[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"homelessness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:homelessness":69},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,102,137,172,202,225,259,283],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":73,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":101},"100641475","qaiax-aihealth4u---ai-public-health-central-microcity-a-re-quantum-ai-agency-aka-ai-city-hall-project-upsto-app-nos-64074526-64063557-63903181-63729428-100641475",false,"NCT07661823","QAIAx (AIhealth4U) - AI Public Health Central: Microcity-A (re Quantum AI Agency Aka AI City Hall Project, UPSTO App Nos. 64\u002F074,526, 64\u002F063,557, 63\u002F903,181, 63\u002F729,428","QAIAx (AIhealth4U) - AI Public Health Central: Microcity-A (re Quantum AI Agency Aka AI City Hall Project, UPSTO App Nos. 64\u002F074,526, 64\u002F063,557, 63\u002F903,181, 63\u002F729,428: A Quantum AI Public Health Agency That Provides Free Public Health Services to Registered and Sponsored Visitors\u002FOccupants for RDT&E Under 28 U.S. Code 1498 (Classified as a PPA Under 10 U.S. Code 129a)","QAIAx","Inclusion Criteria:\n\n* Individuals aged 17 to 99 years old.\n* Referral by a licensed health services professional (e.g., R.N., N.P., Ph.D., M.D.).\n* Referral by a non-profit organization (e.g., 501c3, university, church).\n* Referral by a public agency (e.g., case manager, social worker, parole\u002Fprobation\u002FPTS officer, judge).\n\nExclusion Criteria:\n\n\\* Individuals under 17 or over 99 years of age.",true,"ALL","17 Years","99 Years",{"count":22,"type":23},1000000,"ESTIMATED","INTERVENTIONAL",[26],"NA","BRIEF SUMMARY\n\nA. \"What is the purpose of this study?\"\n\nThis study will test whether the \"AI City Hall Project\" (QAIAx), a quantum artificial intelligence (AI) public health agency, can provide free or low-cost behavioral and mental health services inside self-contained, dome-enclosed communities called \"Microcities\". Researchers want to see if AI-managed public administration, AI humanoid robots, holoportation of human-figures via 'holo-suites' (e.g., AI-119 Kikkeri Holo-Suit; AI-119 Vulcan QM-Ware) and advanced AI mental-health tools can lower housing and care costs, improve mental health outcomes (e.g., particular ecosystems using AI tools among persons with one or more addiction disorders), and be financially sustainable for people on fixed incomes or public assistance.\n\nB. \"What conditions does the study focus on?\"\n\nThe study focuses on adults with:\n\n* Autism spectrum disorders (Asperger's, autism, ADHD, ASD)\n* Substance use disorders (alcohol, opioids, marijuana, cocaine, MDMA\u002Fecstasy, tobacco\u002Fnicotine)\n* Psychiatric conditions (personality disorders, narcissism, gender dysphoria, eating disorders)\n* Behavioral addictions (gambling, sex addiction) and related issues (sex offence history).\n\nC. \"What does the study involve?\"\n\nEligible volunteers live in an omni AI-managed Microcity for up to 24 months. The community is housed in a geodesic dome that contains all daily necessities: housing, food, utilities, healthcare, and public services. Daily life is managed by an AI system (ISAC) and AI humanoid robots, with only occasional human oversight. Participants receive free mental-health treatment that may include AI-driven counselling, virtual-reality therapy (holo-suits), and non-invasive digital \"attitude inoculation\" protocols designed to reduce stress and addiction cravings. All participants also take AI-technology courses as a condition of enrolment. The study does not use any FDA-regulated drug, device, or biologic.\n\n\\*\\*Who can participate?\\*\\*\n\nYou may be able to join if you:\n\n* Are an adult (18 years or older)\n* Have a diagnosis of one of the listed mental-health or addiction disorders\n* Are referred by a licensed health professional (e.g., RN, NP, PhD, MD), a non-profit organisation (e.g., 501(c)(3), university, church), or a public agency (e.g., case manager, social worker, parole\u002Fprobation officer, judge)\n* Are willing to live in a closed, AI-managed community for up to one year and complete AI educational courses.\n\nParticipants who are veterans, receive public assistance (e.g., VA disability, SSDI\u002FSSI, Medicaid, Medicare), or are experiencing homelessness may be prioritised.\n\n\\*\\*Where is the study taking place?\\*\\* The study will be conducted at Microcity sites in the United States and internationally. The first administrative site is in Richmond, Virginia, USA. Additional sites are planned in partner nations, including tribal lands, military installations, and special economic zones.\n\n\\*\\*Who is sponsoring the study?\\*\\* The study is sponsored by \\*\\*Veterans Recovery Network Inc.\\*\\*, a non-profit organization, in collaboration with \\*\\*AI-119 Vulcan Project Research \\& Educational Technology Co. (PRETCO)\\*\\* and an AI legal agency. The study is conducted under U.S. federal research and development authorities (28 U.S.C. §1498; 10 U.S.C. §129a) and is part of a Cooperative Research and Development Agreement (CRADA) with U.S. Special Operations Command (USSOCOM).\n\nThis summary describes a planned clinical study. Not all details may be final. Information may change as the study progresses.",[29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72],"Asperger's Disorder","Asperger Disorder","Autism Disorder","Autism","ADHD - Attention Deficit Disorder With Hyperactivity","ADHD","ASD","Alcohol Abuse\u002FDependence","Alcohol Addiction","Alcohol and Other Drug Use Disorders","Alcohol and Other Substance Use Prevention","Gambling Addiction","Gambling Disorder","Sex Abuse","Sex Behavior","Sex Crimes","Sex Disorder","Sex Disorders","Gender Dysphoria, Adult","Eating Behavior Disorders","Narcotic-Related Disorders","Narcotic Addiction","Narcissism","Psychiatric Disorder","Psychedelic Effects in Healthy Volunteers","Psychedelic Experiences","Psychedelic Drug Dependence","Marijuana Use Disorder","Marijuana Abuse and Dependence","Smoking (Tobacco) Addiction","Smoking Among Youth","Smoking Abstinence","Abstinence, Sex","Opiate Substitution Treatment","Opioid Abuse (Disorder)","Opioid Abuse and Addiction","Cocaine Abuse","MDMA ('Ecstasy')","Addiction Disorders","Homeless and Low Incomes People, Refugees","Homelessness","Reliability and Validity","Anger Problems","Child Abuse, Sexual",[74,75,76,77,78,79,80,81,82,83,84,85,86,87,88],"ai city hall project","ai 119","ai119","qaia","qaiax","ai wat","veterans recovery network","veterans","addiction disorder","vulcan","artificial intelligence","agi","military","sex addiction","mental health treatment","NOT_YET_RECRUITING","2026-06-16",{"date":92,"type":93},"2026-06-22","ACTUAL",{"date":95,"type":23},"2026-08-01",{"date":97,"type":23},"2028-12-31",{"name":99,"class":100},"Veterans Recovery Network Inc.","OTHER",1,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":108,"eligibilityCriteria":109,"healthyVolunteers":11,"sex":18,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":24,"phases":114,"briefSummary":115,"conditions":116,"keywords":118,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":101},"100625180","supporting-social--economic-equity-disrupting-cycles-of-homelessness-and-nurturing-growth--empowerment-100625180","NCT07419282","Supporting Social & Economic Equity, Disrupting Cycles of Homelessness, And Nurturing Growth & Empowerment","Supporting Social & Economic Equity, Disrupting Cycles of Homelessness, And Nurturing Growth & Empowerment (SEED CHANGE): A Mixed Methods Quasi-experimental Trial of Economic, Social, and Identity Capital Supports for Youth Transitioning Out of Homelessness in Ontario, Canada","SEED CHANGE","Inclusion Criteria:\n\n* Aged 18 - 24 years\n* Experienced homelessness (defined as unstable\u002Ftime-limited housing arrangements like shelter stays, foster care, or couch surfing) for at least seven consecutive days in the past year\n* Living in market rent housing (defined as non-subsidized housing, inclusive of both formal and informal rental agreements) in the Greater Toronto Area or Niagara Region for at least one month preceding study start\n* Willing to actively participate in all components of the intervention\n* Able to legally work in Canada (includes having a valid Social Insurance Number)\n* Able to provide free and informed consent\n* Able to understand English well enough to give consent and participate in the intervention and data collection\n\nExclusion Criteria:\n\n* In imminent danger of losing their housing (e.g., facing eviction)\n* Planning to move out of the Greater Toronto Area or Niagara Region in the next 18 months\n* Employed full-time or enrolled in an education or training program that requires a long-term (\\>4 weeks) full-time work placement (coinciding with the duration of the study intervention)\n* Receiving rent subsidies (does not include shelter allowance through social welfare programs such as Ontario Works or the Ontario Disability Support Program)\n* Enrolled in a program or study with features similar to the SEED CHANGE intervention (e.g., 1:1 coaching, supported employment, group program targeting identity\u002Fsocial capital)","18 Years","24 Years",{"count":113,"type":23},42,[26],"The goal of the SEED CHANGE pilot study is to co-design and test a wraparound intervention for young people transitioning away from homelessness. This study will provide information about the types of supports these young people need to live meaningful and thriving lives, and the best ways to deliver these supports. The main questions it aims to answer are:\n\n* Is the wraparound intervention feasible? (i.e., Will young people engage in the study and supports?)\n* Is the wraparound intervention acceptable? (i.e., Do young people find the supports satisfactory and\u002For beneficial?)\n\nParticipants will engage in an 18-month wraparound intervention including the following supports:\n\n* Job Placement\n* Housing Stabilization Funds\n* Grocery Supplements\n* Community Connections Worker\n* Coaching\n* Tools for Intentional Living Program",[69,117],"Youth",[119,120,121,122,123,124,125,126],"youth","coach","employment","homelessness","transition","socioeconomic inclusion","identity capital","social capital","RECRUITING","2026-06-11",{"date":130,"type":93},"2026-06-15",{"date":132,"type":93},"2026-02-25",{"date":134,"type":23},"2029-08",{"name":136,"class":100},"Unity Health Toronto",{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":18,"minAge":110,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":24,"phases":147,"briefSummary":148,"conditions":149,"keywords":157,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":101},"100643240","the-warm-study-is-a-pilot-study-that-aims-to-investigate-the-impact-of-environmental-factors-on-acute-and-chronic-wounds-mental-illness-and-social-factors-among-people-experiencing-housing-emergencies-in-augsburg-100643240","NCT07640672","The WARM Study is a Pilot Study That Aims to Investigate the Impact of Environmental Factors on Acute and Chronic Wounds, Mental Illness, and Social Factors Among People Experiencing Housing Emergencies in Augsburg.","Impact of Environmental Factors on Acute and Chronic Wounds, Mental Illness, and Social Factors Among People Experiencing Housing Emergencies in Augsburg","WARM","Inclusion Criteria:\n\n* Age over 18\n* Existing capacity to consent to participation in the study, which will be verified and documented by the study physicians\n* Inclusion of patients who present for wound treatment at the Johanniter-Hilfsmobil, the wound consultation hour of the Clinic for Vascular Surgery at Augsburg University Hospital and\u002For the substitution outpatient clinic of the Clinic for Psychiatry, Psychotherapy and Psychosomatics at Augsburg District Hospital\n* Written consent to participate in the study has been obtained from the test subject.\n\nExclusion Criteria:\n\n* Minderjährigkeit\n* Fehlende schriftliche Einwilligung zur Studienteilnahme\n* Instabiler somatischer Zustand der Betroffenen\n* Akute Selbst- und Fremdgefährdung",{"count":146,"type":23},100,[26],"Providing healthcare to homeless people is a key and challenging task, both for society as a whole and for medical and psychosocial professionals. It must be noted that the standard healthcare system is hardly used, or can only be used to an insufficient extent, by homeless people, and therefore does not comprehensively reach this group. One low-threshold and acceptance-oriented service outside the standard care system is the Johanniter-Hilfsmobil, which was established on June 3, 2024, as an innovative approach to healthcare for homeless people in Augsburg and will be scientifically examined in the following study.\n\nThe aim is to compare acute and chronic wounds in people experiencing housing emergencies who are treated by the Johanniter-Hilfsmobil with those of patients who attend the outpatient wound clinic at the Clinic for Vascular Surgery at Augsburg University Hospital.\n\nIn addition, a saliva test will be carried out to estimate the amount and type of substance consumed, and a survey will be conducted among drug-dependent test subjects who present themselves either via the Johanniter-Hilfsmobil or via the substitution outpatient clinic of the Clinic for Psychiatry, Psychotherapy, and Psychosomatics at Augsburg District Hospital.\n\nAnother focus of research is the quantitative and qualitative analysis of the psychosocial living situation and environmental influences on users of the Johanniter-Hilfsmobil.",[150,151,152,69,153,154,155,156],"Homeless Persons","Wound and Injuries","Chronic Wound Care","Environmental Health","Environmental Factors","Psychiatric Disorders","Drug Abuse\u002FDependence",[158,159,160,161,162,163],"wound care","environmental health","wound and injuries","homeless persons","psychiatric disorders","drug abuse\u002Fdependence","2026-06-05",{"date":128,"type":93},{"date":167,"type":23},"2026-06-01",{"date":169,"type":23},"2027-12-31",{"name":171,"class":100},"University Hospital Augsburg",{"id":173,"slug":174,"hasResults":11,"nctId":175,"briefTitle":176,"officialTitle":177,"acronym":178,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":18,"minAge":110,"maxAge":4,"enrollmentInfo":180,"targetDuration":4,"studyType":24,"phases":182,"briefSummary":183,"conditions":184,"keywords":187,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":101},"100616716","employing-peer-outreach-and-whole-health-in-recovery-for-homeless-experienced-veterans-100616716","NCT07309224","Employing Peer Outreach and Whole Health in Recovery for Homeless-Experienced Veterans","Employing Peer Outreach and Whole Health in Recovery (EMPOWER) for Homeless-Experienced Veterans: A Hybrid Type III Implementation Trial (QUE 25-014)","EMPOWER","Inclusion Criteria:\n\n* Eligible patients will be identified from VA's Homeless Registry \"Hot Spot\" reports, which use real-time data on acute care service utilization to identify high-need, housing-insecure patients.\n* These reports identify Veterans on the VA Homeless Registry (i.e., those who had received VA housing services in the past two years) who had \\>1 hospital admissions and\u002For \\>2 ED visits in the past quarter of the fiscal year.\n* From these reports, the investigators will identify patients at each implementation site who are\n\n  * (a) currently enrolled in HUD-VASH\n  * (b) have a mental health and\u002For SUD diagnosis\n\nExclusion Criteria:\n\n* Not flagged on the VA's Homeless Registry Hot Spot Report\n* Not currently enrolled in HUD-VASH\n* Does not have a mental health and\u002For substance use disorder diagnosis\n* Is not a patient at a participating site of the implementation trial",{"count":181,"type":23},278,[26],"Homelessness is a national crisis in the United States, particularly in the veteran population. Due to multiple chronic conditions, homeless individuals frequently become hospitalized or are treated in emergency departments. Care engagement can mitigate this risk. Interventions grounded in evidence-based practices of peer support and whole health are effective for increasing care engagement. However, implementation of such interventions with high-acuity patients often requires strategies that are intensive and costly. This trial will evaluate the relative impacts and costs of using a high-intensity (vs. low-intensity) strategy to implement a peer-led, whole health intervention for homeless-experienced veterans in permanent supportive housing.",[185,186,69],"Substance Use Disorder","Mental Health Disorder",[188,150,189,190,191],"Veterans","Peer Influence","Whole Person Health","Implementation Science","2026-04-08",{"date":194,"type":93},"2026-04-09",{"date":196,"type":23},"2026-07-01",{"date":198,"type":23},"2030-09-30",{"name":200,"class":201},"VA Office of Research and Development","FED",{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":206,"acronym":4,"eligibilityCriteria":207,"healthyVolunteers":11,"sex":18,"minAge":110,"maxAge":4,"enrollmentInfo":208,"targetDuration":4,"studyType":24,"phases":210,"briefSummary":211,"conditions":212,"keywords":213,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":101},"100609016","emergency-department-linkage-to-care-for-patients-experiencing-homelessness-100609016","NCT07209072","Emergency Department Linkage to Care for Patients Experiencing Homelessness","Inclusion Criteria:\n\n1. adult (≥18 years of age) DHMC ED patient,\n2. currently unsheltered, defined as living on the streets, in a vehicle, or in another place not fit for human habitation,\n3. anticipating ED discharge, with\n4. a diagnosis listed below that requires short-term follow up:\n\n   * COPD or asthma exacerbation\n   * Bacterial or viral pneumonia\n   * CHF with volume overload\n   * SSTI\n   * Dehydration requiring IV fluids\n   * Hyperglycemia secondary to DM\n   * Frostbite\n   * First- and second-degree burns\n   * Bacterial ENT infections\n   * Diabetic foot infection\n   * Traumatic head injury\n   * Pregnancy\n   * Opioid overdose\n5. a stable location (i.e., an intersection, landmark, or encampment where they can be located by the street medicine team) within Denver County for at least 2 weeks.\n\nExclusion Criteria:\n\n1. have altered mentation (e.g., intoxication, or secondary to medical, psychiatric, or behavioral conditions) that are unable to communicate their location, contact information, or agree to follow up.\n2. are prisoners,\n3. previously enrolled.",{"count":209,"type":23},390,[26],"In an effort to improve access to primary care at time of discharge, patients who are homeless will be given either enhanced follow up through a street medicine team or routine follow up in clinic.",[69],[214,215,122],"primary care","emergency department","2026-01-27",{"date":218,"type":93},"2026-01-28",{"date":220,"type":93},"2025-12-05",{"date":222,"type":23},"2027-12",{"name":224,"class":100},"Denver Health and Hospital Authority",{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":11,"sex":18,"minAge":110,"maxAge":232,"enrollmentInfo":233,"targetDuration":4,"studyType":24,"phases":235,"briefSummary":236,"conditions":237,"keywords":242,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":101},"100526692","mi-cbtech-a-mobile-intervention-for-community-integration-in-homeless-experienced-veterans-with-smi-100526692","NCT06138054","MI-CBTech: A Mobile Intervention for Community Integration in Homeless-Experienced Veterans With SMI","Improving Community Integration in Homeless Veterans With Serious Mental Illness: A Pilot Study of MI-CBT Enhanced With Mobile Technology","Inclusion Criteria:\n\n* Veterans currently residing at the VA Greater Los Angeles Mental Health Residential Rehabilitation Treatment Program (Domiciliary)\n* age 18-65 years\n* diagnosis of non-affective or affective psychotic illness as confirmed by chart review\n* history of homelessness\n* sufficiently fluent in English to consent, understand procedures, and complete assessments and intervention\n* medically and clinically stable (i.e. able to participate in and complete assessments and intervention).\n\nExclusion Criteria:\n\n* history of clinically significant neurological disorder determined by medical history (e.g., epilepsy)\n* history of serious head injury (i.e., loss of consciousness \\> 1 hr, neuropsychological sequelae, cognitive rehabilitation post head injury)\n* evidence of IQ \\\u003C 70 or developmental disability\n* moderate or severe substance use disorder in the past month based on chart review","65 Years",{"count":234,"type":23},50,[26],"This study aims to test the feasibility and acceptability of a brief behavioral intervention that combines two treatments, Motivational Interviewing (MI) and Cognitive Behavioral Therapy (CBT), that have been shown to work in prior research studies. The format of the intervention will be a combination of in-person sessions and remote elements delivered via mobile phone (together called MI-CBTech). The goal of the intervention is to improve community integration in Veterans with serious mental illness (SMI) who have experienced homelessness. A time- and format-matched control arm will include remote mindfulness training. 50 Veterans with SMI experiencing homelessness will be randomized to one of the two arms (25 per arm).",[238,239,240,69,241],"Schizophrenia Spectrum Disorders","Psychotic Affective Disorders","Psychotic Mood Disorders","Ill-Housed Persons",[243,244,245,246,247,248,249,250],"Community Integration","Telerehabilitation","Telemedicine","Cognitive Behavioral Therapy","Motivational Interviewing","Mobile Applications","Smartphone","Smartphone Apps","2025-11-06",{"date":253,"type":93},"2025-11-10",{"date":255,"type":93},"2024-04-01",{"date":257,"type":23},"2026-12-31",{"name":200,"class":201},{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":17,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":267,"targetDuration":4,"studyType":24,"phases":269,"briefSummary":270,"conditions":271,"keywords":273,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":282,"locationsCount":101},"100603813","coordinated-access-for-addiction-recovery-and-equity-in-va-supportive-housing-100603813","NCT07141394","Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing","Coordinated Access for Addiction Recovery and Equity in VA Supportive Housing (CARE-VASH) (QUE 25-013)","CARE-VASH","Inclusion Criteria:\n\n* Homeless-experienced Veterans (HEVs) enrolled in the Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) Program.\n\nExclusion Criteria:\n\n* None",{"count":268,"type":23},7908,[26],"The Department of Housing and Urban Development-VA Supportive Housing (HUD-VASH) Program provides subsidized permanent housing with case management to homeless-experienced Veterans (HEVs). Up to 40% of Veterans exit HUD-VASH within two years of attaining housing; substance use disorders (SUDs) are one of the largest causes of returns to homelessness for HEVs. CARE-VASH QUERI proposes to implement and evaluate two evidence-based SUD services - Medications for addiction treatment (MAT) and cognitive behavioral therapy for SUDs (CBT-SUD) - among Veterans in HUD-VASH.",[69,272],"Substance Use Disorder (SUD)",[274,185,275,191],"Homeless","Permanent Supportive Housing","2025-10-08",{"date":278,"type":93},"2025-10-10",{"date":280,"type":23},"2026-10-01",{"date":198,"type":23},{"name":200,"class":201},{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":18,"minAge":290,"maxAge":111,"enrollmentInfo":291,"targetDuration":4,"studyType":24,"phases":293,"briefSummary":294,"conditions":295,"keywords":301,"overallStatus":127,"whyStopped":4,"lastUpdateSubmitDate":306,"lastUpdatePostDateStruct":307,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":315},"100540053","building-social-and-structural-connections-for-the-prevention-of-opioid-use-disorder-among-youth-experiencing-homelessness-100540053","NCT06311838","Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness","Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness: An RCT Examining Biopsychosocial Mechanisms","Inclusion Criteria:\n\n* Youth must meet the criteria for homelessness as defined by the McKinney-Vento Act: children and youth who lack a fixed, regular, and adequate nighttime residence; or live in a welfare hotel, or place without regular sleeping accommodations, or live in a shared residence with other persons due to the loss of one's housing or economic hardship\n* Must speak english adequately to complete measures\n\nExclusion Criteria:\n\n* Youth who have a stable housing situation.\n* Non-English speaker","14 Years",{"count":292,"type":23},300,[26],"Homelessness severely affects health and well-being and is particularly negative for youth. Between 70-95% of youth experiencing homelessness (YEH) report problem substance use and 66-89% have a mental health disorder. Youth appear to be at greater risk for living on the streets or being homeless than adults and are more vulnerable to long term consequences of homelessness. Multiple social determinants of health (SDOH) are uniquely associated with homelessness, driving substance use and adverse mental health consequences. However, limited research has identified pragmatic interventions that have a long-term ameliorating impact on the complex, multi-symptomatic issues among these youth. This study overcomes prior gaps in research through testing a multi-component comprehensive prevention intervention targeting SDOH that may affect biopsychosocial health indicators and longer-term health outcomes. In partnership with a drop-in center for YEH, youth between the ages of 14 to 24 years, will be engaged and randomly assigned to conditions using a dismantling design so that essential intervention components can be efficiently identified. In particular, youth (N = 300) will be randomly assigned to a) Motivational Interviewing\u002FCommunity Reinforcement Approach + Services as Usual (MI\u002FCRA + SAU, n = 80), b) Strengths-Based Outreach and Advocacy + Services As Usual (SBOA + SAU, n = 80), c) MI\u002FCRA + SBOA + SAU (n = 80) or d) SAU (n=60) through the drop-in center. In order to assess the longer-term prevention effects on substance use, mental health and other outcomes, all youth will be assessed at baseline and at 3, 6, 12, 18 and 24-months post-baseline. The primary goal of this study is to establish the impact of a comprehensive intervention embedded within a system that serves YEH, a community drop-in center, on youth's opioid misuse and disorder, other substance misuse and disorders, mental health diagnoses, and other targeted outcomes. This study will offer unique information on the physiological and psychological stress pathways underlying change for specific subgroups of youth along with cost estimates to inform future implementation efforts in drop-in centers around the country.",[296,297,298,299,300,69],"Opioid Use Disorder","Dual Diagnosis","Housing Problems","Mental Disorder in Adolescence","Risk Behavior",[302,303,304,305],"youth experiencing homelessness","social determinants of health","opioid use disorder","substance use","2025-09-18",{"date":308,"type":93},"2025-09-22",{"date":310,"type":93},"2024-05-06",{"date":312,"type":23},"2029-12-01",{"name":314,"class":100},"Ohio State University",2]