[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hospitalizations\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hospitalizations":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,79,105,132],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100601264","inspiratory-muscle-training-in-hospitalized-heart-failure-patients-100601264",false,"NCT07108231","Inspiratory Muscle Training in Hospitalized Heart Failure Patients","Effects of Inspiratory Muscle Training on Inspiratory Muscle Strength in Hospitalized Heart Failure Patients: A Randomized Clinical Trial","IMTHHF","Inclusion Criteria:\n\n* Diagnosis of heart failure;\n* age over 18 years;\n* hospital admission due to heart failure;\n* clinical and hemodynamic stability defined as: heart rate \\> 40 bpm and \\\u003C 130 bpm; systolic blood pressure (SBP) \\> 90 mmHg and \\\u003C 180 mmHg; mean arterial pressure (MAP) \\> 60 mmHg and \\\u003C 110 mmHg; respiratory rate \\> 5 breaths per minute and \\\u003C 40 breaths per minute; peripheral oxygen saturation \\> 88%; absence of psychomotor agitation or somnolence\n\nExclusion Criteria:\n\n* pregnancy;\n* head trauma and\u002For brain injury;\n* motor incapacity preventing participation in the institutional rehabilitation protocol of the Cardiointensive Care Unit (ICU);\n* signs and\u002For symptoms of low cardiac output (such as sweating, hypotension, hyperlactatemia, nausea);\n* acute coronary syndrome;\n* advanced heart failure with left ventricular ejection fraction (LVEF) less than 20%\n* presence of untreated tachyarrhythmias or bradyarrhythmias;\n* use of inotropes or vasopressors at high doses or dose escalation in the last 24 hours (dobutamine above 15 mcg\u002Fkg\u002Fmin, milrinone above 0.5 mcg\u002Fkg\u002Fmin, norepinephrine above 0.3 mcg\u002Fkg\u002Fmin).","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","Introduction Exercise intolerance is the most common symptom in patients with heart failure (HF), significantly impacting their quality of life and functional capacity. Muscle metabolism may be impaired due to sympathetic hyperactivation, systemic inflammation, and neurohormonal alterations, contributing to ventilatory inefficiency and exercise intolerance. Inspiratory muscle training (IMT) has been shown to improve inspiratory muscle strength and endurance, reducing fatigue and the sensation of dyspnea.\n\nThere is a gap in the evidence regarding the use of IMT in hospitalized settings, particularly concerning short-term gains in inspiratory muscle strength and the safety of the intervention. This study aims to evaluate the effects of IMT on inspiratory muscle strength, hemodynamic and functional outcomes, as well as the safety of the IMT protocol in hospitalized patients with HF.\n\nMethods A randomized, controlled clinical trial will be conducted in the Cardiac Intensive Care Unit of the University Hospital Pedro Ernesto. The study will include individuals of both sexes, aged 18 years or older, who are hospitalized due to heart failure.\n\nExclusion criteria will include: pregnancy; head trauma and\u002For brain injury; motor disability; signs and\u002For symptoms of low cardiac output; acute coronary syndrome; advanced HF with left ventricular ejection fraction (LVEF) below 20%; presence of untreated tachyarrhythmias or bradyarrhythmias; use of high-dose inotropes or vasopressors or an increase in their dose within the past 24 hours.\n\nPrimary outcomes will include inspiratory muscle strength, safety, functional status, length of stay in the ICU, and hospital readmission within 90 days. After randomization, the intervention group will undergo IMT with a load between 30% and 50% of maximal inspiratory pressure (MIP), while the control group will perform IMT without load.\n\nIt is expected that IMT will be safe and lead to improvements in inspiratory muscle strength and functional status, without significant hemodynamic repercussions.",[27,28,29,30],"Heart Failure","Inspiratory Capacity","Inspiratory Muscle Strength","Hospitalizations",[32,33,34,35],"HEART FAILURE","EXERCISE INTOLERANCE","INSPIRATORY MUSCLE TRAINNING","HOSPITALIZATION","RECRUITING","2026-05-26",{"date":39,"type":40},"2026-05-29","ACTUAL",{"date":42,"type":40},"2026-05-13",{"date":44,"type":21},"2029-10-01",{"name":46,"class":47},"CAROLINA NIGRO DI LEONE","OTHER",2,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":78},"100630699","the-accuracy-and-efficacy-of-large-language-model-written-hospital-course-summaries-100630699","NCT07491068","The Accuracy and Efficacy of Large Language Model Written Hospital Course Summaries","Safety and Workflow Impact of Large Language Model-Assisted Hospital Course Summaries: Protocol for a Randomized, Evaluator-Blinded Non-Inferiority Trial","CLEAN","Inclusion Criteria:\n\n\\- All consecutively discharged patients, including those who died during hospitalization, will be eligible for inclusion.\n\nExclusion Criteria:\n\n* No exclusion criteria",{"count":58,"type":21},786,[24],"Background: Physicians worldwide face an increasing administrative burden that diverts time from direct patient care. Among inpatient documentation tasks, authoring hospital course summaries is particularly time-consuming and critical for safe care transitions. Large language models (LLMs) have shown promise for clinical text generation; however, robust evidence from randomized, evaluator-blinded trials conducted in routine hospital practice remains limited. Objectives: The CLEAN study aims to evaluate whether LLM-assisted, specialistedited generation of hospital course summaries is non-inferior in safety compared with standard clinician-written documentation in routine inpatient care. Secondary objectives include noninferiority assessments of resident-edited and unedited LLMgenerated summaries. Additional objectives are to evaluate summary quality across predefined domains, quantify physician documentation time, assess LLM generation stability, measure clinician adoption following the randomized phase, and examine inter-, intra-observer, and test-retest reliability of expert assessments. Methods: This is a single-centre, double-campus, exploratory randomized controlled non-inferiority trial conducted at a tertiary university hospital. Consecutive hospital discharges across multiple clinical departments are randomized 1:1 to either an LLM-assisted documentation workflow or standard manual authorship. The intervention integrates an on-premise LLM into a parallel hospital information system, generating draft hospital course summaries from complete, uncurated clinical documentation, which physicians may review and edit prior to finalization. Safety, the primary outcome, defined as presence of all important information and absence of incorrect\u002Fhallucinated information, is assessed by an adjudication committee blinded to documentation workflow. Secondary outcomes include content validity, workflow efficiency, generation stability, post-trial clinician adoption, and reliability metrics. A total of 786 discharge episodes are required to assess non-inferiority using a predefined margin of 5 percentage points. Ethics and Dissemination: The study will be conducted in accordance with the Declaration of Helsinki, Good Clinical Practice, and the General Data Protection Regulation. A waiver of informed consent is sought due to minimal risk and exclusive use of routine clinical data. Results will be disseminated through peer-reviewed publication and engagement with healthcare stakeholders.",[30],[63,64,65,66,67],"generative large language models","automated discharge summary","AI","documentation","Electronic health records","NOT_YET_RECRUITING","2026-03-25",{"date":71,"type":40},"2026-03-30",{"date":73,"type":21},"2026-06-01",{"date":75,"type":21},"2027-12-31",{"name":77,"class":47},"Pavol Jozef Safarik University",1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":87,"maxAge":4,"enrollmentInfo":88,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":78},"100629497","prognostic-factors-of-hospitalization-for-patients-aged-75-and-over-in-emergency-department-in-france---monocentric-retrospective-cohort-study-100629497","NCT07475442","Prognostic Factors of Hospitalization for Patients Aged 75 and Over in Emergency Department in France - Monocentric Retrospective Cohort Study","Prognostic Factors of Hospitalization for Patients Aged 75 and Over in Emergency Department in France - Monocentric Retrospective Cohort Study - PROFACTHOS","PROFACTHOS","Inclusion Criteria:\n\n* Adult over or equal 75 years old\n* Patient admitted to the emergency department between 10\u002F01\u002F2022 and 09\u002F30\u002F2023 for the second group, and between 10\u002F01\u002F2024 and 09\u002F30\u002F2025 for the first group\n* Patient and\u002For family and\u002For trusteeship who doesn't refused to participate\n\nExclusion Criteria:\n\n* Patient died before admitted to emergency department\n* Patient already included in the study\n* File created by mistake, identified by the mention \"Erreur de dossier\"\n* Patient deprived of total or partial liberty by a judicial or administrative decision","75 Years",{"count":89,"type":21},967,"OBSERVATIONAL","A geriatric patient is defined as a patient aged 75 and over who meets certain medical or social vulnerability criteria and is characterised by coexisting physical and\u002For psychological dependence. The proportion of patients with a geriatric profile in the general population is growing. The average time spent in the emergency department by the elderly population is about 3 hours longer than for patients under 75 years old in France, which is associated with the risk of decompensation of chronic conditions, confusion, falls or agitation. An overnight stay in the emergency department for these patients increases the risk of mortality and the length of hospital stay.\n\nSeveral prognostic scores for hospitalization have been studied in adult populations. The most widely used scores are the Sydney Triage to Admission Risk Tool (START), the Ambulatory (AMB) and the Glasgow Admission Prediction Score (GAPS). Studies have compared these three scores and demonstrated the greater robustness of GAPS. The CalcuLation of the Elderly Admission Risk in the Emergency Department (CLEARED) tool, developed for the elderly population, has lower performance than GAPS. A systematic review of the literature studied the power of GAPS for the geriatric population and highlighted the need for validation in the target population. No validated hospitalization prognostic score was found in France for this population. The research hypothesis is that GAPS would detect hight probability of admission at the time of triage for the patients aged 75 and over in emergency department in France. The primary objective of this monocentric study is to evaluate the prognostic performance of GAPS for the target population (on the group 1). The secondary objectives consist of developing and internally validating a new score (PROFACTHOS) (on the group 2), then performing a temporal validation of PROFACTHOS with comparison to the GAPS (on the group 1), and finally to determine the threshold for classifying patients with a high probability of hospitalization for the score with the strongest discriminatory performance among GAPS or PROFACTHOS.\n\nGroup 1: Patients aged 75 and over admitted to emergency department from 10\u002F01\u002F2024 to 09\u002F30\u002F2025.\n\nGroup 2 : Patients aged 75 and over admitted to emergency department from 10\u002F01\u002F2022 to 09\u002F30\u002F2023",[93,94,95,30],"Elderly","Emergency Departments","Prognostic Factors","2026-03-10",{"date":98,"type":40},"2026-03-16",{"date":100,"type":21},"2026-03-15",{"date":102,"type":21},"2027-04-15",{"name":104,"class":47},"Poitiers University Hospital",{"id":106,"slug":107,"hasResults":11,"nctId":108,"briefTitle":109,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":17,"minAge":112,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":78},"100626978","frailty-and-outcomes-in-older-emergency-department-patients-with-pneumonia-100626978","NCT07442656","Frailty and Outcomes in Older Emergency Department Patients With Pneumonia","Impact of Clinical Frailty Scale on Morbidity and Mortality in Older Adults Diagnosed With Pneumonia in the Emergency Department: A Prospective Observational Cohort Study","Inclusion Criteria:\n\n* Age ≥65 years\n* Clinical and radiological diagnosis of pneumonia in the emergency department\n* Ability to obtain informed consent from the patient or legal representative\n* Availability of a caregiver or relative able to describe baseline functional status\n\nExclusion Criteria:\n\n* Presentation with cardiopulmonary arrest or ongoing cardiopulmonary resuscitation at admission\n* Confirmed COVID-19 pneumonia\n* Inability to obtain reliable baseline functional history due to absence of an informant\n* Refusal to provide informed consent","65 Years",{"count":114,"type":21},150,"Pneumonia is one of the leading causes of infection-related mortality in the older population. Traditional severity scores used in emergency departments, such as the Pneumonia Severity Index (PSI) and CURB-65, primarily focus on acute physiological derangements and may not adequately capture biological reserve and frailty in older adults. Frailty is a geriatric syndrome reflecting increased vulnerability to stressors and reduced recovery capacity.\n\nThis prospective observational cohort study aims to evaluate the predictive value of the Clinical Frailty Scale (CFS) for in-hospital mortality, 30-day mortality, and morbidity in patients aged 65 years and older presenting to the emergency department with pneumonia. Additionally, the study will assess whether incorporating frailty assessment into existing pneumonia severity scores improves prognostic accuracy.",[117,118,30],"Community-Acquired Pneumonia","Fraility",[118,120,121,122],"Clinical Fraility Scale","Older adults","Geriatric Emergency Medicine","2026-02-26",{"date":125,"type":40},"2026-03-02",{"date":127,"type":40},"2026-01-01",{"date":129,"type":21},"2026-04-30",{"name":131,"class":47},"Ege University",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":142,"conditions":143,"keywords":148,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":159,"lastUpdatePostDateStruct":160,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":4},"100602424","french-aki-registry-fakir-a-multicenter-study-on-the-in-hospital-management-and-outcomes-of-severe-acute-kidney-injury-in-nephrology-units-100602424","NCT07123324","French AKI Registry (FAKIR): A Multicenter Study on the In-Hospital Management and Outcomes of Severe Acute Kidney Injury in Nephrology Units","Prospective Multicenter Observational Study of the Management and Prognosis of Severe Acute Kidney Injury (AKI) in Nephrology Units: The French AKI Registry (FAKIR)","FAKIR","Inclusion Criteria:\n\n* Age ≥ 18 years at admission\n* Hospitalized in a nephrology ward (standard or intensive nephrology care unit)\n* Diagnosis of acute kidney injury (AKI) stage 2 or 3 according to KDIGO criteria at the time of admission\n* Availability of follow-up data at 3 months (clinical or laboratory)\n\nExclusion Criteria:\n\n* AKI stage 1 only\n* AKI acquired outside the nephrology department without subsequent transfer to nephrology\n* Hospitalized for another reason without documented AKI stage 2 or 3\n* Refusal or opposition to data reuse for research purposes\n* Under legal protection (guardianship or trusteeship) without a representative to provide non-opposition\n* Incomplete medical records preventing collection of required baseline data",{"count":141,"type":21},750,"Acute Kidney Injury (AKI) is a common and serious condition in hospitalized patients, especially when it reaches stages 2 or 3 according to the KDIGO classification. These severe forms are associated with high mortality, a risk of progression to chronic kidney disease (CKD), and frequent cardiovascular complications. However, current data on how nephrologists manage these patients during hospitalization-and how these practices influence long-term outcomes-are limited and heterogeneous.\n\nThe FAKIR study (French AKI Registry) is a prospective, multicenter, non-interventional observational study designed to describe the clinical management of patients admitted to nephrology departments for AKI stage 2 or 3 and to assess their renal and cardiovascular outcomes up to one year. The study hypothesizes that better characterization of in-hospital practices and patient trajectories will help identify predictors of renal recovery, progression to end-stage renal disease, and major cardiovascular events.\n\nPatients will be followed during hospitalization and at 3, 6, and 12 months to assess renal function, mortality, cardiovascular events, and rehospitalizations. This registry aims to provide real-life, multicenter data to support future guidelines and the development of structured post-AKI care pathways.",[144,145,146,147,30],"Acute Kidney Injury","Kidney Failure Chronic","Cardiorenal Syndrome","Renal Replacement Therapies",[149,150,151,152,153,154,155,156,157,158],"Kidney injury","Renal function recovery","Dialysis initiation","Kidney biopsy","Cardiovascular complications","Nephrology care","Renal prognosis","Renal cohort","Kidney follow-up","Kidney disease progression","2025-08-07",{"date":161,"type":40},"2025-08-14",{"date":163,"type":21},"2025-11-01",{"date":165,"type":21},"2028-08-01",{"name":167,"class":47},"University Hospital, Strasbourg, France"]