[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hyperbaric-oxygenation\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hyperbaric-oxygenation":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,81],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100641595","acute-effects-of-post-exercise-hyperoxia-on-recovery-in-cycling-100641595",false,"NCT07659301","Acute Effects of Post-Exercise Hyperoxia on Recovery in Cycling","Inclusion Criteria:\n\n* Road cyclists competing in Elite 2 (Elite without professional contract) or Under-23 (U23) categories or equivalent \\[Participation in national-level Belgian competitions within the previous 12 months. No specific ranking, finishing position, or performance threshold is required.\\]\n* ≥ 2 consecutive years of cycling experience at regional or national level, with structured and periodized training\n* Cycling-specific training volume ≥ 8 h a week over the preceding 10 weeks\n* Stable training load in the weeks preceding inclusion, with no major changes due to injury, illness, or abnormal overload\n* Measured VO₂max ≥ 60 ml\u002Fkg\u002Fmin\n\nExclusion Criteria:\n\n* Presence of significant cardiovascular, pulmonary, neurological, ENT, or metabolic disease, including but not limited to: Uncontrolled arterial hypertension (systolic blood pressure ≥ 180 mmHg and\u002For diastolic blood pressure ≥ 110 mmHg) ; Unstable heart disease or decompensated cardiomyopathy\n* Contraindications to hyperbaric exposure, including: Untreated pneumothorax, History of spontaneous pneumothorax without medical clearance ; Pulmonary conditions associated with air trapping (e.g. emphysema or bullous lung disease), or abnormal thoracic imaging when indicated ; Recent thoracic surgery\n* Neurological contraindications, including epilepsy, history of oxygen-induced seizures, or recent seizure activity, and any association with cannabis use\n* Ear, sinus, or Eustachian tube disorders preventing adequate pressure equalization, including active infection or history of severe barotrauma\n* Severe claustrophobia incompatible with chamber exposure",true,"MALE","18 Years","40 Years",{"count":20,"type":21},48,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study examines whether exposition to hyperbaric oxygen after a road-race simulation can help competitive cyclists recover and perform better the following day.\n\nHyperbaric oxygen, which involves breathing oxygen inside a pressurized chamber, is used as a recovery method in elite and professional sport. Its effectiveness, however, remains controversial: despite this widespread use, there is a lack of solid scientific evidence that a single HBO session after strenuous endurance exercise actually improves recovery, or that clarifies how the amount of oxygen exposure influences any benefit.\n\nThe study includes healthy male road cyclists between 18 and 40 years of age who compete at the national level in Belgium. After completing a fatiguing cycling session, each participant is randomly assigned to one of four groups receiving different levels of oxygen exposure during recovery.\n\nTwo groups breathe oxygen under increased pressure inside a chamber at either 2.5 or 1.4 atmospheres absolute. A third group breathes oxygen at normal pressure. The fourth group receives a sham condition that reproduces the treatment setting without active oxygen exposure.\n\nThe study is double-blind, meaning that neither the participants nor the researchers assessing the outcomes know which condition each participant receives.\n\nThe main goal is to determine whether a single session of post-exercise HBO improves next-day endurance performance, and whether higher oxygen exposure produces greater effects.\n\nThe researchers also collect blood samples and physiological measurements to better understand how the body recovers.",[27,28,29,30,31],"Athletic Performance","Hyperbaric Oxygenation","Physical Endurance","Muscle Fatigue","Oxidative Stress","RECRUITING","2026-06-15",{"date":35,"type":36},"2026-06-22","ACTUAL",{"date":38,"type":21},"2026-07-01",{"date":40,"type":21},"2027-12-31",{"name":42,"class":43},"Université Catholique de Louvain","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":15,"sex":53,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":4},"100638741","retrospective-analysis-of-cpet-and-cognitive-tests-of-healthy-individuals-treated-with-60-treatment-of-hbot-100638741","NCT07596641","Retrospective Analysis of CPET and Cognitive Tests of Healthy Individuals, Treated With 60 Treatment of HBOT","Retrospective Analysis of Cardiopulmonary Exercise Tests and Cognitive Tests of Healthy Individuals Age 18+ Years, Treated at the Sagol Center for Hyperbaric Medicine and Research With 60 Hyperbaric Oxygen Therapy Treatments.","HBOT","Inclusion Criteria:\n\n* Adults aged 18-65 years\n* Completed a full treatment series of 60 hyperbaric oxygen therapy (HBOT) sessions at the Sagol Center\n* Availability of pre- and post-treatment cardiopulmonary exercise testing (CPET) data\n* Availability of pre- and post-treatment cognitive assessment data\n\nExclusion Criteria:\n\n* Inability to complete a maximal CPET test, pre and post HBOT or Missing pre- or post-treatment CPET data.\n* Incomplete HBOT treatment series\n* Missing cognitive assessment data","ALL","65 Years",{"count":56,"type":21},1000,"OBSERVATIONAL","This retrospective observational study evaluates physiological and cognitive changes following a series of 60 hyperbaric oxygen therapy (HBOT) sessions in healthy individuals. Participants underwent treatment five days per week, each session included 90 minutes exposure to 100% oxygen at 2ATA with a five-minute air break every 20 minutes. Pre- and post-treatment data include cardiopulmonary exercise testing (CPET) and standardized cognitive assessments. The study aims to characterize associations between changes in cardiorespiratory fitness and cognitive performance following repeated HBOT exposure in a real-world clinical cohort",[28,60,61],"Cardiorespiratory Fitness","Cognition",[51,63,64,65,66,67,68,69],"VO2MAX","VO2 PEAK","cognitive function","CPET","cardiopulmonary exercise testing","hyperbaric oxygen therapy","HEALTH","NOT_YET_RECRUITING","2026-05-17",{"date":73,"type":36},"2026-05-19",{"date":75,"type":21},"2026-12-01",{"date":77,"type":21},"2028-03-30",{"name":79,"class":80},"Assaf-Harofeh Medical Center","OTHER_GOV",{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":53,"minAge":17,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":93,"conditions":94,"keywords":96,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":44},"100634090","phase-2-hyperbaric-oxygen-therapy-as-adjunctive-treatment-for-fracture-related-infection-100634090","NCT07535164","Hyperbaric Oxygen Therapy as Adjunctive Treatment for Fracture-Related Infection","Supplementary Oxygen Therapy After Limb Debridement and Reconstruction Surgery in Infected Extremity Fractures (SOLDIER): a Pilot, Non-blinded, Randomized Controlled Trial","SOLDIER","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Confirmed or highly suspected post-traumatic FRI of the lower limb, for which surgical intervention will be conducted\n\nExclusion Criteria:\n\n* Patients with a known contraindication for HBOT: untreated pneumothorax; epilepsy; middle ear or thorax surgery in the previous 12 months; inability to equalize the ears; COPD grade 4 or other severe air trapping lung disease; presence of a device that is not known to be compatible with HBOT; severe claustrophobia; pregnancy; BMI ≥ 35; obstructive sleep apnoea syndrome or obesity hypoventilation syndrome with a chronic increased PaCO2 \\> 6.4 kPa\n* Patients with an early (i.e. diagnosed \\\u003C6 weeks post initial trauma) FRI, which is treated by DAIR-procedure (Debridement, Antibiotics, Implant Retention) without soft tissue reconstruction\n* Patients with an active isolation precautions protocol which is incompatible with treatment in a hyperbaric chamber (i.e. with multiple patients in the chamber at the same time)\n* Inability to understand Dutch or English",{"count":90,"type":21},50,[92],"PHASE2","A fracture-related infection (FRI) is a difficult to treat condition in which a bone fracture and surrounding tissues are infected. This results in impaired healing and ongoing symptoms such as pain, wound leakage and swelling, which affects patients' functioning and quality of life. Despite adequate treatment in the form of extensive surgical debridement and long-term antibiotics, it is hard to obtain infection eradication.\n\nThis pilot, non-blinded, randomized controlled trial (RCT) will assess the feasibility of a subsequent, larger RCT, in which hyperbaric oxygen therapy (HBOT) will be investigated as potential treatment modality for FRI in adjunction to standard care. HBOT induces an increased oxygen tension in the body and thereby inhibits inflammation and the growth of several bacteria. Furthermore, it stimulates bone and blood vessel formation. Therefore, HBOT might be of added value in the treatment of FRI. Data on process-related outcomes, patient-reported outcome measures, and clinical parameters are obtained during this pilot study to determine whether a subsequent study investigating the efficacy of HBOT is viable.",[95,28],"Fracture Related Infection",[97,98,99,100,101],"Hyperbaric oxygen therapy","Fracture-related infection","Lower extremity","Feasibility studies","Randomized controlled trial","2026-04-09",{"date":104,"type":36},"2026-04-16",{"date":106,"type":21},"2026-08",{"date":108,"type":21},"2028-08",{"name":110,"class":43},"Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)"]