[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"human-papillomavirus-hpv-infection\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:human-papillomavirus-hpv-infection":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,53,86,116,151],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":4},"100644166","comparing-digital-and-collaborative-gamified-reinforcement-strategies-for-hpv-literacy-and-retention-among-nursing-students-100644166",false,"NCT07667127","Comparing Digital and Collaborative Gamified Reinforcement Strategies for HPV Literacy and Retention Among Nursing Students","Comparing Digital and Collaborative Gamified Reinforcement Strategies for HPV Literacy and Retention Among Nursing Students: A Randomized Comparative Study","Inclusion Criteria:\n\n* Being a nursing student\n* Voluntary participation\n* Aged 18 years or older\n* Participation in all measurement points\n* Ownership of a smartphone\n* Internet access\n* Having headphones\n\nExclusion Criteria:\n\n* Incomplete data forms\n* Not participating in intervention sessions\n* Absence in posttest or follow-up",true,"ALL","18 Years","45 Years",{"count":21,"type":22},64,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized comparative study aims to evaluate the effectiveness of two gamified reinforcement strategies, Gimkit and Escape Room, on human papillomavirus (HPV) literacy, short-term retention, and gameful learning experiences among undergraduate nursing students. Following standardized theoretical instruction on HPV infection, participants will be randomly assigned to either a digital quiz-based gamification intervention (Gimkit) or a collaborative Escape Room activity. Outcomes will be assessed using the Human Papillomavirus Literacy Scale (HPV-LS) and the Gameful Experience Scale (GAMEX) at multiple time points, including baseline, post-theoretical instruction, post-intervention, and one-month follow-up.",[28,29,30],"Health Literacy","Human Papillomavirus (HPV) Infection","Nursing Education",[32,33,34,35,36,37,38,39,40],"HPV literacy","nursing education","educational intervention","gimkit","escape room","Human Papillomavirus","game-based learning","gamification","knowledge retention","NOT_YET_RECRUITING","2026-06-30",{"date":44,"type":45},"2026-07-02","ACTUAL",{"date":47,"type":22},"2026-09-21",{"date":49,"type":22},"2026-10-26",{"name":51,"class":52},"Aydin Adnan Menderes University","OTHER",{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":59,"eligibilityCriteria":60,"healthyVolunteers":11,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":4,"studyType":23,"phases":66,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":85},"100609081","secondary-cervical-cancer-prevention-of-vulnerable-women-with-hpv-and-hiv-co-infection-in-india-100609081","NCT07209917","Secondary Cervical Cancer Prevention of Vulnerable Women With HPV and HIV Co-infection in India","Secondary Cervical Cancer Prevention of Vulnerable Women With Human Papillomavirus (HPV) and Human Immunodeficiency Virus (HIV) Co-infection in India","SAKHI","Inclusion Criteria:\n\n1. WLH, 25 - 50 years of age; based on HIV-based guidelines;\n2. Receiving ART for \\> 12 months to ensure medication stabilization, and ensure any impact on the cervical cancer outcomes will not be attributed solely to recent ART initiation, as validated by an ART card given to all ART patients;\n3. Screened as HPV positive by RT-PCR (Reverse Transcription Polymerase Chain Reaction) for oncogenic genes; and assessed to be VIA negative;\n4. Have not participated in Phase I Formative Study.\n\nExclusion Criteria:\n\n1. Pregnant or lactating women due to hormonal and dietary guideline differences;\n2. Women older than age 50. These women will be immediately referred to a gynecology specialist.","FEMALE","25 Years","50 Years",{"count":65,"type":22},348,[25],"Cervical cancer (CC) remains one of the most common malignancies among women in India, with nearly 100,000 women diagnosed annually and over 60,000 preventable deaths annually. With high-risk human papillomavirus (HR-HPV) as the causative agent for CC, one risk factor that places women at high risk for CC is human immunodeficiency virus (HIV), as impaired immune response against Human papillomavirus (HPV) may result in persistent HR-HPV infection, a critical risk factor for progression of HPV-related cervical oncogenesis. Progression of precancerous lesions among women living with HIV (WLH) is also associated with: 1) lack of HPV screening; 2) high levels of depressive symptoms and stigma; and 3) malnutrition, which negatively impacts the activation and proliferation of immune cells. Yet programs that offer WLH with comprehensive services focused on HPV screening and psychological and nutritional support are almost non-existent, and the gap is critical. Nutrition plays an integral role in relationship to HPV\u002FHIV co-infection, as demonstrated by an increased risk of HR-HPV associated with poor nutrition; nutritional deficiencies are likewise linked to cervical intra-epithelial neoplasia. The immunological effect of malnutrition may also be exacerbated among WLH due to elevated energy demands of chronic immune activation; worsened with HPV\u002FHIV co-infection. Further, depressive symptoms (aka depression for brevity) partially mediate the effect of food insecurity on HIV viral suppression. In our completed ASHA-Nutrition R01 study of antiretroviral (ART) adherence, the investigators trained lay community health workers, named Accredited Social Health Activist (ASHA), to improve the health of 600 rural WLH by providing emotional support, skill-building, nutrition education, and\u002For protein-enriched food supplements. In that study, our intervention, co-delivered by our trained ASHA, and guided by nurses, led to increased CD4+ T cell recovery and improved anthropometric and psychosocial outcomes. The investigators found that ASHA support plus protein supplements and nutritional education were significantly associated with improved CD4 counts and increased lean mass at 18 months (P \\\u003C 0.001), as well as significant improvements in depression, ART adherence, social support and internalized stigma. In our sub study, CC screening of 598 of these WLH revealed that 13% were found to have abnormal cervical lesions and 4 (1%) had squamous CC. Preliminary evidence also revealed that nutritional supplements may be associated with a 40% reduction in the risk of abnormal cervical lesions (adjusted odds ratio \\[aOR\\] = 0.60), with an association between serum albumin and reduced risk of abnormal lesions (aOR= 0.39).\n\nWith a focus on secondary prevention of CC, the investigators hope to mitigate the link between HR-HPV persistence and risk of CC as well as improve the health of women co-infected with HPV\u002FHIV (W-Co-V). Our stellar team plans to build upon our prior ASHA-Nutrition intervention, using formative research to refine a nurse-led, ASHA co-delivered, nutrition-enhanced SAKHI HPV intervention, adapted for W-Co-V. This will be followed by a randomized controlled trial (RCT), assessing the efficacy of our refined comprehensive, multifaceted SAKHI HPV intervention, as compared with an enhanced Standard of Care (SOC+) (usual care + 3 sessions \\[wellness, basic nutrition and HPV\u002FHIV health promotion\\]) among 348 high-risk co-infected women to prevent CC while remaining engaged in the HIV treatment cascade, and managing nutritional health. Recruited participants will be individually randomized in a 1:1 ratio into the two study arms. Our Primary outcome is HR-HPV persistence (2 positive tests for the same HR-HPV type, separated by 12-18 months). The two aims incorporating RCT interventions are as follows:\n\nAim 2. To evaluate the efficacy of SAKHI HPV intervention among 348 W-Co-V on the primary outcome (HR-HPV persistence) as compared to the Enhanced Standard of Care (SOC+) program. H2: Compared to the SOC+ participants, SAKHI participants will have lower rates of HR-HPV persistence.\n\nAim 3. Assess the impact of the SAKHI program secondarily on: 1) HIV indices (HIV viral load; CD4 count); 2) Nutritional index (serum albumin) at 6-, 12-, and 18-months.",[69,29,70],"Cervical Cancer","Human Immunodeficiency Virus (HIV) Infection",[72,73,74],"Cervical Cancer Prevention","HPV-HIV Co-Infection","ASHA-Nutrition","RECRUITING","2026-06-23",{"date":78,"type":45},"2026-06-26",{"date":80,"type":45},"2026-02-01",{"date":82,"type":22},"2029-04-30",{"name":84,"class":52},"University of California, Irvine",3,{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":16,"sex":61,"minAge":18,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":23,"phases":96,"briefSummary":97,"conditions":98,"keywords":100,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":115},"100625278","effect-of-different-hpv-education-methods-on-vaccination-intention-in-young-women-100625278","NCT07420556","Effect of Different HPV Education Methods on Vaccination Intention in Young Women","The Effect of Delivering HPV Education Through Different Methods on Young Women's Intention to Receive the Vaccine: A Randomized Controlled Trial","Inclusion Criteria:\n\nParticipants must meet all of the following criteria to be included in the study:\n\nAged 18-24 years,\n\nResiding in Afşin district, Kahramanmaraş province,\n\nWilling to voluntarily participate in the study,\n\nLiterate and able to understand survey questions in Turkish,\n\nHave not previously received the HPV vaccine,\n\nAgree to be available throughout the study period (pre-test, post-education test, and 1-month follow-up test),\n\nYoung women without physical or cognitive impairments or serious health problems that would prevent participation in the study.\n\nExclusion Criteria:\n\nParticipants will be excluded if they meet any of the following conditions:\n\nUnder 18 or over 24 years of age,\n\nHave received the HPV vaccine or started the vaccine series,\n\nHave been diagnosed with HPV infection,\n\nUnable to attend the educational sessions or complete all stages of data collection (pre-test, post-education test, 1-month follow-up test),\n\nIlliterate or unable to understand the study forms in Turkish,\n\nWithdraw from the study or indicate unwillingness to continue participation,\n\nHave serious hearing, vision, or cognitive impairments that would prevent meaningful engagement in the educational sessions.","24 Years",{"count":95,"type":22},117,[25],"Detailed Description Human papillomavirus (HPV) is one of the leading causes of cervical cancer and can be prevented by vaccination. However, HPV vaccination rates among young women are low, largely due to insufficient knowledge and misconceptions about HPV and the vaccine. Therefore, an effective educational program may improve both knowledge and vaccination intention.\n\nThe aim of this randomized controlled trial is to examine the effect of delivering HPV education through different methods (asynchronous online education delivered via a pre-recorded video and face-to-face education) on HPV knowledge level and HPV vaccination intention among women aged 18-24 years.\n\nThe study will be conducted with women aged 18-24 years registered at Family Health Centers in the Afşin district of Kahramanmaraş, Türkiye. Eligible participants will be randomly assigned into three groups: the video-based education group, the face-to-face education group, and the control group.\n\nData will be collected using the Participant Information Form, HPV Knowledge Scale, and HPV Vaccination Attitude and Intention Form. Measurements will be performed at three time points: before the education (pre-test), immediately after the education (post-test), and one month after the education (follow-up test). The video-based education group will receive the education via a pre-recorded online video, while the face-to-face group will receive the same content in person at the Family Health Center. No education will be provided to the control group; only measurements will be obtained.\n\nResearch Questions\n\nDoes HPV education delivered through different methods increase HPV knowledge levels among young women?\n\nDoes HPV education increase HPV vaccination intention compared with the control group?\n\nIs face-to-face education more effective than video-based education in increasing vaccination intention?\n\nAre the improvements in knowledge and vaccination intention sustained one month after the education?",[29,99],"HPV Vaccination Acceptance\u002FIntention",[101,102,103,104,105],"HPV","HPV vaccination","HPV vaccine acceptance","preventive health behavior","health education","2026-02-12",{"date":108,"type":45},"2026-02-19",{"date":110,"type":45},"2025-12-15",{"date":112,"type":22},"2026-03-31",{"name":114,"class":52},"Emel GÜÇLÜ CİHAN",1,{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":4,"eligibilityCriteria":121,"healthyVolunteers":16,"sex":61,"minAge":122,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":23,"phases":126,"briefSummary":127,"conditions":128,"keywords":131,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":115},"100614110","human-papillomavirus-self-sampling-for-enhancing-cervical-screening-during-the-war-in-ukraine-100614110","NCT07275333","Human Papillomavirus Self-sampling for Enhancing Cervical Screening During the War in Ukraine","Inclusion Criteria:\n\n* Female aged 30-60 years\n* Intact uterus (no prior hysterectomy)\n* Eligible for cervical cancer screening according to local guidelines\n* Able to provide informed consent\n* Able to perform self-sampling at home or at a clinic\n\nExclusion Criteria:\n\n* History of total hysterectomy\n* Pregnancy at the time of enrollment\n* Known diagnosis of cervical cancer\n* Inability or unwillingness to provide informed consent\n* Unable to perform self-sampling or comply with study procedures","30 Years","60 Years",{"count":125,"type":22},1000,[25],"In 2020, a cervical screening center was established in Zaporizhzhia (Ukraine), initiating a pilot project to evaluate the prevalence of HPV among women in Eastern Ukraine. The findings were intended to lay the groundwork for the Ukrainian Ministry of Health in establishing a structured national screening program. However, all efforts were halted due to the nearby armed conflict, situated just 40 kilometers from the border.\n\nThe World Health Organization's goal to eliminate cervical cancer globally has a gap when it comes to managing cancer control during crises like armed conflicts. We propose a demonstration project to assess whether a simpler, yet modern, cervical cancer control strategy (based on using self-sampling for HPV detection) could also be effective for cervical cancer screening in Zaporizhzhia.\n\nWomen aged 30-60 years who have not had a recent negative HPV test will be invited to participate. Participants receive a self-sampling kit from their primary care provider and can return the sample free of charge to the clinic or community volunteers. All samples are analyzed in accredited laboratories in Zaporizhzhia.\n\nHPV-positive women will receive follow-up care according to national guidelines, including referral to gynecologists for additional tests and treatment if needed. HPV-negative women will be reassured and advised on future screening intervals.\n\nThe study also evaluates how well the screening program can be implemented during conflict conditions. This includes measuring women's acceptance of self-sampling, the willingness of providers to adopt the procedures, and whether the screening process is feasible, practical, and sustainable. Additional process evaluation will explore how the program adapts to challenges such as migration, disrupted health services, and safety concerns.\n\nThis project is conducted through collaboration between Zaporizhzhia State Medical and Pharmaceutical University, the Charitable Foundation \"World Against Cancer,\" and Karolinska Institutet in Sweden, which provides quality assurance support for laboratory procedures. The goal is to establish a safe, effective, and sustainable cervical cancer screening model that can be used in conflict-affected regions and similar settings.\n\nThis work is supported by a grant from the Union for International Cancer Control (UICC), as part of the Reimagining Cancer Research in Europe Initiative.",[69,129,29,130],"Cervical Cancer Screening","Cervical Intraepithelial Neoplasia",[132,133,134,135,136,137,138,139,140,141],"hpv self-sampling","hpv testing","cervical cancer prevention","cervical screening","implementation science","war-affected regions","ukraine","High-risk HPV","self-collection","Screening uptake","2025-12-11",{"date":144,"type":45},"2025-12-18",{"date":146,"type":45},"2025-04-01",{"date":148,"type":22},"2026-08-31",{"name":150,"class":52},"Karolinska Institutet",{"id":152,"slug":153,"hasResults":11,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":4,"eligibilityCriteria":157,"healthyVolunteers":11,"sex":61,"minAge":62,"maxAge":158,"enrollmentInfo":159,"targetDuration":4,"studyType":23,"phases":161,"briefSummary":163,"conditions":164,"keywords":165,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":4},"100570290","phase-2-cnidium-monnieri-detoxification-formula-for-persistent-high-risk-human-papillomavirus-infection-of-cervix-100570290","NCT06705322","Cnidium Monnieri Detoxification Formula for Persistent High-risk Human Papillomavirus Infection of Cervix.","A Phase II, Multicenter Study on the Clinical Effectiveness of Cnidium Monnieri Detoxification Formula for Persistent High-risk Human Papillomavirus Infection of Cervix.","Inclusion Criteria:\n\n* Age ≥ 25 years to ≤ 75 years，with sexual life history\n* Meet the diagnostic criteria for high-risk human papillomavirus (HR-HPV) persistent infection\n* After surgery or physical therapy for high-grade squamous intraepithelial lesions (HSIL) of the cervix or high-grade squamous intraepithelial lesions (VaINIII) of the vagina, or radical surgery for cervical\u002Fvaginal cancer or radical chemoradiotherapy, the examination remained positive for HR-HPV ≥6 months after the end of treatment, with the same type or multiple types as before treatment, and no progression or recurrence of the disease.\n* No local or systemic therapy has been administered to patients in the last 3 months\n* Patients were informed of the study protocol, agreed to cooperate with the treatment, and signed informed consent.\n\nExclusion Criteria:\n\n* Only low-risk HPV infection\n* Colposcopy for high-grade intraepithelial lesions or cancer of the cervix, vagina, vulva, who have not received or are receiving treatment\n* Immunocompromised or immunosuppressant\n* Pregnant and lactating women\n* Patients with other malignant tumors not controlled, serious heart, lung, liver, renal insufficiency and coagulation dysfunction\n* People with communication or cognitive impairment\n* Patients have contraindications to oral administration of traditional Chinese medicine preparations\n* In the same period, other anti-HPV measures were used to treat, which affected the efficacy judgment","75 Years",{"count":160,"type":22},79,[162],"PHASE2","The purpose of this study is to evaluate the clinical efficacy and safety of Cnidium Monnieri Detoxification Formula in clearing HPV infection, improving clinical symptoms and quality of life in female patients with persistent cervical high-risk HPV infection.",[29,69],[166,167],"Human papillomavirus infection","Cervical cancer","2024-11-23",{"date":170,"type":45},"2024-11-26",{"date":172,"type":22},"2024-12-01",{"date":174,"type":22},"2027-03-27",{"name":176,"class":52},"Fudan University"]