[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"humans\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:humans":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,63,107,141,174,205,233,276,306,334,362,396],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":38,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":51,"lastUpdatePostDateStruct":52,"startDateStruct":55,"completionDateStruct":57,"leadSponsor":59,"locationsCount":62},"100635793","supporting-just-in-time-consent-for-prenatal-screening-the-inform-study-100635793",false,"NCT07557303","Supporting Just-In-Time Consent for Prenatal Screening: The INFORM Study","Inclusion Criteria:\n\n* Currently pregnant and receiving care at a participating collaborative site - University of North Carolina, Chapel Hill; Zuckerberg Chan San Francisco General Hospital; University of Florida Health, Jacksonville.\n* 18 years of age and older\n* Able to read, speak, and understand English or Spanish\n* Has not previously been offered prenatal genetic screening for the current pregnancy\n* 24 weeks (6 months) gestational age or less\n\nExclusion Criteria:\n\n* Not pregnant, not a patient at a partner clinical site\n* Younger than 18 years of age\n* Not being able to read, speak, and understand English or Spanish\n* Has previously been offered prenatal genetic screening for the current pregnancy\n* Greater than 24 weeks gestational age (6 months)",true,"FEMALE","18 Years",{"count":19,"type":20},1400,"ESTIMATED","INTERVENTIONAL",[23],"NA","This clinical trial is about prenatal genetic screening. It will test an intervention to help people make decisions about screening. The intervention is a short set of information cards about screening. This intervention is for pregnant participants. They will use the intervention on their mobile phone before they see their doctor.\n\nThe study has one main question:\n\n* Do participants who use the intervention feel more confident when they make a decision about screening?\n\nResearchers will compare participants who use the intervention to participants who do not. All participants will have their usual care when they visit their doctor.\n\nWhat will participants do?\n\n* Participants must be pregnant. They will sign up for the study before their first doctor's visit for their pregnancy. This is the visit where their doctor usually talks with them about screening.\n* Some participants will use the intervention before their first doctor's visit. Other participants will not use it.\n* All participants will talk with a researcher on the phone after their first doctor's visit.\n* Participants who use the intervention will answer a short survey on their phone.\n* A few participants who use the intervention will talk with a researcher a second time on the phone.",[26,27,28,29,30,31,32,33,34,35,36,37],"Delivery of Health Care","Genetic Testing","Humans","Pregnancy","Noninvasive Prenatal Testing","Informed Consent","Internet-Based Intervention","Self Efficacy","Pregnant People","Decision Making","Health Education","Patient Education as Topic\u002FMethod",[39,40,41,42,43,44,45,46,47,48,49],"Non-invasive prenatal screening (NIPS)","Non-Invasive Prenatal Testing (NIPT)","Cell-free DNA (cfDNA)","Prenatal genetic screening","Informed consent","Decision making","Surveys and Questionnaires","Informed choice","Educational intervention","Decision Regret","Decision Satisfaction","NOT_YET_RECRUITING","2026-06-30",{"date":53,"type":54},"2026-07-01","ACTUAL",{"date":56,"type":20},"2026-08-01",{"date":58,"type":20},"2028-06-30",{"name":60,"class":61},"Case Western Reserve University","OTHER",3,{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":71,"minAge":17,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":21,"phases":74,"briefSummary":75,"conditions":76,"keywords":86,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100603978","early-exercise-based-rehabilitation-in-patients-hospitalized-for-acute-pulmonary-embolism-100603978","NCT07143539","Early Exercise-Based Rehabilitation in Patients Hospitalized for Acute Pulmonary Embolism","Early Exercise-based Rehabilitation in High-risk Patients Hospitalized for Acute Pulmonary Embolism: a Pragmatic Multicenter Randomized Partially Blinded Superiority Trial","RehabPE","Inclusion Criteria:\n\n1. Age ≥18 years\n2. Hospitalization for objectively confirmed acute symptomatic PE, defined as intraluminal filling defect of a segmental or more proximal pulmonary artery on computed tomography pulmonary angiography (CTPA) or a high-probability ventilation-perfusion scintigraphy, and admission within the past 7 days\n3. Increased risk for post-PE syndrome, defined as simplified Pulmonary Embolism Severity Index (sPESI) ≥1 point at the time of admission\n4. Written informed consent\n\nExclusion Criteria:\n\n1. Contraindication to EBR (known unstable cardiac conditions like angina pectoris, severe valvular heart disease, or severe resting pulmonary hypertension)\n2. Medical condition that clearly precludes participation in EBR (e.g., inability to walk, unstable joints, severe neurological impairment)\n3. Recently completed (i.e., \\\u003C6 months), ongoing, or planned in- or outpatient EBR, or planned supervised outpatient physiotherapy for any indication\n4. Planned hospitalization during follow-up (e.g., elective surgery or inpatient chemotherapy)\n5. Contraindication to anticoagulation\n6. Life expectancy \\\u003C1 year based on the treating physician's clinical judgement\n7. Known pregnancy\n8. Inability to speak German or French\n9. Participation in another study that prohibits concurrent participation in RehabPE\n10. Unable to provide informed consent (e.g., due to dementia)\n11. Unwilling to provide informed consent\n12. Prior enrollment in this study","ALL",{"count":73,"type":20},160,[23],"Up to half of patients with pulmonary embolism (PE) suffer from impaired quality of life, reduced physical capacity, and symptoms like shortness of breath even three months after diagnosis, despite standard treatment with anticoagulation (blood thinners). The randomized RehabPE trial investigates whether an early, structured rehabilitation program with physical training and patient education can prevent such long-term effects.\n\nThe study includes hospitalized patients with acute symptomatic PE who are at increased risk of impaired quality of life three months after diagnosis. After informed consent, patients are randomly assigned to one of two groups: one receives an early 6-8-week, center-based rehabilitation program; the other receives standard follow-up care without rehabilitation. The intervention group completes 16-18 outpatient sessions of endurance and strength training, along with two education sessions covering the condition, treatment, and symptom management.\n\nOver 180 days, changes in quality of life, physical exercise capacity, breathlessness, and psychological symptoms, and the time to return to work \u002F usual daily activities will be monitored and compared between groups.",[77,78,79,80,28,81,82,83,84,85],"Venous Thromboembolism (VTE)","Exercise Therapy","Quality of Life (QOL)","Anxiety Depression","Exercise Tolerance","Rehabilitation Exercise","Dyspnea","Functional Status","Pulmonary Embolism (Diagnosis)",[87,88,89,90,91,92,93,94,95],"pulmonary embolism","deep vein thrombosis","excercise-based rehabilitation","post-PE syndrome","health-related quality of life","anxiety","depression","dyspnea","impact of early excercise-based rehabilitation","RECRUITING","2026-06-11",{"date":99,"type":54},"2026-06-12",{"date":101,"type":54},"2025-12-17",{"date":103,"type":20},"2028-06",{"name":105,"class":61},"Insel Gruppe AG, University Hospital Bern",6,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":71,"minAge":114,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":21,"phases":117,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":140},"100447554","light-in-frail-elderly---the-effect-of-a-dynamic-light-for-sleep-and-circadian-rhythm-100447554","NCT05107947","Light in Frail Elderly - the Effect of a Dynamic Light for Sleep and Circadian Rhythm","LIFE","Inclusion Criteria:\n\n* Over the age of 65 years\n* Admitted to one of the included study rooms\n\nExclusion Criteria:\n\n* Overdose addictive substance\n* Acute neurological disease\n* Melatonin treatment\n* Probable survival \\\u003C5 days\n* Severe visual impairment that makes reading impossible\n* Age \\\u003C65 years\n* Inability to understand Swedish in speech and writing\n* Inability to consent to participate in the study\n* The patient is on any of the following medicines:\n\n  * Medications for Parkinson's disease\n  * Neuroleptics (including lithium)\n  * Dementia","65 Years",{"count":116,"type":20},300,[23],"The aim of this project is to evaluate the effect of a dynamic light in order to improve the circadian rhythm, provide a better sleep and well-being, and in the long run an improved recovery. The primary question is whether dynamic artificial light with circadian stimulus can affect the circadian rhythm. The secondary question is whether this also provides better sleep and well-being.\n\nThe group that is particularly interesting to study is a geriatric population that is more sensitive to circadian rhythm disorders, sleep disorders and confusion in connection with hospitalization and that can be of particular benefit from this intervention.",[120,121,122,123,28,124,125,126,127,128,129,130],"Aged","Circadian Rhythm","Cognition","Fatigue","Light","Melatonin","Sleep","Biocentric","Frailty","Karolinska Sleepiness Score","Inflammation","2026-01-09",{"date":133,"type":54},"2026-01-12",{"date":135,"type":54},"2022-10-31",{"date":137,"type":20},"2028-09",{"name":139,"class":61},"Region Skane",1,{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":71,"minAge":17,"maxAge":4,"enrollmentInfo":148,"targetDuration":4,"studyType":21,"phases":150,"briefSummary":151,"conditions":152,"keywords":159,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":140},"100619052","flapless-periodontal-regeneration-using-hyaluronic-acid-versus-enamel-matrix-derivative-100619052","NCT07339605","Flapless Periodontal Regeneration Using Hyaluronic Acid Versus Enamel Matrix Derivative","Clinical and Radiographic Outcomes After Flapless Approach of Intrabony Defects With the Application of Enamel Matrix Derivative Versus Hyaluronic Acid: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Periodontitis stage III or IV, grade A or B (Tonetti et al., 2017): attachment loss ≥ 5mm, radiographic bone loss extending to to the middle third and beyond, tooth loss ≥4 due to periodontitis, probing depth (PD) ≥ 6mm.\n* Older adults ≥ 18 years. The number per sex shall be balanced.\n* Plaque index (PI) \\\u003C 1 following initial periodontal therapy and hygiene instructions.\n* Bleeding on probing (BoP) ≤ 10%.\n* Only patients with optimal compliance, assessed during etiological therapy, will be selected.\n* At least a 2-3 wall interproximal bone defect with a radiographically moderate or deep intrabony defect (≥3mm), PD≥ 6mm using a Williams probe on uniradicular teeth or mandibular molars without furcation involvement after non-surgical periodontal treatment.\n* Vital teeth or teeth with well-performed root canal treatment.\n* Absence of caries, prosthetic restoration or periapical infection in the tooth to be regenerated.\n* Absence of systemic pathology.\n* Negative history of pregnancy.\n* Signed informed consent.\n* The participant is willing and able to comply with the necessary visits for the treatments and evaluations scheduled during the clinical study.\n\nExclusion Criteria:\n\n* The participant is pregnant, breastfeeding or plans to become pregnant in the next 6 months.\n* Smoking ≥10 cigarettes\u002Fday.\n* Daily alcohol intake \\> 4U.\n* Chronic illness or reduced mental capacity that may influence compliance with the protocol.\n* Medications or drugs that alter the patient's healing or with concomitant oral manifestations that, in the opinion of the investigator, could interfere with the assessment of safety or efficacy.\n* Systemic diseases that may influence treatment such as diabetes mellitus or rheumatoid disease.\n* Allergies to drug compounds.\n* Antibiotic intake 3 months prior to the start of the study or systemic condition requiring antibiotic coverage at the time of periodontal treatment.\n* Periodontal treatment 6 months prior to the start of the study.",{"count":149,"type":20},60,[23],"The goal of this clinical trial is to radiographically assess the effectiveness of minimally invasive non-surgical technique (MINST) combined with local administration of sodium hypochlorite gel (Perisolv®) and 1.6% cross-linked hyaluronic acid (HA, Hyadent BG®) compared to a neutral formulation of EDTA (Prefgel®) and enamel matrix derivative (EMD, Emdogain® FL) in periodontal regeneration. The main questions it aims to answer are:\n\n* ¿Does the combination of MINST with the local administration of sodium hypochlorite gel and 1.6% cross-linked hyaluronic acid show a potential for periodontal regeneration similar to evaluating clinical and radiographic variables compared to a neutral formulation of EDTA and enamel matrix derivative?\n* ¿What is the patient perception and satisfaction with the received treatment?\n\nResearchers will compare A (MINST with Perisolv® + Hyadent BG®), B (MINST with PrefGel® + Emdogain® FL) and C(MINST without any bioactive product).\n\nThe sample will be distributed according to the following treatments:\n\n* Experimental group: Scaling and root planing (SRP), MINST with Perisolv® + Hyadent BG®.\n* Active comparator group: SRP, MINST with PrefGel® + Emdogain® FL.\n* Control group: SRP, MINST without any bioactive product.\n\nPatients will be screened by a first visit in which they will be assigned their periodontal status. If they meet the eligibility criteria, they will be treated according to the EFP clinical guideline for periodontitis treatment: step I and step II.If the periodontal defect persists at the 12-week re-evaluation, patients will be randomised to treatment A, B or C.\n\nAfter the intervention, all participants will be checked weekly for the first 6 weeks to remove accumulated plaque, and every 3 months for 1 year. Periodontal parameters will be re-evaluated 6 and 12 months after periodontal regenerative intervention.",[153,154,155,156,28,157,158],"Guided Tissue Regeneration, Periodontal \u002F Methods","Dental Enamel Proteins* \u002F Therapeutic Use","Alveolar Bone Loss* \u002F Therapy","Hyaluronic Acid* \u002F Therapeutic Use","Intrabony Defect","Flapless",[160,161,162,163,164],"Periodontitis","Intrabony defect","Hyaluronic acid","Enamel matrix derivative","Periodontal regeneration","2026-01-04",{"date":167,"type":54},"2026-01-14",{"date":169,"type":54},"2024-10-26",{"date":171,"type":20},"2027-07",{"name":173,"class":61},"University of Valencia",{"id":175,"slug":176,"hasResults":11,"nctId":177,"briefTitle":178,"officialTitle":178,"acronym":4,"eligibilityCriteria":179,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":180,"targetDuration":4,"studyType":182,"phases":4,"briefSummary":183,"conditions":184,"keywords":190,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":195,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":140},"100613914","maternal-informing-on-labor-induction-impact-on-childbirth-experience-100613914","NCT07272785","Maternal Informing on Labor Induction: Impact on Childbirth Experience","Inclusion Criteria:\n\n* Planned induction of labor at the antenatal ward or at the outpatient clinic\n* Adequate language skills (Finnish, Swedish, English)\n\nExclusion Criteria:\n\n* Induction at the delivery ward or at the obstetric emergency care clinic\n* Spontaneous onset of labor or a planned cesarean delivery\n* Age below 18 years at the time of recruitment",{"count":181,"type":20},50,"OBSERVATIONAL","The aim of this study is to explore the information provided to mothers about labor induction and its connection to their childbirth experience. In addition, the study examines how the use of social media may influence the birth experience among patients undergoing labor induction.",[185,186,29,28,187,188,189],"Labor, Induced","Labor, Obstetric","Prospective Study","Prospective Study , Questionaires","Childbirth Experience",[191,192,29,193,194],"Childbirth experience","Induction of labor","Childbirth","Obstetrics","2025-12-16",{"date":197,"type":54},"2025-12-23",{"date":199,"type":54},"2025-12-08",{"date":201,"type":20},"2026-06",{"name":203,"class":204},"Turku University Hospital","OTHER_GOV",{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":71,"minAge":17,"maxAge":4,"enrollmentInfo":213,"targetDuration":215,"studyType":182,"phases":4,"briefSummary":216,"conditions":217,"keywords":222,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":228,"completionDateStruct":230,"leadSponsor":231,"locationsCount":140},"100612796","romanian-validation-and-cross-cultural-adaptation-of-the-qor-15ro-100612796","NCT07258238","Romanian Validation and Cross-cultural Adaptation of the QoR-15Ro","Romanian Validation and Cross-cultural Adaptation of the QoR-15 Post-anesthetic Recovery Quality Questionnaire: The QoR-15Ro","QoR-15Ro","Inclusion Criteria:\n\n* Patients over 18 years old.\n* Comprehensive and sign informed consent.\n* Knows and understands the Romanian language.\n* Undergo a scheduled surgical intervention under any type of anesthetic procedure from the specialties of general surgery, urology, neurosurgery, plastic and reconstructive surgery.\n* Score \\> 26 points in the Mini Mental State Examination (MMSE) test.\n\nExclusion Criteria:\n\n* Patients under 18 years old.\n* Not having signed the informed consent.\n* Not knowing or understanding the Romanian language.\n* Surgical intervention from other specialties than general surgery, urology, neurosurgery, plastic and reconstructive surgery.\n* Score \\\u003C 27 points in the Mini Mental State Examination (MMSE) test.",{"count":214,"type":20},250,"15 Days","Optimal postoperative recovery after any surgical procedure requiring anesthesia is essential to achieving high-quality care. The Quality of Recovery questionnaire (QoR-15) was validated by its authors in 2013 in the study \"Development and psychometric evaluation of a postoperative quality of recovery score: the QoR-15.\" This instrument enables a comprehensive evaluation by integrating traditional physiological measures with the patient's subjective perception of their health status. With the consent of the original author, the present study aims to validate the Romanian version of the questionnaire and adapt it to our clinical environment.",[28,218,219,220,221],"Anesthesia","Recovery","Postoperative Care","Postoperative Period",[223,224,225],"Quality of Recovery","Postoperative Recovery","QoR-15","2025-12-01",{"date":199,"type":54},{"date":229,"type":20},"2026-01-01",{"date":51,"type":20},{"name":232,"class":61},"SUUMC Central Military Hospital Dr Carol Davila",{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":237,"acronym":238,"eligibilityCriteria":239,"healthyVolunteers":15,"sex":71,"minAge":4,"maxAge":240,"enrollmentInfo":241,"targetDuration":4,"studyType":21,"phases":243,"briefSummary":244,"conditions":245,"keywords":259,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":275},"100609268","infant-microbiota-restoration-with-maternal-microbes-100609268","NCT07212361","Infant Microbiota Restoration With Maternal Microbes","MaMi","Inclusion Criteria:\n\n* Healthy mother and healthy pregnancy\n* Singleton pregnancy,\n* Mothers who speak Finnish or Swedish\n* Mothers who are planning to breastfeed or give breastmilk by bottle to the infant\n* Infants who are expected to be healthy and who will not require BCG vaccination.\n\nExclusion Criteria:\n\n* Participants who lives further than a 2-hour drive from Meilahti, Helsinki, Finland\n* Mothers who are not planning to breastfeed or feed breastmilk by bottle to the infant\n* Mothers who are diagnosed with gestational diabetes, pre-eclampsia or who have been receiving antibiotics during the pregnancy or delivery\n* Premature infants born before the pregnancy week 37\n* Infants, who are born by urgent cesarean section or emergency cesarean section\n* Infants, who receive antibiotics during the first week of life\n* Infants, who are diagnosed with a disease, congenital anomaly or who receive less than 9 Apgar points at 5 minutes.\n* Infants, who receive BCG-vaccine","50 Years",{"count":242,"type":20},100,[23],"The goal of this clinical trial is to test the ability of different bacterial products in restoring natural gut microbiota in C-section born infants. The main question it aims to answer is:\n\nDo maternally derived strains of bacteria perform better than commercially available probiotic strains in restoring the gut microbiota of C-section born infants? Researchers will compare the gut microbiota of treated infants to that of untreated C-section born infants and untreated vaginally born infants to see if the bacterial treatments cause the microbiota to resemble that of vaginally born infants.\n\nParticipants will be given a bacterial product orally once daily for either one or four weeks and be asked to collect faecal, urine and saliva samples.",[246,247,248,249,250,251,252,253,254,255,256,257,28,29,258],"Infant, Newborn","Gut -Microbiota","Gut Dysbiosis","Cesarean Delivery Affecting Newborn","Cesarean Section","Vaginal Delivery","Gastrointestinal Microbiota","Microbiota, Cesarean Section, Probiotics, Dysbiosis","Feces","Delivery, Obstetric","Microbiota","Microbiology","Neonate",[260,261,262,263,264,265],"Infant","newborn","cesarean section","neonate","restore","gut microbiota","2025-09-30",{"date":268,"type":54},"2025-10-08",{"date":270,"type":54},"2025-07-17",{"date":272,"type":20},"2035-12-31",{"name":274,"class":61},"University of Helsinki",2,{"id":277,"slug":278,"hasResults":11,"nctId":279,"briefTitle":280,"officialTitle":281,"acronym":4,"eligibilityCriteria":282,"healthyVolunteers":15,"sex":71,"minAge":17,"maxAge":283,"enrollmentInfo":284,"targetDuration":4,"studyType":182,"phases":4,"briefSummary":286,"conditions":287,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":140},"100402865","liver-disease-and-other-systemic-diseases-100402865","NCT04525833","Liver Disease and Other Systemic Diseases","The Association of Liver Disease With Other Systemic Diseases, Focus on Diseases Progression, Treatments, and Clinical Outcomes: Analyses From the Hospital Database of Buddhist Tzu Chi Medical Foundation","Inclusion Criteria:\n\n* Individuals who visited the gastroenterology clinics of the Tzu Chi Hospitals, Buddhist Tzu Chi Medical Foundation\n\nExclusion Criteria:\n\n* Age younger than 18 or older than 99 years","99 Years",{"count":285,"type":20},15000,"Examine the association of chronic liver diseases (including hepatitis B, hepatitis C, alcoholic liver disease, fatty liver, liver cirrhosis, and hepatocellular carcinoma) with other systemic diseases by retrospectively analyzing the data from the Hospital Database of Buddhist Tzu Chi Medical Foundation.",[288,28,289,290,291,292,293,294,295,296],"Liver Diseases","Progression","Carcinogenesis","Fatty Liver Disease","Hepatitis C","Hepatitis B","Hepatocellular Carcinoma","Liver Cirrhoses","Treatment Outcome","2025-09-16",{"date":299,"type":54},"2025-09-19",{"date":301,"type":54},"2020-01-01",{"date":303,"type":20},"2026-12-31",{"name":305,"class":61},"Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation",{"id":307,"slug":308,"hasResults":11,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":4,"eligibilityCriteria":312,"healthyVolunteers":15,"sex":71,"minAge":17,"maxAge":313,"enrollmentInfo":314,"targetDuration":4,"studyType":21,"phases":316,"briefSummary":317,"conditions":318,"keywords":321,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":325,"lastUpdatePostDateStruct":326,"startDateStruct":328,"completionDateStruct":330,"leadSponsor":332,"locationsCount":140},"100509233","human-learning-of-new-structured-information-across-time-and-sleep-100509233","NCT05910762","Human Learning of New Structured Information Across Time and Sleep","Learning Novel Structure Across Time and Sleep","Inclusion Criteria:\n\n* Between 18 and 35 years of age (all aims)\n* Not a member of a vulnerable population (all aims)\n* Normal or corrected-to-normal vision (all aims)\n* Normal hearing (all aims)\n* Able to speak English fluently (all aims)\n* No prior history of major psychiatric or neurological disorders (Aims 1 and 2; MRI-specific)\n* Not currently taking any antidepressants or sedatives (Aims 1 and 2; MRI-specific)\n* No known neurological disorders (Aim 3; EEG-specific)\n\nExclusion Criteria:\n\n* The investigators will exclude individuals with MR contraindications such as non-removable biomedical devices or metal in or on the body (Aims 1 and 2; MRI-specific)\n* Claustrophobia (Aims 1 and 2; MRI-specific)\n* Pregnant women will also be excluded from neuroimaging, as the effects of MR on pregnancy are not fully understood (Aims 1 and 2; MRI-specific)","35 Years",{"count":315,"type":20},105,[23],"Acting adaptively requires quickly picking up on structure in the environment and storing the acquired knowledge for effective future use. Dominant theories of the hippocampus have focused on its ability to encode individual snapshots of experience, but the investigators and others have found evidence that it is also crucial for finding structure across experiences. The mechanisms of this essential form of learning have not been established. The investigators have developed a neural network model of the hippocampus instantiating the theory that one of its subfields can quickly encode structure using distributed representations, a powerful form of representation in which populations of neurons become responsive to multiple related features of the environment.\n\nThe first aim of this project is to test predictions of this model using high resolution functional magnetic resonance imaging (fMRI) in paradigms requiring integration of information across experiences. The results will clarify fundamental mechanisms of how humans learn novel structure, adjudicating between existing models of this process, and informing further model development. There are also competing theories as to the eventual fate of new hippocampal representations. One view posits that during sleep, the hippocampus replays recent information to build longer-term distributed representations in neocortex. Another view claims that memories are directly and independently formed and consolidated within the hippocampus and neocortex.\n\nThe second aim of this project is to test between these theories. The investigators will assess changes in hippocampal and cortical representations over time by re-scanning participants and tracking changes in memory at a one-week delay. Any observed changes in the brain and behavior across time, however, may be due to generic effects of time or to active processing during sleep.\n\nThe third aim is thus to assess the specific causal contributions of sleep to the consolidation of structured information. The investigators will use real-time sleep electroencephalography to play sound cues to bias memory reactivation. The investigators expect that this work will clarify the anatomical substrates and, critically, the nature of the representations that support encoding and consolidation of novel structure in the environment.",[319,28,320,126],"Learning","Consolidation",[322,323,324],"memory","sleep","learning","2025-07-29",{"date":327,"type":54},"2025-08-01",{"date":329,"type":54},"2023-06-05",{"date":331,"type":20},"2028-03",{"name":333,"class":61},"University of Pennsylvania",{"id":335,"slug":336,"hasResults":11,"nctId":337,"briefTitle":338,"officialTitle":339,"acronym":340,"eligibilityCriteria":341,"healthyVolunteers":15,"sex":71,"minAge":342,"maxAge":4,"enrollmentInfo":343,"targetDuration":4,"studyType":21,"phases":344,"briefSummary":345,"conditions":346,"keywords":350,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":357,"completionDateStruct":359,"leadSponsor":360,"locationsCount":140},"100532933","intraoperative-aberrometry-vs-conventional-intraocular-lens-calculation-a-prospective-study-100532933","NCT06219252","Intraoperative Aberrometry vs Conventional Intraocular Lens Calculation, a Prospective Study.","Intraoperative Aberrometry vs Conventional Introcular Lens Calculation ( Barrett Universal II \u002F Barrett True K ), Refractive and Visual Outcomes, a Prospective Study.","ORAVSCTRL","Inclusion Criteria:\n\n* patients with senile cataract, patients undergoing phacoemulsification, complete biometric profile, axial length calculated by interferometer.\n\nExclusion Criteria:\n\n* glaucoma, uncontrolled diabetic retinopathy, pseudoexfoliation syndrome, aged macular degeneration , dry eye syndrome, other ocular pathologies.","40 Years",{"count":116,"type":20},[23],"the goal of this intervention study is to compare prospectively the accuracy of the power calculation between both groups, the intraoperative aberrometry (ORA) vs barrett universal II preoperative calculation (control group) .\n\nResearchers will compare ORA group vs control to see changes in spherical equivalent and uncorrected distance visual acuity",[347,348,28,349],"Intraocular Lens Implantation","Cataract","Ocular, Refraction",[351,352,353],"biometry","aberrometry","prospective study","2025-05-09",{"date":356,"type":54},"2025-05-14",{"date":358,"type":54},"2023-11-03",{"date":303,"type":20},{"name":361,"class":61},"Instituto de Oftalmología Fundación Conde de Valenciana",{"id":363,"slug":364,"hasResults":11,"nctId":365,"briefTitle":366,"officialTitle":367,"acronym":4,"eligibilityCriteria":368,"healthyVolunteers":11,"sex":71,"minAge":17,"maxAge":369,"enrollmentInfo":370,"targetDuration":4,"studyType":21,"phases":372,"briefSummary":373,"conditions":374,"keywords":381,"overallStatus":50,"whyStopped":4,"lastUpdateSubmitDate":387,"lastUpdatePostDateStruct":388,"startDateStruct":390,"completionDateStruct":392,"leadSponsor":394,"locationsCount":4},"100471348","efficacy-of-transcutaneous-vagus-nerve-stimulation-paired-with-tailor-made-notched-music-therapy-versus-tailor-made-notched-music-training-for-chronic-subjective-tinnitus-100471348","NCT05417711","Efficacy of Transcutaneous Vagus Nerve Stimulation Paired With Tailor-Made Notched Music Therapy Versus Tailor-made Notched Music Training for Chronic Subjective Tinnitus","Efficacy of Transcutaneous Vagus Nerve Stimulation Paired With Tailor-Made Notched Music Therapy Versus Tailor-made Notched Music Training for Chronic Subjective Tinnitus: A Multicenter, Randomized, Double-blind, Controlled Clinical Trial","Inclusion Criteria:\n\n* Patients with tinnitus as the main complaint: the patients subjectively feel the sound in the ear or deep part of the head without internal or external sound stimulation, and therefore seek medical treatment\n* Chronic (≥ 6 months) and tonal tinnitus\n* Age 18-60\n* Tinnitus frequency is 125-8000 Hz\n* Hearing threshold at each frequency shall not exceed 70 dB HL\n\nExclusion Criteria:\n\n* Patients with conductive deafness, history of middle ear surgery, pulsatile tinnitus caused by vascular distortion and tinnitus caused by Meniere disease\n* History of head trauma, central nervous system diseases, mental diseases and drug abuse","60 Years",{"count":371,"type":20},388,[23],"This clinical study is a prospective, multicenter, randomized, controlled, double-blind clinical study. Sun Yat Sen Memorial Hospital of Sun Yat sen University was the central unit, and Nanjing First Hospital, Sun Yat Sen people's Hospital, Guanfzhou Panyu central Hospital and Zhuhai integrated traditional Chinese and Western medicine hospital were the cooperative units. In this study, 388 patients with chronic subjective tinnitus were recruited. In view of chronic subjective tinnitus, a common ear disease, the study gave the patients three months of treatment with transcutaneous vagus nerve stimulation paired with tailor-made notched music therapy or tailor-made notched music training alone. By comparing the changes of subjective scale scores related to tinnitus before and after treatment in patients receiving two different therapies, such as THI, VAS, BAI, BDI, PSQI, to evaluate the efficacy of the two therapies, so as to judge whether transcutaneous vagus nerve stimulation paired with tailor-made notched music therapy is better than tailor-made notched music training alone. In addition, the study will continue to follow up the patients after the treatment for one year to observe the difference in the long-term sustained efficacy of the two therapies. This clinical study will also evaluate the two therapies from the perspective of compliance and safety, and explore the factors that affect the efficacy of the two therapies.",[375,376,377,378,379,380,28,296],"Tinnitus, Subjective","Vagus Nerve Stimulation","Music Therapy","Double-Blind Method","Female","Male",[382,383,384,385,386],"Chronic subjective tinnitus","Tailor-made notched music training","Vagus nerve stimulation","Electroencephalogram","Clinical trial","2023-11-22",{"date":389,"type":54},"2023-11-27",{"date":391,"type":20},"2023-11-23",{"date":393,"type":20},"2026-09-01",{"name":395,"class":61},"Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University",{"id":397,"slug":398,"hasResults":11,"nctId":399,"briefTitle":400,"officialTitle":401,"acronym":4,"eligibilityCriteria":402,"healthyVolunteers":15,"sex":71,"minAge":403,"maxAge":4,"enrollmentInfo":404,"targetDuration":4,"studyType":182,"phases":4,"briefSummary":406,"conditions":407,"keywords":416,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":435,"completionDateStruct":437,"leadSponsor":439,"locationsCount":140},"100311532","the-nutrinet-sant-study-100311532","NCT03335644","The NutriNet-Santé Study","The NutriNet-Santé Study. A Web-based Prospective Cohort Study of the Relationship Between Nutrition and Health and of Dietary Patterns and Nutritional Status Predictors","Inclusion Criteria:\n\n* aged over 15 years\n* access to internet\n\nExclusion Criteria:\n\n* aged under 15 years","15 Years",{"count":405,"type":20},170000,"The NutriNet-Santé study was set up to investigate nutrition and health relationships. Specifically, it was the first web-based cohort worldwide on such a large scale (n=171 000 as of 2021) focused on the complex link between nutrition and health status. It is characterized by a very detailed assessment of nutritional exposure and dietary behavior.\n\nhttps:\u002F\u002Fetude-nutrinet-sante.fr\u002F https:\u002F\u002Finfo.etude-nutrinet-sante.fr\u002Fen",[408,409,410,411,412,413,28,414,45,415],"Diet, Food, and Nutrition","Exercise","Diseases Category","Cohort Studies","Adult","Anthropometry","Internet","Mortality",[417,418,419,420,421,422,423,424,425,426,427,428,429,430,431],"determinants of dietary patterns and nutritional status","Food additives, Food processing","Exclusion diets, vegetarian diet, vegan diet","Organic food, pesticide exposure, sustainability","Gut microbiota","Food labeling","Dietary supplements","Food based dietary guidelines","Psychological determinants of food behavior","Geographical determinants of food behavior","Breastfeeding","Mental health","Cancer","Cardiovascular and cardiometabolic health","Multimorbidity","2021-07-22",{"date":434,"type":54},"2021-07-26",{"date":436,"type":54},"2009-05-11",{"date":438,"type":20},"2029-05-11",{"name":440,"class":61},"University of Paris 13"]