[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hpv-1618\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hpv-1618":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100616487","multicenter-prospective-non-randomized-controlled-study-of-ala-pdt-for-lsil-with-hpv1618-infection-100616487",false,"NCT07306247","Multicenter Prospective Non-randomized Controlled Study of ALA-PDT for LSIL With HPV16\u002F18 Infection","Multicenter Prospective Non-randomized Controlled Study of Ella Photodynamic Therapy for Cervical Low-grade Squamous Intraepithelial Lesions With HPV16\u002F18 Infection","PDT for LSIL","Inclusion Criteria:\n\n1. Female, 20-60 years, understands study procedures and consents to participate;\n2. HPV 16 or 18 positive;\n3. Colposcopy-guided cervical biopsy within 3 months showing LSIL;\n4. Provides written informed consent.\n\nExclusion Criteria:\n\n1. Cytology showing ASC-H, HSIL, AGC, or AIS; or evidence of malignant cells on cytology\u002Fhistology, or suspicion of malignancy or invasive cancer;\n2. Colposcopy findings suggestive of invasive cancer or lesion extension to the vaginal wall;\n3. Severe pelvic, cervical, or other gynecological inflammatory conditions identified clinically;\n4. Undiagnosed vaginal bleeding;\n5. Active allergic disease, porphyria, or history of allergy to the study drug or structurally similar agents;\n6. Severe cardiovascular, neurological, psychiatric, endocrine, hepatic, or hematologic disorders; known immunodeficiency; long-term glucocorticoid or immunosuppressant use; active autoimmune disease; or other malignancies;\n7. Pregnant or breastfeeding women;\n8. History of hysterectomy, cervical cancer treatment, or cervical excision\u002Fablation within 6 months (e.g., conization, LEEP, laser);\n9. Use of interferon or antiviral therapy within 3 months;\n10. Any other condition deemed unsuitable for participation by the investigator.",true,"FEMALE","20 Years","60 Years",{"count":22,"type":23},225,"ESTIMATED","INTERVENTIONAL",[26],"NA","This multicenter, prospective trial assesses ALA-PDT versus observation for efficacy and safety in treating cervical LSIL with HPV16\u002F18 infection.",[29,30,31],"HPV-16\u002F18","Photodynamic Therapy (PDT)","LSIL, Low Grade Squamous Intraepithelial Lesion",[33,34,35,36],"cervical low-grade squamous intraepithelial lesions","aminolevulinic acid-mediated photodynamic therapy","efficacy","human papillomavirus","NOT_YET_RECRUITING","2025-12-14",{"date":40,"type":41},"2025-12-29","ACTUAL",{"date":43,"type":23},"2026-01",{"date":45,"type":23},"2027-12",{"name":47,"class":48},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",5]