[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hip-replacement-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hip-replacement-surgery":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100512299","phase-4-mini-dose-dexmedetomidine-esketamine-infusion-and-perioperative-sleep-quality-100512299",false,"NCT05950646","Mini-dose Dexmedetomidine-Esketamine Infusion and Perioperative Sleep Quality","Effect of Mini-dose Dexmedetomidine-Esketamine Infusion on Sleep Quality in Older Patients Undergoing Knee or Hip Replacement Surgery: A Multicenter Randomized Controlled Trial","Inclusion Criteria:\n\n* Age ≥65 years and \\\u003C90 years;\n* Scheduled to undergo unilateral knee or hip arthroplasty.\n\nExclusion Criteria:\n\n* Refuse to participate;\n* Hypnotic therapy for sleep disorders within 3 months;\n* Preoperative history of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis;\n* Diagnosed as obstructive sleep apnea, or at high risk of moderate to severe obstructive sleep apnea according to the Stop-Bang questionnaire;\n* Inability to communicate in the preoperative period because of coma, profound dementia, or language barrier;\n* Sick sinus syndrome, severe sinus bradycardia (heart rate \\\u003C50 beats\u002Fmin), or atrioventricular block above grade II without pacemaker implanted;\n* Severe hepatic dysfunction (Child-Pugh class C), renal dysfunction (required preoperative dialysis), or expected survival ≤24 hours;\n* Receiving treatment with dexmedetomidine, clonidine, or esketamine;\n* Allergy to dexmedetomidine or esketamine.","ALL","65 Years","90 Years",{"count":20,"type":21},154,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Sleep disturbances are prevalent in older patients with osteoarthrosis or fracture who are scheduled for knee or hip replacement surgery. The occurrence of sleep disturbances is associated with worse outcomes including increased risk of delirium and cardiac events, and worsened functional recovery. Dexmedetomidine is a highly selective α2-adrenergic agonist with sedative, anxiolytic, and analgesic properties. It exerts sedative effects via activating the endogenous sleep pathways and produces a state like non-rapid eye movement sleep, which is different from opioid- and benzodiazepine-induced sedation. Esketamine is a N-methyl-D-aspartic acid receptor antagonist and has been used as an anesthetic and analgesic. Recent studies showed that low-dose esketamine has anti-depressive and sleep-promoting effects. The investigators suppose that mini-dose dexmedetomidine-esketamine combined infusion at night can improve perioperative sleep quality in patients scheduled for knee or hip replacement surgery.",[27,28,29,30,31,32],"Old Age","Knee Replacement Surgery","Hip Replacement Surgery","Dexmedetomidine","Esketamine","Sleep Quality",[27,28,29,30,31,32],"RECRUITING","2025-07-29",{"date":37,"type":38},"2025-07-30","ACTUAL",{"date":40,"type":38},"2023-11-01",{"date":42,"type":21},"2025-12",{"name":44,"class":45},"Peking University First Hospital","OTHER",{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100594265","opposed-anterior-hip-arthroplasty-regional-anesthesia-study-study-100594265","NCT07017192","OPPOSED (anteriOr hiP arthroPlasty regiOnal aneSthEsia stuDy) Study","OPPOSED (anteriOr hiP arthroPlasty regiOnal aneSthEsia stuDy) Study. Regional Anesthesia Techniques for Anterior Approach Hip Arthroplasty Analgesia: SIFI Block Versus Lumbar ESP Block","Inclusion Criteria:\n\n* Age \\>=18 years and =\\\u003C85 years\n* patients undergoing elective unilateral THA with direct anterior approach\n* patients able to understand the purposes of the study and provide signed informed consent\n\nExclusion Criteria:\n\n* pregnancy\n* Age \\\u003C18 years or \\>85 years\n* revision or bilateral surgeries\n* psychiatric pathology or cognitive deficits, mental retardation, inability to provide valid informed consent\n* History of illicit drugs and\u002For alcohol abuse\n* urgent\u002Femergent surgery with admission to Intensive Care under sedation and mechanical ventilation or complications that do not allow evaluation\n* known allergy to the drugs used in the study\n* refusal to provide informed consent","18 Years","85 Years",{"count":56,"type":21},50,[58],"NA","Main indications for total hip arthroplasty (THA) are degenerative osteoarthritis of the coxofemoral joint, osteonecrosis of the hip, congenital disorders such as dysplasia and inflammatory arthritis. More recently, surgery using the direct anterior approach is getting popularity: this method, in fact, granting a significant sparing of the hip muscles, is associated with favorable results compared to other techniques, such as a lower risk of dislocation, limitated damage to soft tissues with better recovery and early discharge.\n\nPatients undergoing this procedure may although experience moderate to severe postoperative pain in the first few hours (with peaks observed in the first 12 hours), as well as potential complications such as nausea and vomiting related to opioids use.\n\nIt has been shown that adequate pain control influences early mobilization and rehabilitation, ensuring a quicker recovery. The role of regional anesthesia techniques has been established in almost all areas of orthopedic surgery, and in particularly in the management of postoperative pain following hip replacement surgery, but definitive data are missing with regard to direct anterior approach.\n\nRegional anesthesia consists of infiltrating local anesthetics in sites (fascial planes or nerves), in order to limit or even eliminate the use of traditional painkillers, with a significant reduction in the side effects.\n\nThe aim of this study is to compare the impact of two techniques, the Suprainguinal Fascia Iliaca (SIFI) block and the lumbar Erector Spinae Plane (ESP) block, in managing postoperative pain in subjects undergoing total hip replacement surgery performed by direct anterior approach.\n\nThe primary objective of the study is the incidence of residual femoral and obturator nerves block (knee extension and hip adduction according to ASIA score) 8 hours after surgery in the two treatment groups.\n\nSecondary objectives include: • Time elapsed between the end of surgery and the recovery of lower limb motility enough to allow the patient to mobilize independently; • Total opioid consumption (calculated as morphine equivalents) at 8, 24 and 48 hours after surgery; • Pain according to NRS (numerica rating scale) at 8, 24 and 48 hours after surgery; • Extent of sensory block of the three branches of the lumbar plexus (femoral, obturator, lateral femorocutaneuous nerves) at 8, 24 and 48 hours after surgery; • Timing of hospital discharge; • Incidence of chronic or persistent postoperative pain (at 30 and 90 days after surgery); • Any postoperative complication",[29,61,62,63,64,65,66,67],"Hip Replacement, Total","Hip Pain","Hip Arthroplasty","Hip Replacement Postoperative","Hip Surgery","Pain,Postoperative","Mobility and Independence","2025-06-27",{"date":70,"type":38},"2025-06-29",{"date":72,"type":38},"2025-06-23",{"date":74,"type":21},"2026-09-23",{"name":76,"class":45},"A.O.U. Città della Salute e della Scienza",1]