[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypertrophic-scar\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypertrophic-scar":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,42,73,101,123,148],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100553578","differential-pressure-distribution-orthosis-by-3d-printing-process-in-the-treatment-of-post-burn-hypertrophic-scarring-100553578",false,"NCT06487910","Differential Pressure Distribution Orthosis by 3D Printing Process in the Treatment of Post-burn Hypertrophic Scarring","Pilot Study on the Design of a 3D-printed Differential Pressure Distribution Orthosis for the Treatment of Post-burn Hypertrophic Scarring","EPIDERM","Inclusion Criteria:\n\n* Adult Patients aged \\> 18 years old\n* Patient with at least one hypertrophic burn scar in the process of healing localized on a skin area that can benefit from a compression garment and requiring the use of an ORDP\n* Patient able to give informed consent\n* Patient affiliated to a social security scheme\n\nExclusion Criteria:\n\n* Patients under guardianship, curatorship or safeguard of justice\n* Pregnant or breast-feeding women","ALL","18 Years",{"count":20,"type":21},25,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a pilot, single-center, feasibility study to evaluate a new 3D printing method for ORDP design.\n\nTo our knowledge, there is no technical or clinical evaluation of ORDPs, particularly in the treatment of hypertrophic scars. The aim of our study is therefore to assess the feasibility of an innovative method of designing ORDPs for the curative treatment of post-burn hypertrophic scars, using a 3D printing process, and to describe the procedures (production time and cost).",[27,28],"Burns","Hypertrophic Scar","RECRUITING","2026-06-20",{"date":32,"type":33},"2026-06-24","ACTUAL",{"date":35,"type":33},"2025-01-10",{"date":37,"type":21},"2027-01-10",{"name":39,"class":40},"Centre Hospitalier Régional Metz-Thionville","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":50,"sex":17,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":59,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":41},"100604257","evaluating-the-efficacy-of-force-modulating-tissue-bridge-device-in-preventing-hypertrophic-scars-following-gender-affirming-mastectomy-100604257","NCT07147166","Evaluating the Efficacy of Force Modulating Tissue Bridge Device in Preventing Hypertrophic Scars Following Gender-Affirming Mastectomy","Evaluating the Efficacy of Force Modulating Tissue Bridge Device in Preventing Hypertrophic Scars Following Gender-Affirming Mastectomy: A Randomized Self-Controlled Trial","FMTB Brij","Inclusion Criteria:\n\n1. Age ≥ 19\n2. Undergoing double incision gender affirming mastectomy\n3. Ability to adhere to Brijjit therapy after surgery\n4. Willing to return for follow-up visits and undergo study evaluations\n\nExclusion Criteria:\n\n1. History of keloid formation\n2. Radiation therapy history\n3. Prior surgeries of the chest or breast\n4. History or use following prescription medications: 1) accutane within the past year. 2) chronic systemic steroids\n5. Active smoker\n6. Disorder known to negatively affect wound healing (autoimmune, connective tissue, uncontrolled diabetes)\n7. Any other condition determined by PI to preclude subject from joining study",true,"19 Years",{"count":53,"type":21},78,[24],"The goal of this randomized, prospective, interventional clinical trial is to evaluate the use of Brijjit® in reducing the incidence of hypertrophic scarring in individuals undergoing gender-affirming bilateral double incision mastectomies at a single-institution, single-surgeon site (Esther A. Kim, MD). Patients will serve as a self-control (one side of the chest receives intervention, the other serves as a control). Primary endpoints include scar appearance and quality. Secondary endpoints include patient perception of the scar using the Patient and Observer Scar Assessment Scale (POSAS).\n\nParticipants will be taught how to apply Brijjit® at home if any units fall off before 6 weeks postop.",[57,58,28],"Gender Dysphoria","Mastectomy",[60,61,62,63],"Gender-affirming","Gender-affirming care","Gender-affirming mastectomy","Hypertrophic scarring","2026-06-02",{"date":66,"type":33},"2026-06-04",{"date":68,"type":33},"2025-02-03",{"date":70,"type":21},"2032-06-01",{"name":72,"class":40},"University of California, San Francisco",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":4,"eligibilityCriteria":79,"healthyVolunteers":50,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":22,"phases":82,"briefSummary":84,"conditions":85,"keywords":91,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":41},"100328836","early-phase-1-zinc-oxide-versus-petrolatum-following-skin-surgery-100328836","NCT03561376","Zinc Oxide Versus Petrolatum Following Skin Surgery","Zinc Oxide Versus Petrolatum Following Skin Surgery: A Head-to-head, Prospective, Split-scar Study","Inclusion Criteria:\n\n1. ≥ 18 years of age\n2. Linear closure, non-scalp site\n3. ≥ 4.5 cm in length (final incision\u002Fclosure length)\n4. End to end symmetry (surgical site is not grossly asymmetric from end to end)\n5. Grossly uninfected site\n\nExclusion Criteria:\n\n1. ≤ 18 years\n2. Visibly asymmetric linear scar\n3. Grossly infected surgical site\n4. History of allergy to topical zinc oxide",{"count":81,"type":21},30,[83],"EARLY_PHASE1","Patients undergoing routine surgery in the Department of Dermatology for any indication on non-scalp skin and closed in linear fashion with scar greater than or equal to 4.5cm in length will be invited to participate in this split scar, head to head study comparing zinc oxide and petrolatum. Patients will apply respective ointments to each half of scar daily for one month and maintain a log of these activities. They will be seen at 1 week, 4 weeks, 8 weeks, and 6 months post-operatively for photographic scar assessment and to complete the patient portion of the Patient and Observer Scar Assessment Scale (POSAS), a quantitative objective assessment of scar appearance. Trained observers (board-certified dermatologists) will score the observer portion of the scale. POSAS outcomes, post-operative infections, linear density of epidermal seal will be assessed at the 1 week, 4 weeks, 8 weeks, and 6 months post-operative periods and compared between the two groups. Participants will have parking validated for all visits and upon completion of all portions of the study will receive a standardized skin care gift bag containing samples for hypoallergenic skin care products (washes, moisturizers, etc.).",[86,87,88,89,90,28],"Surgical Incision","Surgery--Complications","Surgical Wound","Surgical Site Infection","Scar",[90],"2025-08-12",{"date":94,"type":33},"2025-08-14",{"date":96,"type":33},"2021-09-01",{"date":98,"type":21},"2026-10-30",{"name":100,"class":40},"Melissa Pugliano-Mauro",{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":41},"100586275","cost-effectiveness-of-eswt-plus-rehabilitation-vs-rehabilitation-alone-in-post-burn-scars-100586275","NCT06913257","Cost-Effectiveness of ESWT Plus Rehabilitation vs Rehabilitation Alone in Post-Burn Scars","Cost-Effectiveness Analysis of Extracorporeal Shock Wave Therapy (ESWT) Combined With Standard Rehabilitation Versus Standard Rehabilitation Alone in Managing Post-Burn Scars: A Randomized Controlled Trial With Integrated Economic Evaluation","Inclusion Criteria:\n\nAdults aged 18-65 years. Documented hypertrophic scars following a burn injury, with scars present and stable for at least 6 months.\n\nModerate to severe scar severity as measured by a standardized clinical assessment.\n\nExperiencing significant pain and\u002For pruritus related to the scar, with a baseline VAS score of ≥4.\n\nAble to provide informed consent and comply with study procedures. Employed or engaged in daily activities such that indirect costs (absenteeism\u002Freduced productivity) can be recorded.\n\nExclusion Criteria:\n\nPregnant or lactating women. Individuals with previous surgical scar revision or other invasive scar treatments within the last 6 months.\n\nPatients with comorbid conditions (e.g., severe cardiovascular disease, uncontrolled diabetes) that could interfere with rehabilitation or ESWT.\n\nActive skin infection in the area of the scar. Use of concurrent investigational therapies for scar management.","65 Years",{"count":110,"type":21},104,[24],"This randomized controlled trial (RCT) will evaluate the cost-effectiveness of combining extracorporeal shock wave therapy (ESWT) with standard rehabilitation versus standard rehabilitation alone for the management of hypertrophic post-burn scars in adults. The study will assess clinical outcomes-such as pain intensity, pruritus, and scar quality-alongside economic outcomes including cost per quality-adjusted life year (QALY) gained, direct medical costs, and indirect costs (e.g., absenteeism and reduced productivity). Results will inform health policy and resource allocation decisions for advanced burn rehabilitation interventions.",[28],"2025-03-30",{"date":116,"type":33},"2025-04-06",{"date":118,"type":21},"2025-04-22",{"date":120,"type":21},"2027-06-01",{"name":122,"class":40},"Al Hayah University In Cairo",{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":130,"targetDuration":4,"studyType":22,"phases":132,"briefSummary":133,"conditions":134,"keywords":135,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":41},"100401362","silicone-taping-for-the-improvement-of-abdominal-donor-site-scars-100401362","NCT04506255","Silicone Taping for the Improvement of Abdominal Donor Site Scars","Silicone Taping for the Improvement of Abdominal Donor Site Scars Following Autologous Breast Reconstruction; A Randomized, Prospective Controlled Trial","Inclusion Criteria:\n\n* undergoing de novo abdominoplasty procedures as part of their breast reconstruction\n\nExclusion Criteria:\n\n* patients with a history of collagen disease, connective tissue disorders, psoriasis or lupus\n* patients with scleroderma\n* patients with a history of adverse reaction to adhesives or silicone allergy\n* patients with signs of dehiscence or infection resulting in modification to the experimental or control dressings\n* patients who are unable to care for their incisions\n* patients who are current smokers\n* patients who are currently on steroids.",{"count":131,"type":21},32,[24],"This study will look at silicone tape compared to the current no dressing standard at the investigators institution, to determine if silicone tape provides a significant improvement in post-abdominoplasty scar appearance. Silicone tape will be added to half of the abdominoplasty incision of patients undergoing abdominally-based breast reconstruction procedures two weeks after their operation. They will be followed up and assessed at specific timepoints to determine whether the silicone improves scar outcomes in these patients.",[28,90],[136,90,137,138],"Silicone","Abdominoplasty","Breast Reconstruction","2025-02-16",{"date":141,"type":33},"2025-02-18",{"date":143,"type":33},"2020-11-16",{"date":145,"type":21},"2026-12",{"name":147,"class":40},"Nova Scotia Health Authority",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":152,"acronym":4,"eligibilityCriteria":153,"healthyVolunteers":50,"sex":17,"minAge":154,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":22,"phases":158,"briefSummary":159,"conditions":160,"keywords":161,"overallStatus":163,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":168,"leadSponsor":170,"locationsCount":4},"100577836","pulsed-high-intensity-laser-versus-extracorporeal-shockwave-therapy-on-hypertrophic-scar-post-burn-100577836","NCT06803472","Pulsed High Intensity Laser Versus Extracorporeal Shockwave Therapy on Hypertrophic Scar Post Burn","Inclusion Criteria:\n\n* The patients age will range from 20 to 45 years.\n* All patients will be free from any other pathological conditions or histories except hypertrophic scar.\n* patients will be selected from both gender.\n* All patients will have hypertrophic scars post burn injuries.\n\nExclusion Criteria:\n\n* The patients who have open wound at or near treatment site.\n* The patients who have cardiac pacemakers or other implanted electronic devices.\n* The patients who have any significant health problem such as diabetes, circulatory\n* disorders or history of skin malignancy in the treated area.\n* uncooperative patients.\n* The patients who have a deep venous thrombosis (DVT).","20 Years","45 Years",{"count":157,"type":21},60,[24],"The goal of this clinical trial stydy : is to compare between the effect of pulsed high intensity laser and extracorporeal shockwave therapy on hypertrophic scar on post burned patients.\n\nThe main questions is it aims to answer is :\n\n* Which is more effective on hypertrophic scar post burn Extracorporeal shockwave therapy or pulsed high intensity laser therapy?\n* Participants will receive the treatment for 6 weeks.\n* Assesment will be don before and after treatment.",[28],[162],"Hypertrophic scar","NOT_YET_RECRUITING","2025-01-26",{"date":166,"type":33},"2025-01-31",{"date":164,"type":21},{"date":169,"type":21},"2025-03-25",{"name":171,"class":40},"Cairo University"]