[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hyperbaric-oxygen\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hyperbaric-oxygen":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100592926","assessment-of-the-impact-of-increased-production-of-reactive-oxygen-species-produced-during-repeated-sessions-of-hyperbaric-oxygen-therapy-in-patients-undergoing-radiotherapy-for-neoplasia-on-the-occurrence-of-dna-damage-100592926",false,"NCT06999785","Assessment of the Impact of Increased Production of Reactive Oxygen Species Produced During Repeated Sessions of Hyperbaric Oxygen Therapy in Patients Undergoing Radiotherapy for Neoplasia, on the Occurrence of DNA Damage","OXYBAR","Inclusion Criteria:\n\n* Adults (≥18 years old)\n* Having signed an informed consent form\n* Affiliated with or beneficiary of a national health insurance system\n* Admitted to the hyperbaric medicine department for HBOT treatment\n* Either for a complication related to prior radiotherapy (administered for an underlying neoplastic disease), such as:\n\nRadiation cystitis Radiation proctitis \u002F enteritis Radiation dermatitis Mandibular osteoradionecrosis Or for another indication, without any underlying neoplastic disease\n\nExclusion Criteria:\n\n* Patients with a contraindication to hyperbaric oxygen therapy (HBOT)\n* Pregnant, breastfeeding, or postpartum women\n* Patients deprived of liberty by judicial or administrative decision\n* Patients undergoing involuntary psychiatric treatment\n* Patients under legal guardianship or protective custody","ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","Hyperbaric Oxygen Therapy (HBOT) is a treatment involving the administration of oxygen at pressures higher than atmospheric pressure, with numerous potential indications such as radiation-induced tissue damage, chronic wounds, and more. HBOT significantly increases the amount of dissolved oxygen in tissues, thereby promoting wound healing.\n\nHowever, this \"hyperoxygenation\" may also exert toxic effects, particularly through the production of reactive oxygen species (ROS), which can induce DNA damage and potentially promote mutagenesis, thereby increasing long-term neoplastic risk.\n\nA single HBOT session is associated with a significant increase in ROS production, which may persist for up to 48 hours post-exposure, and is also linked to DNA damage. DNA repair is typically a rapid process, with the activation of protective mechanisms.\n\nThe effects of repeated HBOT sessions remain a matter of debate. Reported outcomes range from attenuation of genotoxicity, to exacerbation of DNA damage, or no effect at all (8). In patients with cancer or comorbidities associated with impaired DNA repair capacity, repeated HBOT could be more detrimental, potentially increasing genotoxic effects and cancer risk. This increased oxygen susceptibility in cancer patients has already been observed in normobaric conditions during abdominal surgery, where hyperoxygenation strategies were associated with increased mortality in this subgroup.\n\nA potential pro-carcinogenic effect of HBOT in cancer patients has also been suggested in some case series, though not confirmed by larger studies.\n\nCurrent literature on HBOT safety remains generally reassuring; however, the possibility of DNA damage and its potential long-term genotoxic consequences cannot be entirely excluded. This question is of particular importance given that many primary indications for HBOT involve patients with a history of malignancy or active cancer",[26,27,28],"Hyperbaric Oxygen","Genotoxicity","Malignancy","RECRUITING","2026-03-31",{"date":32,"type":33},"2026-04-06","ACTUAL",{"date":35,"type":33},"2025-07-08",{"date":37,"type":20},"2027-11-15",{"name":39,"class":40},"University Hospital, Angers","OTHER_GOV",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":63,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":5},"100613193","effect-of-hydrogen-gas-on-hyperbaric-oxygen-toxicity-100613193","NCT07263399","Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity","Effect of Hydrogen Gas on Hyperbaric Oxygen Toxicity - A Randomized Controlled Cross-Over Trial","Inclusion Criteria:\n\n* Military divers actively serving, aged 20-64 years\n* Meeting the Swedish Armed Forces physical standards for diving\n\nExclusion Criteria:\n\n* Ongoing infection or illness that may impact pulmonary function\n* Use of alcohol or smoking cigarettes within 48 hours\n* Diving with any breathing gas within 48 hours\n* Diving with oxygen-enriched gas (100% O₂) within 2 weeks\n* Use of medications that could affect oxidative stress, lung function, or neurological status\n* Medical history of serious diving-related injuries or long-term complications",true,"20 Years","64 Years",{"count":53,"type":20},32,[23],"The goal of this trial is to investigate whether adding a small fraction of hydrogen gas to an oxygen-enriched breathing mixture can reduce pulmonary oxygen toxicity (POT) in healthy and active divers from the Swedish Armed Forces. The main questions it aims to answer are:\n\n* Does hydrogen gas reduce oxidative stress and changes in pulmonary function associated with prolonged hyperbaric oxygen exposure?\n* What are the underlying pathophysiological mechanisms of pulmonary oxygen toxicity?\n\nResearchers will compare oxygen-enriched breathing gas with 1-2% hydrogen to oxygen-enriched gas with 1-2% nitrogen (control) to see if hydrogen provides protective effects against POT during hyperbaric exposure.\n\nParticipants will:\n\n* Complete two hyperbaric exposure sessions (hydrogen vs. nitrogen), each lasting 240 minutes at 1.75 ATA\n* Undergo pulmonary function tests and sampling of blod and urin before and after each session\n* Serve as their own controls in a double-blind, randomized, crossover study design",[57,58,59,26,60,61,62],"Oxygen Toxicity","Oxidative Stress","Hyperoxia","Healthy Subjects (HS)","Diving Medicine","Hydrogen-oxygen Gas",[64,65,66,67,26,68,69],"Pulmonary Oxygen Toxicity","Hydrogen Gas","Diving Physiology","Lung Function","Human Study","Military Divers","NOT_YET_RECRUITING","2025-12-01",{"date":73,"type":33},"2025-12-04",{"date":75,"type":20},"2026-01",{"date":77,"type":20},"2030-12",{"name":79,"class":80},"Blekinge Institute of Technology","OTHER"]