[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypocalcemia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypocalcemia":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,49,87,116,148,177,202,230],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100625855","postoperative-hypocalcemia-after-thyroidectomy-100625855",false,"NCT07428057","Postoperative Hypocalcemia After Thyroidectomy","A Ten-Year Cohort Study of Clinical and Surgical Predictors for Hypocalcemia Post-Thyroidectomy","Inclusion Criteria:\n\n* Adult patients aged 18 years or older at time of surgery\n* Underwent thyroidectomy at Minia University Hospital\n* Availability of medical records with complete surgical and postoperative data\n* Documented serum calcium levels measured postoperatively\n* Minimum follow-up of 6 months postoperatively or documented outcome status\n\nExclusion Criteria:\n\n* Age less than 18 years at time of surgery\n* Preoperative hypocalcemia (serum calcium \\\u003C8.0 mg\u002FdL or ionized calcium \\\u003C1.0 mmol\u002FL)\n* Pre-existing parathyroid disorders (primary hyperparathyroidism, hypoparathyroidism, secondary or tertiary hyperparathyroidism)\n* Chronic kidney disease Stage 3 or higher (estimated glomerular filtration rate \\\u003C60 mL\u002Fmin\u002F1.73m²)\n* Malabsorption syndromes affecting calcium metabolism (celiac disease, inflammatory bowel disease,short bowel syndrome)\n* Concurrent planned parathyroidectomy\n* History of neck irradiation\n* Chronic use of medications significantly affecting calcium metabolism (bisphosphonates, denosumab,cinacalcet, chronic corticosteroids)\n* Incomplete medical records lacking essential data including surgical details, postoperative calcium levels,or follow-up data\n* Patients lost to follow-up before 6-month endpoint without documented outcome status","ALL","18 Years","75 Years",{"count":20,"type":21},600,"ESTIMATED","OBSERVATIONAL","This retrospective cohort study investigates predictors of postoperative hypocalcemia following thyroidectomy procedures at Minia University Hospital over a 10-year period (2014-2024). Postthyroidectomy hypocalcemia is one of the most common complications of thyroid surgery, affecting 20-50% of patients. The study aims to identify demographic, clinical, laboratory, and surgical factors associated with the development of both transient and permanent hypocalcemia. Results will inform risk stratification, patient counseling, and perioperative management strategies.",[25,26,27,28,29],"Thyroid Nodule","Thyroid Dysfunction","Hypocalcemia","Thyroid Cancer","Postoperative Complications",[31,32,33,34,35],"Thyroidectomy","Postoperative hypocalcemia","Hypoparathyroidism","Parathyroid gland injury","Total thyroidectomy","RECRUITING","2026-06-27",{"date":39,"type":40},"2026-06-30","ACTUAL",{"date":42,"type":40},"2026-03-04",{"date":44,"type":21},"2026-08-01",{"name":46,"class":47},"Minia University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":4,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":65,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":82,"completionDateStruct":83,"leadSponsor":85,"locationsCount":48},"100640349","niraf-guided-parathyroid-identification-during-thyroidectomy-100640349","NCT07617584","NIRAF-Guided Parathyroid Identification During Thyroidectomy","Near-Infrared Autofluorescence-Guided Parathyroid Identification During Thyroidectomy","Inclusion Criteria:\n\n* Age 18 years or older.\n* For Component A: planned thyroidectomy of any extent with an intact specimen available for ex vivo evaluation.\n* For Component B: planned total or completion thyroidectomy.\n* Ability to provide written informed consent before surgery.\n* Willingness to comply with routine postoperative laboratory testing and follow-up when feasible.\n\nExclusion Criteria:\n\n* Known pre-existing hypoparathyroidism or prior parathyroid surgery.\n* Severe chronic kidney disease or end-stage renal disease expected to substantially confound calcium and parathyroid hormone interpretation, as defined by the site investigator.\n* Pregnancy.\n* For Component B only: gross nodal disease or a surgical plan requiring extensive nodal packet dissection in the current study phase.\n* Any condition that, in the judgment of the investigator, would make participation unsafe or compromise protocol adherence.",{"count":57,"type":21},280,"INTERVENTIONAL",[60],"NA","This is a single-site, two-component prospective study evaluating whether near-infrared autofluorescence (NIRAF) imaging can improve intraoperative identification of parathyroid glands during thyroidectomy and reduce postoperative hypocalcemia.\n\nThe investigational platform is a modified wearable stereoscopic goggle system configured for label-free NIRAF imaging. Parathyroid tissue is excited with near-infrared light at approximately 780 nm and emits autofluorescence centered near 800 nm. No injected dye or external contrast agent is used. The goggles are used only during a brief mapping interval after thyroid exposure and for ex vivo interrogation of the resected thyroid specimen.\n\nComponent A is a prospective observational run-in validation cohort of 30 adults undergoing thyroidectomy of any extent. NIRAF-positive foci on the intact thyroidectomy specimen are suture-marked and correlated with targeted pathology.\n\nComponent B is a randomized clinical study of 250 adults undergoing total or completion thyroidectomy. Participants are randomized 1:1 to standard surgery or standard surgery plus brief in vivo NIRAF mapping, ex vivo specimen interrogation, and rescue autotransplantation when indicated. The primary outcome for Component B is transient biochemical hypocalcemia on postoperative day 1, defined using albumin-corrected serum calcium.",[27,33,63,64,25,31],"Thyroid Diseases","Goiter, Nodular",[66,67,68,69,31,70,71,72,73,74,75,76,77],"Near-Infrared Autofluorescence","NIRAF","Parathyroid Identification","Parathyroid Preservation","Completion Thyroidectomy","Total Thyroidectomy","Postoperative Hypocalcemia","Intact Parathyroid Hormone","iPTH","Rescue Autotransplantation","Wearable Imaging","Post-thyroidectomy hypocalcemia","NOT_YET_RECRUITING","2026-05-29",{"date":81,"type":40},"2026-06-01",{"date":81,"type":21},{"date":84,"type":21},"2029-12-01",{"name":86,"class":47},"Ss. Cyril and Methodius University of Skopje",{"id":88,"slug":89,"hasResults":11,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":4,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":58,"phases":96,"briefSummary":97,"conditions":98,"keywords":101,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":110,"completionDateStruct":112,"leadSponsor":114,"locationsCount":48},"100624939","comparing-pteye-assisted-versus-conventional-total-thyroidectomy-100624939","NCT07416149","Comparing PTeye-assisted Versus Conventional Total Thyroidectomy","Reducing Post-operative Hypoparathyroidism With Probe-based Near Infrared Autofluorescence (NIRAF)- Assisted Total Thyroidectomy Versus Conventional Total Thyroidectomy, a Randomized-controlled Trial","Inclusion Criteria:\n\n* Adult patients ≥18 years of age\n* Undergoing total thyroidectomy, or completion total thyroidectomy\n* Pre-operative serum adjusted calcium levels within normal ranges\n\nExclusion Criteria:\n\n* Patients on pre-operative calcium or vitamin D supplements\n* Patients with pre-operative vitamin D deficiency, defined as serum vitamin D\\\u003C30nmol\u002FL\n* Patients with untreated primary or secondary hyperparathyroidism\n* Patient with known non-surgical hypoparathyroidism diseases\n* Patients with estimated glomerular filtration rate \\\u003C30ml\u002F1.73m2\u002Fmin, on dialysis, or having a history of kidney transplant",{"count":95,"type":21},210,[60],"This is a prospective, single-blinded, randomized controlled trial to evaluate whether PTeye™ can reduce post-operative hypoparathyroidism (PH). The study will enroll consecutive patients undergoing total thyroidectomy in a teritary endocrine surgery unit in Hong Kong, randomizing them into receiving conventional surgery versus PTeye™-assisted surgery. Subjects will be assigned to the two groups before surgery. Subjects will be under medical care as in usual practice.",[27,99,100,71],"Parathyroid","Hypoparathyroidism Post-surgical",[31,102,103,104,105,106],"calcium","hypocalcemia","post operation","hypoparathyroidism","PTeye™ parathyroid detection system","2026-02-12",{"date":109,"type":40},"2026-02-17",{"date":111,"type":40},"2025-09-16",{"date":113,"type":21},"2028-12-31",{"name":115,"class":47},"The University of Hong Kong",{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":122,"eligibilityCriteria":123,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":124,"targetDuration":4,"studyType":58,"phases":126,"briefSummary":127,"conditions":128,"keywords":132,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":48},"100596250","white-cap-intra-operative-parathyroid-tissue-sensor-pts-guided-assessment-of-parathyroid-viability-and-surgical-decision-making-100596250","NCT07043010","WHITE CAP: Intra-operative Parathyroid Tissue Sensor (PTS)-Guided Assessment of Parathyroid Viability and Surgical Decision-Making","WHITE CAP Trial: Optical Parathyroid Tissue Sensor-Guided Assessment of Parathyroid Viability and Its Impact on Clinical Decision-Making","WHITE CAP-PTS","Inclusion Criteria:\n\n* Age 18 to 75 years, able to give informed consent.\n* Biochemically proven primary hyperparathyroidism (elevated serum calcium and inappropriately high PTH).\n* Pre-operative imaging (sestamibi scan, 4-phase CT, or ultrasound) concordant with a single parathyroid adenoma.\n* Planned minimally invasive parathyroidectomy using near-infrared parathyroid tissue sensor (PTS) guidance.\n\nExclusion Criteria:\n\n* Multiple endocrine neoplasia (MEN 1 or 2) or suspicion of multi-gland disease (\\>1 enlarged gland on imaging).\n* Prior parathyroid or extensive neck surgery causing distorted anatomy.\n* Need for simultaneous total thyroidectomy or other major neck procedure.\n* Estimated glomerular filtration rate (eGFR) \\\u003C 30 mL\u002Fmin\u002F1.73 m².\n* Pregnancy or breastfeeding.\n* Inability to tolerate general anaesthesia or contraindication to intra-operative PTS imaging.",{"count":125,"type":21},120,[60],"Primary hyperparathyroidism is usually cured by removing the single over-active parathyroid adenoma. During surgery, however, surgeons often see a thin rim of normal parathyroid tissue that still \"glows\" under a near-infrared parathyroid tissue sensor (PTS). It is unclear whether keeping this tissue in place helps preserve hormone function or whether it leaves behind cells that could become over-active again.\n\nThe WHITE CAP study will compare two common surgical choices:\n\nPreservation strategy - the surgeon removes only the adenoma and leaves the glowing rim of normal tissue untouched.\n\nEn-bloc strategy - the surgeon removes the adenoma together with the glowing rim; if too little parathyroid tissue remains, a small fragment is transplanted into the forearm muscle.\n\nAbout 120 adult patients who have a single parathyroid adenoma will be randomly assigned (like tossing a coin) to one of the two strategies. All operations will use the same FDA-cleared PTS camera that shows the glands in real time without dye or radiation.\n\nThe main question is whether preserving the normal rim lowers the rate of temporary low blood-calcium (numbness, tingling) during the first two days after surgery. The study will also check long-term results-blood calcium and parathyroid hormone (PTH) levels, symptoms, and any return of the disease-over two years.\n\nThe PTS imaging itself is painless and adds only a few minutes to the operation. Risks are the same as for standard parathyroid surgery, and participants can withdraw at any time without affecting their usual care.",[129,130,131,27],"Hyperparathyroidism, Primary","Parathyroid Neoplasms","Parathyroid Adenoma",[66,133,134,135,136,137,138],"Parathyroid Tissue Sensor","Parathyroid Viability","Peri-adenoma Rim Preservation","Intra-operative Imaging","Calcium Homeostasis","PTS Camera","2025-06-27",{"date":141,"type":40},"2025-06-29",{"date":143,"type":21},"2025-07-01",{"date":145,"type":21},"2029-12-31",{"name":147,"class":47},"Fujian Medical University",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":154,"eligibilityCriteria":155,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":156,"targetDuration":4,"studyType":58,"phases":158,"briefSummary":161,"conditions":162,"keywords":165,"overallStatus":78,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":4},"100579157","phase-2-calcium-administration-in-life-saving-management-during-massive-hemorrhage-100579157","NCT06820645","Calcium Administration in Life-saving Management During Massive Hemorrhage","CALM: Calcium Administration in Life-saving Management of Trauma Patients Undergoing Massive Hemorrhage Protocol: a Single Centre Feasibility Study","CALM","Inclusion Criteria:\n\n* Adult trauma patients undergoing the MHP at Victoria Hospital, London, Ontario\n\nExclusion Criteria:\n\n* Under the age of 18\n* Pregnant",{"count":157,"type":21},81,[159,160],"PHASE2","PHASE3","This study evaluates the feasibility of conducting a larger study on the impact of treating massive hemorrhage with calcium in trauma patients. Patients undergoing the Massive Hemorrhage Protocol (MHP) will be randomly assigned to receive either calcium gluconate or placebo drug after every 4 packs of units of RBCs received during the MHP.",[163,164,27],"Massive Hemorrhage","Trauma",[166,167],"Calcium","Massive Hemorrhage Protocol","2025-02-05",{"date":170,"type":40},"2025-02-11",{"date":172,"type":21},"2025-05-01",{"date":174,"type":21},"2026-05",{"name":176,"class":47},"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's",{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":183,"eligibilityCriteria":184,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":185,"targetDuration":4,"studyType":58,"phases":187,"briefSummary":188,"conditions":189,"keywords":190,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":201},"100422019","phase-3-total-post-thyroidectomy-hypocalcemia-after-preoperative-cholecalciferol-supplementation-100422019","NCT04775381","Total Post-thyroidectomy Hypocalcemia After Preoperative Cholecalciferol Supplementation","Study of Total Post-thyroidectomy Hypocalcemia After Preoperative Cholecalciferol Supplementation","CAVITHY","Inclusion Criteria:\n\n* Patient ≥ 18 years old\n* Patient shall be operated on for a total thyroidectomy in one time for any indication\n* Written informed consent (IC) obtained\n* Patients with affiliation to the social security system\n\nExclusion Criteria:\n\n• Medical history of : Thyroid or parathyroid surgery Hyperparathyroidism Granulomatosis flare-up\n\n* Hypocalcemia, hypercalcemia\u002F hypercalciuria, or symptom of Hypocalcemia, hypercalcemia\u002F hypercalciuria, not due to thyroid pathologies\n* Chronic kidney disease grade ≥4\n* Severe liver failure\n* 25OHD supplementation within last 3 months before surgery\n* Malabsorption syndrome\n* Known hypersensitivity to vitamin D\n* Medical history of calcic lithiasis\n* Pregnant women\n* Vulnerable populations (guardianship or trusteeship)\n* Allergies to one of the components of the fruit juice",{"count":186,"type":21},200,[160],"This prospective study evalue the inflence of pre operative vit D3 administration on post operative hypocalcemia in patients undergoing Total thyroidectomy",[27],[35,103,191],"cholecalciferol supplementation","2025-01-17",{"date":194,"type":40},"2025-01-20",{"date":196,"type":40},"2021-06-30",{"date":198,"type":21},"2026-03",{"name":200,"class":47},"Hôpital NOVO",6,{"id":203,"slug":204,"hasResults":11,"nctId":205,"briefTitle":206,"officialTitle":206,"acronym":4,"eligibilityCriteria":207,"healthyVolunteers":208,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":209,"targetDuration":4,"studyType":58,"phases":211,"briefSummary":212,"conditions":213,"keywords":215,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":48},"100495567","phase-2-the-use-of-dexamethasone-in-total-thyroidectomy-to-improve-voice-outcome-and-hypocalcaemia-100495567","NCT05732883","The Use of Dexamethasone in Total Thyroidectomy to Improve Voice Outcome and Hypocalcaemia","Inclusion Criteria:\n\n* Aged 18 or above\n* Patients undergoing total thyroidectomy for benign pathologies\n* MNG\n* Toxic nodular goitre\n* Graves' disease\n\nExclusion Criteria:\n\n* Non-communicable patients\n* Patients contraindicated for steroid (DM, Hepatitis carrier, Tuberculosis, peptic ulcer disease)\n* Patients contraindicated for analgesics including Panadol, Celebrex, Tramadol or Levobupivacaine\n* Malignant thyroid disease\n* Patients with previous thyroid surgery, or neck surgery\n* Pre-existing hoarseness of voice of any cause or pre-existing vocal cord palsy\n* Pregnancy \u002F Lactating female patients\n* Pre-existing renal disease \u002F autoimmune disease on steroids\n* Patients who require steroid cover during operation e.g. hydrocortisone perioperatively",true,{"count":210,"type":21},100,[159],"Thyroidectomy is a standard procedure for benign and malignant pathologies of the thyroid gland. Each year, some 100 total thyroidectomies are performed in Kowloon East Cluster, Hospital Authority, Hong Kong. Total thyroidectomy is associated with voice dysfunction and temporary hypocalcaemia in up to 80% and 50%, respectively. Previous study from our institute showed a 3% rate of permanent vocal cord palsy and 16% of permanent hypoparathyroidism requiring calcium and\u002For vitamin D supplements. The use of dexamethasone has been studied in the past in total thyroidectomy patients and has been shown to be safe and effective in improving post-operative nausea and vomiting. No complications or drug related side effects were associated with a single dose of steroid. Recent studies have also shown that Dexamethasone is effective in improving voice outcome and hypocalcaemia in thyroidectomy patients. The investigators aim to study the effect of Dexamethasone in post-operative voice outcome and hypocalcaemia. Objective assessment of the vocal cords during phonation will be performed pre-operative and post-operatively. Serum Calcium level will be monitored.",[214,27],"Voice Change",[216,217,218,27,33,31,219,220],"Voice dysfunction","Hoarseness of Voice","Vocal cord palsy","Dexamethasone","Steroid","2024-07-06",{"date":223,"type":40},"2024-07-09",{"date":225,"type":40},"2024-07-01",{"date":227,"type":21},"2026-09-30",{"name":229,"class":47},"Tseung Kwan O Hospital, Hong Kong",{"id":231,"slug":232,"hasResults":11,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":4,"eligibilityCriteria":236,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":237,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":239,"conditions":240,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":48},"100484250","registry-for-hypoparathyroidism-wuerzburg-100484250","NCT05585593","Registry for Hypoparathyroidism Wuerzburg","Registry and Biobank for Patients With Hypoparathyroidism Wuerzburg","Inclusion Criteria:\n\n* age of 18\n* chronic hypoparathyroidism (\\>12 months) under established therapy or chronic pseudohypoparathyroidism (\\>12 months) under established therapy\n* written informed consent\n\nExclusion Criteria:\n\n* age \\\u003C18 years\n* no detailed documentation of hypo- or pseudohypoparathyroidism",{"count":238,"type":21},300,"Long-term conventional treatment of chronic hypoparathyroidism does not fully restore calcium homeostasis leading to increased morbidity, emergency events and reduced subjective health status. To further investigate general morbidity, hypocalcemic events, subjective and daily life performance in patients with chronic hypoparathyroidism a standardized interview as well as blood sampling and examinations such as echocardiography and renal ultrasound are performed.",[241,242,27,243,244],"Comorbidities and Coexisting Conditions","Morality","Hypercalcemia","Quality of Life","2022-11-02",{"date":247,"type":40},"2022-11-08",{"date":249,"type":40},"2017-10-18",{"date":251,"type":21},"2032-01-01",{"name":253,"class":47},"University of Wuerzburg"]