fracture is treated with proximal femoral nailing, partial hip replacement, and total hip replacement surgeries. Studies have reported that patients experience very high rates of moderate to severe pain following hip fracture surgery. This situation shows that the approach to pain management in hip surgery is still inadequate and that investigators need different perspectives on postoperative pain in these patients. It is known that hip fracture is associated with serious morbidity, mortality, and disability in the elderly. Inadequate pain management in these patients is associated with low motivation and has a high impact on functional recovery. Therefore, adequate pain management is important in patients with hip fractures to prevent mental and physical complications and to ensure appropriate compliance with rehabilitation. It is known that pain is affected by many factors such as biophysiological, biochemical, demographic, psychosocial, behavioral and moral variables and age. It is known that unmanaged postoperative pain will significantly affect cardiopulmonary and thromboembolic complications, morbidity and mortality, hospital discharge, quality of life and daily activities. In this context, determining the factors that predict acute pain will allow earlier intervention. Thus, short- and long-term morbidity, medication use, hospital stay and, accordingly, healthcare expenses will be reduced.This study aimed to evaluate the relationship between preoperative hip fracture type, surgery type, nutritional status and postoperative pain and prognosis (complications and hospital stay) in geriatric patients who will undergo hip surgery due to hip fracture. Secondly, it was aimed to determine which of the above-mentioned nutritional risk screening tools would be more appropriate in these patients and which nutritional risk screening tool could predict postoperative pain and prognosis in patients who will undergo hip surgery.",[565,131,28,566],"Nutrition","Geriatric",[568,569,570,571,572],"nutritional status","hip surgery.","geriatric patients","postoperative pain","postoperative prognosis","2025-02-11",{"date":546,"type":42},{"date":395,"type":42},{"date":334,"type":22},{"name":553,"class":49},{"id":579,"slug":580,"hasResults":11,"nctId":581,"briefTitle":582,"officialTitle":583,"acronym":584,"eligibilityCriteria":585,"healthyVolunteers":11,"sex":17,"minAge":96,"maxAge":19,"enrollmentInfo":586,"targetDuration":4,"studyType":23,"phases":587,"briefSummary":588,"conditions":589,"keywords":591,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":594,"lastUpdatePostDateStruct":595,"startDateStruct":597,"completionDateStruct":599,"leadSponsor":601,"locationsCount":50},"100560862","assessing-the-effectiveness-and-safety-of-pericapsular-nerve-group-peng-block-in-hip-fracture-patients-on-antithrombotic-therapy-100560862","NCT06582667","Assessing the Effectiveness and Safety of Pericapsular Nerve Group (PENG) Block in Hip Fracture Patients on Antithrombotic Therapy","Assessing the Effectiveness and Safety of Pericapsular Nerve Group (PENG) Block in Hip Fracture Patients on Antithrombotic Therapy: A Randomized Controlled Trial","PENG Block","Inclusion Criteria:\n\n* Age 65 years or older\n* diagnosis of hip fracture\n* scheduled for surgical intervention within 48 hours\n* Informed consent obtained.\n\nExclusion Criteria:\n\n* Allergy to local anesthetics,\n* Contraindications to the PENG block\n* inability to provide informed consent.",{"count":290,"type":22},[25],"PENG block will be done on patients with hip fracture either receiving antithrombotic therapy or not under ultrasound guidance",[28,590,584],"Antithrombotic Therapy",[592,593],"antithrombotic therapy","PENG block","2024-08-30",{"date":596,"type":42},"2024-09-03",{"date":598,"type":22},"2024-09-17",{"date":600,"type":22},"2025-04-17",{"name":602,"class":86},"Alexandria University"]