[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypersensitivity-immediate\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypersensitivity-immediate":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100574130","risk-stratified-testing-for-safe-removal-of-penicillin-allergy-labels-100574130",false,"NCT06755281","Risk-stratified Testing for Safe Removal of Penicillin Allergy Labels","Inclusion Criteria:\n\n1. Adult outpatients or inpatients with a penicillin allergy label\n2. Willing and able to give consent.\n3. PEN-FAST score of 0-2 points\n\nExclusion Criteria:\n\n1. Age \\\u003C18 years\n2. Concurrent immunosuppressive therapy with 20 mg of prednisolone per day or steroid equivalent\n3. Concurrent antihistamine therapy\n4. Pregnancy\n5. Significantly impaired general condition\n6. Unstable or therapeutically inadequately controlled bronchial asthma\n7. History of stem cell transplantation\n8. History of acute interstitial nephritis\n9. Chronic urticaria\n10. Mastocytosis","ALL","18 Years",{"count":18,"type":19},100,"ESTIMATED","INTERVENTIONAL",[22],"NA","The aim of this clinical trial is to analyze the negative predictive capacity and safety of risk-stratified direct drug provocation tests for patients with self-reported penicillin allergies. Patients reporting immediate or delayed penicillin allergies and defined as low-risk by the PEN-FAST score will receive drug provocation tests without prior skin testing.",[25,26,27,28],"Penicillin Allergy","Hypersensitivity, Immediate","Hypersensitivity, Delayed","Hypersensitivity Response",[30,31,32],"PEN-FAST","penicillin allergy","allergy delabeling","RECRUITING","2025-04-09",{"date":36,"type":37},"2025-04-10","ACTUAL",{"date":39,"type":37},"2025-01-08",{"date":41,"type":19},"2027-02",{"name":43,"class":44},"Deniz Göcebe","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":20,"phases":56,"briefSummary":57,"conditions":58,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":73},"100471596","repertoire-and-properties-of-anti-drug-antibodies-involved-in-immediate-hypersensitivity-in-the-operating-room-100471596","NCT05420935","Repertoire and Properties of Anti-drug Antibodies Involved in Immediate Hypersensitivity in the Operating Room","MEDIREP","Inclusion Criteria:\n\nCommon to both groups:\n\n* Age ≥ 18 years old and ≤ 70 years old\n* Patient having presented an allergic reaction in the operating room in the last 10 years, regardless of the grade of severity, the causative agent or the type of anesthesia\n* Patient having benefited from an allergy-anaesthesia consultation in the investigator center\n\nFor IgE group:\n\n\\- presence of at least one positive skin test to one of the suspected agent (curare and\u002For antibiotic) during the allergist consultation\n\nFor the IgG group:\n\n\\- presence of circulating IgG-type antibodies directed against one of the suspected agents (curare, antibiotic, antiseptic), identified in the routine biological tests carried out at the time of the shock and \u002F or the consultation of allergology.\n\nExclusion Criteria:\n\nCommon to both groups:\n\n* Absence of written informed consent\n* Protected person: under guardianship or curatorship\n* Patient without social security\n* Pregnancy of breast feeding\n* Ongoing immunosuppressive or chemotherapy\n* Acute heart failure\n* Patient included in another interventional research with an exclusion period\n\nFor IgE group:\n\n* Taking oral or injectable anticoagulants\n* Taking a double antiplatelet aggregation\n* Previous sternotomy\n* Previous thoracic radiation therapy\n* Known allergy to local anesthesic or iodinated skin products\n* Previous major sternal cutaneous lesions\n\nPrerequisites for carrying out the sternal sample in order to carry out a myelogram (IgE group):\n\n* Leukocytes \\> 4 giga\u002FL in the 2 months preceding inclusion\n* Platelets \\> 100,000 \u002F mm3 in the 2 months preceding inclusion\n\nFor the IgG group\n\n* Orthostatic hypotension\n* Realization of a blood donation in the 6 to 8 weeks preceding inclusion\n\nPrerequisites for performing the blood sample (IgG group):\n\n\\- Hemoglobin \\> 12.5 g\u002FdL for women and \\> 13 g\u002FdL for men in the 2 months preceding inclusion","70 Years",{"count":55,"type":19},40,[22],"Acute per-anesthetic hypersensitivity reaction (HSA-PA) is a rapidly occurring systemic reaction following injection of a drug during anesthesia (mortality between 3 and 9%). The substances responsible for these reactions in France are curare in 60% of cases, followed by antibiotics. The main mechanism mentioned is an immediate systemic hypersensitivity immune reaction mediated by IgE antibodies (anaphylaxis). NeuroMuscular Blocking Agents (NMBA; curare) relax skeletal muscles to facilitate surgeries and permit intubation, but lead to adverse reactions: (a) severe hypersensitivity reactions (anaphylaxis) thought to rely on pre-existing anti-NMBA antibodies; (b) complications due to postoperative residual curarization. Identification of patients at risk remains suboptimal due to the lack of adequate tools to detect anti-NMBA antibodies. A capturing agent exists for only one out of the four most used NMBAs, allowing reversal of profound curarization. Case reports suggested that it might also ameliorate an ongoing anaphylaxis due to that NMBA.\n\nBased on strong preliminary results, our study proposes to characterize anti-drugs antibody repertoires in patients with various NMBA or antibiotics-anaphylaxis, describe activation pathways leading to anaphylaxis, develop and validate diagnostic and therapeutic molecules to ameliorate patient screening, NMBA-anaphylaxis and reverse profound neuromuscular block.",[26,59,60,61],"Peri-operative Injury","Antibiotic Allergy","Antibody Hypersensitivity",[63],"Hypersensitivity, IgE, IgG, repertoire, NMBA, anaphylaxis","2024-09-02",{"date":66,"type":37},"2024-09-19",{"date":68,"type":37},"2023-04-12",{"date":70,"type":19},"2033-12-15",{"name":72,"class":44},"Assistance Publique - Hôpitaux de Paris",1,{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":81,"sex":15,"minAge":16,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":20,"phases":85,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":89,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":4},"100557439","assessment-of-eryag-laser-for-the-control-of-hypersensitivity-during-tooth-whitening-with-hydrogen-peroxide-100557439","NCT06538129","Assessment of Er:YAG Laser for the Control of Hypersensitivity During Tooth Whitening With Hydrogen Peroxide","Assessment of Er:YAG Laser for the Control of Hypersensitivity During Tooth Whitening With Hydrogen Peroxide: Protocol for a Split-Mouth Controlled Clinical Trial","Inclusion Criteria:\n\n* All anterior teeth present without caries or restorations;\n* Absence of cervical lesions, dental pain and hypersensitivity prior to treatment;\n* Not having previously undergone any tooth whitening procedure.\n\nExclusion Criteria:\n\n* Smokers;\n* Pregnant or nursing women;\n* Individuals with gingivitis or periodontitis, those with enamel cracks detected by the transillumination test;\n* Those with enamel defects or stains caused by tetracycline;\n* Those with systemic diseases;\n* Those taking nonsteroidal anti-inflammatory.",true,"45 Years",{"count":84,"type":19},28,[22],"Introduction: Tooth whitening is an aesthetic procedure with rapid results that improves the self-esteem and self-image of patients. However, one of the side effects is dentinal hypersensitivity. The aim of the study is to assess the effectiveness of Er:YAG laser administered prior to bleaching with 35% hydrogen peroxide hypersensitivity.\n\nMethods: The maxillary arch of participants 18 to 45 years of age will be treated using the split-mouth method. Grupo experimental: Hypersensitivity prevention protocol with Er:YAG laser followed by bleaching with 35% hydrogen peroxide; control group: hypersensitivity prevention protocol with neutral sodium fluoride for four minutes followed by bleaching with 35% hydrogen peroxide. Er:YAG laser (2940 nm) will be used with the following parameters: 0.15 W, 10 mJ, 15 Hz and SP mode (pulse duration: 300 µs), TIP: Cylindrical Quartz 1000\u002F4, using the H14 handpiece (H14 for LightWalker AT; Fotona dd, Ljubljana, Slovenia). Each tooth (central incisor, lateral incisor and canine) will be irradiated twice for 10 s in an unfocused scanning motion in the cervical region at a working distance of 1 cm. The absolute risk and intensity of dentinal hypersensitivity during treatment will be assessed using the visual analogue scale. The change in color will be determined using an intraoral spectrophotometer in contact with the tooth. Assessments will be conducted before and after preventive treatment, immediately after treatment as well as 48 hours and one week after treatment. Different statistical tests will be used, with the significance level set at 5% (p ≤ 0.05).",[88,26,28],"Hypersensitivity","NOT_YET_RECRUITING","2024-07-31",{"date":92,"type":37},"2024-08-05",{"date":94,"type":19},"2024-11-01",{"date":96,"type":19},"2026-09-01",{"name":98,"class":44},"University of Nove de Julho"]