[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"histamine\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:histamine":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,49,73,91,110,128,145],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100614856","histamines-and-central-hemodynamics-100614856",false,"NCT07285031","Histamines and Central Hemodynamics","The Role of Histamines on Central Hemodynamics","Inclusion Criteria:\n\n1. Age: 19 - 39.\n2. Willing to visit the lab on 3 separate occasions.\n\nExclusion Criteria:\n\n1. Previously diagnosed heart condition,\n2. Previously diagnosed lung condition (including asthma),\n3. Previously diagnosed metabolic condition,\n4. Currently smokers (cigarettes, electronic cigarettes, cannabis) or who have smoked within the last 3 months,\n5. Resting blood pressure \\>140\u002F90 mmHg,\n6. Unable to obtain appropriate quality ultrasound images of the heart.,\n7. Individuals without tricuspid regurgitation at rest to allow assessment of the primary outcome,\n8. Pregnant or trying to become pregnant,\n9. Breastfeeding,\n10. Chronically take antihistamines (i.e. daily),\n11. History of adverse reactions to antihistamines,\n12. Never taken antihistamines previously,\n13. Currently taking any medications (including oral contraceptives).",true,"ALL","19 Years","39 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","When we exercise, more blood flow goes to our muscles, challenging our blood vessels. Following exercise, blood flow remains elevated and seems to be the reason for many of the positive cardiovascular benefits that occur with exercise. When the actions of histamine, a molecule primarily known for its role in allergies, are blocked, there is an attenuated blood flow response following exercise. However, this effect has never been studied in the blood vessels that supply our lungs. The purpose of this study is to examine the effects of histamines on pulmonary hemodynamics following exercise.",[28,29],"Histamine","Exercise",[31,32,33,34,35],"histamine","exercise","pulmonary blood flow","pulmonary function","femoral blood flow","RECRUITING","2025-12-16",{"date":39,"type":40},"2025-12-23","ACTUAL",{"date":42,"type":22},"2025-12",{"date":44,"type":22},"2026-08",{"name":46,"class":47},"University of British Columbia","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":48},"100541337","itch-sensation-induced-by-multiple-applications-of-pruritogens-temporal-summation-100541337","NCT06328543","Itch Sensation Induced by Multiple Applications of Pruritogens (temporal Summation)","Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception","Inclusion Criteria:\n\n* Healthy men and women\n* 18-60 years\n* Speak and understand Englis\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Drug addiction defined as any use of cannabis, opioids, or other addictive drugs\n* Previous or current history of neurological (e.g. neuropathy), immunological (e.g. asthma, immune deficiencies, arthritis), musculoskeletal (e.g. muscular pain in the upper extremities,), cardiac disorder, or mental illnesses that may affect the results\n* Lack of ability to cooperate\n* Current use of medications that may affect the trial such as antihistamines, antipsychotics, and pain killers, as well as systemic or topical steroids\n* Skin diseases (e.g. atopic dermatitis, pruritus nodularis, eczema, psoriasis)\n* Moles, scars, or tattoos in the area to be treated or tested.\n* Consumption of alcohol or painkillers 24 hours before the study days and between these\n* Acute or chronic pain\n* Participation in other trials within one week of study entry (four weeks in the case of pharmaceutical trials)","18 Years","60 Years",{"count":59,"type":22},26,[25],"In This experiment, the investigators would like to design a new itch model based on the temporal summation of pruritic stimuli. The hypothesis behind this study (temporal summation) is that two overlapped applications of pruritogens will result in a higher itch sensation compared with a single application.",[28,63],"Cowhage","2024-11-20",{"date":66,"type":40},"2024-11-22",{"date":68,"type":40},"2024-11-01",{"date":70,"type":22},"2026-12-31",{"name":72,"class":47},"Aalborg University",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":80,"targetDuration":4,"studyType":23,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":86,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":90,"locationsCount":48},"100522386","investigation-of-the-effects-of-sleep-fragmentation-on-itch-and-pain-sensitivity-100522386","NCT06081946","Investigation of the Effects of Sleep Fragmentation on Itch and Pain Sensitivity","Investigation of the Effects of Sleep Provocations on Itch and Pain Sensitivity","Inclusion Criteria:\n\n* Healthy men and women\n* 18-60 years\n* Speak and understand English\n* Access to a smartphone during the experimental nights\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Drug addiction defined as any use of cannabis, opioids, or other drugs\n* Previous or current history of neurological, dermatological, immunological musculoskeletal, cardiac disorder or mental illnesses (psychiatric diagnosis) that may affect the results (e.g., neuropathy, muscular pain in the upper extremities, anxiety, depression, schizophrenia etc.)\n* Moles, wounds, scars, or tattoos in the area to be treated or tested\n* Current use of medications that may affect the trial such as antihistamines and pain killers.\n* Skin diseases\n* Consumption of alcohol or painkillers 24 hours before the study days and between these\n* Acute or chronic pain and itch\n* Participation in other trials within 1 week of study entry (4 weeks in the case of pharmaceutical studies)\n* Lack of ability to cooperate",{"count":81,"type":22},30,[25],"In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch:\n\n* To investigate similarity and differences between itch and pain by comparing the effect of sleep deprivation in them.\n* To evaluate the inflammatory state induced by sleep fragmentation via the analysis of C-reactive protein (CRP) levels from blood samples.\n* To correlate the anxiety and depression scores (evaluated through questionnaires) with itch and pain sensitivity and evaluate how they are affected by sleep fragmentation.",[28,63,85],"Sleep Fragmentation",{"date":66,"type":40},{"date":88,"type":40},"2023-12-15",{"date":70,"type":22},{"name":72,"class":47},{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":98,"targetDuration":4,"studyType":23,"phases":100,"briefSummary":101,"conditions":102,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":109,"locationsCount":48},"100542251","investigate-the-relationship-between-catastrophizing-and-the-perception-of-itch-intensity-in-healthy-individuals-100542251","NCT06340438","Investigate the Relationship Between Catastrophizing and the Perception of Itch Intensity in Healthy Individuals","Investigation of the Neurophysiological and Psychological Aspects of Itch","Inclusion Criteria:\n\n* Healthy men and women\n* 18-60 years\n* Speak and understand English\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Drug addiction defined as any use of cannabis, opioids, or other addictive drugs\n* Previous or current history of neurological (e.g. neuropathy), immunological (e.g. asthma, immune deficiencies, arthritis), musculoskeletal (e.g. muscular pain in the upper extremities,), cardiac disorder, or mental illnesses that may affect the results\n* Lack of ability to cooperate\n* Current use of medications that may affect the trial such as antihistamines, antipsychotics, and pain killers, as well as systemic or topical steroids\n* Skin diseases (e.g. atopic dermatitis, pruritus nodularis, eczema, psoriasis)\n* Moles, scars, or tattoos in the area to be treated or tested.\n* Consumption of alcohol or painkillers 24 hours before the study days and between these\n* Acute or chronic pain\n* Participation in other trials within one week of study entry (four weeks in the case of pharmaceutical trials)",{"count":99,"type":22},46,[25],"This project aims to investigate the relationship between different dimensions of catastrophizing (rumination, magnification, and helplessness) as well as some specific personality traits related to catastrophizing tendencies like anxiety sensitivity and fear sensitivity in the modulation of itch and pain intensities in an experimental setting.",[28,63],"2024-06-19",{"date":105,"type":40},"2024-06-24",{"date":107,"type":40},"2024-04-27",{"date":70,"type":22},{"name":72,"class":47},{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":54,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":116,"targetDuration":4,"studyType":23,"phases":118,"briefSummary":119,"conditions":120,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":127,"locationsCount":48},"100541336","itch-sensation-induced-by-simultaneous-application-of-pruritogens-spatial-summation-100541336","NCT06328530","Itch Sensation Induced by Simultaneous Application of Pruritogens (Spatial Summation)","Inclusion Criteria:\n\n* Healthy men and women\n* 18-60 years\n* Speak and understand English\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Drug addiction defined as any use of cannabis, opioids, or other addictive drugs\n* Previous or current history of neurological (e.g. neuropathy), immunological (e.g. asthma, immune deficiencies, arthritis) musculoskeletal (e.g. muscular pain in the upper extremities,), cardiac disorder, or mental illnesses that may affect the results\n* Lack of ability to cooperate\n* Current use of medications that may affect the trial such as antihistamines, antipsychotics, and pain killers, as well as systemic or topical steroids\n* Skin diseases (e.g. atopic dermatitis, pruritus nodularis, eczema, psoriasis)\n* Moles, scars, or tattoos in the area to be treated or tested.\n* Consumption of alcohol or painkillers 24 hours before the study days and between these\n* Acute or chronic pain\n* Participation in other trials within one week of study entry (four weeks in the case of pharmaceutical trials)",{"count":117,"type":22},24,[25],"In This experiment, the investigators would like to design a new itch model based on the spatial summation of pruritic stimuli. The hypothesis behind this study (spatial summation) is that two simultaneous applications of pruritogens will result in higher itch sensation compared with a single application of pruritogen.",[28,63],"2024-05-03",{"date":123,"type":40},"2024-05-06",{"date":125,"type":40},"2024-04-01",{"date":70,"type":22},{"name":72,"class":47},{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":133,"targetDuration":4,"studyType":23,"phases":134,"briefSummary":135,"conditions":136,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":144,"locationsCount":48},"100522390","investigation-of-the-effects-of-sleep-deprivation-on-itch-and-pain-sensitivity-100522390","NCT06081998","Investigation of the Effects of Sleep Deprivation on Itch and Pain Sensitivity",{"count":81,"type":22},[25],"In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep deprivation on itch:\n\n* To investigate similarity and differences between itch and pain by comparing the effect of sleep deprivation in them.\n* To evaluate the inflammatory state induced by sleep fragmentation via the analysis of C-reactive protein (CRP) levels from blood samples.\n* To correlate the anxiety and depression scores (evaluated through questionnaires) with itch and pain sensitivity and evaluate how they are affected by sleep. In This experiment, the investigators would like to test following hypotheses regarding the influence of sleep fragmentation on itch:\n* To investigate similarity and differences between itch and pain by comparing the effect of sleep deprivation in them.\n* To evaluate the inflammatory state induced by sleep fragmentation via the analysis of C-reactive protein (CRP) levels from blood samples.\n* To correlate the anxiety and depression scores (evaluated through questionnaires) with itch and pain sensitivity and evaluate how they are affected by sleep deprivation.",[28,63,137],"Sleep Deprivation","2023-12-14",{"date":140,"type":40},"2023-12-20",{"date":142,"type":40},"2023-11-01",{"date":70,"type":22},{"name":72,"class":47},{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":16,"sex":152,"minAge":56,"maxAge":153,"enrollmentInfo":154,"targetDuration":4,"studyType":23,"phases":156,"briefSummary":157,"conditions":158,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":165,"locationsCount":48},"100527802","the-role-of-histamine-in-muscle-protein-synthesis-following-resistance-training-100527802","NCT06152497","The Role of Histamine in Muscle Protein Synthesis Following Resistance Training","The Role of Histamine in Muscle Protein Synthesis Following Chronic Resistance Training","Inclusion Criteria:\n\n* Male\n* 18-45 years\n* Not to medium physically active\n\nExclusion Criteria:\n\n* Smoking\n* Chronic disease\n* High blood pressure\n* Supplement or medication intake\n* Seasonal allergies\n* Vegetarian \u002F vegan\n* Resistance trained","MALE","45 Years",{"count":155,"type":22},50,[25],"Blocking histamine H1\u002FH2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: \"What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle.\" Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.",[28],"2023-12-06",{"date":161,"type":40},"2023-12-13",{"date":163,"type":40},"2023-09-01",{"date":70,"type":22},{"name":166,"class":47},"University Ghent"]