[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hyperoxemia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hyperoxemia":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,57,91,117],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":33,"overallStatus":44,"whyStopped":4,"lastUpdateSubmitDate":45,"lastUpdatePostDateStruct":46,"startDateStruct":49,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100624025","oxygen-reserve-index-guided-oxygen-titration-during-surgery-in-the-beach-chair-position-100624025",false,"NCT07404267","Oxygen Reserve Index-Guided Oxygen Titration During Surgery in the Beach Chair Position","The Utility of Oxygen Reserve Index Guidance in Inspiratory Oxygen Titration for Patients Undergoing Surgery in the Beach Chair Position: A Prospective Comparative Study","ORI-BCP","Inclusion Criteria:\n\n* Adult patients aged 18 to 65 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective orthopedic surgery in the beach chair position\n* Body mass index (BMI) \\\u003C35 kg\u002Fm²\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 or ≥65 years\n* Finger deformities preventing the use of Oxygen Reserve Index (ORi) monitoring\n* Severe anemia (hemoglobin \\\u003C8 g\u002FdL)\n* Pregnancy\n* Refusal or inability to provide informed consent\n* History of stroke or significant vascular pathology\n* Severe cardiac or respiratory disease",true,"ALL","18 Years","65 Years",{"count":22,"type":23},80,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study aims to evaluate whether guidance by the Oxygen Reserve Index (ORi) improves inspiratory oxygen fraction (FiO₂) titration compared with conventional pulse oximetry (SpO₂)-guided oxygen administration in adult patients undergoing surgery in the beach chair position.\n\nOxygen therapy is routinely used during general anesthesia to prevent hypoxemia; however, excessive oxygen administration may result in hyperoxia, which has been associated with adverse cardiovascular and pulmonary effects. Standard pulse oximetry may not adequately detect hyperoxia when oxygen saturation values are high.\n\nIn this prospective comparative study, patients will receive oxygen titration guided either by SpO₂ alone or by combined ORi and SpO₂ monitoring. The primary outcome is the incidence of intraoperative hyperoxemia, assessed by arterial blood gas analysis. Secondary outcomes include intraoperative oxygenation parameters and hemodynamic variables.",[29,30,31,32],"Hyperoxemia","Intraoperative Oxygen Therapy","Beach Chair Position","Cerebral Oxygenation",[34,35,36,37,38,39,40,41,42,43],"Oxygen Reserve Index","ORİ","FiO2 titration","Hyperoxia","Pulse oximetry","Arterial blood gas","Near-infrared spectroscopy","General anesthesia","Beach chair position","Orthopedic surgery","NOT_YET_RECRUITING","2026-02-09",{"date":47,"type":48},"2026-02-11","ACTUAL",{"date":50,"type":23},"2026-02-15",{"date":52,"type":23},"2026-07-31",{"name":54,"class":55},"Fatih Sultan Mehmet Training and Research Hospital","OTHER",1,{"id":58,"slug":59,"hasResults":11,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":65,"targetDuration":4,"studyType":24,"phases":66,"briefSummary":67,"conditions":68,"keywords":73,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":56},"100621941","hyper-mind---hyperoxia-effects-on-cerebral-hemodynamics-100621941","NCT07377162","HYPER MIND - Hyperoxia Effects on Cerebral Hemodynamics","HYPERMIND - Hyperoxia Effects on Cerebral Hemodynamics","HYPER-MIND","Inclusion Criteria\n\n* Adult patients aged ≥18 years\n* Admitted to the intensive care unit (ICU)\n* Intubated and mechanically ventilated for ≤72 hours\n* Receiving volume-controlled mechanical ventilation\n* Arterial partial pressure of carbon dioxide (PaCO₂) between 35 and 45 mmHg\n* Invasive arterial blood pressure monitoring in place\n* Adequate transcranial Doppler (TCD) acoustic window\n* Clinically judged to be suitable for a brief normobaric hyperoxic stimulus\n* Expected to receive one or two hyperoxic steps based on baseline FiO₂ requirements: a) Baseline FiO₂ \\\u003C 0.5: two-step hyperoxic stimulus (FiO₂ 0.5 followed by FiO₂ 1.0); b) Baseline FiO₂ ≥ 0.5: one-step hyperoxic stimulus (FiO₂ 1.0)\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Pregnancy\n* Extracorporeal membrane oxygenation (ECMO)\n* Continuous renal replacement therapy (CRRT)\n* Contraindications to hyperoxia, as judged by the treating physician\n* Severe hemodynamic instability requiring changes in vasopressor dose during the recording period\n* Inability to obtain a reliable transcranial Doppler signal through the temporal acoustic windows\n* Any clinical condition deemed by the treating physician to pose unacceptable risk during hyperoxic exposure",{"count":22,"type":23},[26],"This study aims to better understand how short periods of exposure to high oxygen levels affect blood flow in the brain of patients who are intubated and mechanically ventilated in the Intensive Care Unit (ICU). Many ICU patients receive more oxygen than strictly necessary, and high blood oxygen levels (hyperoxemia) are very common. However, the immediate effects of short hyperoxic exposures on cerebral circulation and autoregulation remain poorly understood.\n\nIn this study, patients who already require mechanical ventilation for medical reasons will undergo a brief and controlled increase in the oxygen delivered through the ventilator (FiO₂). During this time, we will continuously monitor blood flow in one of the main brain arteries using a non-invasive ultrasound technique called transcranial Doppler (TCD). The goal is to evaluate how cerebral blood flow, pulsatility, and autoregulatory capacity change during and after a short hyperoxic stimulus.\n\nNo additional invasive procedures are required beyond standard ICU monitoring, except for the temporary adjustment of the ventilator's oxygen settings and arterial blood gas sampling, which are part of usual care in critically ill patients. Participation does not provide direct clinical benefit but may help improve future oxygen management in ICU patients. The study involves minimal risk, as short hyperoxic exposures are already common in routine care and will be interrupted immediately in case of any adverse event.",[29,69,70,71,72],"Cerebrovascular Circulation","Cerebral Autoregulation","Critical Illness","Mechanical Ventilation",[74,75,76,77,71,78,79,80],"hyperoxemia","brain hemodynamics","tcd","cerebral autoregulation","intensive care unit","hyperoxia","oxygen","RECRUITING","2026-01-22",{"date":84,"type":48},"2026-01-29",{"date":86,"type":48},"2024-01-01",{"date":88,"type":23},"2028-12-31",{"name":90,"class":55},"Erasme University Hospital",{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":11,"sex":18,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":102,"phases":4,"briefSummary":103,"conditions":104,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":116},"100523960","comparison-of-pulse-oximetry-spo2-with-different-oximeters-and-arterial-saturation-sao2-oxygap2-study-100523960","NCT06102499","Comparison of Pulse Oximetry (SpO2) With Different Oximeters and Arterial Saturation (SaO2): Oxygap2 Study","Oxygap 2","Adult population\n\nInclusion Criteria:\n\n* ≥ 18 years old (adult population) -\n* Patients admitted to the Intensive Care Unit\n* Artery catheter already installed\n\nPediatric population\n\n* Below 18 years old\n* Patients admitted to the Intensive Care Unit\n* Artery catheter already installed\n\nExclusion Criteria:\n\n* No or poor signal with the usual pulse oximeter\u002Fbased on clinician judgment\n* High dose of vasopressors or inotropes (epinephrine or norepinephrine ˃ 1mcg\u002Fkg\u002Fmin), shock state (lactates above 3 mmoles\u002FL)\n* Pigmented nails or nail polish\n* Methemoglobinemia history\n* Hemoglobin below 80 g\u002FL\n* Patient in isolation (multi-resistant bacteria, C-Difficile, SARS-COV-2…)\n* Prone position, Extra Corporel Membrane Oxygenator","0 Years","100 Years",{"count":101,"type":23},200,"OBSERVATIONAL","The oximeter is used to monitor intensive care patients undergoing oxygen therapy. It indicates pulsed oxygen saturation (SpO2), a reflection of arterial oxygen saturation (SaO2) which enables detection of hypoxemia and hyperoxia, both deleterious state. Current SpO2 recommendations aim to reduce both risk of hypoxemia and hyperoxia. SpO2 is considered the 5th vital sign.\n\nCurrent recommendations for SpO2 targets do not consider the variability of oximeters used in clinical practice. This variability and lack of specification represent an obstacle to an optimal practice of oxygen therapy.\n\nThus, this study aims to compare the SpO2 values of different oximeters (General Electric-GE, Medtronic, Masimo and Nonin) used in clinical practice with the SaO2 reference value obtained by an arterial gas in order to specify the precision and the systematic biases of the oximeters studied. This data will also make it possible to refine the recommendations concerning optimal oxygenation",[105,106,29],"Respiratory Failure","Hypoxemia","2025-08-27",{"date":109,"type":48},"2025-08-28",{"date":111,"type":48},"2024-06-20",{"date":113,"type":23},"2026-12-30",{"name":115,"class":55},"Laval University",3,{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":123,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":102,"phases":4,"briefSummary":127,"conditions":128,"keywords":4,"overallStatus":81,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":137},"100421775","oxygap--comparison-between-different-pulse-oximeter-and-with-the-arterial-blood-gase-100421775","NCT04772183","OxyGap : Comparison Between Different Pulse Oximeter and With the Arterial Blood Gase","OxyGap : Comparison Between Different Pulse Oximeter and With the Arterial Blood","OxyGap","Inclusion Criteria:\n\n* ≥ 18 years old\n* Patients admitted to the Intensive Care Unit\n* Artery catheter already installed\n\nExclusion Criteria:\n\n* No signal with the oximeter\n* Pigmented nails or nail polish\n* Methemoglobinemia\n* Patient in isolation (multi-resistant bacteria, C-Difficile, COVID-19…)\n* Prone position",{"count":126,"type":23},300,"The oximeter is used to monitor intensive care patients undergoing oxygen therapy. It indicates pulsed oxygen saturation (SpO2), a reflection of arterial oxygen saturation (SaO2) which enables detection of hypoxemia and hyperoxia, both deleterious state. Current SpO2 recommendations aim to reduce both risk of hypoxemia and hyperoxia. SpO2 is considered the 5th vital sign.\n\nCurrent recommendations for SpO2 targets do not consider the variability of oximeters used in clinical practice. This variability and lack of specification represent an obstacle to an optimal practice of oxygen therapy.\n\nThus, this study aims to compare the SpO2 values of different oximeters (Nonin, Masimo, Philips, Nellcor) used in clinical practice with the SaO2 reference value obtained by an arterial gas in order to specify the precision and the systematic biases of the oximeters studied. This data will also make it possible to refine the recommendations concerning optimal oxygenation",[105,106,29],"2024-06-17",{"date":131,"type":48},"2024-06-18",{"date":133,"type":48},"2021-03-24",{"date":135,"type":23},"2025-06-30",{"name":115,"class":55},2]