[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"htn-hypertension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:htn-hypertension":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":4},"100644842","prospective-cohort-of-acute-cardiology-referrals-in-an-ambulatory-day-hospital-setting-100644842",false,"NCT07675434","Prospective Cohort of Acute Cardiology Referrals in an Ambulatory Day-Hospital Setting","CESAR Study: Prospective Cohort of Consecutive Patients Undergoing Cardiologic Evaluation in a Specialized Ambulatory Referral Unit","CESAR","Inclusion Criteria:\n\n\\- The study will include all consecutive patients referred to ambulatory day-hospital unit for suspicion of acute or sub-acute cardiovascular disease at the Cardiology Department of Lariboisière University Hospital.\n\nExclusion Criteria:\n\n* Patient unable to provide informed consent\n* Patient not affiliated to French social security","ALL","18 Years",{"count":20,"type":21},25000,"ESTIMATED","10 Years","OBSERVATIONAL","Suspected acute or subacute cardiovascular diseases-including chest pain, dyspnea, and palpitations-are among the most common reasons for unscheduled emergency department visits and pre-hospital referrals. Despite this high clinical burden, the diagnostic yield is often limited, with a frequent mismatch between initial clinical suspicion and final diagnosis, contributing to substantial healthcare utilization and hospitalization rates. Current evidence is largely focused on specific conditions such as acute coronary syndromes, heart failure, arrhythmias, or pulmonary embolism, and rarely integrates the full spectrum of clinical, biological, and imaging data obtained during initial evaluation.\n\nTo address this gap, we will establish a prospective cohort of all consecutive patients referred to the ambulatory day-hospital cardiology unit at Lariboisière University Hospital. This unit acts as a specialized downstream referral structure within the emergency care pathway, receiving patients after triage by emergency physicians, pre-hospital regulation services (SAMU), mobile intensive care units (SMUR), or emergency departments. Although it does not capture all suspected cardiovascular emergencies, it represents a selected real-world population deemed to require specialized acute cardiology assessment.\n\nThe primary objective is to assess the frequency of cardiac conditions diagnosed in this cohort. Secondary objectives include characterization of patient profiles and diagnostic pathways; evaluation of the diagnostic and prognostic performance of clinical, biological, imaging, and multimodal parameters using final Heart Team diagnosis as reference; analysis of prior health history and healthcare utilization; and assessment of the medico-economic burden of suspected acute cardiovascular disease. The study will further support the development of a dedicated biobank and the validation of next-generation biomarkers, including AI-driven and voice-based markers, as well as decision-support algorithms for binary classification of cardiac involvement. Through integration of multimodal data and linkage with national health records, this approach aims to improve diagnostic accuracy, risk stratification, and understanding of the healthcare impact of acute cardiovascular presentations in a real-world setting.",[26,27,28,29,30],"Acute Coronary Syndromes","Heart Failure","Pulmonary Embolism, Deep Vein Thrombosis","HTN-Hypertension","Arrhythmia",[32,33,34,35,36],"Cardiovascular emergencies","Multimodality Imaging","Acute care","Prospective cohort","Biomarkers","NOT_YET_RECRUITING","2026-06-26",{"date":40,"type":41},"2026-06-30","ACTUAL",{"date":43,"type":21},"2026-08-01",{"date":45,"type":21},"2041-08-01",{"name":47,"class":48},"Assistance Publique - Hôpitaux de Paris","OTHER",{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":80},"100503926","pulmonary-vein-isolation-pvi-combined-with-renal-denervation-rdn-in-atrial-fibrillation-af-and-hypertension-htn-100503926","NCT05841615","Pulmonary Vein Isolation (PVI) Combined With Renal Denervation (RDN) in Atrial Fibrillation (AF) and Hypertension (HTN)","Evaluation of the Safety and Efficacy of Pulmonary Vein Isolation (PVI) Combined With Renal Denervation (RDN) in Patients With Atrial Fibrillation (AF) and Hypertension (HTN)","Inclusion Criteria:\n\n* 18\\\u003Cage\\\u003C75years\n* clinic blood pressure≥140\u002F90mmHg or 24-hour ambulatory blood pressure monitoring average blood pressure ≥135\u002F85mmHg\n* Ecg diagnosis of atrial fibrillation ;\n* who signed informed consent and were approved by the Ethics Committee of the First Affiliated Hospital of Xiamen University.\n\nExclusion Criteria:\n\n* pregnant women or lactating patients;\n* Patients who were unsuitable for ablation before surgery （unilateral or bilateral renal artery shape and structure were found： renal artery stenosis exceeding 50%, renal aneurysm, previous renal artery interventional surgery, renal artery malformation, renal artery diameter \\\u003C 4mm or length of treatable segment \\\u003C 20mm）\n* Patients who only have one kidney or have a history of kidney transplantation\n* Patients with a history of renal arterial intervention or renal denervation\n* identified secondary hypertension or Pseudo hypertension except for renal parenchymal hypertension;\n* malignant tumors or end-stage diseases;\n* Severe peripheral vascular disease, abdominal aortic aneurysm\n* whose left atrium is larger than 55mm\n* obvious bleeding tendency and blood system diseases;\n* Severe peripheral vascular disease, abdominal aortic aneurysm;\n* A history of the acute coronary syndrome within two weeks;\n* acute or severe systemic infection;\n* drug or alcohol dependence or refusal to sign informed consent.\n* Other conditions that are not suitable for PVI and RDN","75 Years",{"count":58,"type":21},120,"INTERVENTIONAL",[61],"NA","The close relationship between the increase of sympathetic tension, AF, and HTN cannot be ignored. In addition, the significant failure rate of PVI (20-50%) in the treatment of AF makes it very necessary to explore the effect of RDN on AF. Therefore, this study aims to compare the effects and safety of PVI alone and PVI combined with RDN with AF combined with HTN, which will open a new chapter for PVI combined with RDN in the treatment of AF.",[64,29],"AF - Atrial Fibrillation",[66,67,68,69],"Pulmonary Vein Isolation (PVI)","Renal Denervation (RDN)","Atrial Fibrillation (AF)","Hypertension (HTN)","RECRUITING","2024-03-11",{"date":73,"type":41},"2024-03-13",{"date":75,"type":41},"2023-09-01",{"date":77,"type":21},"2028-04-30",{"name":79,"class":48},"The First Affiliated Hospital of Xiamen University",1]