[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hormonal-contraception\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hormonal-contraception":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,72,97],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100642254","energy-deficiency-on-hormones-in-contraceptive-users-100642254",false,"NCT07651800","Energy Deficiency on Hormones in Contraceptive Users","Effects of a Modest Energy Deficit on Reproductive Hormones Across the Menstrual Cycle in Contraceptive Users","Inclusion Criteria:\n\n* Female, aged 18-35 years\n* Recreationally active (engaging in structured exercise between 8-15 hours per week)\n* BMI of 18.5-29.9 as a BMI below or above these cut points results in highly varied menstrual cycle lengths17\n* Not currently experiencing an eating disorder or disordered eating, or having a diagnosed eating disorder in the last 3 years\n* Non-pregnant or planning to become pregnant\n* Medically free from chronic diseases\n* Currently using one of the following contraceptive methods for ≥3 months:\n\nMonophasic oral contraceptive\n\n* Hormonal intrauterine device (H-IUD)\n* Copper intrauterine device\n* Weight stable (no weight change \\>5% body weight within the past 3 months)\n* Weight greater than or equal to 110 lbs\n* Not suffering from known gynecological disease (i.e., PCOS, endometriosis, etc.) that may influence menstrual cycle regularity\n* Willing and able to maintain current exercise habits throughout the study\n* Willing to follow study dietary guidance to achieve a \\~250 kcal\u002Fday energy deficit during Cycle 2\n\nExclusion Criteria:\n\n* Amenorrhea or oligomenorrhea\n* Perimenopausal or menopausal\n* Currently pregnant, planning pregnancy, or breastfeeding\n* Use of hormonal contraception other than monophasic oral contraceptives or hormonal IUD (implant, nuvaring, etc.)\n* Initiation or change of contraceptive method within the past 3 months\n* Diagnosis of polycystic ovary syndrome (PCOS), endometriosis, hypothalamic amenorrhea, or other known reproductive endocrine disorder\n* Current or history of eating disorder or clinically diagnosed disordered eating\n* Current participation in intentional weight loss or weight gain program\n* Use of medications known to affect metabolism or hormone levels (e.g., systemic corticosteroids, thyroid medications, insulin, GLP-1 agonists)\n* Known metabolic, cardiovascular, renal, hepatic, or endocrine disease\n* Musculoskeletal injury limiting exercise participation within the past 3 months\n* Smoking or nicotine use\n* Contraindications to DXA scanning (e.g., pregnancy, recent high-radiation diagnostic imaging exceeding institutional limits)\n* Inability or unwillingness to comply with study procedures","FEMALE","18 Years","35 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of the present study is to characterize the endocrine and metabolic responses to a modest, short-term energy deficiency (\\~250 kcal\u002Fday) across the menstrual cycle in recreationally active women using different contraceptive methods (oral contraceptive, hormonal IUD, and non-hormonal IUD). This study will leverage daily urinary hormone metabolite tracking and comprehensive metabolic assessments, providing foundational data addressing an important and previously unexamined interaction between energy availability and hormonal regulation in contraceptive users.",[27,28],"Energy Deficiency Due to Short-term Fasting","Hormonal Contraception","NOT_YET_RECRUITING","2026-06-10",{"date":32,"type":33},"2026-06-16","ACTUAL",{"date":35,"type":21},"2026-09",{"date":37,"type":21},"2027-12",{"name":39,"class":40},"University of Southern California","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":41},"100601849","effect-of-different-sex-hormone-profiles-for-the-response-to-physical-training-100601849","NCT07115849","Effect of Different Sex Hormone Profiles for the Response to Physical Training","Inclusion Criteria:\n\n* BMI 19-25\n\nExclusion Criteria:\n\n* Training more than 2 times per week\n* Smoking\n* Pregnancy\n* Taking any medications known to affect the outcome parameters",true,{"count":50,"type":21},60,[24],"The aim of the project is to elucidate the impact of diverse sex hormone profiles on the adaptability of muscle mass to physical training. Additionally, the project aims to investigate secondary effects on adipose tissue, tendons, and other physiological parameters associated with physical function.",[54,55,28],"Eumenorrhea","Intrauterine Devices, Medicated",[57,58,59,60,61],"IUD","POPs","Progestin","sex hormone profile","physical training","RECRUITING","2026-02-27",{"date":65,"type":33},"2026-03-02",{"date":67,"type":33},"2025-08-05",{"date":69,"type":21},"2028-12",{"name":71,"class":40},"University of Aarhus",{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":81,"phases":4,"briefSummary":82,"conditions":83,"keywords":84,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":41},"100586707","quality-of-life-during-different-regimens-of-combined-hormonal-contraceptives-in-women-of-reproductive-age-100586707","NCT06918873","Quality of Life During Different Regimens of Combined Hormonal Contraceptives in Women of Reproductive Age","Inclusion Criteria:\n\n* women of childbearing age (aged 18-40) who seek advice for use of combined hormonal contraception (CHC).\n* stable relationship","40 Years",{"count":80,"type":21},400,"OBSERVATIONAL","The aim of the present study is to investigate the psychosexual effects of combined hormonal contraception regimens, comparing them in terms of estrogen type and dosage, hormonal combination regimen and different routes of administration, in women seeking a hormonal contraception method to prevent unwanted pregnancies. In particular, the study focuses on the incidence of mood disorders and sexual dysfunctions associated with distress in the entire study population using combined hormonal contraception. It will also examine the incidence of these conditions under the influence of specific combined hormonal contraceptives, as well as whether different types of progestins and the route of administration (oral, vaginal or transdermal) may affect the occurrence of mood disorders and sexual dysfunctions.",[28],[85,86,87],"combined hormonal contraception","female sexual dysfunction","mood disorders","2025-04-02",{"date":90,"type":33},"2025-04-09",{"date":92,"type":33},"2014-05-05",{"date":94,"type":21},"2026-01",{"name":96,"class":40},"Fondazione IRCCS Policlinico San Matteo di Pavia",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":4,"eligibilityCriteria":103,"healthyVolunteers":48,"sex":16,"minAge":17,"maxAge":78,"enrollmentInfo":104,"targetDuration":4,"studyType":22,"phases":106,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":41},"100533202","oxytocin-and-reward-processing-in-women-100533202","NCT06222749","Oxytocin and Reward Processing in Women","The Role of Oxytocin in Reward Processing Across the Menstrual Cycle and With Oral Contraceptive Use","Inclusion Criteria:\n\n* Body-mass index (BMI): 18-28 kg\u002Fm2\n* Sex: female (since birth)\n* Normal or corrected vision\n* Natural menstrual cycle (NC) or intake of hormonal oral contraceptives (OC)\n* NC: No hormonal contraception for at least 6 months; regular menstrual cycle (between 25 and 31 days) prior to participation\n* OC: No hormonal contraception for at least 4 months, regular intake of OC pill\n\nExclusion Criteria:\n\n* No German language fluency (due to German language test content)\n* Smoking\n* Medication taken within the last 6 weeks (except for OCs in the respective group)\n* Current neurological or psychiatric disease (anamnestic survey)\n* Current medical problems such as hormonal, metabolic, or chronic diseases (e.g., severe hypertension, diabetes, dysfunctions of the thyroid, or congestive heart failure)\n* Pregnancy, delivery and lactation (current and within the last year; anamnestic survey, current pregnancy test)\n* Premenstrual dysphoric disorder (PMDD), endometriosis or polycystic ovary syndrome (PCOS)\n* Shift work\n* NC: Any kind of hormonal treatment or contraception\n* OC: Any kind of hormonal treatment or contraception (except OCs)\n* Contraindication for MRI:\n* Non-removable metal objects on or in the body\n* Tattoos (if MRI-incompatible according to expert guidelines)\n* Pathological hearing or increased sensitivity to loud noise\n* Claustrophobia\n* Operation less than three months ago\n* Neurological disease or injury\n* Moderate or severe head injury\n* Intake of antidepressants or neuroleptics\n* Restricted vision",{"count":105,"type":21},100,[24],"Oxytocin is a hypothalamic neuropeptide that is best known for its peripheral physiological effects in the female organism i.e., uterine contractions during birth. The neuropeptide furthermore affects reward processing and metabolic functions such as eating behavior and body weight. Oxytocin receptors are present in brain regions associated with the processing of rewards, e.g., ventral tegmental area (VTA), nucleus accumbens (NAcc) and nucleus stria terminalis.\n\nPrevious studies indicate that oxytocin interacts with sex hormones such as estradiol in a sex-specific manner. Despite known sex differences in oxytocin function, most studies i.e., on the metabolic effects of oxytocin in humans have so far focused on young, healthy men.\n\nIntranasal oxytocin administration has emerged as a method to experimentally investigate central nervous effects of oxytocin in the absence of relevant side effects.\n\nIn the proposed study the investigators aim to systematically investigate the acute effect of intranasal oxytocin on reward processing in relation to circulating and synthetic sex hormones in healthy, naturally cycling women and in women taking hormonal oral contraceptive pills. The investigators will administer 24 international units (IU) of intranasal oxytocin vs. placebo and investigate neural correlates in a 3T MRI scanner including functional imaging during a reward processing task, changes in brain anatomy and connectivity. Additionally, metabolic functions, eating behavior and changes in mood and wellbeing will be assessed and blood will be drawn to assess parameters of hormonal and metabolic status.",[109,28],"Menstrual Cycle",[111,112,113,114,115,116,117,118,119,120,121,122,123,124],"Oxytocin","Intranasal oxytocin","magnetic resonance imaging","MRI","fMRI","energy homeostasis","metabolism","reward processing","motivation","menstrual cycle","hormonal contraceptives","sex hormones","eating behavior","women's mental health","2024-02-27",{"date":127,"type":33},"2024-02-28",{"date":129,"type":33},"2024-02-16",{"date":131,"type":21},"2026-12-31",{"name":133,"class":40},"International Research Training Group 2804"]