[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hiv-1-subtype-a6-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hiv-1-subtype-a6-infection":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100621440","long-acting-cabotegravir-and-rilpivirine-in-people-living-with-hiv-1-subtype-a6-a-real-world-retrospective-study-100621440",false,"NCT07370649","Long-Acting Cabotegravir and Rilpivirine in People Living With HIV-1 Subtype A6: A Real-World Retrospective Study","Long-Acting Cabotegravir And Rilipivirine In People Living With HIV-1 Subtype A6. A Multicentre Real-world, Retrospective Matched Case Study","LACRIS","Inclusion Criteria:\n\n* Confirmed diagnosis of HIV-1 infection\n* Age ≥18 years at the time of initiation of long-acting cabotegravir plus rilpivirine (CAB\u002FRPV LA)\n* Received at least one dose of CAB\u002FRPV LA as part of routine clinical care\n* Availability of relevant clinical data in medical records for retrospective analysis\n* Signed informed consent for use of clinical data\n* Agreement to provide an additional blood sample for proviral DNA genotyping, if HIV-1 subtype was unknown at treatment initiation\n\nExclusion Criteria:\n\n\\- Lack of patient consent for use of clinical data for research purposes","ALL","18 Years",{"count":20,"type":21},250,"ESTIMATED","24 Months","OBSERVATIONAL","This study evaluates the real-world effectiveness and safety of a long-acting injectable HIV treatment consisting of cabotegravir and rilpivirine in people living with HIV-1. The focus is on individuals with HIV-1 subtype A6, which is common in Eastern Europe and among people who acquired HIV in that region, and on comparison with individuals with subtype B and those with an unknown subtype.\n\nAlthough long-acting cabotegravir and rilpivirine are widely used and effective, limited real-world data are available on how well this treatment works in people with HIV-1 subtype A6. This is important because subtype A6 has been suggested as a potential risk factor for treatment failure, but current evidence is inconclusive.\n\nThe study uses existing medical records from treatment centers in Poland, Germany, and the Czech Republic. It includes adults with HIV who have received at least one injection of long-acting cabotegravir and rilpivirine and follows their clinical outcomes for up to 24 months. Researchers will assess viral suppression, treatment persistence, adherence to injection schedules, and reasons for treatment discontinuation.\n\nThe results of this study will help clinicians better understand whether HIV-1 subtype A6 affects treatment outcomes and whether knowing a patient's HIV subtype is important when deciding to switch to long-acting injectable therapy. The findings may support safer and more effective use of this treatment in diverse patient populations.",[26,27,28,29],"Human Immunodeficiency Virus (HIV)-1 Infection","HIV-1 Subtype A6 Infection","HIV-1 Subtype B Infection","Virologically Suppressed HIV-1 Infection Receiving Long-Acting Antiretroviral Therapy",[31,32,33,34,35,36,37,38,39,40,41,42,43],"HIV-1","Long-Acting Antiretroviral Therapy","Cabotegravir","Rilpivirine","CAB\u002FRPV LA","HIV-1 Subtype A6","HIV-1 Subtype B","Virologic Suppression","Real-World Study","Retrospective Study","Injectable HIV Therapy","Treatment Persistence","Virologic Failure","RECRUITING","2026-06-09",{"date":47,"type":48},"2026-06-11","ACTUAL",{"date":50,"type":48},"2026-05-12",{"date":52,"type":21},"2027-03",{"name":54,"class":55},"Pomeranian Medical University Szczecin","OTHER",7]