[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypotension-after-spinal-anesthesia\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypotension-after-spinal-anesthesia":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,40,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100624934","phase-2-comparison-of-hypotension-after-spinal-anesthesia-with-hyperbaric-vs-isobaric-bupivacaine-in-elective-cesarean-after-colloid-preloading-100624934",false,"NCT07416084","Comparison of Hypotension After Spinal Anesthesia With Hyperbaric Vs Isobaric Bupivacaine in Elective Cesarean After Colloid Preloading.","Comparison of Maternal Hypotension After Spinal Anesthesia With Hyperbaric Bupivacaine Vs Isobaric Bupivacaine in Elective Cesarean Section With Colloid Preloading","Inclusion Criteria:\n\n* ASA II parturient with normal pregnancy Parturients undergoing elective cesarean section under spinal anesthesia Parturient refusing normal trial of labor, planned for ELLSCS under spinal anesthesia\n\nExclusion Criteria:\n\n* Patient refusal Parturient with known drug allergy to local anesthetics Parturients undergoing emergency cesarean section Spinal anesthesia converted to general anesthesia.","FEMALE","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","To assess the hemodynamic difference after spinal anesthesia with hyperbaric bupivacaine and isobaric bupivacaine in elective cesarean section",[26],"Hypotension After Spinal Anesthesia","NOT_YET_RECRUITING","2026-02-16",{"date":30,"type":31},"2026-02-17","ACTUAL",{"date":33,"type":20},"2026-02-01",{"date":35,"type":20},"2026-07-30",{"name":37,"class":38},"Liaquat National Hospital & Medical College","OTHER",1,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":47,"enrollmentInfo":48,"targetDuration":4,"studyType":21,"phases":50,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100620860","comparison-of-the-efficacy-of-continuous-metaraminol-infusion-versus-continuous-norepinephrine-infusion-for-the-prevention-of-hypotension-during-cesarean-section-under-spinal-anaesthesia-a-randomised-controlled-trial-100620860","NCT07363109","Comparison of the Efficacy of Continuous Metaraminol Infusion Versus Continuous Norepinephrine Infusion for the Prevention of Hypotension During Cesarean Section Under Spinal Anaesthesia. A Randomised Controlled Trial.","Prevention of Hypotension During Elective Cesarean Section Under Spinal Anaesthesia With Fixed-rate Metaraminol Infusion Versus Fixed-rate Norepinephrine Infusion: A Double-blind Randomised Controlled Clinical Trial.","Inclusion Criteria:\n\nadult parturients, singleton gestation, elective cesarean section\n\nExclusion Criteria:\n\nASA \\>II, age \\\u003C18 years, Body Mass Index (BMI) \\>40 kg\u002Fm2, body weight \\\u003C50 kg, body weight\\>100 kg, height\\\u003C150 cm, height\\>180 cm, multiple gestation, fetal abnormality, fetal distress, active labor, emergency CT, cardiovascular disease or cerebrovascular disease, pre-existing or pregnancy-induced hypertension, use of antihypertensive medication during pregnancy, preeclampsia, any contraindication for regional anesthesia, such as thrombocytopenia or coagulation disorder, communication or language barriers, lack of informed consent","48 Years",{"count":49,"type":20},80,[51],"NA","The aim of this double-blind randomised study will be to compare a fixed-rate prophylactic metaraminol infusion to a fixed-rate prophylactic norepinephrine infusion during elective cesarean section under combined spinal-epidural anaesthesia.",[26,54],"Hypotension During Cesarean Delivery",[56,57,58,59,60],"metaraminol","norepinephrine","prevention of hypotension","cesarean section","maternal hemodynamics","2026-01-15",{"date":63,"type":31},"2026-01-23",{"date":65,"type":20},"2026-02",{"date":67,"type":20},"2029-03",{"name":69,"class":38},"Aretaieion University Hospital",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":77,"minAge":17,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":4},"100559500","phase-3-preoperative-oral-heptaminol-hydrochloride-in-preventing-hypotension-after-spinal-anesthesia-100559500","NCT06564935","Preoperative Oral Heptaminol Hydrochloride in Preventing Hypotension After Spinal Anesthesia","Preoperative Oral Heptaminol Hydrochloride in Preventing Hypotension After Spinal Anesthesia in Lower Limb Surgeries With Tourniquet: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age from 18 to 50 years old.\n* Both sexes.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n* Undergoing elective orthopedic lower limb operations with a tourniquet or plastic surgeries under spinal anesthesia.\n\nExclusion Criteria:\n\n* Patient refusal.\n* History of hypertension, cardiovascular \\[disorders of the heart and blood vessels and including coronary heart disease, rheumatic heart disease and other conditions\\], and cerebrovascular diseases \\[conditions that affect blood flow and the blood vessels in the brain. Problems with blood flow may occur from blood vessel narrowing (stenosis), clot formation (thrombosis), artery blockage (embolism), or blood vessel rupture (hemorrhage)\\].\n* Baseline SBP \\>160 mm Hg before administration of the drug.\n* Any contraindications to spinal anesthesia such as coagulopathy, local skin infection, swelling, trauma, or deformity.\n* Medical conditions, which release vasoconstrictors such as pheochromocytoma.\n* Patients taking vasoconstrictors or uncorrected tachyarrhythmia.\n* History of drug allergy.\n* Psychiatric, neuromuscular disorder, major systemic diseases.\n* Pregnancy or lactating women.\n* Inadequate effect of spinal anesthesia or supplemented with other types of anesthesia.","ALL","50 Years",{"count":80,"type":20},160,[82],"PHASE3","Methodologies and approaches have been implemented with differing degrees of success to prevent neuraxial hypotension. Currently utilized approaches to prevent hypotension during spinal anesthetic administration consist of physical precautions such as leg restraints and compression hosiery, as well as sympathomimetic medications Through a competitive inhibition of noradrenaline uptake, heptaminol hydrochloride prevented orthostatic hypotension and increased the plasma concentration of noradrenaline. This inhibitory effect might account for a portion of the antihypotensive effect After thorough research of the literature, studies evaluating the role of preoperative oral heptaminol hydrochloride in preventing hypotension after spinal anesthesia in lower limb surgeries with tourniquets are lacking.",[26],"2024-08-19",{"date":87,"type":31},"2024-08-21",{"date":89,"type":20},"2024-08",{"date":91,"type":20},"2025-03",{"name":93,"class":38},"Cairo University"]