[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"human-milk-nutrition\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:human-milk-nutrition":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,40],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":24,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100585635","determinants-of-the-nutritional-composition-of-donor-human-milk-100585635",false,"NCT06904924","Determinants of the Nutritional Composition of Donor Human Milk","Study of Determinants of the Nutritional Composition of Donor Human Milk","Inclusion Criteria:\n\n* Human milk donors at BLHN\n* Informed consent of the participant\n\nExclusion Criteria:\n\n* None","FEMALE",{"count":18,"type":19},80,"ESTIMATED","OBSERVATIONAL","Human milk is the most complete and correct way to feed a newborn, as it provides all the nutrients and bioactive factors essential for adequate growth and neurodevelopment. In special circumstances, such as prematurity or illness, breast milk is not always available, and donor human milk (DHM) is an option. Some studies have reported growth retardation in babies fed DHM, probably due to the less adequate nutritional composition. There are several factors that contribute to changes in its nutritional composition. Among the various factors, the following are worth highlighting: wide variety of donors with different characteristics (e.g. gestational age, lactation phase, diet); inconsistency of the collection method; impact of milk processing, i.e. the pasteurization process.\n\nAs the Human Milk Bank of North (BLHN - Banco de Leite Humano do Norte) is the first in the North region of Portugal, and there are few studies developed in this area in Portugal, the present project aims to study the influence of the following factors on the composition of the DHM:\n\n* Pasteurization process;\n* Dietary habits of donors;\n* Body composition of donors.",[23],"Human Milk Nutrition",[25,26],"Donor human milk","Human milk nutrition","NOT_YET_RECRUITING","2025-03-24",{"date":30,"type":31},"2025-04-01","ACTUAL",{"date":33,"type":19},"2025-05",{"date":35,"type":19},"2028-06",{"name":37,"class":38},"Universidade do Porto","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":48,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":53,"conditions":54,"keywords":62,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":76},"100583027","optimizing-nutrition-and-milk-opti-num-project-100583027","NCT06870981","Optimizing Nutrition and Milk (Opti-NuM) Project","Improving Growth and Neurodevelopment of Very Low Birth Weight Infants Through Precision Nutrition: The Optimizing Nutrition and Milk (Opti-NuM) Project","Opti-NuM","Inclusion Criteria:\n\n• Secondary data and biospecimens from participants of the MaxiMoM Platform RCTs\n\nExclusion Criteria:\n\n• Data and biospecimens from infants who are not enrolled in the three trials are eligible for this project.","ALL","1 Hour","21 Days",{"count":52,"type":19},1100,"Early nutrition critically influences growth, neurodevelopment and morbidity among infants born of very low birth weight (VLBW), but current one-size-fits-all feeding regimes do not optimally support these vulnerable infants. There is increasing interest in \"precision nutrition\" approaches, but it is unclear which Human Milk (HM) components require personalized adjustment of doses. Previous efforts have focused on macronutrients, but HM also contains essential micronutrients as well as non-nutrient bioactive components that shape the gut microbiome. Further, it is unclear if or how parental factors (e.g. body mass index, diet) and infant factors (e.g. genetics, gut microbiota, sex, acuity) influence relationships between early nutrition and growth, neurodevelopment and morbidity. Understanding these complex relationships is paramount to developing effective personalized HM feeding strategies for VLBW infants. This is the overarching goal of the proposed Optimizing Nutrition and Milk (Opti-NuM) Project.\n\nThe Opti-NuM Project brings together two established research platforms with complementary expertise and resources: 1) the MaxiMoM Program\\* with its clinically embedded translational neonatal feeding trial network in Toronto (Dr. Deborah O'Connor, Dr. Sharon Unger) and 2) the International Milk Composition (IMiC) Consortium, a world-renowned multidisciplinary network of HM researchers and data scientists collaborating to understand how the myriad of HM components contribute \"as a whole\" to infant growth and development, using systems biology and machine learning approaches. Members of the IMiC Corsortium that will work with on this study are located at the University of Manitoba (Dr. Meghan Azad), University of California (Dr. Lars Bode) and Stanford (Dr. Nima Aghaeepour).",[55,56,57,58,59,60,23,61],"Very Low Birth Weight Baby","Early Nutrition and the Preterm Infant","Nutritional Requirements","Human Milk Fortification","Human Milk Microbiome","Human Milk Feeding","Growth &Amp; Development",[63,64,65],"Very Low Birth Weight Infants","Early nutrition and the preterm infant","Human milk feeding","RECRUITING","2025-03-06",{"date":69,"type":31},"2025-03-11",{"date":71,"type":31},"2010-10-01",{"date":73,"type":19},"2027-12",{"name":75,"class":38},"The Hospital for Sick Children",6]