[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypertension-resistant\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypertension-resistant":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100568079","phase-4-intraprocedural-feedback-optimized-renal-denervation-based-on-measurements-obtained-through-renal-artery-stimulation-a-randomized-controlled-trial-inform-100568079",false,"NCT06676553","INtraprocedural Feedback-Optimized Renal Denervation Based on Measurements Obtained Through Renal Artery Stimulation: a Randomized Controlled Trial (INFORM)","INtraprocedural Feedback-Optimized Renal Denervation Based on Measurements Obtained Through Renal Artery Stimulation: a Randomized Controlled Proof-of-concept Trial to Assess Whether Renal Denervation Guided by Renal Artery Stimulation Outperforms Conventional Renal Denervation in 6-month Ambulatory Blood Pressure Reductions","INFORM","Inclusion Criteria:\n\n* Patients with hypertension and are willing to undergo renal denervation.\n* Patients are treated with antihypertensive medications, or with an office systolic blood pressure (SBP) \\>140 mm Hg or diastolic blood pressure (DBP) \\>90 mm Hg, and 24-hour SBP of \\>130 mmHg or DBP \\>80 mm Hg, irrespective of antihypertensive treatment.\n\nExclusion Criteria:\n\n* An unsuitable renal artery anatomy for renal denervation, assessed by computed tomographic angiography (main renal artery lumen diameter \\\u003C3 mm or a total length \\\u003C20 mm).\n* Secondary hypertension, including hyperaldosteronism, pheochromocytoma, and renal artery stenosis (\\>50% stenosis in one or both arteries).","ALL","18 Years",{"count":20,"type":21},32,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","Our previous study (Huang HC, Pan HY, Wang TD, Circ Cardiovasc Interv 2023;16:e012779) demonstrated that when renal artery stimulation continues to trigger systolic blood pressure increases (\\>=20 mmHg increase compared to baseline) after the initial procedure, patients show poor blood pressure reduction 6 months following renal denervation. Based on this finding, we designed a proof-of-concept trial comparing two approaches: a guided strategy versus conventional renal denervation. In the guided strategy, we perform additional ablations of main and\u002For branch renal arteries if immediate post-procedure stimulation still elevates systolic blood pressure (\\>=20 mmHg increase compared to baseline). The conventional approach involves no repeat procedures. This trial aims to determine whether the guided strategy leads to better clinical outcomes, measured by 6-month ambulatory blood pressure changes, and to establish the value of using intraprocedural feedback to assess and guide renal denervation treatment.",[27,28,29],"Hypertension, Uncontrolled","Hypertension, Resistant","Hypertension",[29,31,32,33,34],"Renal denervation","Electric stimulation","Renal artery","Radiofrequency ablation","RECRUITING","2024-11-04",{"date":38,"type":39},"2024-11-06","ACTUAL",{"date":41,"type":39},"2024-10-14",{"date":43,"type":21},"2028-06-30",{"name":45,"class":46},"National Taiwan University Hospital","OTHER"]