[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypotension-postprocedural\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypotension-postprocedural":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,73,108],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100631426","preoperative-shock-indexes-and-post-spinal-hypotension-in-cesarean-surgery-100631426",false,"NCT07500519","Preoperative Shock Indexes and Post-Spinal Hypotension in Cesarean Surgery","Predictive Performance of Preoperative Shock Index and Modified Shock Index for Hypotension Following Spinal Anesthesia in Elective Cesarean Surgery","Inclusion Criteria:\n\n* Patients over 18 years old\n* ASA II-III patients undergoing elective cesarean section\n\nExclusion Criteria:\n\n* ASA IV patients\n* Patients with known neurologic or psychiatric disorders\n* Patients with clinically significant cardiovascular, respiratory, hepatic, renal or metabolic disease\n* Patients with alcohol or drug addiction\n* Mentally disabled patients\n* Patients with BMI\\>30\n* Patients who develop massive bleeding or coagulopathy","FEMALE","18 Years",{"count":19,"type":20},300,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to evaluate the predictive performance of preoperative Shock Index (SI) and Modified Shock Index (MSI) for hypotension following spinal anesthesia in elective cesarean surgery. Post-spinal hypotension is a common complication that can affect maternal and fetal outcomes, and early identification of at-risk patients is essential for effective perioperative management.",[24,25,26],"Spinal Anesthesia","Pregnancy","Hypotension Postprocedural",[28,29,24,30],"Hypotension","Cesarean Section","Shock Index","RECRUITING","2026-03-25",{"date":34,"type":35},"2026-03-30","ACTUAL",{"date":37,"type":35},"2025-10-15",{"date":39,"type":20},"2026-08-30",{"name":41,"class":42},"Marmara University","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":55,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":43},"100618149","phase-3-comparison-of-classic-and-sequential-spinal-techniques-for-preventing-hypotension-during-cesarean-delivery-100618149","NCT07327866","Comparison of Classic and Sequential Spinal Techniques for Preventing Hypotension During Cesarean Delivery.","Incidence of Post-Spinal Anaesthesia Hypotension in Caesarean Delivery: A Randomized Trial of Classic Versus Sequential Spinal Technique","Inclusion Criteria:\n\n* Adult women aged 18-45 years.\n* ASA physical status II-III.\n* Scheduled for elective cesarean section under standardized spinal anesthesia.\n\nExclusion Criteria:\n\n* Allergy to local anesthetics.\n* Emergency cesarean section.\n* Contraindication to spinal anesthesia (e.g., coagulopathy, infection at the puncture site).\n* Preexisting hypertension on medication or pre-eclampsia with severe features.\n* Known cardiac disease accompanied by hemodynamic instability.\n* Allergy to study drugs.\n* Fetal distress or non-reassuring cardiotocography (CTG).\n* BMI \\>40 kg\u002Fm².\n* Refusal to sign informed consent.","45 Years",{"count":53,"type":20},94,"INTERVENTIONAL",[56],"PHASE3","Given the clinical importance of maternal hypotension, the potential advantages of sequential spinal dosing warrant formal evaluation in a prospective, adequately powered randomized controlled trial. We therefore designed this study to compare the incidence of post-spinal hypotension between the classic single-shot spinal and the sequential fractionated spinal techniques in elective cesarean delivery.",[59,26],"Caesarean Delivery",[61,62],"Classic","Sequential Spinal Technique","NOT_YET_RECRUITING","2025-12-26",{"date":66,"type":35},"2026-01-08",{"date":68,"type":20},"2026-01-28",{"date":70,"type":20},"2026-12-30",{"name":72,"class":42},"Al-Azhar University",{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":81,"minAge":17,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":54,"phases":84,"briefSummary":86,"conditions":87,"keywords":94,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":107},"100589322","femoral-versus-radial-invasive-arterial-pressure-monitoring-in-cardiac-surgery-patients-100589322","NCT06952907","Femoral Versus Radial Invasive Arterial Pressure Monitoring in Cardiac Surgery Patients","Femoral Versus Radial Artery Catheterization for Invasive Arterial Pressure Monitoring in Cardiac Surgery Patients: the FERARI Randomized Superiority Study","FERARI","Inclusion Criteria:\n\n* Male and female patients ≥18 years\n* Scheduled cardiac surgery with cardiopulmonary bypass (time between anesthesia consultation and surgery \\> 48 hours)\n* ASA physical status ≥II\n* Affiliation with or beneficiary of the French national health insurance system\n* Signed informed consent indicating that the participant has understood the purpose and procedures of the study and agrees to participate and comply with its requirements and restrictions\n\nExclusion Criteria:\n\n* Emergency surgery (before the next working day after decision to operate)\n* Surgery requiring the use of two arterial pressure monitoring sites: e.g., aortic arch surgery, aortic dissection, etc.\n* Heart transplantation surgery\n* Mechanical circulatory support\n* Contraindication to radial artery catheterization: failed Allen test, Raynaud syndrome, Buerger disease, major hyperlipidemia\n* Contraindication to femoral artery catheterization: puncture of vascular prosthetic material in the femoral area (e.g., femoral bypass, femoral stenting, femoral trifurcation endarterectomy, femoral angioplasty)\n* Pregnant or breastfeeding women\n* Persons deprived of liberty by judicial or administrative decision; persons under compulsory psychiatric care; persons admitted to a healthcare or social institution for reasons other than research\n* Adults under legal protection measures (guardianship, trusteeship, or legal safeguard) or unable to give informed consent\n* Subjects currently under exclusion period of another clinical trial or listed in the national registry of research volunteers","ALL",{"count":83,"type":20},340,[85],"NA","Background: Acute circulatory failure, often presenting as arterial hypotension, is a major contributor to postoperative morbidity and mortality. Accurate blood pressure (BP) monitoring is essential for timely therapeutic intervention, particularly in patients undergoing major surgery. Among invasive BP measurement sites, the radial artery is commonly used due to its accessibility and ease of catheterization. However, physiologically, the radial artery may underestimate central arterial pressure compared to the femoral artery, especially in patients receiving vasopressors or in critical conditions. This discrepancy can lead to overtreatment with vasopressors and associated complications. Current literature on the accuracy of radial versus femoral BP monitoring is outdated and based solely on observational studies. There is a lack of high-quality randomized data to inform clinical guidelines.\n\nHypothesis: Femoral arterial pressure monitoring, by offering more accurate hemodynamic data, reduces the need for vasopressor support, particularly norepinephrine, compared to radial artery monitoring.\n\nPrimary Objective: To compare the effect of femoral versus radial invasive BP monitoring on the proportion of patients requiring norepinephrine from anesthetic induction to postoperative day 7 (D7) following elective cardiac surgery. Norepinephrine treatment is defined by continuous intravenous administration of norepinephrine for more than 1 minute.\n\nSecondary Objectives :\n\nTo compare the following outcomes between the two strategies within the first 7 postoperative days: incidence of acute kidney injury (AKI) according to KDIGO criteria, incidence of cardiac complications (arrhythmias requiring treatment, myocardial injury (troponin \\>99th percentile or \\>20% rise from baseline), myocardial infarction, cardiogenic shock, cardiac arrest), vaso-inotropic score (VIS), duration of any vasopressor therapy (days), ICU and hospital length of stay (days), all-cause mortality at day 7 and day 30, total duration (hours\u002Fdays) and maximal dose of norepineprhine therapy, intraoperative hypotension episodes (MAP\\\u003C65 mmHg \\> 5 min), incidence of arterial catheter-related complications (hematoma, bleeding, infection, thrombosis, arterial occlusion, malfunction, dislodgement).\n\nPrimary Endpoint: The proportion of patients receiving continuous intravenous norepinephrine from anesthesia induction to postoperative day 7.\n\nSecondary Endpoints:\n\nAKI occurrence or need for renal replacement therapy; cardiac complications: atrial\u002Fventricular arrhythmias requirinf treatment, myocardial injury (troponin \\>99th percentile or \\>20% rise from baseline), myocardial infarction (biomarker elevation + ECG or echocardiographic abnormalities), cardiogenic shock, cardiac arrest; maximum VIS in the OR, ICU admission, and day 1; intraoperative hypotension episodes (MAP\\\u003C65 mmHg \\> 5 min); total norepinephrine support duration (in hours); duration of any vasopressor therapy; arterial line complications: malfunction, dislodgement, hematoma, thrombosis, infection, bleeding, arterial occlusion; ICU and hospital length of stay (days); all-cause mortality at day 7 and day 30\n\nStudy Design: A prospective, multicenter (Besançon and Dijon University Hospitals), randomized, superiority, single-blind, intention-to-treat clinical trial in adults undergoing elective cardiac surgery. Patients are randomized to femoral or radial artery catheterization for continuous BP monitoring.\n\nSample Size: Based on an expected norepinephrine use rate of 70%, a 15% absolute risk reduction, α = 0.05, and power = 90%, 162 patients per group are required. Accounting for 5% data loss, 340 patients will be enrolled.\n\nStudy Arms:\n\nRadial group: invasive BP monitoring via radial artery catheterization Femoral group: invasive BP monitoring via femoral artery catheterization The arterial line is placed under ultrasound guidance in the operating room and maintained postoperatively in the ICU or critical care unit until no longer clinically indicated.\n\nEligibility Criteria Inclusion: adults patients ≥18 years undergoing elective on-pump cardiac surgery with informed consent.\n\nExclusion: emergency surgery, use of dual arterial lines, heart transplantation, mechanical circulatory support, contraindications to radial\u002Ffemoral catheterization, legal or ethical inability to consent.\n\nStudy Timeline Inclusion period: 36 months Patient follow-up: 7 days post-surgery Total study duration: 36 months\n\nData Collection: Clinical data are collected by research staff using an electronic case report form (e-CRF) via CleanWeb™ software.\n\nExpected Impact: There are currently no guidelines specifying the optimal site for invasive BP monitoring. This study aims to provide robust evidence on whether femoral BP monitoring improves clinical outcomes, reduces vasopressor use, and minimizes adverse events. Positive findings could inform future practice guidelines and lead to broader investigations in other clinical settings.",[88,89,90,91,92,26,93],"Vasoplegia Syndrome","Vasoplegia","Cardiac Surgical Procedures","Arterial Pressure","Hypotension During Surgery","Norepinephrine",[95,96,97,93],"Invasive arterial blood pressure monitoring","Vasoplegia syndrome","Cardiac surgery","2025-12-16",{"date":100,"type":35},"2025-12-22",{"date":102,"type":35},"2025-06-15",{"date":104,"type":20},"2027-08-01",{"name":106,"class":42},"Guillaume BESCH",2,{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":81,"minAge":115,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":54,"phases":118,"briefSummary":119,"conditions":120,"keywords":121,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":43},"100609987","brain-autoregulation-research-study-100609987","NCT07221721","Brain Autoregulation Research Study","A Pilot Study to Assess the Feasibility and Safety of Targeting Mean Arterial Pressure to Reduce Intra-operative Hypotension","Inclusion Criteria:\n\n* All neonates (\\\u003C30 days of age)\n* Undergoing cardiothoracic surgery with cardiopulmonary bypass\n\nExclusion Criteria:\n\n* Less than full term (\\\u003C37 weeks gestation)\n* Weight \\\u003C 2.50kg\n* Genetic abnormality or syndrome except heterotaxy syndrome\n* Major non-cardiac anomalies (e.g. congenital diaphragmatic hernia, - omphalocele, holoprosencephaly, anencephaly)","30 Days",{"count":117,"type":20},130,[85],"Randomized, multi-site, study assessing the feasibility of lower limit of autoregulation targeted mean arterial pressure (MAP) vs. standard MAP management in neonates undergoing cardiac surgery with cardiopulmonary bypass. After eligibility screening and consent, subjects will be randomized to either the intervention (study) or control group.",[92,26],[122,123,124],"hypotension","neonates","cardiothoracic surgery with cardiopulmonary bypass","2025-10-28",{"date":127,"type":35},"2025-10-30",{"date":129,"type":20},"2025-11",{"date":131,"type":20},"2028-12",{"name":133,"class":42},"Bradley Marino"]