[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypermobility-syndrome\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypermobility-syndrome":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,49,79,107,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100537405","exercise-in-patients-with-hypermobile-joints-and-knee-pain-100537405",false,"NCT06277401","Exercise in Patients With Hypermobile Joints and Knee Pain","High-load Resistance Training Compared With Usual Care for Treatment of Painful Knee Joint Hypermobility in Young Adults: A Randomised Controlled Trial (the HIPEr-Knee Study)","HIPEr-Knee","Inclusion criteria\n\n* Persistent knee pain for ≥ 3 months (self-reported)\n* Knee pain ≥ 30mm during the last week using a 0-100 mm visual analogue scale (VAS; 0=no pain and 100=worst imaginable pain) (self-reported)\n* Generalised joint hypermobility assessed with the Five-Part Hypermobility Questionnaire (positive ≥ 2\u002F5) (self-reported)\n* Local knee joint hypermobility using the passive hyperextension of the knee in standing (positive \\> 10 degrees of hyperextension) and confirmed in supine lying (heel resting on 20 cm high block on the bench surface), with passive knee hyperextension (positive \\> 10 degrees) (objectively measured)\n\nExclusion criteria\n\n* Diagnosed with patellar tendinopathy\n* Pregnancy or childbirth within the past year (due to increased levels of relaxin that could affect joint stability)\n* Knee surgery within the past year\n* Participation in regular structured resistance training within the past six months\n* Inability to speak and understand Danish.\n* All types of Ehlers-Danlos syndrome\n* Other heritable connective tissue disorders such as Marfan syndrome, osteogenesis imperfecta, Loeys-Dietz syndrome, Stickler syndrome, skeletal dysplasias\n* Autoimmune rheumatic connective tissue disorders such as lupus, rheumatoid arthritis; Chromosomal conditions such as Fragile X syndrome, Kabuki syndrome, Down syndrome\n* Neuromuscular disorders that can cause joints to become unstable, such as multiple sclerosis","ALL","18 Years","45 Years",{"count":21,"type":22},90,"ESTIMATED","INTERVENTIONAL",[25],"NA","Pain associated with knee joint hypermobility is common in the adult population, but evidence on treatment is sparse. This study investigates if high-load resistance training is superior to usual care in improving activity-related pain in young patients (18-45 years) with hypermobile joints and knee pain.",[28,29,30],"Hypermobility, Joint","Hypermobility Syndrome","Knee Discomfort",[32,33,34,35],"Hypermobility","Knee pain","Treatment","Randomised controlled trial","RECRUITING","2026-04-28",{"date":39,"type":40},"2026-04-29","ACTUAL",{"date":42,"type":40},"2024-02-21",{"date":44,"type":22},"2027-12",{"name":46,"class":47},"University of Southern Denmark","OTHER",2,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":4},"100626687","dynamic-lycra-garments-for-hip-dysplasia-feasibility-study-100626687","NCT07438873","Dynamic Lycra Garments for Hip Dysplasia Feasibility Study","Dynamic Lycra Garments to Address Pain and Instability Associated With Hip Dysplasia: a Single Cohort Observational Pilot Study","HIPlycra","Inclusion Criteria:\n\n* 18 years of age or over\n* Clinical diagnosis of Develomental Dysplasia of the Hip (DDH)\n* Clinical diagnosis of hypermobility\n\nExclusion Criteria:\n\n* Under 18 years of age\n* Clinical diagnosis of additional musculoskeletal pathology affecting hips or pelvis",{"count":58,"type":22},12,[25],"Dynamic lycra garments are deployed in rehabilitation and exercise to support unstable areas of the body, enhance sensory feedback to improve movement patterns, reduce fatigue and pain and improve function.\n\n2 case studies have respectively highlighted the effective use of postural correction to reduce hip pain in an adult with acetabular dysplasia while lycra orthoses have reduced pain and improved stability in the hip. Larger scale studies assessing the effect of lycra garments across a clinical population of those presenting with combined hypermobility and hip dysplasia are needed to investigate the extent of generalisable effects.\n\nThe research question underpinning the project is as follows,\"Can the use of dynamic compression shorts during daily activities improve short term treatment outcomes in hip dysplasia patients?\".\n\nThe intention of this single cohort, observational pilot is primarily to establish the feasibility of studying the effect of the garments and assess the justification for further quantitative study, rather than the adjunctive effect of the shorts themselves.\n\nThe investigators are aiming to recruit 8-10 participants who will form a single cohort for observation, with the aim of gathering chiefly qualitative outcomes. This feasibility study is not intended to be blinded.",[62,29],"Hip Dysplasia",[32,64,65,66,67,68],"Orthotic","Hip dysplasia","Physiotherapy","Lycra","Dynamic lycra garments","NOT_YET_RECRUITING","2026-02-23",{"date":72,"type":40},"2026-02-27",{"date":74,"type":22},"2026-03-03",{"date":76,"type":22},"2027-09-08",{"name":78,"class":47},"Royal National Orthopaedic Hospital NHS Trust",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":106},"100506194","functional-instability-in-patients-suffering-from-collagen-disease-and-joint-hypermobility-100506194","NCT05871216","Functional Instability in Patients Suffering From Collagen Disease and Joint Hypermobility","Evaluation of Functional Instability Using the \"Delos Proprioceptive System\" in Patients Suffering From Collagen Disease and Joint Hypermobility","VIPIA","Inclusion Criteria:\n\n* Patients with moderate (Beighton-Horan Joint Mobility Index score from 3 to 4) or severe (Beighton-Horan Joint Mobility Index score from 5 to 9) joints hyperlaxity at the clinical evaluation\n\nExclusion Criteria:\n\n* Obesity (BMI \\> 25) and weight \\> 90 kg\n* Practice of competitive sport\n* Orthopedic (complex surgery of the spine and lower limbs), neurological (spasticity, stroke), and oncological comorbidities\n* Orthostatic \u002F walking inability\n* Absence of joints hyperlaxity at the clinical evaluation (Beighton-Horan Joint Mobility Index score from 0 to 2)","60 Years",{"count":89,"type":22},30,"OBSERVATIONAL","A joint is considered \"hypermobile\" when it has a greater range of motion than normal for a given age, ethnicity or gender. Many people have asymptomatic hyperlaxity in multiple joints, a condition called Generalized Joint Hypermobility (GJH).\n\nConversely, hyperlaxity can be symptomatic, a condition that has been defined \"Joint Hypermobility Syndrome\" - JHS.\n\nDiagnosis of JHS is commonly performed by applying the revised Brighton criteria. Based on these criteria, an individual is diagnosed with JHS with a Beighton score \\>\u002F= 4\u002F9, and arthralgia for 3 or more months in 4 or more joints (major criteria).\n\nThe dynamic body balance test (i.e. the stability test with multiple single-leg jumps) can provide information regarding the effectiveness of the feedforward and feedback mechanisms in correcting the postural deviations necessary to achieve successful performance during daily and sporting activities. Such assessment may also be useful to demonstrate deficiencies in balance, especially in young patients with increased physical activity.\n\nThe aim of this study is to examine the postural balance of individuals with JHS by performing stability tests in monopodalic and bipodalic stance with the \"Delos Postural Proprioceptive System\"",[29,93,94,95,96],"Danlos Disease, Ehlers","Collagen Diseases","Joint Hypermobility","Laxity of Ligament","2025-07-18",{"date":99,"type":40},"2025-07-20",{"date":101,"type":40},"2020-10-01",{"date":103,"type":22},"2026-03-30",{"name":105,"class":47},"Istituto Ortopedico Rizzoli",1,{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":113,"enrollmentInfo":114,"targetDuration":115,"studyType":90,"phases":4,"briefSummary":116,"conditions":117,"keywords":4,"overallStatus":69,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":122,"leadSponsor":124,"locationsCount":4},"100596403","evaluation-of-balance-and-physical-performance-under-dual-task-conditions-in-individuals-with-and-without-generalized-joint-hypermobility-100596403","NCT07044999","Evaluation of Balance and Physical Performance Under Dual Task Conditions in Individuals With and Without Generalized Joint Hypermobility","Inclusion Criteria:\n\n* Aged between 18 and 40 years\n* A Beighton score of 4 or higher (indicative of Generalized Joint Hypermobility)\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Younger than 18 or older than 40 years\n* Presence of neurological disorders (e.g., stroke, multiple sclerosis, peripheral neuropathy)\n* History of vestibular system disorders (e.g., benign paroxysmal positional vertigo, vestibular neuritis)\n* History of orthopedic conditions affecting the lower extremities (e.g., fracture, joint replacement, ligament injury)\n* Cognitive impairment preventing the execution of cognitive tasks\n* Diagnosis of systemic musculoskeletal diseases (e.g., rheumatoid arthritis, Ehlers-Danlos syndrome)\n* Pregnancy\n* Participation in balance training or neurological\u002Fphysiotherapy programs within the last 6 months","40 Years",{"count":48,"type":22},"1 Day","This study aims to evaluate balance and physical performance under dual task conditions in individuals with and without Generalized Joint Hypermobility (GJH), as determined by the Beighton score. All participants will undergo the One-Leg Stance Test and 30-Second Sit-to-Stand Test under both single-task (balance only) and dual-task (simultaneous cognitive task) conditions. The cognitive task will involve counting backward by sevens from a given number. Participants will also complete the Timed Up and Go (TUG) test under both single- and dual-task conditions. Additionally, the Berg Balance Scale (BBS) will be used for comprehensive balance assessment. Balance confidence will be evaluated using the Activities-specific Balance Confidence Scale (ABC-16), and fear of falling will be assessed with the Falls Efficacy Scale-International (FES-I). Changes in performance under dual-task conditions will be expressed as a percentage using the Dual Task Cost (DTC) formula",[29],"2025-06-22",{"date":120,"type":40},"2025-07-01",{"date":120,"type":22},{"date":123,"type":22},"2025-08-01",{"name":125,"class":47},"Beylikduzu State Hospital",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":87,"enrollmentInfo":133,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":135,"conditions":136,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":106},"100492922","comparison-of-mbr--suture-tape-mbr-and-anatomic-reconstruction-for-clai-in-gjl-cases-a-prospective-cohort-study-100492922","NCT05698446","Comparison of MBR + Suture Tape, MBR, and Anatomic Reconstruction for CLAI in GJL Cases: A Prospective Cohort Study","Comparison of Modified Broström Repair + Suture Tape and Anatomic Reconstruction for CLAI in Chronic Lateral Ankle Instability in Generalized Joint Laxity Cases: A Prospective Cohort Study","Inclusion Criteria:\n\n* Clinical diagnosis of lateral ankle pain and instability Beighton score ≥4 Age with 18 to 60 years\n\nExclusion Criteria:\n\n* Patients with an acute or subacute ankle injury (within 3 months) Injury of the deltoid ligament Alignment of lower extremity greater than 5 degrees Fractures of the lower extremity Stage III or IV osteoarthritis Patients who refused to participate in the study",{"count":134,"type":22},114,"GJL is a risk factor for postoperative recurrent instability following an MBR for CLAI. BPR with suture tape augmentation and anatomic reconstruction may provide more strength and stability. However, BPR with suture tape augmentation may lead to rejection of the suture tape, while anatomic reconstruction may be associated with more trauma. In addition, the outcomes between the BPR with suture tape augmentation and anatomic reconstruction were unknown.",[137,29],"Ankle Sprains","2025-04-08",{"date":140,"type":40},"2025-04-11",{"date":142,"type":40},"2021-11-01",{"date":144,"type":22},"2025-06-01",{"name":146,"class":47},"Peking University Third Hospital"]