[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypercapnic-respiratory-failure-copd\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypercapnic-respiratory-failure-copd":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100624782","how-nocturnal-hypoventilation-predicts-long-term-response-to-non-invasive-ventilation-in-hypercapnic-copd-patients-100624782",false,"NCT07414108","How Nocturnal Hypoventilation Predicts Long-term Response to Non-invasive Ventilation in Hypercapnic COPD Patients","Role of Nocturnal Hypoventilation in Predicting the Long-Term Ventilatory Response in Hypercapnic COPD Patients Treated With Non-Invasive Ventilation: A Prospective Observational Study With Clinical, Functional, and Radiological Assessment","HYPONIV","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Patients with COPD and hypercapnia, defined as PaCO₂ \\> 50 mmHg either chronically or 4 weeks after an acute exacerbation requiring invasive or non-invasive mechanical ventilation\n* Provision of informed consent\n\nExclusion Criteria:\n\n* Progressive neurodegenerative diseases\n* Diaphragmatic disorders\n* Severe hemodynamic instability (\\>1 vasoactive agent for at least 24 hours)\n* Acute coronary syndrome (unstable angina \u002F myocardial infarction)\n* Severe arrhythmias\n* Presence of contraindications to NIV\n* Cognitive impairment interfering with treatment adherence\n* Active and unstable coronary artery disease\n* Malignancies undergoing active treatment\n* Patients already receiving home non-invasive mechanical ventilation","ALL","18 Years",{"count":20,"type":21},25,"ESTIMATED","OBSERVATIONAL","The study is an observational, single-center, prospective cohort study aiming to evaluate respiratory mechanics data, as well as clinical and functional parameters commonly used in clinical practice in patients with COPD and hypercapnic respiratory failure. The study population consists of patients with COPD and hypercapnia requiring NIV. The primary objective of the study is to evaluate the association between the reduction in partial pressure of carbon dioxide in arterial blood (PaCO₂) levels at 6 and 12 months after initiating non-invasive ventilation (NIV) and the presence of nocturnal hypoventilation detected at baseline in patients with COPD and chronic hypercapnia. Secondary objectives of this study are the evaluation of the following parameters measured at baseline and\u002For after 6 and 12 months of NIV treatment in patients with COPD and chronic hypercapnia:\n\n* Magnitude of esophageal pressure swing during nocturnal monitoring.\n* Diaphragm thickness and diaphragmatic thickening fraction assessed by thoracic ultrasound.\n* Presence of overlap syndrome (COPD + OSA).\n* Radiological classification of COPD subtypes to assess the association between radiological findings, functional profile, severity of nocturnal hypoventilation, and patterns of chronic hypercapnia.\n* Respiratory functional parameters, including FEV₁, FVC, FEV₁\u002FFVC ratio, carbon monoxide diffusion capacity (DLCO), and airway resistance (R5 and R20).\n* Frequency of severe exacerbations and subsequent rehospitalizations during follow-up.\n* Rate of compliance with respiratory treatment.",[25,26,27,28],"COPD","COPD (Chronic Obstructive Pulmonary Disease)","Hypercapnia","Hypercapnic Respiratory Failure, COPD","RECRUITING","2026-02-10",{"date":32,"type":33},"2026-02-17","ACTUAL",{"date":35,"type":33},"2025-12-10",{"date":37,"type":21},"2028-06",{"name":39,"class":40},"IRCCS Azienda Ospedaliero-Universitaria di Bologna","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100584349","survey-on-niv-settings-in-the-intensive-care-unit-for-acute-exacerbation-of-copd-100584349","NCT06888180","Survey on NIV Settings in the Intensive Care Unit for Acute Exacerbation of COPD","Survey on Non-Invasive Ventilation Settings in the Intensive Care Unit for Acute Exacerbation of Chronic Obstructive Pulmonary Disease","NIV-ICU","Inclusion Criteria:\n\n* Adult COPD Patient\n* Known or suspected COPD diagnosis as assessed by the attending physicians\n* Admitted to a medical intensive care unit (MICU), respiratory intensive care unit, or MICU\n* Hypercapnic respiratory distress\n* NIV indication determined by the physician\n* Covered by social security\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding women\n* Other obstructive diseases (asthma, bronchiectasis, cystic fibrosis, bronchiolitis, pulmonary fibrosis, restrictive thoracic syndrome) Central hypoventilation (Ondine's syndrome, iatrogenic), neurological (neuromuscular disease), osteoarticular (kyphoscoliosis), or ENT-related causes\n* Immediate need for intubation\n* Acute pulmonary edema\n* Contraindications to NIV (untreated pneumothorax, shock, cardiac arrest, uncontrolled vomiting, upper gastrointestinal bleeding, cervicofacial trauma, coma except when related to hypercapnia)\n* Patients under legal guardianship\n* Incarcerated individuals",{"count":51,"type":21},976,"Introduction Chronic obstructive pulmonary disease (COPD) is a common condition and the fourth leading cause of death worldwide. With the rise of non-invasive ventilation (NIV), mortality among patients admitted for acute hypercapnic respiratory failure has decreased, though to a lesser extent than reported in the studies that validated this technique. We hypothesize that inappropriate initial ventilatory parameter settings for NIV could be associated with increased morbidity and mortality in this context.\n\nObjective The primary objective of this study is to assess the initial NIV settings used in intensive care units (ICUs) and respiratory intensive care or medical intensive care units (MICUs) in this patient population. A secondary objective is to evaluate whether specific ventilatory settings are associated with mortality or the need for invasive mechanical ventilation (IMV).\n\nMethods This is a prospective multicenter observational study aiming to include 976 patients. NIV settings will be recorded at initiation, after the first recommended arterial blood gas (ABG) evaluation (between 1.5 and 2 hours of ventilation), and at 24 and 48 hours. Patient characteristics, including medical history, clinical and biological parameters at admission, will be collected. Vital status and the need for IMV will be recorded at ICU discharge and on day 28 (D28).",[26,54,28],"Acute Exacerbation of COPD",[25,56,57,58],"Acute exacerbation of COPD","Non invasive ventilation","Hypercapnic respiratory failure","NOT_YET_RECRUITING","2025-03-24",{"date":62,"type":33},"2025-03-26",{"date":64,"type":21},"2025-09",{"date":66,"type":21},"2027-09",{"name":68,"class":40},"University Hospital, Caen"]