[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"human-papilloma-virus-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:human-papilloma-virus-infection":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,41],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100552042","effects-of-chinese-medicine-and-lactobacillus-in-persistent-hpv-infection-100552042",false,"NCT06467942","Effects of Chinese Medicine and Lactobacillus in Persistent HPV Infection","Effects of Estrogen-like Chinese Medicine and Vaginal Lactobacillus on HPV Clearance and Vaginal Microbiota Change in Women With Persistent HPV Infection","ELIMVLHPV","Inclusion Criteria:\n\n* Women over 25 years of age with the same type of high-risk HPV infection lasting for more than 1 year, atypical squamous cell (ASCUS) or Low-grade squamous intraepithelial disease (LSIL) cytologically negative or undiagnosable, and pathological biopsy results negative or LSIL\n* Consent to use the device for contraception during the study period;\n* agree with medicine and follow-up management procedure.\n\nExclusion Criteria:\n\n* High cytological risk, including atypical squamous cells (ASC-H),HSIL and atypical glandular cell (AGC), which could not rule out high-grade squamous intraepithelial lesions;\n* pathological biopsy for HSIL and above;\n* for any drug allergies;\n* pregnancy or lactation","FEMALE","25 Years",{"count":20,"type":21},240,"ESTIMATED","INTERVENTIONAL",[24],"NA","High risk human papillomavirus (hr-HPV) persistent infection is a high risk factor for cervical cancer. 85% to 90% of hr-HPV infections have the ability to clear on their own, while 10% to 15% of HPV persists further will lead to the development of high-grade intraepithelial lesions (HSIL) and even to invasive cervical cancer. Long-term follow-up results for persistent hr-HPV infection showed that cervical HSIL mostly occurred after 5-7 years of persistent hr-HPV infection, among which the risk of HPV16 and 18 was the highest, followed by HPV31 and 33. The role of the vaginal microbiome (CVM) in persistent hr-HPV infection has been increasingly valued, and women with persistent HPV infection that progresses to HSIL have a more unstable vaginal microenvironment. The previous study found that Lactobacillus vaginalis may contribute to HPV clearance by improving the vaginal microenvironment. In addition, previous studies have found that estrogen-like Chinese medicine could increase glycogen, improve mucosal estrogen levels, increase lactobacillus content, and promote HPV clearance. It is a challenge to make clinical management on when and how to intervene among hr-HPV persistent infection but whose pathology does not suggest HSIL. This study intends to analyze the correlation between the duration of HPV infection and the current vaginal microbiome, HPV load and PAX1 methylation in people with persistent HPV infection at different ages, and observe the changes of the above indicators after the administration of drugs to improve the vaginal microenvironment, which is helpful for preventing HPV persistent infection and developing into true precancerous lesions. It has the clinical and practical value of \"preparing for a rainy day\".",[27],"Human Papilloma Virus Infection","RECRUITING","2024-06-15",{"date":31,"type":32},"2024-06-21","ACTUAL",{"date":34,"type":32},"2023-03-01",{"date":36,"type":21},"2024-12-31",{"name":38,"class":39},"Peking University People's Hospital","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":58,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":40},"100478504","diagnostic-cervical-conization-for-persistent-infection-or-integration-of-hpv-100478504","NCT05510830","Diagnostic Cervical Conization for Persistent Infection or Integration of HPV","A Study of the Value of Diagnostic Cervical Conization for Persistent Infection or Integration of Human Papillomavirus","Inclusion Criteria:\n\n1. The patients are referred to colposcopy and biopsy examinations due to abnormal cervical screening results with no precancerous lesions discovered by pathology.\n2. The cervical precancerous lesions are highly suspected by clinicians with one or more following risk factors:\n\n   * The course of HPV type 16\u002F18 persistent infection is more than two years.\n   * The integration reads of HPV is more than 15.\n   * The impression of colposcopy indicates precancerous lesions.\n   * The cervical TCT indicates ASC-H\u002FHSIL\u002FSCC\u002FAGC-FN\u002FAIS\u002FAC.\n\nExclusion Criteria:\n\n1. Pregnant women.\n2. Vaginal intraepithelial neoplasia is highly suspected by colposcopy and pathological examinations.\n3. The patients are suffering malignant tumors of other system and have not been cured.\n4. There is acute inflammation of the lower genital or anal tract.\n5. The patients' health will be severely harmed by the colposcopy and cervical conization due to some circumstances such as severe insufficiency of liver and kidney function, blood diseases and acute inflammation of other systems.","70 Years",{"count":50,"type":21},250,[24],"For the patients with cervical persistent infection or integration of HPV, we has designed a program to perform cervical conization for certain patients to earlier and better diagnose and cure the diseases of HPV infection and related cervical intraepithelial neoplasia\u002Fcancer.",[27,54,55,56,57],"Human Papilloma Virus Integration","Cervical Intraepithelial Neoplasia","Cervical Cancer","Cervical Conization",[59,60,61],"HPV persistent infection","HPV integration","diagnostic cervical conization","NOT_YET_RECRUITING","2022-09-07",{"date":65,"type":32},"2022-09-08",{"date":67,"type":21},"2022-10",{"date":69,"type":21},"2030-01",{"name":71,"class":39},"Tongji Hospital"]