[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hiv-viremia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hiv-viremia":31},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,56,83],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":33,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100562583","optimizing-prevention-and-care-for-pregnant-and-postpartum-adolescent-girls-and-young-women-with-hiv-in-tanzania-100562583",false,"NCT06605053","Optimizing Prevention and Care for Pregnant and Postpartum Adolescent Girls and Young Women With HIV in Tanzania","ENding HIV Transmission to Infants by Generating Evidence to Optimize Prevention and Care for Pregnant and Postpartum Adolescent Girls and Young Women With HIV in Tanzania (ENGAGE)","ENGAGE","Sub-study 1 (registry-based cohort analysis):\n\nInclusion Criteria:\n\n* Pregnant\u002Fpostpartum adolescent girls and young women (AGYW) with HIV aged 15-24 years, who started PMTCT services between January 1, 2018, and December 31, 2020.\n* Infants born to the included AGYW during this period.\n\nExclusion Criteria:\n\n* AGYW whose ART (Antiretroviral Therapy) status was not recorded.\n* Women who had not started ART.\n\nSub-study 2 (qualitative):\n\nInclusion Criteria:\n\n* AGYW living with HIV who are currently pregnant, previously pregnant\u002Fpostpartum, and never pregnant).\n* HCPs (Health Care Providers) at clinics providing PMTCT services.\n* Spouses\u002Fpartners\u002Fparents of AGYW and community stakeholders within the study setting.\n\nExclusion criteria\n\n\\- Mentally or severely ill individuals unable to participate in the study activities.\n\nSub-study 3 (co-production)\n\nInclusion criteria:\n\n* AGYW, HCPs, spouses\u002Fpartners, parents, and community stakeholders who participated in the qualitative study II.\n* Research team members.\n\nExclusion criteria:\n\n\\- Mentally or severely ill individuals unable to participate in the study activities.\n\nSub-study 4 (cluster-randomized implementation trial)\n\nInclusion criteria:\n\n\\- Pregnant AGYW living with HIV (new, previously diagnosed, and transfers) receiving vertical HIV prevention services in routine healthcare between January 1, 2026, and June 30, 2026, and followed up for at least one year until June 30, 2027.\n\nExclusion criteria:\n\n* AGYW whose ART (Antiretroviral Therapy) status was not recorded.","FEMALE","15 Years",{"count":20,"type":21},222,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to find better ways to care for pregnant and postpartum adolescent girls and young women (AGYW) aged 15-24 years with HIV in Tanzania, and to prevent them from passing HIV to their babies. The main questions it aims to answer are:\n\n* How often do young pregnant women with HIV go to their health appointments and stay on their treatment up to two years after giving birth?\n* How many babies born to young women with HIV stay HIV-free for two years?\n* How soon do young women with HIV get pregnant again after giving birth, and what factors affect this?\n* What are the best ways to help young women with HIV stay in care and stay healthy during and after pregnancy?\n* What social and structural factors affect whether young pregnant women with HIV go to their health appointments and stay on their treatment?\n* How can we work with young women with HIV to create and test a package of interventions to improve their healthcare during and after pregnancy?\n* Can this package of interventions help young women with HIV stay in care and remain healthy during and after pregnancy?\n\nParticipants will:\n\n* Have their health data analyzed via health service records of all women who received HIV prevention services between 2018 and 2020, and were followed until 2023, across 559 health facilities in Tanzania.\n* Participate in qualitative interviews to share their experiences and challenges with staying in care.\n* Help to co-create a package of interventions to improve care.\n* Take part in a cluster-randomized trial to test these interventions. Researchers will compare the outcomes of the intervention package to see if they improve care engagement, retention, and health outcomes for AGYW with HIV during and after pregnancy.",[27,28,29,30,31,32],"HIV Antiretroviral Therapy (ART) Adherence","PMTCT","Pregnancy","Retention in Care","HIV Viremia","Early Infant HIV Diagnosis",[34,35,36,28,37,38,39,40,41,42],"Adolescent girls and young women","HIV","Vertical transmission","Co-production","Co-design","Intervention","Tanzania","Sub-Saharan Africa","Retention in care","RECRUITING","2025-06-27",{"date":46,"type":47},"2025-06-29","ACTUAL",{"date":49,"type":47},"2024-10-07",{"date":51,"type":21},"2027-12",{"name":53,"class":54},"Karolinska Institutet","OTHER",2,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":63,"minAge":4,"maxAge":4,"enrollmentInfo":64,"targetDuration":4,"studyType":22,"phases":66,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":55},"100594564","person-centered-approaches-to-viremia-connection-rapport-and-engagement-study-100594564","NCT07021092","PERSON-CENTERED APPROACHES TO VIREMIA: CONNECTION, RAPPORT, AND ENGAGEMENT STUDY","P-CoRE","Inclusion Criteria:\n\n1. Patients that are lost to follow up (\\[LTFU\\] from HIV care i.e. confirmed \\>30 days late for a scheduled appointment) at the time of sampling. (i.e. not people who were previously LTFU but then returned and have a documented VL.)\n2. Individuals returning to care after being out of care and not taking ART with no VL measure (i.e., unmeasured viremia)\n3. Patients that are 6 months late for a scheduled Viral Load (VL) according to Ministry of Health guidelines at the time of sampling (regardless of care status)\n4. Patients that have a last documented VL that is elevated, \\> 1000 copies\u002Fml at time of sampling in current clinic population (CCP) (regardless of care status)\n5. Participant that are willing to provide written informed consent in English, or any of the local languages that include Nyanja or Bemba.\n\nExclusion Criteria:\n\n1. Patients that are unable to provide consent or unwilling to participate in the study\n2. Participant who is NOT living with HIV\u002FAIDS;\n3. Participant is too sick i.e., failing to talk, general discomfort and emergency cases);","ALL",{"count":65,"type":21},3000,[24],"The study aims to increase the reach of the person-centred interpersonal practices by developing and accessing a tailored, scalable, and sustainable approach that meets the distinctive needs of populations identified as most disproportionately affected by viremia in Zambia. The study population include pregnant and breastfeeding women, children, adolescents and adult that are more than thirty -30 days late for their next hospital appointments.The study will be implemented over a period of 36 months in 24 facilities in Lusaka and Central province, Zambia.",[31,69],"HIV -1 Infection",[71,72,73],"Uncontrolled Viremia","Person Centred Care","Unmonitored Viral Load","2025-06-12",{"date":76,"type":47},"2025-06-13",{"date":78,"type":47},"2025-04-01",{"date":80,"type":21},"2027-06-30",{"name":82,"class":54},"Centre for Infectious Disease Research in Zambia",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":63,"minAge":90,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":94,"conditions":95,"keywords":96,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":107},"100468260","optimizing-a-bio-behavioral-intervention-for-sustained-viral-suppression-100468260","NCT05377463","Optimizing a Bio-behavioral Intervention for Sustained Viral Suppression","Optimizing a Bio-behavioral Intervention to Promote Viral Suppression Among HIV+ People Who Inject Drugs on the U.S.-Mexico Border","Inclusion Criteria:\n\n* be at least 18 years of age\n* be able to provide informed consent\n* be eligible to receive free HIV care services in Mexico\n* be HIV positive\n* have injected drugs in the last 30 days\n* not be on methadone replacement therapy\n* be willing to discuss MAT uptake with a peer\n* sign a medical release form to have medical data abstracted\n* agree to submit and describe locator information\n* agree to return to follow-up visits\n* able to communicate in Spanish\n* screen positive for depression on the PHQ-2\n* have no plans of moving outside the study area in the next 12-months\n* meet one of the following:\n\n  1. not currently in possession of ART or not taking ART but prescribed ART or\n  2. sub-optimal ART adherence as at least one 4-day treatment interruption in the past 90 days or\n  3. sub-optimal retention in HIV care - never engaged or disengaged from HIV care as 2 or more missed clinic appointments in the last 9 months or\n  4. no viral load test done in the past six months or\n  5. self-reports a detectable viral load within the past 6 months\n\nExclusion Criteria:\n\n* has not injected drugs in the last 30 days or do not have a verifiable opioid use disorder\n* is not HIV positive\n* is receiving methadone\n* is unwilling to discuss methadone uptake with a peer\n* does not screen positive for depression\n* is not able to provide informed consent\n* does not speak Spanish\n* has plans to move out of the city\n* does not qualify to receive free HIV care services in Mexico\n* has an appearance of psychological disturbance or severe cognitive impairment that could limit understanding of study procedures as determined by study staff","18 Years",{"count":92,"type":21},220,[24],"The study will test two behavioral intervention components to identify the combination of the two components that best supports people who inject drugs to achieve and sustain HIV viral load suppression.\n\nThe study design is a 2-to-the-2 factorial experiment. The 2 represents the level of each component: 0 (receive) or 1 (don't receive). The 2 represents the number of components being tested. The four components are: 1) receiving (or not receiving) peer support services for medication-assisted treatment (MAT) uptake and persistence and 2) behavioral activation therapy for depression (BAT). Therefore, in order to test which combination of components produce the best outcome, this factorial design randomizes people to 1 of 4 conditions. Each condition represents a possible combination of the 2 components above. All participants will receive patient navigation for care engagement.",[31],[97],"HIV viral suppression","2024-08-28",{"date":100,"type":47},"2024-09-03",{"date":102,"type":47},"2023-05-10",{"date":104,"type":21},"2026-07-31",{"name":106,"class":54},"University of Texas, El Paso",1]