[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypotension-during-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypotension-during-surgery":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,46,83,114,142,169,195,216,254,283],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100618233","effect-of-titrated-administration-of-ciprofol-on-perioperative-hypotension-in-elderly-patients-undergoing-laparoscopic-abdominal-surgery-a-randomized-controlled-trial-100618233",false,"NCT07328958","Effect of Titrated Administration of Ciprofol on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial","Effect of Titrated Administration of Ciprofol Combined With Remifentanil on Perioperative Hypotension in Elderly Patients Undergoing Laparoscopic Abdominal Surgery: A Randomized Controlled Trial","TAPH","Inclusion Criteria:\n\n* Age ≥65 years, scheduled for elective laparoscopic abdominal surgery\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Requirement for invasive arterial blood pressure monitoring\n\nExclusion Criteria:\n\n* Participation in other clinical trials that may interfere with the intervention or outcomes of this study\n* Severe hepatic or renal disease (GFR ≤30 mL\u002Fmin\u002F1.73 m², requirement for renal replacement therapy, or Child-Pugh class C liver function)\n* Uncontrolled severe hypertension (preoperative SBP ≥180 mmHg or DBP ≥110 mmHg)\n* Patients with severe mental disorders (such as schizophrenia), epilepsy, or Parkinson's disease, severe cognitive or intellectual impairment, severe visual or hearing impairments affecting assessment, or long-term alcohol abuse or use of sedative\u002Fanalgesic medications;\n* Known allergy to drugs used in this study\n* Requirement for continuous vasopressor infusion before surgery, or intraoperative need for prolonged hemodynamic manipulation due to surgical factors\n* Anticipated blood loss \\>15% of estimated blood volume\n* Expected surgical duration \\\u003C1 hours or \\>6 hours\n* Expected postoperative hospital stay \\\u003C72 hours","ALL","65 Years",{"count":20,"type":21},500,"ESTIMATED","INTERVENTIONAL",[24],"NA","Elderly patients are frequently burdened with age-associated comorbidities and frailty, accompanied by physiological changes such as vascular stiffening, cardiac dysfunction, and impaired autonomic regulation. These factors not only increase the risk of adverse perioperative outcomes but also heighten sensitivity to anesthetic agents, making elderly patients particularly susceptible to anesthesia-related complications, especially hypotension. Consequently, optimizing anesthesia strategies for this high-risk population has become a critical goal in perioperative management.\n\nTitrated anesthesia, which individualizes anesthetic drug delivery based on patient response to achieve predefined endpoints, offers a potential approach to mitigating anesthetic risks. Ciprofol, a novel intravenous anesthetic, has been associated with less hemodynamic suppression compared with traditional agents; however, higher single doses may still predispose patients to hypotension. Remifentanil, an ultra-short-acting opioid, exerts significant cardiovascular depressive effects, further contributing to perioperative hypotension.\n\nIt is hypothesized that titrated administration of anesthetic agents during both the induction and maintenance phases, compared with conventional fixed-dose protocols, may reduce the incidence of perioperative hypotension in elderly patients.",[27],"Hypotension During Surgery",[29,30,31,32],"elderly","general anesthesia","titrated","ciprofol","RECRUITING","2026-06-07",{"date":36,"type":37},"2026-06-10","ACTUAL",{"date":39,"type":37},"2026-01-16",{"date":41,"type":21},"2027-01-30",{"name":43,"class":44},"Sixth Affiliated Hospital, Sun Yat-sen University","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":59,"conditions":60,"keywords":67,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":5},"100577740","phase-4-the-choice-of-vasopressor-to-prevent-postoperative-acute-kidney-injury-after-major-non-cardiac-surgery-100577740","NCT06802224","The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery","Norepinephrine vs Phenylephrine as the First-line Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-cardiac Surgery","VEGA-2","Inclusion Criteria:\n\n* Age 18 years or older\n* Surgery under general anesthesia with a surgery duration of 2 hours or more\n* Received intravenous vasopressors during surgery\n\nExclusion Criteria:\n\n* Cardiac surgery\n* Extra-corporeal membrane oxygenation\n* Organ transplantation\n* Obstetric procedures\n* Procedures on the kidney\n* Outpatient procedures\n* Already receiving NE or PE or inotropes before induction of anesthesia (at the time of anesthesia start)\n* American Society of Anesthesiologists physical status classification 5 or 6\n* Patient for whom a local protocol recommends a specific first line vasopressor\n* Most recent documented estimated glomerular filtration rate (eGFR) \\\u003C 15 mL\u002Fmin\u002F1.73m\\^2 or preoperative renal replacement therapy within 60 days before surgery\n* Patients who do not have a preoperative creatinine value within 60 days before surgery\n* Alive patients who do not have a postoperative creatinine value","18 Years",{"count":56,"type":21},18000,[58],"PHASE4","Low blood pressure, also known as hypotension, is very common during major surgery under general anesthesia. Prolonged or severe hypotension can lead to complications such as kidney injury after surgery that slow down patient recovery. Anesthesiologists commonly administer medications called vasopressors to treat low blood pressure during surgery. These medications help raise the blood pressure back up to a safe range. Two vasopressor medications are commonly used for this purpose: norepinephrine and phenylephrine. Each of these medications has slightly different effects on the heart and blood vessels (cardiovascular system). It remains unknown which of these standard medications is better for treating low blood pressure during surgery. The goal of this clinical trial is to determine which of these two medications is better at preventing injury to the kidneys after major noncardiac surgery as well as other complications such as heart problems. Major surgeries are defined as those lasting at least two hours under general anesthesia. This trial will randomize about ten centers in North America to use either norepinephrine or phenylephrine as the primary medication to treat low blood pressure in adults undergoing major noncardiac surgery. Each hospital will prioritize one of the drugs each month, and the assigned drug will rotate each month at each hospital. No further participant involvement will be required as de-identified data are collected as part of standard medical care.",[61,62,63,27,64,65,66],"Anesthesia","Surgery With General Anesthesia","Noncardiac Surgery","Acute Kidney Injury (AKI)","Myocardial Injury After Noncardiac Surgery (MINS)","Vasopressor",[68,69,70,71,72,73],"Norepinephrine","Phenylephrine","Major adverse kidney events","Pragmatic","Cluster randomized","Crossover","2026-05-20",{"date":76,"type":37},"2026-05-26",{"date":78,"type":37},"2025-04-01",{"date":80,"type":21},"2028-07",{"name":82,"class":44},"University of California, San Francisco",{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":91,"targetDuration":4,"studyType":22,"phases":93,"briefSummary":94,"conditions":95,"keywords":101,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":45},"100589322","femoral-versus-radial-invasive-arterial-pressure-monitoring-in-cardiac-surgery-patients-100589322","NCT06952907","Femoral Versus Radial Invasive Arterial Pressure Monitoring in Cardiac Surgery Patients","Femoral Versus Radial Artery Catheterization for Invasive Arterial Pressure Monitoring in Cardiac Surgery Patients: the FERARI Randomized Superiority Study","FERARI","Inclusion Criteria:\n\n* Male and female patients ≥18 years\n* Scheduled cardiac surgery with cardiopulmonary bypass (time between anesthesia consultation and surgery \\> 48 hours)\n* ASA physical status ≥II\n* Affiliation with or beneficiary of the French national health insurance system\n* Signed informed consent indicating that the participant has understood the purpose and procedures of the study and agrees to participate and comply with its requirements and restrictions\n\nExclusion Criteria:\n\n* Emergency surgery (before the next working day after decision to operate)\n* Surgery requiring the use of two arterial pressure monitoring sites: e.g., aortic arch surgery, aortic dissection, etc.\n* Heart transplantation surgery\n* Mechanical circulatory support\n* Contraindication to radial artery catheterization: failed Allen test, Raynaud syndrome, Buerger disease, major hyperlipidemia\n* Contraindication to femoral artery catheterization: puncture of vascular prosthetic material in the femoral area (e.g., femoral bypass, femoral stenting, femoral trifurcation endarterectomy, femoral angioplasty)\n* Pregnant or breastfeeding women\n* Persons deprived of liberty by judicial or administrative decision; persons under compulsory psychiatric care; persons admitted to a healthcare or social institution for reasons other than research\n* Adults under legal protection measures (guardianship, trusteeship, or legal safeguard) or unable to give informed consent\n* Subjects currently under exclusion period of another clinical trial or listed in the national registry of research volunteers",{"count":92,"type":21},340,[24],"Background: Acute circulatory failure, often presenting as arterial hypotension, is a major contributor to postoperative morbidity and mortality. Accurate blood pressure (BP) monitoring is essential for timely therapeutic intervention, particularly in patients undergoing major surgery. Among invasive BP measurement sites, the radial artery is commonly used due to its accessibility and ease of catheterization. However, physiologically, the radial artery may underestimate central arterial pressure compared to the femoral artery, especially in patients receiving vasopressors or in critical conditions. This discrepancy can lead to overtreatment with vasopressors and associated complications. Current literature on the accuracy of radial versus femoral BP monitoring is outdated and based solely on observational studies. There is a lack of high-quality randomized data to inform clinical guidelines.\n\nHypothesis: Femoral arterial pressure monitoring, by offering more accurate hemodynamic data, reduces the need for vasopressor support, particularly norepinephrine, compared to radial artery monitoring.\n\nPrimary Objective: To compare the effect of femoral versus radial invasive BP monitoring on the proportion of patients requiring norepinephrine from anesthetic induction to postoperative day 7 (D7) following elective cardiac surgery. Norepinephrine treatment is defined by continuous intravenous administration of norepinephrine for more than 1 minute.\n\nSecondary Objectives :\n\nTo compare the following outcomes between the two strategies within the first 7 postoperative days: incidence of acute kidney injury (AKI) according to KDIGO criteria, incidence of cardiac complications (arrhythmias requiring treatment, myocardial injury (troponin \\>99th percentile or \\>20% rise from baseline), myocardial infarction, cardiogenic shock, cardiac arrest), vaso-inotropic score (VIS), duration of any vasopressor therapy (days), ICU and hospital length of stay (days), all-cause mortality at day 7 and day 30, total duration (hours\u002Fdays) and maximal dose of norepineprhine therapy, intraoperative hypotension episodes (MAP\\\u003C65 mmHg \\> 5 min), incidence of arterial catheter-related complications (hematoma, bleeding, infection, thrombosis, arterial occlusion, malfunction, dislodgement).\n\nPrimary Endpoint: The proportion of patients receiving continuous intravenous norepinephrine from anesthesia induction to postoperative day 7.\n\nSecondary Endpoints:\n\nAKI occurrence or need for renal replacement therapy; cardiac complications: atrial\u002Fventricular arrhythmias requirinf treatment, myocardial injury (troponin \\>99th percentile or \\>20% rise from baseline), myocardial infarction (biomarker elevation + ECG or echocardiographic abnormalities), cardiogenic shock, cardiac arrest; maximum VIS in the OR, ICU admission, and day 1; intraoperative hypotension episodes (MAP\\\u003C65 mmHg \\> 5 min); total norepinephrine support duration (in hours); duration of any vasopressor therapy; arterial line complications: malfunction, dislodgement, hematoma, thrombosis, infection, bleeding, arterial occlusion; ICU and hospital length of stay (days); all-cause mortality at day 7 and day 30\n\nStudy Design: A prospective, multicenter (Besançon and Dijon University Hospitals), randomized, superiority, single-blind, intention-to-treat clinical trial in adults undergoing elective cardiac surgery. Patients are randomized to femoral or radial artery catheterization for continuous BP monitoring.\n\nSample Size: Based on an expected norepinephrine use rate of 70%, a 15% absolute risk reduction, α = 0.05, and power = 90%, 162 patients per group are required. Accounting for 5% data loss, 340 patients will be enrolled.\n\nStudy Arms:\n\nRadial group: invasive BP monitoring via radial artery catheterization Femoral group: invasive BP monitoring via femoral artery catheterization The arterial line is placed under ultrasound guidance in the operating room and maintained postoperatively in the ICU or critical care unit until no longer clinically indicated.\n\nEligibility Criteria Inclusion: adults patients ≥18 years undergoing elective on-pump cardiac surgery with informed consent.\n\nExclusion: emergency surgery, use of dual arterial lines, heart transplantation, mechanical circulatory support, contraindications to radial\u002Ffemoral catheterization, legal or ethical inability to consent.\n\nStudy Timeline Inclusion period: 36 months Patient follow-up: 7 days post-surgery Total study duration: 36 months\n\nData Collection: Clinical data are collected by research staff using an electronic case report form (e-CRF) via CleanWeb™ software.\n\nExpected Impact: There are currently no guidelines specifying the optimal site for invasive BP monitoring. This study aims to provide robust evidence on whether femoral BP monitoring improves clinical outcomes, reduces vasopressor use, and minimizes adverse events. Positive findings could inform future practice guidelines and lead to broader investigations in other clinical settings.",[96,97,98,99,27,100,68],"Vasoplegia Syndrome","Vasoplegia","Cardiac Surgical Procedures","Arterial Pressure","Hypotension Postprocedural",[102,103,104,68],"Invasive arterial blood pressure monitoring","Vasoplegia syndrome","Cardiac surgery","2025-12-16",{"date":107,"type":37},"2025-12-22",{"date":109,"type":37},"2025-06-15",{"date":111,"type":21},"2027-08-01",{"name":113,"class":44},"Guillaume BESCH",{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":121,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":22,"phases":124,"briefSummary":125,"conditions":126,"keywords":127,"overallStatus":131,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":141},"100609987","brain-autoregulation-research-study-100609987","NCT07221721","Brain Autoregulation Research Study","A Pilot Study to Assess the Feasibility and Safety of Targeting Mean Arterial Pressure to Reduce Intra-operative Hypotension","Inclusion Criteria:\n\n* All neonates (\\\u003C30 days of age)\n* Undergoing cardiothoracic surgery with cardiopulmonary bypass\n\nExclusion Criteria:\n\n* Less than full term (\\\u003C37 weeks gestation)\n* Weight \\\u003C 2.50kg\n* Genetic abnormality or syndrome except heterotaxy syndrome\n* Major non-cardiac anomalies (e.g. congenital diaphragmatic hernia, - omphalocele, holoprosencephaly, anencephaly)","30 Days",{"count":123,"type":21},130,[24],"Randomized, multi-site, study assessing the feasibility of lower limit of autoregulation targeted mean arterial pressure (MAP) vs. standard MAP management in neonates undergoing cardiac surgery with cardiopulmonary bypass. After eligibility screening and consent, subjects will be randomized to either the intervention (study) or control group.",[27,100],[128,129,130],"hypotension","neonates","cardiothoracic surgery with cardiopulmonary bypass","NOT_YET_RECRUITING","2025-10-28",{"date":134,"type":37},"2025-10-30",{"date":136,"type":21},"2025-11",{"date":138,"type":21},"2028-12",{"name":140,"class":44},"Bradley Marino",1,{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":147,"acronym":4,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":149,"enrollmentInfo":150,"targetDuration":4,"studyType":22,"phases":152,"briefSummary":153,"conditions":154,"keywords":155,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":141},"100535096","the-hypotension-prediction-index-in-major-abdominal-surgery-100535096","NCT06247384","The Hypotension Prediction Index in Major Abdominal Surgery","The Hypotension Prediction Index in Major Abdominal Surgery - a Prospective Randomized Clinical Trial.","Inclusion Criteria:\n\n* Patients qualified for elective major abdominal surgery, defined as an expected duration of more than two hours, an estimated blood loss of \\>15% of blood volume, or an expected transfusion requirement of at least two packed red blood cells with general or combined anaesthesia.\n* Patients with American Society of Anesthesiologists (ASA) status III or IV.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Patients under 18 years\n* Lack of health insurance\n* Pregnancy\n* Known history of congenital heart disease, severe aortic and\u002For mitral stenosis, heart failure and ejection fraction \\\u003C 35 %\n* Persistent atrial fibrillation and other arrhythmias impairing arterial pressure cardiac output monitoring","80 Years",{"count":151,"type":21},226,[24],"The goal of this randomized clinical trial is to compare different types of advanced hemodynamic monitoring in patients undergoing major abdominal surgery.\n\nParticipants undergoing major abdominal surgery will receive anesthesia with two different types of hemodynamic monitoring - group A will receive arterial pressure cardiac output algorithm with the FloTrac sensor and group B will receive hemodynamic monitoring with the Hypotension Prediction Index.\n\nThe main question the study aims to answer is:\n\n• will the hypotension prediction index algorithm reduce the rate of hypotension in comparison to arterial pressure cardiac output algorithm.",[27],[156,157,158,159],"hypotension prediction index","major abdominal surgery","arterial pressure cardiac output","intraoperative hypotension","2025-07-30",{"date":162,"type":37},"2025-08-03",{"date":164,"type":37},"2025-01-01",{"date":166,"type":21},"2025-12-31",{"name":168,"class":44},"Jakub Szrama",{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":175,"sex":17,"minAge":54,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":179,"phases":4,"briefSummary":180,"conditions":181,"keywords":183,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":187,"lastUpdatePostDateStruct":188,"startDateStruct":190,"completionDateStruct":191,"leadSponsor":193,"locationsCount":141},"100594650","incidence-of-hypotension-in-the-post-anesthesia-care-unit-pacu-100594650","NCT07022210","Incidence of Hypotension in the Post-anesthesia Care Unit (PACU).","Inclusion Criteria:\n\n* patients over 18 years old\n* patients undergoing a procedure under general anesthesia\n* patients who have consented to data processing\n* postoperative stay in PACU\n\nExclusion Criteria:\n\n* patients younger than 18 years old.\n* patients transferred directly to the ICU\u002FAnesthesiology and Resuscitation Department after surgery without staying in the recovery room.\n* patients with incomplete medical documentation or missing blood pressure values in the recovery room.\n* patients with a pre-existing diagnosis of resistant hypotension or unstable hemodynamics before surgery\n* patients with a history of long-term use of anxiolytics, antipsychotics, or other psychotropic medications that may affect cognitive function, emotional state, or predictive outcomes\n* patient refusal to participate in the study (including cases where they initially consented), with an emphasis on respecting patient autonomy",true,"105 Years",{"count":178,"type":21},100,"OBSERVATIONAL","The perioperative period poses a heightened risk of complications for patients, including hypotension. While the issue of intraoperative hypotension is well-documented in medical literature, the occurrence and causes of hypotension in the post-anesthesia care unit often receive less attention. This phase of postoperative care, however, is vital for ensuring patient stability and preventing severe consequences. Failure to identify and manage a drop in blood pressure can lead to hypoperfusion of critical organs, increasing the risk of morbidity and mortality. The aim of this study is to examine the frequency of hypotension in the post-anesthesia care unit-defined as systolic blood pressure \\\u003C90 mmHg or a drop of more than 20% from baseline-and to identify factors contributing to its development.",[27,182],"Surgery-Complications",[128,184,185,186],"post-anesthesia care unit","surgery","adult","2025-07-06",{"date":189,"type":37},"2025-07-10",{"date":109,"type":37},{"date":192,"type":21},"2026-05-01",{"name":194,"class":44},"Tomas Bata Hospital, Czech Republic",{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":17,"minAge":201,"maxAge":4,"enrollmentInfo":202,"targetDuration":121,"studyType":179,"phases":4,"briefSummary":204,"conditions":205,"keywords":206,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":214,"locationsCount":141},"100585065","external-validation-of-prediction-algorithm-using-non-invasive-monitoring-device-for-intraoperative-hypotension-100585065","NCT06897514","External Validation of Prediction Algorithm Using Non-invasive Monitoring Device for Intraoperative Hypotension","Inclusion Criteria:\n\n* Adults patients aged 19 or more\n* Elective surgery under general anesthesia\n* American Society of Anesthesiologists physical status I - III\n\nExclusion Criteria:\n\n* Vasopressor\u002FInotrope usage before surgery\n* Patients who needs invasive arterial cannulation\n* Emergency surgery\n* Pregnant or lactating women","19 Years",{"count":203,"type":21},200,"The goal of this prospective observational study is to externally validate the prediction algorithm using non-invasive monitoring device for intraoperative hypotension. The main question it aims to answer is: Does the prediction algorithm predict intraoperative hypotension effectively?",[27],[159,207],"prediction algorithm","2025-05-14",{"date":210,"type":37},"2025-05-15",{"date":212,"type":37},"2025-04-11",{"date":166,"type":21},{"name":215,"class":44},"Samsung Medical Center",{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":222,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":224,"targetDuration":4,"studyType":179,"phases":4,"briefSummary":226,"conditions":227,"keywords":232,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":253},"100513064","pressure-recording-analytical-method-parameters-and-their-relationship-with-hypotension-in-hypertensive-patients-100513064","NCT05960604","Pressure Recording Analytical Method Parameters and Their Relationship With Hypotension in Hypertensive Patients","Observational Study to Evaluate the Pressure Recording Analytical Method Parameters in Patients Susceptible to Post-induction Hypotension Due to Hypertension, Diabetes Mellitus, Cardiovascular Risk Factors, or Major Surgery","PRAM-in-HYPO","Inclusion Criteria:\n\n* Age at least 18 years\n* Undergoing major surgery under general anesthesia\n* Expected surgery time \\>2 h\n* Expected length of postoperative stay \\>2 d\n* Invasive blood pressure (radial or femoral) and Mostcare monitoring\n* Indication for a passive leg raising test: risk of hypovolemia (preoperative fasting, bowel preparation, loss of appetite, limited access to water) or expected major surgery, expected blood loss, cardiovascular comorbidity (hypertension, diabetes mellitus, coronary artery disease, peripheral artery disease, hyperlipidemia, morbidity, active smoking).\n* Recruitment after booking for surgery with sufficient time to read, understand and question study patient information prior to attending for surgery.\n* Ability and willingness to provide informed consent\n\nExclusion Criteria:\n\n* Refuse to consent to the study\n* Arterial wave form distortion\n* Cardiac arrhythmia\n* Inappropriate identification of the dicrotic notch for any reason\n* Planned intraoperative mean arterial blood pressure \\\u003C 65 mmHg\n* Hemodynamic instability defined as mean arterial blood pressure \\\u003C 65 mmHg\n* Preoperative requirement of inotrope\u002Fvasopressor infusion\n* Preoperatively receiving vasoactive drugs\n* Patients fitted with an intra-aortic balloon pump\n* Patients fitted with Extracorporeal Membrane Oxygenation\n* Critically ill patients requiring preoperative intensive care unit\n* Presence of intraabdominal hypertension\n* New York Heart Association Class 3-4 heart failure\n* Congestive heart failure with ejection fraction \\\u003C 35%\n* Glomerular filtration rate \\\u003C 30 ml\u002Fmin\u002F1.73 m2\n* Ongoing renal replacement therapy",{"count":225,"type":21},660,"Perioperative anesthesiologists can benefit from easily obtainable hemodynamic variables detecting or quantifying the lack of an adequate compensatory capacity of the cardiovascular system in order to optimize patient management and improve patient outcomes. Parameters of the Pressure Recording Analytical Method (PRAM; Vygon, Padua, Italy) of the MostCare system, specifically cardiac cycle efficiency has been proposed as such variables. Yet, their value in anesthesia and especially in hypertensive patients is not studied. The goal of the PRAM-in-HYPO study is to prospectively evaluate the relationship between cardiac reserve and efficiency and cardiovascular risk factors in patients wo will undergo major surgical procedures using the state-of-the-art hemodynamic monitors. Also the investigators aim to build a predictive model to identify patients with decreased cardiac reserve due to hypertension and other cardiovascular risk factors, who are susceptible to post-induction hypotension. The investigators seek to include high-risk patients or patients presenting for major surgery, who are monitored with an advanced hemodynamic monitor to adequately evaluate the differences in cardiac reserve and cardiac efficiency.",[228,229,230,231,27],"Cardiovascular Diseases","Surgery","Hypotension","Hypotension on Induction",[233,234,235,236,237,238,239,240,241,242,243],"Mostcare","Pressure Recording Analytical Method","Pulse contour analysis","Hemodynamic monitoring","Effective arterial elastance","Cardiac cycle efficiency","Cardiac power output","Myocardial contraction","Cardiac output","Stroke volume","Systemic vascular resistance","2025-04-08",{"date":246,"type":37},"2025-04-09",{"date":248,"type":37},"2024-02-19",{"date":250,"type":21},"2027-06",{"name":252,"class":44},"Recep Tayyip Erdogan University",5,{"id":255,"slug":256,"hasResults":11,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":11,"sex":262,"minAge":54,"maxAge":263,"enrollmentInfo":264,"targetDuration":4,"studyType":22,"phases":266,"briefSummary":267,"conditions":268,"keywords":269,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":141},"100522250","phase-4-goal-directed-fluid-therapy-during-deep-inferior-epigastric-perforator-diep-free-flap-breast-reconstruction-100522250","NCT06080178","Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction","Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast Reconstruction - a Randomised Controlled Trial","GDFT DIEP-flap","Inclusion Criteria:\n\n* Female adult patients, between 18 and 70 years of age\n* Patients scheduled for DIEP free flap breast reconstruction\n* Signed written informed consent form (ICF)\n\nExclusion Criteria:\n\n* present atrial fibrillation (AF)\n* heart failure New York Heart Association (NYHA) classification 2 or higher\n* chronic kidney disease (CKD) stage 3B or higher\n* American Society of Anesthesiologists (ASA) classification III or higher\n* known allergy to study specific medication\n* participation in another clinical trial\n* Inability of the patient to understand Dutch sufficiently\n* Patients who are pregnant or breastfeeding","FEMALE","70 Years",{"count":265,"type":21},82,[58],"Adequate free flap perfusion during Deep Inferior Epigastric Perforator (DIEP) flap breast reconstruction surgery requires maintaining blood pressure above 100 mmHg and avoiding excessive fluid administration. This study aims to determine whether the use of a measurement of preload dependency (Pulse Pressure Variation = PPV), can guide fluid therapy and if it decreases the risk of flap oedema. For this purpose, two fluid management strategies will be compared:\n\n* Static intraoperative fluid management: Administration of crystalloid fluids is limited to 5ml\u002Fkg\u002Fh\n* Dynamic intraoperative fluid management: Crystalloid fluids are only administered if PPV exceeds 12% The purpose of this study is to compare the static and dynamic (= targeted) fluid strategy and to evaluate the effect on flap oedema and flap perfusion.",[27],[270,271,272,273],"arterial hypotension","postoperative hypotension","Goal-directed Fluid Therapy","DIEP free flap breast reconstruction","2025-01-27",{"date":276,"type":37},"2025-01-28",{"date":278,"type":37},"2023-11-23",{"date":280,"type":21},"2026-10-01",{"name":282,"class":44},"Algemeen Ziekenhuis Maria Middelares",{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":175,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":290,"targetDuration":4,"studyType":22,"phases":291,"briefSummary":292,"conditions":293,"keywords":297,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":302,"lastUpdatePostDateStruct":303,"startDateStruct":305,"completionDateStruct":307,"leadSponsor":309,"locationsCount":141},"100542468","the-effects-of-general-versus-spinal-anesthesia-on-postoperative-myocardial-injury-100542468","NCT06343259","The Effects of General Versus Spinal Anesthesia on Postoperative Myocardial Injury","Comparison of The Effects of General Anesthesia and Spinal Anesthesia on The Development of Postoperative Myocardial Injury in Elderly Patients Undergoing Hip Surgery","Inclusion Criteria:\n\n* who will undergo hip surgery\n* ASAII-III\n* Over the age of 65\n\nExclusion Criteria:\n\n* Patients diagnosed with sepsis, pulmonary embolism, decompensated heart failure, chronic kidney failure.\n* Patients who underwent cardioversion in the last 6 months or experienced myocardial infarction.\n* Patients with a surgical history in the last month.\n* Patients who required intubation in the intensive care unit.\n* Patients with a baseline Hs-Troponin T value exceeding 20 ng\u002FL.\n* Patients with a postoperative peak Hs-Troponin T value higher than baseline.",{"count":178,"type":21},[24],"In this prospective, randomized, single-blind study, we aim to compare the effects of general anesthesia and spinal anesthesia on postoperative myocardial injury in elderly patients undergoing hip surgery. Cardiovascular events are a leading cause of mortality and morbidity following non-cardiac surgery, with myocardial injury after non-cardiac surgery (MINS) being a significant concern. MINS, characterized by asymptomatic elevation of troponin levels without accompanying ECG findings, is closely associated with postoperative mortality. With the increasing prevalence of comorbidities in the elderly population and the rising frequency of non-cardiac surgeries in this demographic, understanding the effects of different anesthesia types on postoperative myocardial injury is crucial.",[294,27,295,296],"Myocardial Injury After Non-cardiac Surgery","Anesthesia, General","Anesthesia, Spinal",[298,295,296,299,300,301],"MINS","Hip Fractures","Myocardial Infarction","Troponin T","2024-07-22",{"date":304,"type":37},"2024-07-23",{"date":306,"type":37},"2024-04-05",{"date":308,"type":21},"2024-08-18",{"name":310,"class":44},"Sisli Hamidiye Etfal Training and Research Hospital"]