[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hyperthermia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hyperthermia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,45,62,104,126,154,196,218,238,262,286,313,334,352,373,391],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":4},"100596481","work-design-interventions-for-older-workers-during-consecutive-days-in-the-heat-100596481",false,"NCT07046026","Work Design Interventions for Older Workers During Consecutive Days in the Heat","Inclusion Criteria:\n\n* Healthy individuals\n* 18-29 years old and 40-65 years old\n* Completes at least 120 minutes of moderate to vigorous physical activity each week for at least the past 4 weeks\n* Resistance trained or have recently held a job involving box carrying or a similar task\n\nExclusion Criteria:\n\n* History of cardiovascular, metabolic, respiratory, neural, or renal disease\n* Hypertensive (systolic blood pressure \\> 139 mmHg or diastolic blood pressure \\> 89 mmHg) or tachycardic (resting heart rate \\> 100 bpm) during the screening visit\n* Current nicotine use or previous use within the past 6 months\n* Current of previous musculoskeletal injury limiting physical activity\n* A positive pregnancy test at any point during the study\n* Currently breastfeeding\n* Study physician discretion based on any other medical condition or medication",true,"ALL","18 Years","65 Years",{"count":20,"type":21},32,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this project is to compare different ways to schedule a workday to see if older workers should follow a specific work protocol to reduce strain on the heart and muscles across two consecutive days of work.\n\nParticipants will come to the lab a total of six times. During four of the visits participants will complete a box carrying task, simulating unloading a delivery truck. This will take place in a hot and humid room to simulate being outdoors during the summer.",[27,28,29],"Hyperthermia","Fatigue; Heat","Work-Related Condition",[31,32],"hyperthermia","worker","NOT_YET_RECRUITING","2026-06-26",{"date":36,"type":37},"2026-06-30","ACTUAL",{"date":39,"type":21},"2028-09",{"date":41,"type":21},"2030-09",{"name":43,"class":44},"State University of New York at Buffalo","OTHER",{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":50,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":56,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":4},"100562178","work-design-interventions-for-heat-resilience-100562178","NCT06599788","Work Design Interventions for Heat Resilience",{"count":20,"type":21},[24],"The goal of this project is to compare different ways to schedule a workday to see if older workers should follow a specific work protocol to reduce strain on the heart and muscles.\n\nParticipants will come to the lab a total of six times. During four of the visits participants will complete a box carrying task, simulating unloading a delivery truck. This will take place in a hot and humid room to simulate being outdoors during the summer.",[27,28,29],[31,32,55],"fatigue",{"date":36,"type":37},{"date":58,"type":21},"2027-09",{"date":60,"type":21},"2029-09",{"name":43,"class":44},{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":22,"phases":73,"briefSummary":74,"conditions":75,"keywords":88,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":103},"100600783","hyperthermia-in-patients-with-chronic-primary-pain---effects-on-thermoregulation-somatosensory-system-and-movement-evoked-pain-100600783","NCT07101978","Hyperthermia in Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System and Movement Evoked Pain","Hyperthermia in Healthy and Patients With Chronic Primary Pain - Effects on Thermoregulation, Somatosensory System, Movement Evoked Pain (HYPPRI-1)","HYPPRI-1","Inclusion Criteria:\n\npatients:\n\n* Confirmed diagnosis of widespread pain (ICD-11 MG30.01)\n* Widespread Pain Index (WPI) ≥ 7 and Symptom Severity (SS) scale ≥ 5 or WPI) ≥ 3 and SS ≥ 9,\n* Pain \\>= 3 month and VAS \\>= 4,0\n* Body - infrared-A-Bulb Distance \\\u003C 38cm (overweight participants)\n* Signed declaration of consent\n\nhealthy:\n\n* No chronic illnesses\n* No acute infections\n* No regular medication: To avoid interactions\n* BMI ≤ 40kg\u002Fcm2\n* Mental health: No psychiatric diagnoses or psychotropic medication in your medical history\n\nExclusion Criteria:\n\n* Participation in other clinical studies\n* Contraindications for hyperthermia (severe cardiovascular diseases, tumour diseases, acute infections, pregnant and breastfeeding women)\n* Acute and \u002F or feverish microbial infections\n* Participants with severe somatic, rheumatic concomitant endocrine or neurological diseases, in particular neurological diseases associated with cognitive disorders, severe liver or kidney and cardiac diseases\n* participants who are permanently treated with opioids, cannabis, immunosuppressive drugs (e.g. corticoids, immunosuppressants) or alpha\u002Fbeta-A(nta)gonists due to a disease from the group described above\n* participants with pain due to a serious psychiatric illness (bipolar disorder, psychosis, personality disorder, severe depression, substance abuse) and serious systemic or neurological disorders\n* pregnancy or breastfeeding (for women)\n* Intake of medication within 6 weeks that inhibits the reuptake of the neurotransmitter serotonin or binds to receptors of this neurotransmitter group","70 Years",{"count":72,"type":21},60,[24],"This study, in a quasi-experimental matched two-group pre-post design, investigates the effect of serial water-filtered whole-body hyperthermia on circadian core body temperature, the somatosensory system (nociception) and the movement evoked pain in healthy and patients with chronic primary pain (e.g., fibromyalgia). The intervention lasts 3 weeks with two treatment sessions per week.",[27,76,77,78,79,80,81,82,83,84,85,86,87],"Chronic Primary Pain","Widespread Pain","Muscular Disease","Rheumatic Diseases","Musculoskeletal Diseases","Neuromuscular Disease","Fibromyalgia","Circadian Rhythm","Body Temperature Changes","Somatosensory Function","Quantitative Sensory Testing","Healthy",[31,89,90,91,92,93],"widespread pain","chronic primary pain","circadian body temperature","quantitative sensory testing","healthy","2026-05-29",{"date":96,"type":37},"2026-06-02",{"date":98,"type":21},"2026-08-01",{"date":100,"type":21},"2028-12-31",{"name":102,"class":44},"Bern University of Applied Sciences",1,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":110,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":22,"phases":114,"briefSummary":115,"conditions":116,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":103},"100640681","laboratory-heat-biomarker-and-cooling-interventions-100640681","NCT07617649","Laboratory Heat Biomarker and Cooling Interventions","Laboratory Based Identification of Heat Stress Biomarkers and Effective Cooling Interventions","Inclusion Criteria:\n\n* Age 18-50\n* Able to communicate in English or Spanish\n* General good health\n* A lifestyle that includes regular patterns of modest exercise\n* Body weight over 80 pounds\n\nExclusion Criteria:\n\n* Cannot provide informed consent\n* Known history of cardiac arrhythmias or having a pacemaker\n* Difficulty swallowing pills\n* Planned upcoming X-ray tests or MRI\n* Known history of gastroparesis, diverticulosis or diverticulitis, or inflammatory bowel disease\n* Previous surgery on stomach or intestines (except for appendix or gallbladder)\n* Pregnancy\n* Self-reported cardiac, kidney, or pulmonary disease, or diabetes\n* Concurrent use of temperature- or inflammation-modulating medications such as steroids or non-steroidal anti-inflammatory drugs (NSAIDs)\n* Staff under the direct supervision of any project directors or employed in the laboratory of the study investigators","50 Years",{"count":113,"type":21},30,[24],"Our study has two goals. The first goal is to find a blood test that can detect signs of strain from heat in the body (\"a biomarker\"). Second, the study team wants to identify types of devices that can help people cool down quickly.\n\nBy identifying biomarkers for heat strain, scientists can better track and treat the health effects of heat. The study team will identify such biomarkers by simulating, in a laboratory-based environment, the heat and physical work that real-world workers experience.\n\nIn addition, the study team plans to test two cooling technologies that might keep people cool during physical activity.",[27],"2026-05-23",{"date":119,"type":37},"2026-06-01",{"date":121,"type":21},"2026-06",{"date":123,"type":21},"2028-06",{"name":125,"class":44},"Stanford University",{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":15,"sex":16,"minAge":132,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":135,"briefSummary":136,"conditions":137,"keywords":139,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":103},"100590016","ieem-heat-and-heart-failure-100590016","NCT06961929","IEEM-Heat and Heart Failure","Inclusion Criteria for healthy control participants:\n\n* Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants must be 45+ years.\n\nExclusion Criteria for healthy control participants:\n\n* Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. Current smokers, as well as individuals who regularly smoked within the past 12 months, will be excluded. Subjects who cannot be age and gender matched to an individual in the heart failure group will be excluded.\n\nInclusion Criteria for Participants with CHF:\n\n\\- The participant must have a diagnosis of congestive heart failure (e.g., heart failure with reduced ejection fraction), with the severity categorized as New York Heart Association (NYHA) class II or III. Participants must be 45+ years.\n\nExclusion Criteria for Participants with CHF:\n\n-Patients who do not have confirmed diagnosis of NYHA class II or III heart failure will be excluded from the clinical group. Potential participants with cancer, diabetes, neurological disease, lung disease, and\u002For uncontrolled hypertension will be excluded. Potential participants with a left bundle branch block on ECG will be excluded. Patients on anticoagulant therapy will also be excluded. Current smokers, as well as individuals who regularly smoked within the past 12 months, will be excluded. Further exclusions will include severe valvular or congenital heart disease, acute myocarditis, NYHA Class IV heart failure, and\u002For manifest\u002Fprovocable ischemic heart disease.","45 Years",{"count":134,"type":21},88,[24],"We will test the hypothesis that increasing skin wetness, and thus evaporative cooling, will attenuate the increase in core body temperature and accompanying cardiac stress during heat wave conditions in individuals with congestive heart failure. Secondly, we propose that wearing a water-saturated T-shirt will also be beneficial to attenuate the increase in core body temperature and accompanying cardiac stress during heat wave conditions in individuals with congestive heart failure. To accomplish these objectives, individuals with congestive heart failure and otherwise healthy control individuals will be exposed to the simulated heat wave condition (hot and dry) with the following cooling modalities: A) control trial (no limb immersion or skin wetting), B) skin wetting only trial, and C) water-saturated T-shirt trial in a randomized crossover fashion. Thermoregulatory and cardiovascular responses will be evaluated throughout these simulated heat wave exposures.\n\nPrimary outcomes variables will be skin and core temperatures, while secondary variables will include measures of cardiovascular stress, myocardial perfusion, heart rate, and echo-based measures of cardiac function.",[138,27],"Heart Failure",[140,141,142,143],"heat wave","cardiovascular","cooling strategies","myocardial perfusion","RECRUITING","2026-05-21",{"date":147,"type":37},"2026-05-26",{"date":149,"type":37},"2025-10-01",{"date":151,"type":21},"2030-07-01",{"name":153,"class":44},"University of Texas Southwestern Medical Center",{"id":155,"slug":156,"hasResults":11,"nctId":157,"briefTitle":158,"officialTitle":159,"acronym":160,"eligibilityCriteria":161,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":162,"targetDuration":4,"studyType":22,"phases":164,"briefSummary":165,"conditions":166,"keywords":172,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":195},"100632159","title-icarus---psycho-physiological-profiling-of-low-and-high-heat-resilient-individuals-100632159","NCT07510061","Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals","Physiological Phenotyping","ICARUS","Study Population\n\nHealthy adult volunteers residing in Denmark (Northern Europe) or Greece (Southern Europe).\n\nInclusion Criteria\n\n* Age 18-65 years (or your protocol-specific age range)\n* Healthy as determined by medical history screening questionnaire\n* Able to provide written informed consent\n* Able to complete heat exposure and light exercise protocol\n* No heat acclimatization or extensive sun exposure in the previous 4 weeks\n* Fitzpatrick skin type I-IV (if applicable for UV testing)\n* Willing to undergo blood sampling, urine collection, and skin biopsy\n\nExclusion Criteria\n\n* History of cardiovascular, metabolic, neurological, or dermatological disease\n* History of heat-related illness (e.g., heat stroke)\n* Use of medications affecting thermoregulation or cardiovascular function\n* Smoking or substance abuse\n* Pregnancy or breastfeeding\n* Abnormal ECG or uncontrolled hypertension\n* Recent severe sunburn or UV treatment\n* Contraindications to skin biopsy\n* Inability to tolerate heat exposure during screening",{"count":163,"type":21},80,[24],"The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans. Excess morbidity and mortality during heat waves provides strong evidence for fatal outcomes. However, it is unclear why some people are particularly vulnerable and get sick from hyperthermia, while others adapt and tolerate exposure.\n\nThe Icarus project aims to provide a psycho-physiological framework for improved mitigation of the health threats associated with global warming. Combining expertise in integrative thermal physiology, pharmacology, photobiology, psychology and machine learning, we will collaborate on comprehensive cross-scientific studies using controlled lab-exposure combined with investigations in ecological settings including vulnerable and highly tolerant people across populations from northern to southern Europe.\n\nAdvanced algorithms will be developed to generate personalized alerts and advising based on behavioral patterns, psychological profiling, predicted vulnerability and willingness to adopt resilience-building strategies.\n\nGlobal warming is projected to continue towards the end of the 21st century and constitutes an increasing threat to human health unless we as individuals and collectively become better in preventing acute effects, as well as devise sustainable strategies to limit further anthropogenic warming of the climate system. Acutely, improved guidance is important for both individual and public health, where Icarus aims at providing a highly improved basis for preventing heat-related disease, advising or nudging people towards pro-health behavior, including smarter use of technologies to mitigate heat stress, or adjusting medication to reduce adverse effects during heat events. In support of the sustainability agenda, our framework also forms a novel basis for developing advising algorithms relevant for optimization of climate change mitigation policy-making.",[167,168,169,27,170,171],"Skin Cancer","Heat Tolerance","Heat-related Illness","Heat Stress","Ultraviolet Radiation-Related Skin Damage",[170,173,174,175,27,176,177,178,179,180,181,182,183,184,185],"Heat-Related Illness","Heat Vulnerability","Heat Intolerance","Environmental Heat Exposure","Thermal Stress","Ultraviolet Radiation Exposure","Skin DNA Damage","Cardiovascular Strain (Heat-Induced)","Cognitive Impairment (Heat-Induced)","Occupational Heat Stress","Climate Change and Health","Heat Resilience","Heat Acclimatization","2026-03-27",{"date":188,"type":37},"2026-04-03",{"date":190,"type":37},"2025-11-01",{"date":192,"type":21},"2027-04-30",{"name":194,"class":44},"University of Thessaly",2,{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":200,"acronym":201,"eligibilityCriteria":202,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":203,"targetDuration":4,"studyType":22,"phases":205,"briefSummary":206,"conditions":207,"keywords":208,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":215,"leadSponsor":216,"locationsCount":103},"100626238","the-effectiveness-of-emergency-room-protocols-for-treating-hyperthermia-100626238","NCT07433036","The Effectiveness of Emergency Room Protocols for Treating Hyperthermia","EDCP","Inclusion Criteria:\n\n* Active, healthy individuals\n\nExclusion Criteria:\n\n* Pregnant or planning on becoming pregnant\n* Have a pacemaker\n* Currently taking any prescribed or over the counter medications or nutritional supplements known to influence thermoregulatory responses\n* Experience lingering pain from a previous musculoskeletal injury (i.e. knee, hip, or back pain)\n* Use tobacco\u002Fnicotine products",{"count":204,"type":21},50,[24],"This study will help us as scientists and clinicians understand how effective commonly used cooling protocols in emergency departments are and which of the protocols is the most effective.\n\nIt consists of a single, approximately 1 hour preliminary session and five, approximately 3 hour experimental sessions, equaling an approximate 16 hour total time commitment.\n\nThe purpose of this research is to test the effectiveness of three cooling protocols.\n\n1. Cooling packs\n2. \"Ice Sheets\", which are bed sheets soaked in ice water, wrapped around the participant, while a fan blows air on them.\n3. Body bag filled with ice, commonly used in emergency departments to treat hyperthermia\n\nAdditionally, a negative control (passive cooling in air-conditioned room) and a positive control (cold water immersion).",[27],[27,209],"Exercise","2026-02-18",{"date":212,"type":37},"2026-02-25",{"date":214,"type":37},"2025-07-01",{"date":100,"type":21},{"name":217,"class":44},"University of Colorado, Colorado Springs",{"id":219,"slug":220,"hasResults":11,"nctId":221,"briefTitle":222,"officialTitle":222,"acronym":4,"eligibilityCriteria":223,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":224,"enrollmentInfo":225,"targetDuration":4,"studyType":22,"phases":227,"briefSummary":228,"conditions":229,"keywords":4,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":103},"100552611","predicting-responses-to-exhausting-prolonged-and-repeated-exercise-demands-prepared-for-heat-100552611","NCT06475339","Predicting Responses to Exhausting, Prolonged, And Repeated Exercise Demands (PREPARED) for Heat","Inclusion Criteria:\n\n* Healthy individuals\n* Physically active\n\nExclusion Criteria:\n\n* History of cardiovascular, metabolic (such as clinical thyroid disease), respiratory, neural, or renal disease\n* Hypertensive (systolic blood pressure \\> 139 mmHg, diastolic blood pressure \\> 89 mmHg) or tachycardic (heart rate \\> 100 bpm) during the screening visit\n* Taking medications or supplements known to effect physiologic responses to exercise or thermoregulation (e.g., beta blockers, omega-3 fatty acids, statins, aspirin)\n* Tobacco or nicotine use currently or in the past six months\n* Musculoskeletal injury expected to impact exercise in the protocol\n* A positive pregnancy test at any point in the study\n* Study physician discretion based on any other medical condition or medication\n* Inability to understand or follow instructions or the protocol\n* Gastrointestinal disease or previous surgery prohibiting core temperature capsule use. Participants with a contraindication can opt to insert the pill rectally as a suppository.","39 Years",{"count":226,"type":21},24,[24],"The overall goal of this project is to identify a work\u002Frest cycle that allows for faster mission completion needed in emergency situations, compared to current Army heat guidance, while mitigating heat strain and neuromuscular fatigue. This project will determine the trade-off between faster mission completion and risk of heat strain and physical performance decrements. Completion of this project will allow military leaders to make informed decisions by understanding the impact of their choices on the magnitude of physical performance decrements and expected heat casualties, setting up hot weather missions for success.",[27,28],"2026-01-22",{"date":232,"type":37},"2026-01-26",{"date":234,"type":37},"2024-11-01",{"date":236,"type":21},"2027-03",{"name":43,"class":44},{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":15,"sex":16,"minAge":18,"maxAge":4,"enrollmentInfo":245,"targetDuration":4,"studyType":22,"phases":247,"briefSummary":248,"conditions":249,"keywords":251,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":103},"100476500","heat-waves-and-the-elderly---cooling-modalities-100476500","NCT05484739","Heat Waves and the Elderly - Cooling Modalities","Heat Waves in the Elderly: Reducing Thermal and Cardiovascular Consequences","Inclusion Criteria:\n\n* 65 years of age or older\n* Free of any significant underlying medical problems based upon a detailed medical history and physical exam\n\nExclusion Criteria:\n\n* Known heart disease\n* Other chronic medical conditions requiring regular medical therapy including cancer, diabetes, uncontrolled hypertension, and uncontrolled hypercholesterolemia etc;\n* Abnormality detected on routine screening suggestive of provokable ischemia or previously undetected cardiac disease or resting left bundle branch block on screening electrocardiogram.\n* Current smokers, as well as individuals who regularly smoked within the past 3 years\n* Subject with a body mass index ≥31 kg\u002Fm2\n* Pregnant individuals",{"count":246,"type":21},100,[24],"The purpose of this study is to assess how well cooling modalities work in reducing cardiovascular stress of the elderly to heat wave conditions",[250,27],"Aging",[252,140,141,253],"aging","low-energy cooling","2025-10-21",{"date":256,"type":37},"2025-10-23",{"date":258,"type":37},"2023-02-21",{"date":260,"type":21},"2026-08-31",{"name":153,"class":44},{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":266,"acronym":267,"eligibilityCriteria":268,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":269,"targetDuration":4,"studyType":271,"phases":4,"briefSummary":272,"conditions":273,"keywords":4,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":103},"100550854","postoperative-re-irradiation-with-and-without-hyperthermia-toxicity-quality-of-life-and-survival-in-patients-with-locoregional-recurrent-breast-cancer-100550854","NCT06452485","Postoperative Re-irradiaTion With and Without HYPERthermia: Toxicity, Quality of Life and Survival in Patients With Locoregional Recurrent Breast Cancer","RT-HYPE","Inclusion Criteria:\n\n* WHO performance scale ≤2\n* \\>=18 years\n* Patients with a LRR breast cancer after postoperative irradiation of the primary breast cancer. LRR is defined as a local and\u002For regional recurrence, including patients with a second primary ipsilateral breast cancer.\n* Patients treated with salvage mastectomy with high-risk\\* tumor characteristics or local excision with an indication for postoperative re-irradiation.\n* Previously treated with whole or partial breast irradiation.\n* (Neo)adjuvant systemic therapy (NST) is allowed.\n* Use of (FES\u002FFDG-)PET-CT in staging of nodal and disseminated disease.\n* Oligometastases in lymph nodes in the mediastinum, neck, contralateral axillary\u002Fsupraclavicular region (up to a maximal number of five) is allowed.\n* Adequate communication and understanding skills of the Dutch language.\n\nExclusion Criteria:\n\n* Diagnosed with primary breast sarcoma\n* Have a low-risk LRR after previous breast-conserving surgery\u002Ftherapy",{"count":270,"type":21},500,"OBSERVATIONAL","In the Netherlands, breast cancer patients with locoregional recurrence (LRR) and high-risk factors are treated with postoperative re-irradiation with or without hyperthermia. Retrospective studies showed that 3-year locoregional control after postoperative re-irradiation with hyperthermia was 68-83%, and severe toxicity in up to 40% of LRR patients. Unfortunately, no prospective (randomized) data are available on clinical outcomes. Consequently, variation exists in hyperthermia-treatment and re-irradiation schedules. Prospective real-world data on oncological outcomes, toxicity and quality of life is highly needed for shared decision-making between patients and professionals. These data will be used in the design of a future randomized trial comparing postoperative re-irradiation and hyperthermia-treatment in high-risk LRR patients.",[274,275,276,27],"Locoregional Recurrence","Breast Cancer","Re-irradiation","2025-09-30",{"date":279,"type":37},"2025-10-06",{"date":281,"type":37},"2024-01-01",{"date":283,"type":21},"2027-05",{"name":285,"class":44},"Amsterdam UMC, location VUmc",{"id":287,"slug":288,"hasResults":11,"nctId":289,"briefTitle":290,"officialTitle":290,"acronym":4,"eligibilityCriteria":291,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":292,"targetDuration":4,"studyType":271,"phases":4,"briefSummary":294,"conditions":295,"keywords":297,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":103},"100590355","ieem--workrest-cycles-in-burn-survivors--humidity-100590355","NCT06966336","IEEM- Work:Rest Cycles in Burn Survivors- Humidity","Inclusion Criteria for Non-burned Individuals:\n\n* Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants must be between the ages of 18 and 65.\n\nExclusion Criteria for Non-burned Individuals:\n\n* Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. Current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. Participants may also be excluded if body mass index is ≥ 31 kg\u002Fm2 will likewise be excluded. Participants must not have had a serious burn injury requiring more than 1 night stay in the hospital.\n\nInclusion Criteria for Individuals with up to 40% of their body surface area burned (moderate burn group):\n\n\\- Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants who have sustained a burn injury must have a burn covering 20-40% of their body surface area and 50% of those burns must be full-thickness burns requiring skin grafts. Participants must be between the ages of 18 and 65.\n\nExclusion Criteria for Individuals with up to 40% of their body surface area burned (moderate burn group):\n\n\\- Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. Current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. Participants may also be excluded if body mass index is ≥ 31 kg\u002Fm2 will likewise be excluded.\n\nInclusion Criteria for Individuals with greater than 40% of their body surface area burned (large burn group):\n\n\\- Participants must be free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram. Participants who have sustained a burn injury must have a burn covering more than 40% of their body surface area and 50% of those burns must be full-thickness burns requiring skin grafts. Participants must be between the ages of 18 and 65.\n\nExclusion Criteria for Individuals with greater than 40% of their body surface area burned (large burn group):\n\n\\- Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, lung disease, etc.; as well as serious abnormalities detected on routine screening. Current smokers, as well as individuals who regularly smoked within the past 3 years will be excluded. Participants may also be excluded if body mass index is ≥ 31 kg\u002Fm2 will likewise be excluded.",{"count":293,"type":21},70,"The purpose of this project is to identify the effects of a severe burn injuries in humans on core temperature responses during work:rest cycles while in a heated environment.",[27,296],"Burn Injury",[298,299,300,301,302,303,304],"Burn Survivor","Burn","humid","dry","core temperature","heat","body temperature","2025-08-19",{"date":307,"type":37},"2025-08-26",{"date":309,"type":37},"2025-08-15",{"date":311,"type":21},"2031-08-01",{"name":153,"class":44},{"id":314,"slug":315,"hasResults":11,"nctId":316,"briefTitle":317,"officialTitle":317,"acronym":4,"eligibilityCriteria":318,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":319,"enrollmentInfo":320,"targetDuration":4,"studyType":22,"phases":322,"briefSummary":323,"conditions":324,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":326,"lastUpdatePostDateStruct":327,"startDateStruct":329,"completionDateStruct":330,"leadSponsor":332,"locationsCount":4},"100600879","analysis-of-hyperthermia-as-an-adjunctive-treatment-to-evidence-based-clinical-intervention-in-subjects-with-plantar-fasciitis-a-double-blind-randomized-clinical-trial-100600879","NCT07103226","Analysis of Hyperthermia as an Adjunctive Treatment to Evidence-based Clinical Intervention in Subjects With Plantar Fasciitis: a Double-blind Randomized Clinical Trial","Inclusion Criteria:\n\n* Have a diagnosis confirmed by performing an ultrasonography of Plantar Fascitis\n* Have not yet received physiotherapy treatment.\n\nExclusion Criteria:\n\n* Have undergone surgery.\n* Those who refuse to participate in this study.\n* Patients with muscle atrophy due to plantar fasciitis.\n* Medical conditions that are contraindications for hyperthermia therapy.","60 Years",{"count":321,"type":21},64,[24],"This project aims to analyze the use of hyperthermia within a treatment protocol for plantar fasciitis, as well as to determine the difference between two and three sessions per week. Study participants will be divided into four intervention groups: the first will receive two sessions per week for a period of six months, while the second will receive three sessions per week for the same period. The treatment protocol will consist of therapeutic physical exercise focused on the foot muscles and stretching the plantar fascia and posterior chain, hyperthermia on the plantar fascia insertion area in the calcaneus and adjacent areas, and the use of an orthotic insole used for walking. The third and fourth intervention groups will receive the same treatment as mentioned above, but without hyperthermia. The third group will receive three sessions per week, while the second group will receive two sessions per week. Two different types of measurement variables will be used: objective variables will be used to measure local pain using an algometer, assess ankle joint range of motion, and use ultrasound imaging techniques. Subjective variables will also be used through validated questionnaires, which will address physical activity, perceived functional limitations in patients with lower limb pathologies, lower limb functional assessment, and a visual analogue scale for pain perception.",[325,27],"Plantar Fascia","2025-08-01",{"date":328,"type":37},"2025-08-05",{"date":326,"type":21},{"date":331,"type":21},"2027-03-31",{"name":333,"class":44},"University of Malaga",{"id":335,"slug":336,"hasResults":11,"nctId":337,"briefTitle":338,"officialTitle":338,"acronym":4,"eligibilityCriteria":339,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":319,"enrollmentInfo":340,"targetDuration":4,"studyType":22,"phases":342,"briefSummary":343,"conditions":344,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":346,"lastUpdatePostDateStruct":347,"startDateStruct":348,"completionDateStruct":349,"leadSponsor":351,"locationsCount":4},"100600598","analysis-of-hyperthermia-as-an-adjunctive-treatment-to-evidence-based-clinical-intervention-in-subjects-with-bursitis-a-double-blind-randomized-clinical-trial-100600598","NCT07099573","Analysis of Hyperthermia as an Adjunctive Treatment to Evidence-based Clinical Intervention in Subjects With Bursitis: a Double-blind Randomized Clinical Trial","Inclusion Criteria:\n\n* Have a diagnosis confirmed by performing an imaging test of Bursitis\n* Have not yet received physiotherapy treatment.\n\nExclusion Criteria:\n\n* Have undergone surgery.\n* Those who refuse to participate in this study.\n* Patients with muscle atrophy.\n* Medical conditions that are contraindications for hyperthermia therapy.",{"count":341,"type":21},120,[24],"This project aims to analyze the use of hyperthermia within a bursitis treatment protocol, as well as to determine the difference between two and three sessions per week. Study participants will be divided into four intervention groups: the first will receive two sessions per week for a period of six months, while the second will receive three sessions per week for the same period. The treatment protocol will consist of therapeutic physical exercise focused on the affected joint, stretching of the involved muscles, and the application of hyperthermia to the bursa and surrounding areas. The third and fourth intervention groups will receive the same treatment as mentioned above, but without hyperthermia. The third group will receive three sessions per week, while the second group will receive two sessions per week. Two different types of measurement variables will be used: on the one hand, the objective variable will be measurement and assessment of the bursa using ultrasound imaging. Subjective measurement variables will also be used through validated questionnaires, which will address physical activity, perceived functional limitations, and the visual analog scale for pain perception.",[345,27],"Bursitis","2025-07-25",{"date":326,"type":37},{"date":326,"type":21},{"date":350,"type":21},"2026-04-30",{"name":333,"class":44},{"id":353,"slug":354,"hasResults":11,"nctId":355,"briefTitle":356,"officialTitle":357,"acronym":4,"eligibilityCriteria":358,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":319,"enrollmentInfo":359,"targetDuration":4,"studyType":22,"phases":361,"briefSummary":362,"conditions":363,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":369,"completionDateStruct":371,"leadSponsor":372,"locationsCount":4},"100588505","analysis-of-hyperthermia-as-a-complementary-treatment-to-evidence-based-clinical-intervention-in-subjects-with-carpal-tunnel-syndrome-100588505","NCT06942273","Analysis of Hyperthermia as a Complementary Treatment to Evidence-based Clinical Intervention in Subjects With Carpal Tunnel Syndrome:","Analysis of Hyperthermia as a Complementary Treatment to Evidence-based Clinical Intervention in Subjects With Carpal Tunnel Syndrome: a Double-blind Randomized Clinical Trial.","Inclusion Criteria:\n\n* Have a diagnosis confirmed by performing an electromyography of Carpal Tunnel Syndrome\n* Have not yet received physiotherapy treatment.\n\nExclusion Criteria:\n\n* Have undergone surgery.\n* Those who refuse to participate in this study.\n* Patients with muscle atrophy due to CTS.\n* Medical conditions that are contraindications for hyperthermia therapy.",{"count":360,"type":21},160,[24],"This project aims to analyze the use of hyperthermia within a treatment protocol for Carpal Tunnel Syndrome (CTS), as well as to determine the difference between two and three sessions per week. Study participants will be divided into four intervention groups: the first will receive two sessions per week for a period of six months, while the second will receive three sessions per week for the same period. The treatment protocol will consist of therapeutic physical exercise focused on the hand flexor muscles and neural stretching, the application of hyperthermia to the carpal tunnel and adjacent areas, and the use of a night splint. The third and fourth intervention groups will receive the same treatment as mentioned above, but without hyperthermia. The third group will receive three sessions per week, while the second group will receive two sessions per week. Two different types of measurement variables will be used: objective variables will be used to measure hand flexor muscle strength and wrist free range of motion. Subjective variables will also be used through validated questionnaires covering physical activity, perceived functional limitations, upper limb functional assessment, neuropathic pain, and a visual analogue scale for pain perception.",[364,27,365],"Carpal Tunnel Syndrome (CTS)","Frequency of Therapy","2025-04-16",{"date":368,"type":37},"2025-04-24",{"date":370,"type":21},"2025-05-01",{"date":350,"type":21},{"name":333,"class":44},{"id":374,"slug":375,"hasResults":11,"nctId":376,"briefTitle":377,"officialTitle":377,"acronym":4,"eligibilityCriteria":378,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":379,"targetDuration":4,"studyType":271,"phases":4,"briefSummary":380,"conditions":381,"keywords":4,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":383,"lastUpdatePostDateStruct":384,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":390,"locationsCount":103},"100580859","impact-of-extreme-heat-on-myocardial-blood-flow-and-flow-reserve-in-young-and-older-adults-100580859","NCT06842784","Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults","Inclusion Criteria:\n\n* Healthy male and female individuals\n* 18-35 years or 65+ years of age\n* Free of any underlying moderate to serious medical conditions\n\nExclusion Criteria:\n\n* Known heart disease; other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, uncontrolled hypertension, and uncontrolled hypercholesterolemia.\n* Taking of any medications (such as beta blockers and non-dihydropyridine calcium channel blockers) that have known influences on either cardiac function or sweating responses.\n* Abnormalities detected on routine screening.\n* Current smokers, as well as individuals who regularly smoked within the past 3 years.\n* Body mass index of greater than 30 kg\u002Fm\\^2\n* Pregnant individuals",{"count":226,"type":21},"Extreme heat causes a disproportionate number of hospitalizations and deaths in older adults relative to any other age group. Importantly, many hospitalizations and deaths are primarily due to cardiovascular events such as myocardial infarction. Previous data indicate that older adults have attenuated skin blood flow and sweating responses when exposed to heat, resulting greater increase in core body temperature. Despite these observations, relatively little is known about the risk for myocardial ischemia potentially contributing to the aforementioned higher morbidity and mortality in older adults during heat waves. The broad objective of this work is to determine the impact of ambient heat exposure on myocardial blood flow and flow reserve in young and older adults. Aim 1 will test the hypothesis that older adults exhibit attenuated myocardial flow reserve compared to young adults during heat stress. Aim 2 will determine if the percent of maximal myocardial flow reserve (assess via vasodilator stress) during heat exposure is higher in older adults compared to young adults. The expected outcome from this body of work will improve our understanding of the consequences of aging on cardiovascular responses to ambient heat stress.",[250,170,27,382],"Heat Strain","2025-02-18",{"date":385,"type":37},"2025-02-24",{"date":387,"type":37},"2025-02-03",{"date":389,"type":21},"2027-02-01",{"name":153,"class":44},{"id":392,"slug":393,"hasResults":11,"nctId":394,"briefTitle":395,"officialTitle":396,"acronym":397,"eligibilityCriteria":398,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":399,"targetDuration":401,"studyType":271,"phases":4,"briefSummary":402,"conditions":403,"keywords":405,"overallStatus":144,"whyStopped":4,"lastUpdateSubmitDate":407,"lastUpdatePostDateStruct":408,"startDateStruct":410,"completionDateStruct":412,"leadSponsor":414,"locationsCount":195},"100515623","prospective-hyperthermia-database-in-cancer-patients-ht-register-100515623","NCT05993910","Prospective Hyperthermia Database in Cancer Patients (HT Register)","Prospektive Hyperthermie-Datenbank Bei Krebspatienten (HTRegister)","HTRegister","Inclusion Criteria:\n\n* Contrazeption with female patients at the capable of bearing children age\n* Written agreement is present (DvH, ICH-GCP)\n* Patients, who participate at the same time in a interventional study, can nevertheless in this register study participate if this none Exclusion criterion for the interventional study represents.\n* With children must the treatment with one of the GPOH agreed Pattern take place\n\nExclusion Criteria:\n\n* Exclusion criteria for the hyperthermia (such as hip prosthesis in the therapeutic area, metal implants\u002Fmarker, patients with cardiac pacemakers)\n* mental disease, what the proper study participation does not allow.",{"count":400,"type":21},1000,"10 Years","This monocentric study registry records all cancer patients at the Charité which are treated with hyperthermia to examine the therapeutic use of hyperthermia in cancer patients in the general application and to obtain an accurate risk-benefit balance\n\nAfter confinement in this database are the patients prospectively in order to complications, disease status and survival status tracked.\n\nFurthermore there is the possibility in the course of this study to an optional take part in translational accompanying research with the aim of prognostic factors for response to hyperthermia treatment.",[27,404],"Cancer",[406,397],"Hyperthermia E02.565","2023-08-14",{"date":409,"type":37},"2023-08-15",{"date":411,"type":37},"2014-11-01",{"date":413,"type":21},"2028-10-31",{"name":415,"class":44},"Pirus Ghadjar"]