[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypotension-drug-induced\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypotension-drug-induced":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,7,0,[8,52,78,111,148,175,209],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100638990","effect-of-lateral-decubitus-position-after-spinal-anesthesia-on-hemodynamic-stability-in-high-risk-geriatric-patients-100638990",false,"NCT07597148","Effect of Lateral Decubitus Position After Spinal Anesthesia on Hemodynamic Stability in High-Risk Geriatric Patients","The Effects of Lateral Decubitus Positioning After Spinal Anesthesia on Hemodynamic Stability in High-Risk Geriatric Patients Undergoing Lower Extremity Orthopedic Surgery: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 65 years or older\n* ASA physical status classification III or IV\n* Scheduled for unilateral lower extremity orthopedic surgery (hip fracture, femur fracture, knee arthroplasty, tibia-fibula fracture, or similar procedures)\n* Eligible for spinal anesthesia\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Contraindications to spinal anesthesia (coagulopathy, recent anticoagulant or antiplatelet use without adequate washout period, local infection at injection site)\n* Severe neurological disease or pre-existing motor or sensory deficit\n* Significant spinal deformity (severe scoliosis, kyphosis) or history of previous spinal surgery\n* Known allergy to local anesthetics\n* Decompensated heart failure (ejection fraction below 30%)\n* Uncontrolled hypertension (systolic blood pressure above 180 mmHg or diastolic blood pressure above 110 mmHg)\n* Emergency surgery\n* Severe hypovolemia or active bleeding\n* Advanced dementia or inability to communicate\n* Body mass index above 40 kg\u002Fm²\n* Refusal to participate","ALL","65 Years",{"count":19,"type":20},70,"ESTIMATED","INTERVENTIONAL",[23],"NA","Spinal anesthesia is a common and preferred anesthetic technique for lower extremity orthopedic surgery in elderly patients. However, it can cause a significant drop in blood pressure (hypotension), especially in high-risk older patients with multiple medical conditions. This complication can lead to serious consequences such as heart attack, stroke, or death in vulnerable patients.\n\nThis study investigates whether keeping patients in a lateral (side-lying) position for 15 minutes after spinal anesthesia - instead of immediately turning them onto their back (supine position) - can reduce the risk of hypotension. When a patient lies on their side after receiving spinal anesthesia with a heavy (hyperbaric) local anesthetic, the medication tends to stay concentrated on the lower (operative) side, resulting in a more limited nerve block. This may help preserve blood pressure stability.\n\nWe will enroll 70 patients aged 65 years or older with high anesthetic risk (ASA physical status III or IV) scheduled for unilateral lower extremity orthopedic surgery under spinal anesthesia. Patients will be randomly assigned to two groups: one group will be kept in the lateral decubitus position (operative side down) for 15 minutes before being turned supine, and the other group will be turned supine immediately after spinal anesthesia. Blood pressure, heart rate, and oxygen saturation will be monitored continuously. The primary outcome is the incidence of hypotension during the first 15 minutes after spinal anesthesia.",[26,27,28,29],"Hypotension Drug-Induced","Spinal Aneshtesia","Geriatric","Orthopedic Surgery Patients",[31,32,33,34,35,36,37,38,39],"hypotension","spinal anesthesia","lateral decubitus position","geriatric","hyperbaric bupivacaine","unilateral spinal block","hemodynamic stability","orthopedic surgery","ASA III-IV","NOT_YET_RECRUITING","2026-05-12",{"date":43,"type":44},"2026-05-19","ACTUAL",{"date":46,"type":20},"2026-06-01",{"date":48,"type":20},"2026-08-10",{"name":50,"class":51},"University of Health Sciences Balikesir Hospital Eduation and Research","OTHER_GOV",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":17,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":63,"conditions":64,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":72,"leadSponsor":74,"locationsCount":77},"100628781","hemodynamic-effects-of-intravenous-paracetamol-in-patients-undergoing-emergency-laparotomy-100628781","NCT07466108","Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy","Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Adult patients, ASA I-III undergoing emergency laparotomy\n\nExclusion Criteria:\n\n* Severe cardiac morbidities (impaired contractility with ejection fraction \\\u003C 40%, heart block, arrhythmias, tight valvular lesions)\n* Hemodynamically unstable patients (defined as patients with MAP \\\u003C 65 mmHg or need vasopressor to maintain MAP\\>65 mmHg).\n* Patients with high shock index (heart rate \u002F systolic blood pressure \\>1)\n* Pregnant or lactating women,\n* Allergy of any of the study drugs","21 Years",{"count":61,"type":20},90,[23],"Emergency laparotomy is a high-risk procedure often performed in patients with severe physiological derangements due to sepsis, making perioperative management challenging. Although multimodal analgesia is essential, options are often limited by factors such as hemodynamic instability, renal dysfunction, and coagulopathy. Intravenous paracetamol is commonly recommended for perioperative analgesia because of its opioid-sparing effect, but evidence suggests it may cause hypotension through peripheral vasodilation, particularly in critically ill patients. Most data on this effect come from observational studies, and evidence regarding its intraoperative hemodynamic impact remains limited.",[65,26,66],"Paracetamol","Emergency Surgery","RECRUITING","2026-03-18",{"date":70,"type":44},"2026-03-20",{"date":68,"type":44},{"date":73,"type":20},"2026-09",{"name":75,"class":76},"Cairo University","OTHER",1,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":16,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":4,"studyType":21,"phases":90,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":102,"lastUpdatePostDateStruct":103,"startDateStruct":105,"completionDateStruct":107,"leadSponsor":109,"locationsCount":77},"100609984","phase-2-comparison-of-supra-vs-infra-inguinal-fascia-iliaca-blocks-for-spinal-positioning-and-analgesia-in-lower-limb-surgery-100609984","NCT07221682","Comparison of Supra vs Infra Inguinal Fascia Iliaca Blocks for Spinal Positioning and Analgesia in Lower Limb Surgery","Comparison For Ease Of Spinal Positioning & Duration Of Post-Op Analgesia Between Ultrasound Guided Supra-Inguinal Fascia Iliaca Block Vs Ultrasound Guided Infra-Inguinal Fascia Iliaca Block In Patients Undergoing Thigh & Knee Surgeries","27G","Inclusion Criteria:\n\n1. Both Genders (Male \u002FFemale).\n2. Age between 30 years to 60 years.\n3. ASA Class I, II, III.\n\nExclusion Criteria:\n\n1. Patient refusal\n2. Other distracting painful pathology\n3. Any contraindication to Spinal Anesthesia or peripheral nerve blocks\n4. Coagulopathic disorders\n5. Patients with significant cognitive impairment\n6. Patients with no pain while sitting by themselves without any support\n7. H\u002FO polytrauma involving other limbs\n8. H\u002FO allergy to the drugs used in study","30 Years","60 Years",{"count":89,"type":20},60,[91,92],"PHASE2","PHASE3","Severe pain associated with thigh and knee fractures makes the positioning for regional anesthesia a challenge. Different modalities to make patient pain free for spinal positioning, post op analgesia and patient satisfaction including supra-inguinal fascia iliaca block (S-FIB) and infra-inguinal fascia iliaca blocks (I-FIB) have been studies. The aim of this study is to compare two blocks in patients undergoing thigh and knee surgeries.\n\nA randomized controlled trial study design will be used and 60 patients fulfilling the inclusion criteria will be included. The patients will be divided into 2 groups by simple random sampling. Group A (S-FIB) (n = 30, those who will receive 30 ml of 0.125% bupivacaine) and Group B (I-FIB) (n = 30, those who will receive 30 ml of 0.125% bupivacaine). Depending on the allotted group, patients will be given the block under the guidance of ultrasound in the preoperative area. After block patients will be assessed for ease of spinal positioning using EOSP Scale, postoperative duration of analgesia and patient satisfaction using Likert Scale and data will be recorded on prescribed proforma.\n\nAll the findings will be noted in a specially designed proforma by the researcher. All the data collected will be entered and analyzed. Quantitative variables will be presented with mean ± SD. Independent sample t-test for duration of postoperative analgesia. Qualitative variables such as ease of spinal positioning and gender will be presented with Chi-Square. A p-value equal to or less than 0.05 will be considered significant.",[95,96,26],"Post Operative Analgesia","Bradycardia",[98,99,100,101],"S-FICB","I-FICB","ASA","EOSP","2026-01-28",{"date":104,"type":44},"2026-01-29",{"date":106,"type":44},"2024-05-06",{"date":108,"type":20},"2027-01-01",{"name":110,"class":51},"Sahiwal medical college sahiwal",{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":4,"eligibilityCriteria":117,"healthyVolunteers":11,"sex":118,"minAge":119,"maxAge":4,"enrollmentInfo":120,"targetDuration":4,"studyType":21,"phases":122,"briefSummary":123,"conditions":124,"keywords":136,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":77},"100607351","incidence-of-pruritus-using-intrathecal-fentanyl-versus-epidural-fentanyl-to-initiate-labour-analgesia-100607351","NCT07187427","Incidence of Pruritus Using Intrathecal Fentanyl Versus Epidural Fentanyl to Initiate Labour Analgesia.","Randomized Trial Comparing the Injection of Intrathecal Fentanyl Versus Epidural Fentanyl for the Initiation of Labour Analgesia on the Incidence of Pruritis.","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Vaginal delivery\n* Gestational age ≥ 37 weeks\n* Requesting neuraxial analgesia\n* French or English language\n\nExclusion Criteria:\n\n* ASA score \\> 3\n* Allergy or contraindication to receiving opioids\u002Flocal anesthesia (morphine or fentanyl)\n* BMI \\> 40 kg\u002Fm²\n* Hepatic or renal failure,\n* Severe preeclampsia and signs of severity according to the criteria of the American College of Obstetricians and Gynecologists\n* Maternal hemorrhage (placental abruption, hepatic subcapsular hematoma,...)\n* Severe scoliosis\n* Biliary cholestasis or polymorphic eruption of pregnancy\n* Inability to provide informed consent, either secondary to mental or physical disability or a significant language barrier (inability to understand English or French)\n* Prior administration of an opioid or opioid misuse","FEMALE","18 Years",{"count":121,"type":20},80,[23],"The purpose of this study is to investigate the effect of neuraxial analgesia initiation on the incidence of pruritus in laboring women. Specifically, this study aim to compare intrathecal fentanyl with epidural fentanyl in order to determine whether the epidural route is associated with a lower occurrence and severity of pruritus. By clarifying these differences, the research seek to optimize analgesic strategies during labor while minimizing opioid-related side effects",[125,26,126,127,128,129,130,131,132,133,134,135],"Pruritis","Urinary Retention","Fetal Bradycardia During Labor","Nausea and Vomitting","Satisfaction, Patient","Labor Analgesia","Neuraxial Opioid","Opioid Analgesic Adverse Reaction","Term Labour","Fentanyl Analgesia","Fentanyl Adverse Reaction",[137,138],"neuraxial opioid induced pruritus during labor","Intrathecal fentanyl versus Epidural fentanyl","2025-11-20",{"date":141,"type":44},"2025-11-26",{"date":143,"type":20},"2026-01",{"date":145,"type":20},"2027-05",{"name":147,"class":76},"St. Justine's Hospital",{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":21,"phases":157,"briefSummary":159,"conditions":160,"keywords":161,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":77},"100432678","phase-4-premedication-with-atenolol-versus-metoprolol-for-controlled-hypotensive-anesthesia-during-nasal-surgeries-100432678","NCT04914234","Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries","Premedication With Atenolol Versus Metoprolol for Controlled Hypotensive Anesthesia During Nasal Surgeries. A Randomized Clinical Trial","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) physical status ≤ II\n* Age from 21 to 50 years\n\nExclusion Criteria:\n\n* ASA physical status \\> II\n* Age \\\u003C 21 years or \\> 50 years\n* Pregnant women\n* Breastfeeding\n* Bronchial asthma\n* Chronic obstructive pulmonary disease\n* Diabetes Mellitus\n* Hypertension\n* Ischemic heart disease\n* Rheumatic heart disease\n* Heart failure\n* Heart block\n* Sick sinus syndrome\n* Sinus bradycardia\n* Chronic hypotension\n* Anemia (Hb \\\u003C 10 g\u002Fdl)\n* Renal or hepatic dysfunction\n* Central nervous system disease\n* Allergic fungal sinusitis\n* Patients on beta-blockers\n* Alcohol or drug abuse\n* Anticoagulation therapy,\n* Bleeding diathesis\n* Agents influencing autonomic nervous system\n* Allergy to the study drugs\n* Any contraindication of oral intake","50 Years",{"count":89,"type":20},[158],"PHASE4","Objectives: To compare the safety and efficacy of oral atenolol versus oral metoprolol as a premedication for controlled hypotensive anesthesia during nasal surgeries.\n\nBackground: Mucosal bleeding is the most frequent complication with nasal surgeries, as it interferes with the optimal visualization of the intranasal anatomy, increases operation time, and consequently increases blood loss. There are several pharmacological and non-pharmacological techniques for the appropriate control of intraoperative bleeding.\n\nPatients and Methods: This was a prospective, randomized, double-blind, phase four, comparative clinical trial; carried out on 60 patients, who were candidates for nasal surgeries under general anesthesia at our hospital. Patients were randomly allocated into two equal groups; group A, received oral atenolol, and group M, received oral metoprolol.",[26],[162,163,164,165],"atenolol","controlled hypotension","metoprolol","nasal surgery","2025-08-20",{"date":168,"type":44},"2025-08-21",{"date":170,"type":44},"2025-08-01",{"date":172,"type":20},"2026-01-30",{"name":174,"class":51},"Damanhour Teaching Hospital",{"id":176,"slug":177,"hasResults":11,"nctId":178,"briefTitle":179,"officialTitle":180,"acronym":4,"eligibilityCriteria":181,"healthyVolunteers":11,"sex":16,"minAge":119,"maxAge":182,"enrollmentInfo":183,"targetDuration":4,"studyType":21,"phases":185,"briefSummary":186,"conditions":187,"keywords":188,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":200,"lastUpdatePostDateStruct":201,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":77},"100541798","phase-4-a-prospective-study-of-vasopressor-on-cerebral-oxygenation-during-general-anesthesia-100541798","NCT06334549","A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia","Effects of Vasopressor on Cerebral Oxygenation During General Anesthesia in Abdominal Surgery","Inclusion Criteria:\n\n* ASA I-III, age 18-80 years\n* Elective abdominal surgery\n* Signed informed consent\n\nExclusion Criteria:\n\n* ASA≥IV\n* Preoperative unstable blood hemodynamics\n* Allergy to ephedrine, phenylephrine or norepinephrine\n* Decrease in MAP \\\u003C20%\n* Severe cardiovascular disorder","80 Years",{"count":184,"type":20},180,[158],"The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.",[26],[189,190,191,192,193,194,195,196,197,198,199],"Abdominal surgery","ephedrine","phenylephrine","norepinephrine","cerebral oxygen saturation","MAP","CO","General anesthesia","Propofol","Sevoflurane","Hypotension Drug-induced","2024-11-04",{"date":202,"type":44},"2024-11-06",{"date":204,"type":44},"2024-03-05",{"date":206,"type":20},"2025-12-05",{"name":208,"class":76},"Dalian Municipal Central Hospital",{"id":210,"slug":211,"hasResults":11,"nctId":212,"briefTitle":213,"officialTitle":214,"acronym":4,"eligibilityCriteria":215,"healthyVolunteers":11,"sex":16,"minAge":119,"maxAge":17,"enrollmentInfo":216,"targetDuration":218,"studyType":219,"phases":4,"briefSummary":220,"conditions":221,"keywords":223,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":77},"100536048","aki-risk-factors-analysis-after-intentional-hypotensive-anesthesia-100536048","NCT06259760","AKI Risk Factors Analysis After Intentional Hypotensive Anesthesia","Incidence and Risk Factors Analysis of Acute Kidney Injury (AKI) After Intentional Hypotensive Anesthesia in Orthognathic Surgery Patients Following Enhanced Recovery After Surgery (ERAS) Guidelines","Inclusion Criteria:\n\n* America society anesthesiologist classification class I to II patients undergoing oro-maxillo-facial surgery\n* unlimited mouth opening\n\nExclusion Criteria:\n\n* patients with arthritis with limited mouth opening\n* persistent liver dysfunction\n* chronic renal insufficiency\n* body mass index ≧35 kg\u002Fm2.\n* past history of malignant hyperthermia or personal or family history\n* diabetes with insulin treatment\n* essential hypertension without controlled",{"count":217,"type":20},50,"7 Days","OBSERVATIONAL","This project investigates intentionally hypotensive management such as NTG (nitroglycerin) or NTG+Trandate during general anesthesia in patients undergoing orthognathic surgery. Throughout the entire surgical procedure, blood biochemical and urine monitoring will be conducted. Serum creatinine (Cr) levels, urine analysis, and perioperative monitoring will be utilized as indicators for assessing renal function during the surgery. The objective is to assess its potential renal injury and identify early risk factors for acute kidney injury (AKI). Timely recognition of these factors will allow for the implementation of appropriate intervention strategies, aiding in the prevention of postoperative acute kidney injury. This approach contributes to achieving the goals of Enhanced Recovery After Surgery (ERAS) for surgical patients, promoting faster postoperative recovery.",[222,26],"Acute Kidney Injury (Nontraumatic)",[224,225,226,227,228],"Acute Kidney Injury","orthognathic surgery","general anesthesia","prospective analysis","intentional hypotension","2024-02-07",{"date":231,"type":44},"2024-02-14",{"date":233,"type":20},"2024-03-01",{"date":235,"type":20},"2026-12-31",{"name":237,"class":76},"Kaohsiung Medical University Chung-Ho Memorial Hospital"]