[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"humerus-shaft-fracture\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:humerus-shaft-fracture":24},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,39,64],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":20,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100614987","ultrasound-assesment-of-radial-nerve-in-humeral-shaft-fracture-patients-with-radial-palsy-100614987",false,"NCT07286734","Ultrasound Assesment Of Radial Nerve In Humeral Shaft Fracture Patients With Radial Palsy","Inclusion Criteria:\n\n* Adult patients aged 18 years or older.\n* Diagnosed with traumatic humeral shaft fracture.\n* Admitted and followed according to the local clinical protocol with a confirmed diagnosis.\n* Underwent required investigations, including high-resolution ultrasonography and\u002For electromyography (EMG).\n* Provided written informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Pathological fractures due to malignancy or metabolic disorder.\n* History of previous humeral fracture or pre-traumatic radial nerve deficit.\n* Clinically detected vascular injury or major soft tissue loss accompanying the fracture.\n* Incomplete diagnostic workup (absence of ultrasound or EMG examination).\n* Declined participation or were lost to follow-up.\n* Persons under 18 years of age.","ALL","18 Years",{"count":18,"type":19},20,"ESTIMATED","12 Months","OBSERVATIONAL","This study investigates how well ultrasound imaging can identify damage to the radial nerve in patients with a broken upper arm bone (humeral shaft fracture). Some of these patients also have weakness or paralysis in their hand and wrist due to injury to the radial nerve. The study compares patients with and without radial nerve problems to see if early ultrasound scans can accurately detect nerve damage before surgery.\n\nAll patients will receive standard care, including surgery to fix the fracture. Those with nerve problems will also have the nerve explored during surgery. The results of the ultrasound will be compared to what is found during the operation. Patients will be followed closely over 12 months to monitor nerve recovery, healing of the bone, and any complications.\n\nThe goal is to improve the early diagnosis and management of nerve injuries in arm fractures, using a safe, non-invasive ultrasound scan that could help guide treatment decisions.",[24,25],"Humerus Shaft Fracture","Radial Nerve Palsy","RECRUITING","2025-12-03",{"date":29,"type":30},"2025-12-16","ACTUAL",{"date":32,"type":30},"2024-01-01",{"date":34,"type":19},"2026-02",{"name":36,"class":37},"Istanbul Medeniyet University","OTHER",1,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":15,"minAge":46,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":49,"conditions":50,"keywords":52,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":38},"100562616","early-fixation-for-diaphyseal-humeral-shaft-fractures-in-the-elderly-patients-100562616","NCT06605482","Early Fixation for Diaphyseal Humeral Shaft Fractures in the Elderly Patients","Early Fixation for Diaphyseal Humeral Shaft Fractures in the Elderly Patients: A Prospective Cohort Study","Inclusion Criteria:\n\n1. Diaphyseal humeral shaft fracture (as defined as superior border of insertion of pectoralis major proximally, to the distal diaphysis)\n2. Ambulatory (with or without the use of walking aides)\n\nExclusion Criteria:\n\n1. Fractures with intra-articular extension\n2. Ipsilateral upper extremity injury\n3. Patients with vascular injury\n4. Brachial plexus injury\n5. Compartment syndrome\n6. Pathological fractures\n7. Open fractures\n8. Periprosthetic fracture\n9. BMI \\>40\n10. Dementia or cognitive impairment that inhibits the collection of outcome measures\n11. Likely problems, in the judgement of the investigator, with maintaining follow-up (i.e. patients with no fixed address, not mentally competent to give consent, intellectually challenged, patients without adequate support, etc.)\n12. Inability to provide informed consent","65 Years",{"count":48,"type":19},94,"The study purpose is to evaluate whether early surgical fixation of upper arm fractures in elderly patients' age 65 years and older improves patient functional and psychological outcome scores compared to the standard of care with non-operative management.",[24,51],"Elderly (People Aged 65 or More)",[53],"patient outcomes","2025-02-26",{"date":56,"type":30},"2025-02-28",{"date":58,"type":30},"2024-11-07",{"date":60,"type":19},"2027-12-31",{"name":62,"class":63},"Fraser Orthopaedic Research Society","NETWORK",{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":71,"enrollmentInfo":72,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":74,"conditions":75,"keywords":87,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100566684","prospective-validation-study-of-the-cd8temra-cells-as-a-prognostic-biomarker-of-healing-outcome-after-fracture-100566684","NCT06658379","Prospective Validation Study of the CD8+TEMRA Cells As a Prognostic Biomarker of Healing Outcome After Fracture","BioBone","Inclusion Criteria:\n\n* male or female subjects\n* subjects \\> 18 to 80 years of age at the time of screening\n* closed fractures\n* fractures of the humerus-shaft, forearm-shaft, femur and tibia\n* Subjects suffering monotrauma or comparable with monotrauma, due to comparable post-surgery mobilisation\n* osteosynthesis\n* subject has signed an informed consent form\n* legal capacity\n\nExclusion Criteria:\n\n* cancer related fractures\n* periprosthetic fractures\n* known active Hepatitis B virus or Hepatitis C virus infection at screening\n* known human immunodeficiency virus (HIV) infection, severe uncontrolled inflammatory disease or severe uncontrolled autoimmune disease (e.g., ulcerative colitis, Crohn's disease\n* active malignancy or history of malignancy within 5 years prior to screening\n* known diagnosis of moderate to severe dementia based on subject's medical history or severe psychiatric disorder\n* known history of drug or alcohol abuse in the past 12 months, based on self-report or medical record\n* history of autologous\u002Fallogeneic bone marrow (BM) or solid organ transplantation\n* exposure to allogeneic cell-based therapy in the past or exposure to autologous cell therapy in the last 12 months before screening\n* pregnancy\n* subject is currently enrolled in an investigational device or drug trial, or has not yet completed a period of at least 30 days since ending other investigational device or drug trial(s).\n* subject is detained or institutionalized under a court order or administrative order\n* in the opinion of the investigator, the subject is unsuitable for participating in the study (patient compliance).","80 Years",{"count":73,"type":19},640,"In approx. 10-15% of all fracture patients, there is a prolonged healing time or even a complete absence of fracture healing (non-union). As a result, these patients require further surgical interventions, combined with renewed or prolonged hospitalisation\u002Frehabilitation and incapacity to work. To summarise, this therefore represents a serious socio-economic problem. At present, there is no prognostic method for the early prediction of patients at risk of a disturbed healing process. However, if these patients are successfully stratified, there are already a variety of therapeutic strategies available to additionally stimulate fracture healing. Therefore, the aim is to conduct a prospective clinical study to validate CD8+ TEMRA cells as a prognostic marker of impaired fracture healing. The investigators assume that preoperative CD8+ TEMRA cell expression represents a prognostic biomarker with high diagnostic precision for differentiating between a) normal healing patients, b) delayed healing patients and c) pseudarthrosis patients. Furthermore, the sensitivity and specificity should be high enough, health-economically significant and realisable in clinical routine.",[76,77,78,24,79,80,81,82,83,84,85,86],"Fracture Non Union","Fracture Healing","Long Bone Delayed-Union Fracture","Forearm Fracture","Femoral Neck Fractures","Femur Distal Fracture","Pertrochanteric Fracture of Femur","Femoral Shaft Fracture","Proximal Tibia Fracture","Tibial Shaft Fracture","Distal Tibia Fracture",[88,89,90,91,92,93,94,95,96],"long bone fracture","impaired fracture healing","fracture non-union","prognosis","prognostic biomarker","Immune system","T cells","radiology","bone fracture healing","2024-10-23",{"date":99,"type":30},"2024-10-26",{"date":101,"type":30},"2016-12",{"date":103,"type":19},"2025-06",{"name":105,"class":37},"Charite University, Berlin, Germany",7]