[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypomineralization-molar-incisor\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypomineralization-molar-incisor":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,51,88,111],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100599142","biosilitace-as-a-desensitizing-agentin-hmi-100599142",false,"NCT07080645","BIOSILITACE AS A DESENSITIZING AGENTIN HMI","Biosilicate as a Desensitizing Agent in Teeth With Molar Incisor Hypomineralization in Children: A Randomized Clinical Trial","BDAHMI","Inclusion Criteria:\n\n* Children of both sexes, aged between 6 and 12 years.\n* Children who have at least one first permanent molar with Molar-Incisor Hypomineralization, showing distinct white or cream opacity (score 21), yellowish or brown opacity (score 22), and\u002For post-eruptive enamel fracture (score 3), and presence of painful sensitivity when stimulated, with a score of 2 or 3 as evaluated using the SCASS scale.\n* Children without systemic and\u002For cognitive impairments.\n\nExclusion Criteria:\n\n* Previous use of desensitizing therapy in the last 6 months;\n* Use of analgesic and anti-inflammatory medications during the previous 3 days;\n* Use of orthodontic appliances;\n* Teeth with extensive restorative procedures, such as stainless steel crowns, which prevent the assessment of painful sensitivity;\n* Teeth with amelogenesis imperfecta or dentinogenesis imperfecta;\n* Children with systemic and\u002For cognitive impairments.","ALL","6 Years","12 Years",{"count":21,"type":22},42,"ESTIMATED","INTERVENTIONAL",[25],"NA","Molar-Incisor Hypomineralization (MIH) is a qualitative enamel defect caused by systemic hypomineralization that affects one to four first permanent molars, and may or may not involve incisors. The clinical repercussions associated with MIH can be characterized by: painful hypersensitivity, post-eruptive fractures, rapid progression of caries lesions in newly erupted first permanent molars, difficulty in achieving effective anesthesia, aesthetic impairments, and patient fear and anxiety. To date, there is no consensus on the best treatment for sensitivity in teeth with MIH, thus managing sensitivity in these teeth remains a significant challenge. The aim of this study is to evaluate the effectiveness of a 10% Biosilicate® solution as a desensitizing agent in MIH teeth in children, compared to Fluoride varnish (Duraphat® Colgate, Brazil). Children aged 6 to 12 years will be selected for this study, with a total of 63 participants diagnosed with MIH, and a sensitivity score ≥2 on the SCASS scale. The children will be randomly divided into two groups (n=21): GI: Duraphat®, GII: Biosilicate®. Interventions will be performed once a week for 4 consecutive weeks, followed by 8 weeks of follow-up. The results will be subjected to statistical tests with a 95% confidence level (α = 0.05).",[28,29,30],"Sensitive Dentin","Hypomineralization Molar Incisor","Pain",[32,33,34,35,36,37],"pain","Molar-Incisor Hypomineralization","biosilicate","dentin hypersensitivity","tooth enamel","child","NOT_YET_RECRUITING","2025-07-20",{"date":41,"type":42},"2025-07-23","ACTUAL",{"date":44,"type":22},"2025-07-30",{"date":46,"type":22},"2025-11-15",{"name":48,"class":49},"University of Sao Paulo","OTHER",2,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":68,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":87},"100416547","colorimetric-ultra-structural-and-elemental-comparison-of-dental-enamel-defects-100416547","NCT04704089","Colorimetric, Ultra-structural and Elemental Comparison of Dental Enamel Defects","Colorimetric Comparison of Email Defects Using Spectrophotometric and Computer Techniques and Biological, Structural and Physico-chemical Analyses of Teeth or Pathological Enamel","COLOEMAIL","For patients :\n\nInclusion Criteria :\n\n1. Age between 8 and 55 years old\n2. Carrier of one of the following 3 quantitative pre-eruptive enamel anomalies : AIH, dental fluorosis or MIH\n3. Information and collection of the non-opposition of the adult patient or of the representative(s) of parental authority present for the minors.\n\nCriteria for non-inclusion :\n\n1. Pregnant or breastfeeding woman\n2. Under guardianship or curators\n3. Opposition of the minor patient\n4. Presenting pre-eruptive anomalies only on the molars (the spectrophotometer can only take pictures of the anterior dental sector (incisors and canines)).\n5. Other types of hypomineralization (post-eruptive, of traumatic or infectious origin, idiopathic).\n6. Having undergone radiotherapy or chemotherapy inducing dental and periodontal damage.\n7. Having systemic abnormalities (unbalanced diseases), haemochromatosis, porphyria\n8. Under medication likely to disturb the coloring of the teeth\n\nFor witnesses :\n\nInclusion Criteria :\n\n1. Age between 8 and 55 years old\n2. Information and collection of the non-opposition of the adult witness or of the representative(s) of parental authority present for the minors.\n3. Free of any anomaly of tooth structure, exogenous dyschromia and carious lesions.\n\nCriteria for non-inclusion :\n\n1. Pregnant or breastfeeding woman\n2. Under guardianship or curators\n3. Opposition of the minor witness\n4. Carrier of a quantitative pre-eruptive enamel anomaly\n5. Polycarpus (preventing the diagnosis of amyl hypomineralization)","8 Years","55 Years",{"count":62,"type":22},80,"OBSERVATIONAL","The study focuses on the analysis of enamel defects grouping together hypomineralization and hypoplasia. It focuses on 3 very characteristic enamel pathologies that are most often encountered in dental consultations: Molar Incisor Hypomineralization (MIH), dental fluorosis (FD) and amelogenesis imperfecta (AI). The research focuses on the use of a spectrophotometer for measuring tooth colors: the Zfx SpectroShade® (MHT) and its software as a means of early diagnosis of pre-eruptive enamel abnormalities. The main objective of the study is to analyze the color parameters of teeth affected with one of the 3 enamel abnormalities for use of the spectrophotometer as a non-invasive diagnostic tool for enamel defects.\n\nThe secondary objective is focused on the biological, structural and physicochemical characterizations of these different enamel pathologies from extracted teeth or enamel biopsies that must be ground to achieve a restoration.",[66,67,29],"Amelogenesis Imperfecta","Dental Fluoroses",[69,70,71,72,73,74,75,76],"Colorimetry (MeSH)","Amelogenesis Imperfecta (MeSH)","Dental Fluorosis (MeSH)","Molar-incisor-Hypomineralization (MeSH)","Developmental Enamel Defects (MeSH)","Shade selection","Dental color matching","Diagnosis (MeSH)","RECRUITING","2025-06-30",{"date":80,"type":42},"2025-07-03",{"date":82,"type":42},"2022-07-18",{"date":84,"type":22},"2026-04-18",{"name":86,"class":49},"Assistance Publique - Hôpitaux de Paris",1,{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":95,"sex":17,"minAge":59,"maxAge":19,"enrollmentInfo":96,"targetDuration":4,"studyType":23,"phases":98,"briefSummary":99,"conditions":100,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":4},"100557440","photobiomodulation-and-new-restorative-material-for-teeth-with-mih-on-control-of-hypersensitivity-and-longevity-100557440","NCT06538142","Photobiomodulation and New Restorative Material for Teeth With MIH on Control of Hypersensitivity and Longevity","Assessment of Photobiomodulation Combined With New Restorative Material for Teeth With Molar Incisor Hypomineralization on Control of Hypersensitivity and Longevity of Restorations: Randomized Controlled Blind Clinical Trial","Inclusion Criteria:\n\n* Male and female children;\n* Eight to 12 years of age;\n* At least one permanent first molar with MIH (codes 5 and 6 of molar-incisor hypomineralization severity scoring system \\[MIH-SSS\\])\n* Presence of hypersensitivity\n* Direct viewing and access.\n\nExclusion Criteria:\n\n* Clinically: signs or symptoms of pulp involvement;\n* Radiographically: evidence of pulp involvement (initial periapical radiograph);\n* Teeth with MIH with no indication for direct restorative treatment (multiple surfaces associated with large extensions);\n* Partially erupted teeth;\n* Previous restorative treatment.",true,{"count":97,"type":22},100,[25],"Introduction: Molar incisor hypomineralization (MIH) is a qualitative defect of enamel development that occurs in the mineralization phase. MIH affects one or more permanent molars and, occasionally, permanent incisors.\n\nObjective: The aim of the proposed study is to determine whether photobiomodulation combined with a new self-cure resin improves hypersensitivity in molars with MIH and caries (primary outcome). Secondary outcomes include assessing the clinical performance of the self-cure composite resin in terms of restoration longevity and comparing the effectiveness of three interventions-photobiomodulation combined with self-cure resin, self-cure resin alone, and photobiomodulation combined with bulkfill photopolymerizable resin-in controlling hypersensitivity over time.\n\nMethods and analysis: Permanent molars with MIH in patients eight to 12 years of age will be allocated to three groups. Group 1: photobiomodulation + self-cure composite resin restoration; Group 2: self-cure composite resin restoration; Group 3: photobiomodulation + restoration in bulk-fill photopolymerizable composite resin. Photobiomodulation will be performed in a single session involving low-level laser administered to four different points. The laser will be used at a wavelength of 808 nm, power of 100 mW and energy of 1 J per points; irradiance will be 3571 mW\u002Fcm², with a total radiant exposure of 35.7 J\u002Fcm². Data normality will be checked using the Shapiro-Wilk test, and variance homogeneity will be assessed with the Levene test. Descriptive statistics will be used to present the data, with continuous variables expressed as mean and standard deviation, and categorical variables by relative frequency. To compare the VAS and SCASS scales, repeated measures ANOVA will be employed, considering the 3 groups and 5 time points. Bonferroni adjustment will be applied for post-hoc comparisons. Sphericity will be tested with Mauchly's test, and if violated, Greenhouse-Geisser correction will be applied. A significance level of 0.05 will be adopted. Ethics and dissemination: This protocol received approval from the Human Research Ethics Committee of Nove de Julho University (certificate number: xxxxxxx). The legal guardians of the children will agree to participation by signing a statement of informed consent. The results will be published in a peer-review journal and the data will be made available upon request.",[29,101],"Hypersensitivity Dentin","2025-01-17",{"date":104,"type":42},"2025-01-22",{"date":106,"type":22},"2025-04-01",{"date":108,"type":22},"2026-09-01",{"name":110,"class":49},"University of Nove de Julho",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":17,"minAge":118,"maxAge":19,"enrollmentInfo":119,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":4},"100571998","prevalence-of-hypomineralized-second-primary-molars-and-its-association-with-molar-incisor-hypomineralization-100571998","NCT06727539","Prevalence of Hypomineralized Second Primary Molars and Its Association with Molar-Incisor Hypomineralization.","Prevalence of Hypomineralized Second Primary Molars in a Group of Egyptian Children and Its Association with Molar-Incisor Hypomineralization: a Cross-Sectional Study.","Inclusion Criteria:\n\n1. Both genders will be included\n2. Children and adolescents with age group from 6-12 years\n3. Participants who agreed to sign rhe informed consent\n\nExclusion Criteria:\n\n1. Patients having enamel defects like fluorosis, amelogenesis imperfecta and dentinogenesis imperfecta\n2. Special health care needs\n3. Non-Egyptian children","7 Years",{"count":120,"type":22},825,"The aim for thid study is to detect the prevalence of HSPM and the possible association between MIH and HSPM in a group of Egyptian children aged from 6-12 years. The study will also observe the possible etiological factors that might predispose hypomineralization of primary teeth.\n\nTo our knowledge, there are no relevant studies that considered the prevalence of HSPM and its possible etiology in Egypt or its association with MIH. So, this study will address this knowledge gap. The possible relationship between HSPM and MIH is highly significant in pediatric dentistry, since the early diagnosis of HSPM as soon as second primary molars erupt makes it possible to initiate more intensive supervision and preventive measures, as these patients are otherwise prone to developing MIH in permanent teeth within a few years.",[123,124,29,125],"Molar Incisor Hypomineralisation","Molar Incisor Hypomineralization","Hypomineralization of Enamel","2024-12-11",{"date":128,"type":42},"2024-12-16",{"date":130,"type":22},"2025-01-01",{"date":132,"type":22},"2026-02",{"name":134,"class":49},"Cairo University"]