[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"his-bundle-pacing\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:his-bundle-pacing":83},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,43,69,101,128],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100459661","his-bundle-corrective-pacing-in-heart-failure-100459661",false,"NCT05265520","His-Bundle Corrective Pacing in Heart Failure","HIS-CRT","Inclusion Criteria:\n\n* Age 18 years or older (no upper age limit)\n* Optimal medical therapy for heart failure by current guidelines\n* Class IIa or IIb guideline-based indication for CRT-D implant in RBBB patients, including one of the following:\n\n  * New York Heart Association (NYHA) class II HF symptoms, LVEF ≤ 30% and QRS≥ 150 ms (IIb); OR\n  * NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration ≥ 150 ms (IIa); OR\n  * NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration 120-149 ms (IIb)\n\nExclusion Criteria:\n\n* Unable to obtain most recent imaging data from echocardiogram within 1 year prior to date of randomization\n* Left bundle branch block (LBBB) or intraventricular conduction delay (IVCD) ECG morphology\n* Unable or unwilling to follow study protocol\n* Less than 12 months life expectancy at consent\n* Pregnancy or planned pregnancy during duration of the study\n* On heart transplant list or likely to undergo heart transplant","ALL","18 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"NA","The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).",[26,27,28,29],"Right Bundle-Branch Block","Heart Failure","His-bundle Pacing","Cardiac Resynchronization Therapy","RECRUITING","2026-02-04",{"date":33,"type":34},"2026-02-09","ACTUAL",{"date":36,"type":34},"2022-12-02",{"date":38,"type":20},"2028-07-01",{"name":40,"class":41},"University of Rochester","OTHER",14,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":68},"100527795","ablate-and-pace-his-study-100527795","NCT06152406","Ablate and Pace HIS Study","Safety and Efficacy of Distal His Bundle Pacing Compared to Right Ventricular Pacing in Patients With Symptomatic Atrial Fibrillation Undergoing AV Node Ablation With Evidence of Heart Failure, a Randomised Control Study","Inclusion Criteria:\n\n* Aged 18 or above\n* Symptomatic AF, New York Heart Association (NYHA) class II-IV\n* Willing to consent for the study\n* AF regardless type, deemed not suitable for rhythm control strategy that has been referred for AVN ablation with one of the following:\n\n  1. Impaired LV function, EF \\\u003C50 %. And or\n  2. Raised N-Terminal Pro B-type Natriuretic Peptide ( NT-ProBNP) \\>365 ng\u002FL\n\nExclusion Criteria:\n\n* Patient who has already got a pacemaker in situ\n* Known severe LVSD when biventricular device is the thought to be the preferred pacing modality\n* Females in child bearing period\n* Lack of capacity to consent\n* Other serious medical condition with life expectancy of less than 1 year\n* Less than 18 years\n* Unwilling to consent for the study","100 Years",{"count":52,"type":20},100,[23],"Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, and estimates suggest its prevalence is increasing. Despite the advances in AF ablation strategies, the outcome of ablation procedures in persistent AF is still unsatisfactory. In addition, many patients are not candidates for ablation due to advanced age, comorbidities and previous failed ablation procedures.\n\nIt is well known that there is no mortality benefit from rhythm versus rate control strategy in AF, therefore the increased number of AV node ablation and pacemaker insertion for patients with symptomatic AF with uncontrolled heart rate. Following AV node ablation, it is understandable that these patients will be paced 100% of the time where the value of physiological pacing will be at its most.\n\nThe current standard practice is to pace the right ventricle for this cohort of patients unless they have severe LV systolic dysfunction when a biventricular pacing might be recommended. Previous data showed that RV pacing only can lead to deterioration of LV function, worsening of heart failure symptoms and increased mortality.\n\nHIS bundle pacing is a novel technique of pacing through placing the pacemaker lead on the junction box between the top and bottom chamber of the heart. This will allow the utilisation of the normal\u002Fintrinsic HIS Purkinjie (eclectic cables) to stimulate the ventricles. This can offer a physiological pacing modality and reduce pacing induced cardiomyopathy specially in pacing dependent pacing.\n\nThe Ablate and Pace HIS Study proposes that the new method of HIS pacing is safe, effective and superior to the existing method of RV pacing in patients with atrial fibrillation who demonstrate signs of heart failure.",[56,57],"HIS Bundle Pacing","Atrial Fibrillation",[56,57],"2025-12-31",{"date":61,"type":34},"2026-01-05",{"date":63,"type":34},"2023-10-24",{"date":65,"type":20},"2028-02-29",{"name":67,"class":41},"University Hospitals, Leicester",1,{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":76,"enrollmentInfo":77,"targetDuration":4,"studyType":21,"phases":79,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":68},"100477030","high-intensity-his-bundle-pacing-in-heart-failure-patients-with-narrow-qrs-outcome-study-100477030","NCT05491655","High Intensity His Bundle Pacing in Heart Failure Patients With Narrow QRS Outcome Study","HIPPOS","Inclusion Criteria:\n\n* Aged 18 or above\n* Ventricular Ejection Fraction (EF) \\\u003C 50%; BNP needs to be ≥250ng\u002FL or N Terminal-pro BNP≥600ng\u002FL for patients with EF 36-50% and they should have an ICD indication\n* New York Heart Association (NYHA) class I-IV\n* Narrow QRS duration (≤110ms) on 12 lead ECG\n\nExclusion Criteria:\n\n* Other serious medical condition with life expectancy of less than 1 year\n* Lack of capacity to consent\n* Pregnancy\n* Previous aortic valve surgery","90 Years",{"count":78,"type":20},34,[23],"Cardiac Resynchronization Therapy (CRT) decreases heart failure hospitalizations and mortality and increases left ventricular Ejection Fraction (EF) in patients with dilated cardiomyopathy, left bundle branch block and QRS duration \\>130msec. His bundle pacing has a similar effect in this category of patients. However, CRT is not beneficial in heart failure (HF) patients with narrow QRS. His-bundle pacing delivers physiological ventricular activation and has been shown to improve acute hemodynamic function in patients with heart failure, a prolonged PR interval, and either a narrow QRS or RBBB through AV delay optimization. We observed an acute hemodynamic effect during application of higher pacing output (3.5 Volts\u002F1 msec) in HF patients with dilated or ischemic cardiomyopathy and narrow QRS independently of the paced QRS duration or AV delay shortening.\n\nThis is a single-center, prospective randomized single-blinded study, recruiting a sub-population of patients with heart failure (dilated or ischemic cardiomyopathy, EF\\\u003C50%, narrow QRS (\\\u003C110 msec), in optimal medical treatment who have an indication for ICD.",[82,83,27,84],"Cardiac Conduction System","His Bundle Pacing","Cardiomyopathies",[86,87,88,89,90,91],"His bundle pacing","conduction system pacing","Heart failure","Cardiomyopathy","narrow QRS","Ejection Fraction","2025-12-15",{"date":94,"type":34},"2025-12-22",{"date":96,"type":34},"2023-03-29",{"date":98,"type":20},"2026-05",{"name":100,"class":41},"Miulli General Hospital",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":21,"phases":111,"briefSummary":112,"conditions":113,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":127},"100501937","physiological-vs-right-ventricular-pacing-outcome-trial-evaluated-for-bradycardia-treatment-protect-hf-100501937","NCT05815745","\"Physiological vs Right Ventricular Pacing Outcome Trial Evaluated for bradyCardia Treatment\" (PROTECT-HF)","Physiological vs Right Ventricular Pacing Outcome Trial Evaluated for bradyCardia Treatment","PROTECT-HF","We will recruit patients who are referred for clinically indicated pacemaker implantation\n\nInclusion Criteria:\n\n1\\. Adults aged over 18 with left ventricular ejection fraction \\>35% and one or more of the following guideline based ventricular pacing indications:\n\n1. Permanent or intermittent 3rd degree AV block\n2. Permanent or intermittent Mobitz type II AV block\n3. First Degree AV block with a pacing indication\n4. Slow chronic Atrial Fibrillation or Proposed AV node ablation\n5. Bifascicular block with a pacing indication\n6. Trifascicular block with a pacing indication\n7. Wenckebach with a pacing indication\n\nExclusion Criteria:\n\n1. Patients who are likely to only need occasional ventricular pacing, i.e. those with isolated sick sinus syndrome.\n2. Pregnant women.\n3. Unable to provide informed consent.\n4. Those with comorbidity leading to a life expectancy \\\u003C1year.",{"count":110,"type":20},2600,[23],"The PROTECT-HF multi-centre randomised controlled trial will compare two different pacing approaches for treating patients with slow heart rates. In it the investigators will compare a long-standing standard approach for pacing; right ventricular pacing, with a new form of pacing, physiological pacing (His and Left bundle area pacing) in 2600 patients.\n\nPatients will be allocated at random to receive either right ventricular pacing or physiological pacing. Endpoint measurements will be undertaken at baseline, and at six-monthly intervals post-randomisation. Treatment allocation will be blinded to the endpoint assessor and the patient.\n\nRecruitment and pacemaker implantation will be carried out at each participating centre. The primary analysis will be intention to treat. The investigators will also perform an on-treatment analysis.\n\n2048 patients are needed to detect the expected effect size with 85% power. A total of 2600 patients will be recruited to allow for patient drop-out and crossover.\n\n500-patient sub-study will assess within patient, and between groups, echocardiographic changes over a 24-month period to try and improve mechanistic understanding of PICM (Pacing Induced Cardiomyopathy).",[114,115,116,83,117],"Bradycardia","Pacing","Right Ventricular Pacing","Left Bundle Branch Area Pacing","2025-11-21",{"date":120,"type":34},"2025-11-28",{"date":122,"type":34},"2023-06-05",{"date":124,"type":20},"2029-12-04",{"name":126,"class":41},"Imperial College London",45,{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":136,"targetDuration":138,"studyType":139,"phases":4,"briefSummary":140,"conditions":141,"keywords":147,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":68},"100394507","pacing-to-maintain-physiologic-ventricular-activation-100394507","NCT04416958","Pacing to Maintain Physiologic Ventricular Activation","Pacing for Cardiac Resynchronisation Using the Intrinsic Conduction System to Maintain Physiologic Ventricular Activation","Pace-Conduct","Inclusion Criteria:\n\n* Pacemaker or ICD Implantation aiming to avoid pacing induced ventricular dyssynchrony according to current guidelines\n* age \\>= 18 years\n\nExclusion Criteria:\n\n* no informed consent for the procedure given\n* no follow-up data",{"count":137,"type":20},200,"1 Year","OBSERVATIONAL","Right ventricular pacing causes ventricular dyssynchrony and may be associated with impaired outcome. In the last decade, several approaches for more physiological pacing became available and were implemented in the latest guidelines. However, compared to conventional device implantation, cardiac resynchronization, His bundle pacing and left bundle area pacing remain demanding procedures in the individual case. Goal of the single center observational \"Pace conduct\" study is to evaluate implantation success, safety and outcome of pacing methods that maintain physiologic ventricular activation.",[142,83,143,144,145,146],"Pacemaker DDD","LBB Area Pacing","Pacing-Induced Cardiomyopathy","Left Bundle-Branch Block","ICD",[86,148,149],"LBB area pacing","cardiac resynchronisation therapy","2024-10-11",{"date":152,"type":34},"2024-10-15",{"date":154,"type":34},"2018-01-01",{"date":156,"type":20},"2030-12-31",{"name":158,"class":41},"Klinikum-Fuerth"]