[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hyposmia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hyposmia":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,51,79,109,135],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100562228","slow-speed-uk-a-double-blind-randomised-feasibility-trial-100562228",false,"NCT06600438","Slow-SPEED UK: A Double-Blind Randomised Feasibility Trial","Slow-SPEED-United Kingdom: A Double-Blind Randomised Feasibility Trial of a Remote Gamified Physical Activity Programme in Adults With Hyposmia.","Slow-SPEED","Inclusion criteria\n\n* Age ≥ 40 years\n* Objective hyposmia, defined as scoring below the 15th percentile (adjusted for age\u002Fsex) on UPSIT\n* Ability and willingness to provide written informed consent\n* Proficiency in written and spoken English sufficient to complete study procedures.\n* Willingness and ability to attend baseline (in-person), 9-month (remote), and 18-month (in-person) assessments.\n* Access to telephone or internet for interim communication. Specifically, in possession of a suitable smartphone (screen size minimum 4.6 inch; Android version 9 or iOS version 15 or newer).\n* Physical activity threshold: During the 4-week eligibility run-in, the mean daily step count must be \\\u003C7,000 steps\u002Fday, calculated over ≥21 valid days (a valid day = ≥10 hours wear time or ≥1,000 steps). If recruitment after the first 2 months is \\\u003C60-70% of target, and subject to TSC\u002FSponsor approval and REC amendment, eligibility may be broadened to \\\u003C10,000 steps\u002Fday (i.e. participants averaging 7,000-9,999 steps\u002Fday become eligible).\n\nExclusion criteria\n\n* Clinical diagnosis of PD, dementia, or other neurodegenerative conditions\n* Severe or unstable medical or psychiatric illness likely to impair participation\n* Use of agents known to alter olfaction (e.g. intranasal zinc, chronic corticosteroids)\n* Current enrolment in an interventional study within the past 3 months (standard research retention guidance).\n* Inability to complete study procedures in English, per investigator assessment\n* Unable to give consent\n* Participants not living independently in the community. Participants in nursing homes, hospitalised persons on in a non-institutionalised setting are excluded.\n* Subject's personal smartphone is Fitbit-incompatible i.e. Huawei P8 Lite; Huawei P9 Lite; Xiaomi Mi 6; Huawei P20 Lite\n* Activity level above threshold during eligibility run-in: mean daily step count ≥7,000 steps\u002Fday (or ≥10,000 steps\u002Fday if the broadened threshold is activated).","ALL","40 Years","100 Years",{"count":21,"type":22},110,"ESTIMATED","INTERVENTIONAL",[25],"NA","Slow-SPEED UK is an 18-month randomised, double-blind feasibility trial evaluating the delivery, adherence, and acceptability of a digitally supported physical activity programme in community-dwelling adults aged 40 and over with objectively confirmed hyposmia (reduced sense of smell) and low baseline physical activity.\n\nParticipants are randomly assigned 1:1 to either a full-dose activity-support programme (targeting a 100% increase in daily step count) or a very low-dose active control (targeting a 10% increase). Both arms are delivered via a smartphone application linked to a wearable activity monitor (Fitbit Charge 6), with personalised weekly goals expressed as relative percentages to maintain blinding. The study is not designed to test clinical efficacy.",[28,29,30],"Hyposmia","Olfactory Dysfunction","Anosmia",[28,32,33,34,35,36,37],"Physical activity","Feasibility randomized controlled trial","Wearable technology","Smartphone application","Olfactory dysfunction","Digital health intervention","RECRUITING","2026-06-24",{"date":41,"type":42},"2026-06-29","ACTUAL",{"date":44,"type":42},"2026-05-27",{"date":46,"type":22},"2027-10-31",{"name":48,"class":49},"Queen Mary University of London","OTHER",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":62,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":50},"100572466","scents-of-progress-leveraging-a-novel-device-for-olfactory-training-in-older-adults-100572466","NCT06733636","Scents of Progress: Leveraging a Novel Device for Olfactory Training in Older Adults","SPLENDOR-OA; Scents of Progress: Leveraging a Novel Device for Olfactory Training in Older Adults","SPLENDOR-OA","Inclusion Criteria:\n\n* Adults 60 years of age or older.\n* English-speaking patients.\n* Patients with a diminished or lost sense of smell.\n* Patients who have not done smell training before\n\nExclusion Criteria:\n\n* Patients who are sensitive to any of the scents used in the study.\n* Patients with a diagnosis of congenital anosmia.","60 Years",{"count":61,"type":22},60,[25],"The goal of this clinical trial is to learn if ScentCare, a novel olfactory training device and accompanying companion web-based application, will lead to improved olfactory and well-being outcomes in elderly patients with Olfactory Dysfunction (OD). The main question it aims to answer is:\n\n\\- What effect does the olfactory training device (ScentCare) and accompanying companion web-based application have on olfaction?\n\nResearchers will compare ScentCare to solving Sudoku puzzles to see the effects of olfactory training using this novel device on olfaction. Previous studies have used Sudoku puzzles when studying the effect of smell training. Since smell training is thought to work by stimulating and engaging higher order cognition, Sudoku is a suitable activity for participants in the control group since it serves as a correlate with similar degree of stimulation.\n\nParticipants will:\n\n* Use ScentCare (intervention) or solve Sudoku puzzles (control) twice daily for 3 months.\n* Visit the clinic twice, once upon enrollment and once three months later.\n* Complete a formal smell test using Sniffin' Sticks smell test at the beginning of the study and again at the end of the study (3 months) during the initial and follow up visit.\n* Complete questionnaires at the beginning of the study and again at the end of the study (3 months) during the initial and follow up visit.",[29,65,30,28],"Smell Loss",[29,67,68,69,65,30,28],"Olfactory Training","Smell Training","Smell Training Device","2026-04-10",{"date":72,"type":42},"2026-04-13",{"date":74,"type":42},"2025-04-15",{"date":76,"type":22},"2027-03-31",{"name":78,"class":49},"Johns Hopkins University",{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":23,"phases":90,"briefSummary":92,"conditions":93,"keywords":94,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":50},"100604606","phase-3-topical-versus-injection-prp-for-olfactory-dysfunction-100604606","NCT07151703","Topical Versus Injection PRP for Olfactory Dysfunction","Carrier-Assisted Topical Application Versus Intranasal Injection of Autologous Platelet-Rich Plasma for Olfactory Dysfunction: A Randomized Controlled Trial","TOP-IN","Inclusion Criteria:\n\n* Aged between 18 and 80 years, regardless of sex\n* Subjective complaint of olfactory dysfunction with confirmed hyposmia or anosmia based on standardized olfactory testing\n* History of at least 3 months of prior olfactory training but with persistent olfactory complaints\n\nExclusion Criteria:\n\n* Congenital anosmia\n* Diagnosed neurological or structural brain abnormalities (e.g., brain tumor, major head trauma, stroke) with low likelihood of olfactory recovery\n* Inability or unwillingness to comply with study procedures or follow-up assessments","18 Years","80 Years",{"count":61,"type":22},[91],"PHASE3","The goal of this clinical trial is to determine whether two different delivery methods of autologous platelet-rich plasma (PRP) can improve olfactory function in adults with persistent olfactory dysfunction lasting more than three months. The main questions it aims to answer are:\n\n1. Does carrier-assisted topical application of PRP lead to comparable or better improvement in smell function than intranasal injection of PRP?\n2. Which method provides greater patient comfort and fewer adverse effects?\n\nResearchers will compare carrier-assisted topical PRP application to intranasal PRP injection to see if one approach is more effective in restoring olfactory function.\n\nParticipants will:\n\n1. Receive a single PRP treatment delivered either by injection or via a PRP-soaked carrier placed into the olfactory cleft.\n2. Continue daily olfactory training for three months following the intervention.\n3. Undergo smell testing (Sniffin' Sticks) before and after treatment and complete quality-of-life questionnaires.",[29,30,28],[30,28,95,96,97],"Platelet-Rich Plasma (PRP)","Intranasal Injection","Randomized Controlled Trial","NOT_YET_RECRUITING","2025-08-25",{"date":101,"type":42},"2025-09-03",{"date":103,"type":22},"2025-10-01",{"date":105,"type":22},"2028-12-31",{"name":107,"class":108},"Taipei Veterans General Hospital, Taiwan","OTHER_GOV",{"id":110,"slug":111,"hasResults":11,"nctId":112,"briefTitle":113,"officialTitle":114,"acronym":4,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":17,"minAge":87,"maxAge":116,"enrollmentInfo":117,"targetDuration":4,"studyType":23,"phases":119,"briefSummary":120,"conditions":121,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":126,"lastUpdatePostDateStruct":127,"startDateStruct":129,"completionDateStruct":131,"leadSponsor":133,"locationsCount":50},"100467236","olfactory-training-on-smell-dysfunction-patients-in-hk-100467236","NCT05364125","Olfactory Training on Smell Dysfunction Patients in HK","Effect of Olfactory Training on Olfactory Dysfunction Patients in Hong Kong Population","Inclusion Criteria:\n\n* Olfactory dysfunction \\> 6 months and \\\u003C 5 years\n\nExclusion Criteria:\n\n* History of significant head injury (fracture, ICH)\n* History of brain surgery\n* History of nasal surgery\n* Active nasal disease\n* Active neurological disease\n* Poor premorbid status\u002F non-communicable patients\n* Mentally incompetent patients\n* \\\u003C18 years' old\n* Pregnancy\n* Hypersensitivity to the aromatic substance.","70 Years",{"count":118,"type":22},80,[25],"* Causes of olfactory dysfunction can be classified into conductive and sensorineural causes.\n* Conductive causes are mainly due to structural nasal problem, which can be treated by nasal surgery\n* Sensorineural causes included post-infection, post-head injury, post Head and Neck irradiation and other central nervous system diseases.\n* Olfactory Training is well established treatment for sensorineural olfactory dysfunction in foreign countries.\n* Olfactory Training by neurological chemosensory stimulation using aromatic substances delivered via electronic portable aromatic rehabilitation (EPAR) diffuser was proved to be effective treatment in COVID-19 related olfactory dysfunction in recent Hong Kong study.\n* However, there is a lack of local study on the effect of Olfactory Training in other non-COVID-19 sensorineural causes of olfactory dysfunction in Hong Kong population.",[122,123,30,28,124,65,125],"Olfaction Disorders","Smell Disorders","Olfactory Impairment","Smell Dysfunction","2025-05-28",{"date":128,"type":42},"2025-06-03",{"date":130,"type":42},"2022-07-01",{"date":132,"type":22},"2027-06-30",{"name":134,"class":49},"Pamela Youde Nethersole Eastern Hospital",{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":17,"minAge":87,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":23,"phases":145,"briefSummary":146,"conditions":147,"keywords":151,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":50},"100468805","olfactory-training-as-a-treatment-for-olfactory-dysfunction-post-covid-19-100468805","NCT05384561","Olfactory Training As a Treatment for Olfactory Dysfunction Post COVID-19","L'entraînement Olfactif Comme Traitement De La Dysfonction Olfactive Post COVID-19","OTTODC19","Inclusion Criteria:\n\n* Patient diagnosed positive for COVID-19 with persistent olfactory dysfunction\n* Willing and able to provide written informed consent\n* Understand and read the French language\n* Have an internet connection and a working email address\n\nExclusion Criteria:\n\n* Anosmia and hyposmia pre-covid-19\n* Be known chronic rhinosinusitis with or without nasal polyposis\n* Have received radiotherapy or chemotherapy for Head and Neck Tumors\n* Have a diagnosis of Alzheimer's, Parkinson's, multiple sclerosis or any other neurodegenerative disease 5. Have a brain tumor or ENT diagnosis 6. History of naso-sinus surgery; 7. History of traumatic brain injury",{"count":144,"type":22},70,[25],"Olfactory dysfunction is a defining symptom of COVID-19 infection. Studies have demonstrated improved olfaction in patients with post infectious olfactory dysfunction after an olfactory training (OT). The aim of this study is to assess the clinical outcomes of olfactory training (12 weeks) therapy in the treatment of persistent olfactory dysfunctions after COVID-19. Specially, we aim to compare the effectiveness of two different olfactory training (different odors).\n\nA group will train themselves with 4 scents (rose, orange, clove and eucalyptus) and another group with 4 different scents (cheese, coffee, strawberries and lemon). Olfaction sensory evaluation will be performed by using different olfaction tests (Sniffin' Sticks and UPSIT) and complete questionnaires to assess olfactory perception and particularly parosmia and phantosmia.",[28,148,149,30,150],"COVID-19","Parosmia","SARS-CoV-2 Infection",[152,153,154],"Olfactory training","Chemosensory impairments","Persistent smell impairment","2024-12-11",{"date":157,"type":42},"2024-12-17",{"date":159,"type":42},"2022-05-31",{"date":161,"type":22},"2025-09",{"name":163,"class":49},"Université du Québec à Trois-Rivières"]