[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypervolemia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypervolemia":30},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100630810","renal-and-hepatic-abnormal-doppler-patterns-in-trauma-100630810",false,"NCT07492511","Renal and Hepatic Abnormal Doppler Patterns in Trauma","Renal and hEpatiC abnoRmal dopplEr pAtterns iN Trauma: a Multicentre Prospective Observational Study","RECREANT","Inclusion Criteria:\n\n* Age 18-65 years;\n* Admission within 24h from traumatic injury;\n* ISS \\>15\n\nExclusion Criteria:\n\n1. Age \\\u003C18 or \\>65;\n2. Known heart failure (NYHA ≥II);\n3. Chronic kidney disease (any stage) or chronic RRT;\n4. Chronic respiratory disease needing home O₂ or ventilation;\n5. Radiological evidence of vascular or parenchymal renal injury on trauma CT precluding reliable Doppler assessment","ALL","18 Years","65 Years",{"count":21,"type":22},350,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to learn about renal and hepatic blood flow abnormalities detected by bedside ultrasound in adult patients admitted to the intensive care unit (ICU) following major trauma.\n\nThe main questions it aims to answer are:\n\n* How reliably can trained operators measure renal Doppler and venous congestion scores (RDRI and VExUS) across different hospitals?\n* How common are abnormal kidney and liver blood flow patterns in major trauma patients during the first 72 hours of ICU admission?\n* Are these abnormal patterns associated with acute kidney injury or the need for mechanical ventilation?\n\nParticipants admitted to ICUs or high-dependency units (HDUs) with major trauma (Injury Severity Score \\>15) will undergo non-invasive bedside ultrasound assessments at admission and at 24, 48, and 72 hours. No additional treatments or interventions will be given as part of this study. Kidney function will also be checked at 6 months after hospital discharge.",[26,27,28,29,30,31],"Trauma (Including Fractures)","Trauma Patients","Kidney Disease","Hypovolemia","Hypervolemia","Kidney Failure",[33,34,35,36,37,38,39,40,41,42],"VEXUS","trauma","kidney injury","kidney failure","Venous congestion","renal perfusion","Renal Doppler resistive index","major trauma","Hemodynamic phenotyping","ICU","RECRUITING","2026-03-19",{"date":46,"type":47},"2026-03-25","ACTUAL",{"date":49,"type":47},"2026-03-01",{"date":51,"type":22},"2030-06-30",{"name":53,"class":54},"Azienda Usl di Bologna","OTHER_GOV",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":4,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":4,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":55},"100420785","diuretic-tuner-clinical-decision-support-100420785","NCT04759274","Diuretic Tuner Clinical Decision Support","Diuretic Tuner Clinical Decision Support Mobile Device Application for Diuretic Titration in Hypervolemic States","Inclusion Criteria:\n\n* The presence of nephrotic range proteinuria (\\> 3 g\u002Fd proteinuria by 24hr urine protein, 24hr urine albumin, spot urine protein\u002Fcreatinine ratio, or spot urine albumin\u002Fcreatinine ratio) or stage 4 or 5 chronic kidney disease (estimated glomerular filtration rate \\\u003C 30 mL\u002Fmin\u002F1.73 m2 by Modification of Diet in Renal Disease equation) PLUS\n* Clinical signs of hypervolemia present (lower extremity edema, ascites, or pleural effusions) with an estimated dry weight (defined as edema-free weight without orthostatic hypotension) 5 lbs less than enrollment body weight\n\nExclusion Criteria:\n\n* Weight \\\u003C 100 lbs or \\> 300 lbs.\n* Autonomic insufficiency resulting in orthostatic hypotension at screening\n* Hypokalemia at enrollment (defined as serum potassium \\\u003C 3.5 mmol\u002FL)\n* Moderate to severe hyponatremia at enrollment (defined as serum sodium \\\u003C 130 mmol\u002FL)\n* Serum creatinine \\> 6 mg\u002FdL or \\> 1.5 times baseline\n* Patients who are unable or unwilling to measure their home blood pressures and weights\n* Patients without a working phone number and smart phone device\n* Expectation that the patient will require dialysis initiation within \\\u003C 3 months\n* Expected lifespan of \\\u003C 6 months\n* The presence of a medical condition that would interfere with effectively using the Diuretic Tuner (dementia, illiteracy, or blindness)\n* Pregnant patients\n* Prisoners",{"count":64,"type":22},30,"INTERVENTIONAL",[67],"NA","This purpose of this study is to determine the effectiveness of a mobile phone application in helping to control body swelling in patients with kidney problems. The application will help in the day to day adjustments in diuretic medication dosing.\n\nParticipants in this study will have an application loaded on to their mobile phone by the study team and be taught how to use it over a 2 hour visit. Participants will need to check their blood pressure and weight daily and enter this information into the mobile phone application every day. Participants will need to follow daily instructions in their medication dosing provided by the application. There will be periodic blood testing. This will happen at 2 weeks, 90 days, and up to 4 other times if necessary. At the end of the study there is a 2 hour study visit during which participants will answer a survey. The total length of the study is 90 days.",[70,30,71,72],"Edema","Chronic Kidney Diseases","Nephrotic Syndrome","2025-09-14",{"date":75,"type":47},"2025-09-16",{"date":77,"type":47},"2023-11-20",{"date":79,"type":22},"2026-08",{"name":81,"class":82},"University of Texas Southwestern Medical Center","OTHER"]