[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypersensitivity-response\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypersensitivity-response":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":5},"100574130","risk-stratified-testing-for-safe-removal-of-penicillin-allergy-labels-100574130",false,"NCT06755281","Risk-stratified Testing for Safe Removal of Penicillin Allergy Labels","Inclusion Criteria:\n\n1. Adult outpatients or inpatients with a penicillin allergy label\n2. Willing and able to give consent.\n3. PEN-FAST score of 0-2 points\n\nExclusion Criteria:\n\n1. Age \\\u003C18 years\n2. Concurrent immunosuppressive therapy with 20 mg of prednisolone per day or steroid equivalent\n3. Concurrent antihistamine therapy\n4. Pregnancy\n5. Significantly impaired general condition\n6. Unstable or therapeutically inadequately controlled bronchial asthma\n7. History of stem cell transplantation\n8. History of acute interstitial nephritis\n9. Chronic urticaria\n10. Mastocytosis","ALL","18 Years",{"count":18,"type":19},100,"ESTIMATED","INTERVENTIONAL",[22],"NA","The aim of this clinical trial is to analyze the negative predictive capacity and safety of risk-stratified direct drug provocation tests for patients with self-reported penicillin allergies. Patients reporting immediate or delayed penicillin allergies and defined as low-risk by the PEN-FAST score will receive drug provocation tests without prior skin testing.",[25,26,27,28],"Penicillin Allergy","Hypersensitivity, Immediate","Hypersensitivity, Delayed","Hypersensitivity Response",[30,31,32],"PEN-FAST","penicillin allergy","allergy delabeling","RECRUITING","2025-04-09",{"date":36,"type":37},"2025-04-10","ACTUAL",{"date":39,"type":37},"2025-01-08",{"date":41,"type":19},"2027-02",{"name":43,"class":44},"Deniz Göcebe","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":15,"minAge":16,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":20,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":60,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100557439","assessment-of-eryag-laser-for-the-control-of-hypersensitivity-during-tooth-whitening-with-hydrogen-peroxide-100557439","NCT06538129","Assessment of Er:YAG Laser for the Control of Hypersensitivity During Tooth Whitening With Hydrogen Peroxide","Assessment of Er:YAG Laser for the Control of Hypersensitivity During Tooth Whitening With Hydrogen Peroxide: Protocol for a Split-Mouth Controlled Clinical Trial","Inclusion Criteria:\n\n* All anterior teeth present without caries or restorations;\n* Absence of cervical lesions, dental pain and hypersensitivity prior to treatment;\n* Not having previously undergone any tooth whitening procedure.\n\nExclusion Criteria:\n\n* Smokers;\n* Pregnant or nursing women;\n* Individuals with gingivitis or periodontitis, those with enamel cracks detected by the transillumination test;\n* Those with enamel defects or stains caused by tetracycline;\n* Those with systemic diseases;\n* Those taking nonsteroidal anti-inflammatory.",true,"45 Years",{"count":55,"type":19},28,[22],"Introduction: Tooth whitening is an aesthetic procedure with rapid results that improves the self-esteem and self-image of patients. However, one of the side effects is dentinal hypersensitivity. The aim of the study is to assess the effectiveness of Er:YAG laser administered prior to bleaching with 35% hydrogen peroxide hypersensitivity.\n\nMethods: The maxillary arch of participants 18 to 45 years of age will be treated using the split-mouth method. Grupo experimental: Hypersensitivity prevention protocol with Er:YAG laser followed by bleaching with 35% hydrogen peroxide; control group: hypersensitivity prevention protocol with neutral sodium fluoride for four minutes followed by bleaching with 35% hydrogen peroxide. Er:YAG laser (2940 nm) will be used with the following parameters: 0.15 W, 10 mJ, 15 Hz and SP mode (pulse duration: 300 µs), TIP: Cylindrical Quartz 1000\u002F4, using the H14 handpiece (H14 for LightWalker AT; Fotona dd, Ljubljana, Slovenia). Each tooth (central incisor, lateral incisor and canine) will be irradiated twice for 10 s in an unfocused scanning motion in the cervical region at a working distance of 1 cm. The absolute risk and intensity of dentinal hypersensitivity during treatment will be assessed using the visual analogue scale. The change in color will be determined using an intraoral spectrophotometer in contact with the tooth. Assessments will be conducted before and after preventive treatment, immediately after treatment as well as 48 hours and one week after treatment. Different statistical tests will be used, with the significance level set at 5% (p ≤ 0.05).",[59,26,28],"Hypersensitivity","NOT_YET_RECRUITING","2024-07-31",{"date":63,"type":37},"2024-08-05",{"date":65,"type":19},"2024-11-01",{"date":67,"type":19},"2026-09-01",{"name":69,"class":44},"University of Nove de Julho"]