[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypersensitivity-dentin\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypersensitivity-dentin":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,50,76],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100614957","effect-of-fluoride-varnish-formulation-on-the-management-of-dentin-hypersensitivity-100614957",false,"NCT07286344","Effect of Fluoride Varnish Formulation on the Management of Dentin Hypersensitivity","Effect of Fluoride Varnish Formulation on the Management of Dentin Hypersensitivity: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Age between 18 and 40 years\n* Absence of systemic diseases with oral manifestations or requiring medications with antisialagogue effects\n* Fully dentate (excluding third molars or teeth extracted for orthodontic reasons)\n* Absence of periodontal disease, or periodontal condition in a stable state\n* Presence of at least one cervical lesion with a Schiff sensitivity score ≥ 1\n* No previous treatment or restorative procedures on the target lesions (including no topical fluoride application within the last 6 months)\n\nExclusion Criteria:\n\n* Patients requiring long-term use of NSAIDs or other analgesic\u002Fanti-inflammatory medications\n* Patients with allergy to milk proteins\n* Patients with allergy to organic resins or pine-derived substances\n* Pregnant or breastfeeding individuals\n* Patients with fixed orthodontic appliances in place","ALL","18 Years","40 Years",{"count":20,"type":21},92,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled clinical trial aims to determine whether different fluoride varnish formulations reduce dentin hypersensitivity (DH) in young adults diagnosed with DH. The primary purpose of this study is to evaluate the clinical effectiveness of two commercially available fluoride varnishes.\n\nThe main questions this study aims to answer are:\n\n* Does Clinpro Clear® (aqueous base, 9,500 ppm NaF) lead to a greater reduction in dentin hypersensitivity compared with Duraphat® (rosin\u002Fresin base, 22,600 ppm NaF)?\n* Do these varnish formulations improve oral health-related quality of life and patient satisfaction?\n\nResearchers will compare a single application of Duraphat® with a single application of Clinpro Clear® to assess differences in hypersensitivity reduction, quality-of-life outcomes, and patient satisfaction.\n\nParticipants will:\n\n* Receive one application of either Duraphat® or Clinpro Clear® under standardized clinical conditions.\n* Complete baseline and post-treatment evaluations, including:\n* Dentin hypersensitivity intensity using a visual analogue scale (VAS)\n* Air-blast response using the Schiff scale\n* Oral health-related quality of life using the OHIP-14\n* Patient satisfaction using the CSAT survey",[27,28],"Hypersensitivity Dentin","Fluoride Varnishes",[30,31,32,33,34,35,36],"Dentin hypersensitivity","Fluoride varnishes","Visual analogue scale (VAS)","Schiff scale","OHIP-14","Desensitizing agents","Aqueous fluoride varnish","RECRUITING","2026-05-29",{"date":40,"type":41},"2026-06-02","ACTUAL",{"date":43,"type":41},"2025-12-04",{"date":45,"type":21},"2026-08-30",{"name":47,"class":48},"University of Concepcion, Chile","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":16,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100557440","photobiomodulation-and-new-restorative-material-for-teeth-with-mih-on-control-of-hypersensitivity-and-longevity-100557440","NCT06538142","Photobiomodulation and New Restorative Material for Teeth With MIH on Control of Hypersensitivity and Longevity","Assessment of Photobiomodulation Combined With New Restorative Material for Teeth With Molar Incisor Hypomineralization on Control of Hypersensitivity and Longevity of Restorations: Randomized Controlled Blind Clinical Trial","Inclusion Criteria:\n\n* Male and female children;\n* Eight to 12 years of age;\n* At least one permanent first molar with MIH (codes 5 and 6 of molar-incisor hypomineralization severity scoring system \\[MIH-SSS\\])\n* Presence of hypersensitivity\n* Direct viewing and access.\n\nExclusion Criteria:\n\n* Clinically: signs or symptoms of pulp involvement;\n* Radiographically: evidence of pulp involvement (initial periapical radiograph);\n* Teeth with MIH with no indication for direct restorative treatment (multiple surfaces associated with large extensions);\n* Partially erupted teeth;\n* Previous restorative treatment.",true,"8 Years","12 Years",{"count":61,"type":21},100,[24],"Introduction: Molar incisor hypomineralization (MIH) is a qualitative defect of enamel development that occurs in the mineralization phase. MIH affects one or more permanent molars and, occasionally, permanent incisors.\n\nObjective: The aim of the proposed study is to determine whether photobiomodulation combined with a new self-cure resin improves hypersensitivity in molars with MIH and caries (primary outcome). Secondary outcomes include assessing the clinical performance of the self-cure composite resin in terms of restoration longevity and comparing the effectiveness of three interventions-photobiomodulation combined with self-cure resin, self-cure resin alone, and photobiomodulation combined with bulkfill photopolymerizable resin-in controlling hypersensitivity over time.\n\nMethods and analysis: Permanent molars with MIH in patients eight to 12 years of age will be allocated to three groups. Group 1: photobiomodulation + self-cure composite resin restoration; Group 2: self-cure composite resin restoration; Group 3: photobiomodulation + restoration in bulk-fill photopolymerizable composite resin. Photobiomodulation will be performed in a single session involving low-level laser administered to four different points. The laser will be used at a wavelength of 808 nm, power of 100 mW and energy of 1 J per points; irradiance will be 3571 mW\u002Fcm², with a total radiant exposure of 35.7 J\u002Fcm². Data normality will be checked using the Shapiro-Wilk test, and variance homogeneity will be assessed with the Levene test. Descriptive statistics will be used to present the data, with continuous variables expressed as mean and standard deviation, and categorical variables by relative frequency. To compare the VAS and SCASS scales, repeated measures ANOVA will be employed, considering the 3 groups and 5 time points. Bonferroni adjustment will be applied for post-hoc comparisons. Sphericity will be tested with Mauchly's test, and if violated, Greenhouse-Geisser correction will be applied. A significance level of 0.05 will be adopted. Ethics and dissemination: This protocol received approval from the Human Research Ethics Committee of Nove de Julho University (certificate number: xxxxxxx). The legal guardians of the children will agree to participation by signing a statement of informed consent. The results will be published in a peer-review journal and the data will be made available upon request.",[65,27],"Hypomineralization Molar Incisor","NOT_YET_RECRUITING","2025-01-17",{"date":69,"type":41},"2025-01-22",{"date":71,"type":21},"2025-04-01",{"date":73,"type":21},"2026-09-01",{"name":75,"class":48},"University of Nove de Julho",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":57,"sex":16,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":49},"100575420","clinical-evaluation-of-short-dentin-etching-100575420","NCT06772051","Clinical Evaluation of Short Dentin Etching","Short Dentin Etching With a Universal Adhesive: Two-Year Double-Blind Trial Comparing Etching Strategies and Durations","Inclusion Criteria:\n\n* Patients with three primary occlusal caries of upper or lower posterior teeth.\n* Patients must have a good oral hygiene;\n* Patients with tooth gives a positive response to testing with an electric pulp tester\n* Patients with normal and full occlusion,\n* Patients with opposing teeth should be natural with no restorations.\n\nExclusion Criteria:\n\n* High caries risk patients with extremely poor oral hygiene\n\n  * Patients involved in orthodontic treatment or periodontal surgery,\n  * Patients with periodontally involved teeth (chronic","35 Years","50 Years",{"count":86,"type":21},30,[24],"To evaluate and compare the two-year clinical performance of Class I resin composite restorations utilizing a universal adhesive used in different etch-and-rinse strategies (15-second and 5-second etching) and self-etch strategies for bonding.",[27,90],"Dental Restoration Failure of Marginal Integrity","2025-01-08",{"date":93,"type":41},"2025-01-13",{"date":95,"type":41},"2024-12-24",{"date":97,"type":21},"2026-12-30",{"name":99,"class":48},"Mansoura University"]