[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypotension\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypotension":27},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,47,0,25,[9,47,88,117,143,169,200,221,254,283,314,346,376,402,439,465,486,508,534,559,580,601,625,650,675],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100645234","pupillary-light-reflex-to-predict-post-spinal-hypotension-in-elective-cesarean-delivery-100645234",false,"NCT07678723","Pupillary Light Reflex to Predict Post-Spinal Hypotension in Elective Cesarean Delivery","Pupillary Light Reflex for Predicting Hypotension Risk After Spinal Anesthesia for Elective Cesarean Section: A Prospective Observational Cohort Study","Inclusion Criteria:\n\nASA II Term pregnancy ≥37 weeks Singleton pregnancy Elective cesarean section Age 18-45 years Written informed consent\n\nExclusion Criteria:\n\nEmergency cesarean section Hypertensive disorders Diabetes mellitus Cardiovascular disease Neurological or autonomic disorders Ophthalmic disease Medications affecting autonomic function BMI \\>40 kg\u002Fm² Failed spinal anesthesia",true,"FEMALE","18 Years","45 Years",{"count":22,"type":23},200,"ESTIMATED","OBSERVATIONAL","This prospective observational cohort study investigates whether pre-anesthetic pupillary light reflex (PLR) parameters can predict the risk of hypotension following spinal anesthesia in women undergoing elective cesarean section. Spinal anesthesia-induced hypotension is common, with reported incidence rates of 50-90%, and current predictors such as baseline blood pressure and BMI have limited accuracy. PLR, a sensitive marker of autonomic nervous system balance, may offer a simple, objective, and non-invasive tool for identifying patients at higher risk. The study evaluates pupillary reaction latency and other PLR parameters and correlates them with post-spinal blood pressure changes to determine their predictive value.",[27,28,29],"Hypotension","Spinal Anesthesia","Cesarean Delivery",[31,32,28,27,33,34],"Pupillary Light Reflex","Pupillometry","Cesarean Section","Obstetric Anesthesia","NOT_YET_RECRUITING","2026-06-25",{"date":38,"type":39},"2026-07-01","ACTUAL",{"date":41,"type":23},"2026-06-28",{"date":43,"type":23},"2026-10-31",{"name":45,"class":46},"Al-Azhar University","OTHER",{"id":48,"slug":49,"hasResults":12,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":55,"minAge":19,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":60,"briefSummary":62,"conditions":63,"keywords":72,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":87},"100644654","impact-of-transcutaneous-spinal-stimulation-on-blood-pressure-and-orthostasis-in-spinal-cord-injury-100644654","NCT07674511","Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury","Impact of Transcutaneous Spinal Stimulation on Blood Pressure and Orthostasis in Spinal Cord Injury: Short and Long-Term Effects","(SCI)","Inclusion Criteria:\n\n* Individuals with a SCI ≥ 1 year after injury\n* Injury level ≥ T6 (thoracic level)\n* AIS grade A-C\n* Cardiovascular dysfunction characterized by one or more of the following:\n\n  1. Persistent hypotension (SBP \\\u003C 90mmHg)\n  2. Orthostatic hypotension (OH, a drop of 20\u002F10 mmHg in SBP\u002FDBP within 5 minutes of standing\u002Fupright positioning).\n\nAdditionally, experiencing orthostatic symptoms in daily life and\u002For requiring medication to manage OH.\n\nExclusion Criteria:\n\n* Current illness (e.g., infection, a pressure injury that might interfere with the intervention)\n* Ventilator-dependent\n* History of implanted brain\u002Fspine\u002Fnerve stimulators\n* Cardiac pacemaker\u002Fdefibrillator or intra-cardiac lines\n* Significant coronary artery or cardiac conduction disease, a recent history of myocardial infarction\n* History of seizures\n* pregnancy\n* Insufficient mental capacity to understand and independently provide consent\n* Deemed unsuitable by the study physician","ALL","75 Years",{"count":58,"type":23},10,"INTERVENTIONAL",[61],"NA","The purpose of this study is to learn whether stimulation applied to the spinal cord through the skin (called transcutaneous spinal stimulation) can help control blood pressure in people with a spinal cord injury.\n\nThe main questions this study attempts to solve:\n\n1. What are the immediate effects of spinal cord transcutaneous stimulation on BP?\n2. Does stimulation produce lasting improvements in BP regulation and subsequently, daily function?",[64,27,65,66,67,68,69,70,71],"Spinal Cord Injuries","Orthostatic Hypotension","Spinal Cord Diseases","Cardiovascular Diseases","Trauma, Nervous System","Central Nervous System Disease","Nervous System Diseases","Blood Pressure",[73,74,75,76,77],"transcutaneous spinal cord stimulation","spinal stimulations","orthostatic hypotension","blood pressure","neuromodulation","2026-06-24",{"date":80,"type":39},"2026-06-29",{"date":82,"type":23},"2026-09",{"date":84,"type":23},"2028-12",{"name":86,"class":46},"Kessler Foundation",1,{"id":89,"slug":90,"hasResults":12,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":4,"eligibilityCriteria":94,"healthyVolunteers":12,"sex":55,"minAge":95,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":59,"phases":98,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":87},"100600435","effectiveness-of-hypotension-prediction-index-hpi-in-preventing-hypotension-in-the-post-anesthesia-care-unit-pacu-100600435","NCT07097454","Effectiveness of Hypotension Prediction Index (HPI) in Preventing Hypotension in the Post-Anesthesia Care Unit (PACU)","Effectiveness of Hypotension Prediction Index (HPI) in Preventing Hypotension in the Post-Anesthesia Care Unit (PACU): A Prospective, Randomized, Controlled Trial","Inclusion Criteria:\n\n* Age ≥ 19 years\n* Undergoing elective surgery under general anesthesia\n* Presence of intra-arterial catheter at the end of surgery\n* Expected PACU stay of ≥ 30 minutes\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Immediate postoperative ICU admission\n* Use of vasopressors during emergence from anesthesia\n* ASA physical status classification of V\n* Known contraindications to arterial line placement\n* Participation in another interventional study within 30 days","19 Years",{"count":97,"type":23},210,[61],"Postoperative hypotension in the post-anesthesia care unit (PACU) is common and linked to adverse outcomes. The Hypotension Prediction Index (HPI) predicts hypotensive events intraoperatively, but its PACU application is unexplored. This study aims to investigate the effectiveness of HPI-guided monitoring in preventing PACU hypotension.",[27,101],"Postoperative Complications",[103,104,105,106,107],"Hypotension Prediction Index (HPI)","PACU","Hemodynamic Monitoring","Arterial Pressure Waveform","HemoSphere","RECRUITING",{"date":110,"type":39},"2026-06-26",{"date":112,"type":23},"2026-07-15",{"date":114,"type":23},"2026-09-11",{"name":116,"class":46},"Wonkwang University Hospital",{"id":118,"slug":119,"hasResults":12,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":12,"sex":55,"minAge":124,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":59,"phases":127,"briefSummary":128,"conditions":129,"keywords":130,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":139,"leadSponsor":141,"locationsCount":87},"100644361","propofol-vs-ciprofol-for-anesthesia-induction-in-frail-elderly-patients-100644361","NCT07663695","Propofol vs. Ciprofol for Anesthesia Induction in Frail Elderly Patients","Comparison of the Effects of Propofol and Ciprofol on the Incidence of Post-induction Hypotension in Frail Elderly Patients Undergoing General Anesthesia","Inclusion Criteria:\n\n* Patients scheduled to undergo major abdominal surgery under general anesthesia.\n* Frailty score \\>= 3\\[cite: 2\\].\n* Age \\>= 60 years\\[cite: 2\\].\n* American Society of Anesthesiologists (ASA) physical status class \\>= II\\[cite: 2\\].\n* Planned invasive blood pressure monitoring\\[cite: 2\\].\n\nExclusion Criteria:\n\n* Severe cardiac arrhythmia\\[cite: 2\\].\n* Severe valvular heart disease\\[cite: 2\\].\n* Poorly controlled hypertension with medication (systolic blood pressure \\>= 180 mmHg and\u002For diastolic blood pressure \\>= 110 mmHg)\\[cite: 2\\].\n* Pre-existing preoperative hypotension (mean arterial pressure \\\u003C 65 mmHg)\\[cite: 2\\].\n* Preoperative renal dysfunction (serum creatinine greater than the upper limit of normal)\\[cite: 2\\].","60 Years",{"count":126,"type":23},96,[61],"Post-induction hypotension (PIH) is a common and critical complication during general anesthesia, particularly in frail elderly patients whose physiological reserves are significantly diminished. PIH is strongly associated with adverse postoperative outcomes, including acute kidney injury (AKI) and myocardial injury. Propofol is the most widely used induction agent but frequently induces circulatory depression. Ciprofol, a novel anesthetic agent developed by optimizing the molecular structure of propofol, has demonstrated improved hemodynamic stability and fewer adverse effects in general populations. However, its specific impact on frail elderly patients remains unestablished.\n\nThe primary purpose of this single-center, randomized, double-blind, controlled trial is to compare the effects of propofol and ciprofol during anesthesia induction on the incidence of PIH in frail elderly patients undergoing major abdominal surgery. The investigator's hypothesis is that ciprofol will significantly lower the incidence of PIH compared to propofol. Additionally, the study will evaluate secondary clinical outcomes, such as postoperative AKI, postoperative cardiac complications, and the overall quality of recovery, to provide an evidence-based clinical guide for selecting optimal induction agents for this vulnerable patient population.",[27],[131,132,133,134],"Propofol","Ciprofol","Anesthesia Induction","Frail Elderly","2026-06-17",{"date":137,"type":39},"2026-06-23",{"date":36,"type":23},{"date":140,"type":23},"2027-01-31",{"name":142,"class":46},"General Hospital of Ningxia Medical University",{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":12,"sex":55,"minAge":19,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":153,"conditions":154,"keywords":155,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":167,"locationsCount":87},"100643702","early-prediction-of-icu-hypotension-using-machine-learning-100643702","NCT07627607","Early Prediction of ICU Hypotension Using Machine Learning","A Prospective Observational Machine Learning Study for the Early Prediction of Hypotension in Adult Intensive Care Unit Patients","ICU-HypoAI","Inclusion Criteria:\n\n* Age 18 years or older\n* Admission to the adult intensive care unit during the study period\n* Length of stay in the intensive care unit of at least 24 hours\n* Availability of routine intensive care unit monitoring data\n* Availability of non-invasive blood pressure and heart rate measurements recorded during ICU monitoring\n* Availability of medication-dose and\u002For fluid-balance records during ICU monitoring\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Length of stay in the intensive care unit of less than 24 hours\n* Absence of usable blood pressure monitoring data\n* Records with irrecoverable timestamp inconsistencies\n* Insufficient monitoring duration for feature construction and future outcome labeling",{"count":152,"type":23},100,"This prospective observational study aims to develop and internally validate a machine learning model for the early prediction of hypotension in adult intensive care unit patients. The model will use routinely collected non-invasive vital signs, heart rate, medication-dose records, and fluid-balance data recorded during standard ICU care. No intervention will be assigned by the study, and patient management will not be changed according to the model output. The primary aim is to predict hypotension 30 minutes before its occurrence; shorter 5- and 15-minute prediction horizons will also be evaluated.",[27],[156,157,158,159,105,160],"Intensive Care Unit","Machine Learning","Artificial Intelligence","Non-Invasive Blood Pressure","Prediction Model","2026-06-04",{"date":163,"type":39},"2026-06-08",{"date":165,"type":39},"2026-03-15",{"date":112,"type":23},{"name":168,"class":46},"Kutahya Health Sciences University",{"id":170,"slug":171,"hasResults":12,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":12,"sex":55,"minAge":19,"maxAge":4,"enrollmentInfo":177,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":179,"conditions":180,"keywords":182,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":87},"100639926","predictors-of-clinically-relevant-hypotension-and-hypoxemia-during-propofol-based-diagnostic-gastrointestinal-endoscopy-100639926","NCT07613073","Predictors of Clinically Relevant Hypotension and Hypoxemia During Propofol-Based Diagnostic Gastrointestinal Endoscopy","Independent Predictors of Clinically Relevant Hypotension and Hypoxemia During During Propofol-Based Diagnostic Gastrointestinal Endoscopy: A Prospective Cohort Study","PRO-GI SAFE","Inclusion Criteria:\n\n* Age 18 years or older\n* Scheduled for diagnostic esophagogastroduodenoscopy, diagnostic colonoscopy, or combined diagnostic upper and lower gastrointestinal endoscopy\n* Planned use of propofol as the primary sedative\u002Fanesthetic agent for diagnostic gastrointestinal endoscopy\n* American Society of Anesthesiologists physical status I to III\n* Able to provide informed consent or has legally authorized representative consent according to local regulations\n\nExclusion Criteria:\n\n* Therapeutic or interventional gastrointestinal endoscopy, including ERCP, EUS-guided intervention, EMR, ESD, endoscopic hemostasis, or polypectomy\n* Planned sedation\u002Fanesthesia without propofol as the primary sedative\u002Fanesthetic agent\n* Known allergy or contraindication to propofol\n* Pregnancy or suspected pregnancy\n* Emergency condition requiring immediate advanced airway control before the procedure\n* Inability to obtain essential baseline or outcome data required for the study",{"count":178,"type":23},1000,"This prospective observational cohort study will evaluate the incidence and independent predictors of clinically relevant hypotension and hypoxemia during propofol-based diagnostic gastrointestinal endoscopy in adult patients at a tertiary referral hospital in Vietnam. Participants undergoing diagnostic upper gastrointestinal endoscopy, colonoscopy, or combined diagnostic procedures with propofol administration will be followed from pre-procedure assessment through the early recovery period. The study will assess demographic, clinical, airway, procedural, and sedation-related variables associated with clinically relevant cardiopulmonary adverse events.",[27,181],"Hypoxemia",[183,184,185,186,187,188,189,190],"Propofol sedation","Gastrointestinal endoscopy","Colonoscopy","Upper gastrointestinal endoscopy","Oxygen desaturation","Hemodynamic instability","Prospective cohort","Procedural sedation","2026-05-21",{"date":193,"type":39},"2026-05-29",{"date":195,"type":23},"2026-05-15",{"date":197,"type":23},"2026-10-30",{"name":199,"class":46},"Bach Mai Hospital",{"id":201,"slug":202,"hasResults":12,"nctId":203,"briefTitle":204,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":12,"sex":55,"minAge":19,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":59,"phases":209,"briefSummary":210,"conditions":211,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":214,"startDateStruct":216,"completionDateStruct":218,"leadSponsor":219,"locationsCount":87},"100432417","feasibility-of-using-the-cgm-guardian-2-interstitial-fluid-glucose-measurement-system-in-intensive-care-medicine-100432417","NCT04910841","Feasibility of Using the \"CGM GUARDIAN 2\" Interstitial Fluid Glucose Measurement System in Intensive Care Medicine","GALI","Inclusion Criteria:\n\n* Patient in septic shock\n* Arterial hypotension requiring noradrenaline\n* Hyperglycaemia requiring insulin therapy\n\nExclusion Criteria:\n\n* Patients under guardianship, curatorship or deprived of liberty\n* Pregnant or breastfeeding women",{"count":208,"type":23},55,[61],"Glycemic imbalances are very common in shock patients admitted to intensive care units. A blood glucose control every 2 hours is routinely performed in patients requiring insulin therapy. In practice, we use a protocol and management software called \"CPG\" (Personalized Control of Blood Glucose). This involves taking capillary samples from the fingertips. In addition to the pain generated, local haematomas and sensitivity disorders have been described. Night-time sampling also leads to repeated awakenings. The \"CGM GUARDIAN 2\" system has been validated for the measurement of glucose in interstitial fluid in insulin-dependent diabetic patients. An electrode is placed on the patient's abdomen or arm for up to 6 days. This electrode consists of a needle that is inserted subcutaneously only during the placement. The sugar level is read using a sensor placed on the electrode and an insulin pump (which will not deliver therapy (for our study) and which will be used only as an information reader to know the glucose level and trends). Interstitial fluid is automatically drawn from the electrode every minute and averaged every 5 minutes.\n\nThis device has not yet been validated in resuscitation patients.",[212,27,213],"Hyperglycemia","Shock, Septic",{"date":215,"type":39},"2026-05-22",{"date":217,"type":39},"2023-09-11",{"date":82,"type":23},{"name":220,"class":46},"Centre Hospitalier Universitaire de Nice",{"id":222,"slug":223,"hasResults":12,"nctId":224,"briefTitle":225,"officialTitle":226,"acronym":227,"eligibilityCriteria":228,"healthyVolunteers":12,"sex":55,"minAge":19,"maxAge":4,"enrollmentInfo":229,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":231,"conditions":232,"keywords":237,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":87},"100640925","peripheral-pulse-assessment-and-arterial-pressure-pulsar-100640925","NCT07609095","Peripheral pULSe Assessment and Arterial pRessure (PULSAR)","Association Between Palpable Peripheral Pulses and Arterial Blood Pressure in Patients With Circulatory Shock: An International Prospective Multicenter Observational Cohort Study","PULSAR","Inclusion Criteria:\n\n* Clinical signs of circulatory shock or impending circulatory failure\n* Availability of non-invasive and\u002For invasive arterial blood pressure monitoring\n* Pulse palpation possible without interfering with emergency care\n\nExclusion Criteria:\n\n* Peripheral vascular conditions preventing reliable pulse palpation\n* Major extremity amputation affecting assessment sites\n* Clinical situations where study procedures interfere with life-saving treatment",{"count":230,"type":23},5000,"This prospective multicenter observational study aims to investigate the relationship between palpable peripheral pulses and simultaneously measured arterial blood pressure in adult patients with circulatory shock or impending circulatory failure. Peripheral pulse palpation is routinely used in emergency medicine, trauma care, critical care, and cardiopulmonary resuscitation as a rapid clinical assessment of circulation. However, the association between palpable pulses and actual arterial blood pressure remains poorly validated.\n\nPatients treated in emergency departments, intensive care units, operating rooms, and other acute care settings will undergo routine pulse palpation at predefined anatomical locations including carotid, femoral, and radial arteries. Simultaneously measured non-invasive and\u002For invasive arterial blood pressure values will be recorded from routine clinical monitoring systems. Additional clinical variables relevant to circulatory status will also be collected.\n\nThe study seeks to define blood pressure thresholds associated with pulse palpability and evaluate the agreement between invasive and non-invasive blood pressure measurements in patients with circulatory shock.",[233,234,27,235,236],"Circulatory Shock","Hemodynamic Instability","Shock","Critical Illness",[233,105,238,239,240,27,241,242,243,234],"Pulse Palpation","Peripheral Pulse","Arterial Blood Pressure","Critical Care","Trauma","Resuscitation","2026-05-19",{"date":246,"type":39},"2026-05-27",{"date":248,"type":23},"2026-06-01",{"date":250,"type":23},"2031-12-31",{"name":252,"class":253},"Region Stockholm","OTHER_GOV",{"id":255,"slug":256,"hasResults":12,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":12,"sex":55,"minAge":19,"maxAge":4,"enrollmentInfo":262,"targetDuration":4,"studyType":59,"phases":264,"briefSummary":267,"conditions":268,"keywords":271,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":279,"leadSponsor":281,"locationsCount":4},"100547252","phase-2-midodrine-in-heart-failure-with-reduced-ejection-fraction-with-hypotension-100547252","NCT06405555","Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension","Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension: A Pilot, Open-label, Randomized Controlled Trial","MIDOH-HF-P","Inclusion Criteria:\n\n* Adults \\>= 18 years of age.\n* LVEF \\\u003C= 40 % within the last 3 months as determined by any one of: Transthoracic echocardiogram, transesophageal echocardiogram, cardiac magnetic resonance imaging, MUGA scan, angiogram with left ventriculogram.\n* AHA\u002FACC Stage B or C Heart Failure\n* Hospitalized patients in the ward setting OR in the cardiac intensive care unit (who are \\>= 48 hours after their last dose of vasopressor or inotrope).\n* Seated upright or supine SBP \\\u003C= 100 mmHg on two or more consecutive BP measurements separated by at least 8 hours\n\nExclusion Criteria:\n\n* Patient OR substitute decision-maker (SDM) unwilling or unable to provide informed consent\n* Documented allergy or intolerance to midodrine\n* Treatment for active infection (either documented infection or empiric treatment) with antimicrobials at the time of recruitment.\n* Current use OR any use within the last 48 hours of an intravenous inotrope or vasopressor medication OR the need for IV inotrope or vasoproessor use to treat hypotension\n* Patient within 72 hours of an acute coronary syndrome.\n* Heart transplant recipient.\n* Presence of temporary or durable mechanical circulatory support device.\n* Severe valvular disease expected to be intervened upon during the incident hospitalization.\n* Hyperkalemia \\>= 5.5 mmol\u002FL.\n* Baseline eGFR (as calculated by the CKD-EPI method) \\\u003C= 20 mL\u002Fmin\u002F1.73 m2 as measured within the last 3 months.\n* A treatable cause for hypotension, including but not limited to: hypovolemia (eg. Bleeding, overdiuresis, poor oral intake), obstructive shock, sepsis, adrenal insufficiency.\n* Clinical diagnosis of ongoing cardiogenic shock, or diagnosed as defined in SHOCK trial: sBP \\\u003C= 90 mmHg with evidence of end-organ hypoperfusion (cool extremities, urine output \\\u003C 30 mL\u002Fhr, HR \\> 60 bpm, or elevated lactate \\>=3.5 mmol\u002FL), invasive hemodynamic measurements (if available) of CI \\\u003C= 2.2 L\u002Fmin\u002Fm2 and a pulmonary capillary wedge pressure (PCWP) of \\>=15 mmHg.\n* Pregnant patient.\n* Anticipated patient discharge in less than two days from enrolment (ie. less than 6 anticipated doses of midodrine, if randomized to treatment\u002Fintervention arm).\n* Acute brain pathology (including, but not limited to intracranial hemorrhage or hematoma) in which most-responsible clinician deems it unsafe to augment blood pressure.\n* Untreated thyrotoxicosis\n* Acute or acute on chronic liver failure\n* Patient unable to take oral medications\n* Bradycardia with resting heart rate less than 50 beats per minute.\n* Patients on an equivalent dose of Lasix \\>= 80 mg IV BID",{"count":263,"type":23},56,[265,266],"PHASE2","PHASE3","The evidence-based pharmacologic treatments available for patients with heart failure with reduced ejection fraction (HFrEF) has been established over the last few decades of cardiovascular research. These treatments, termed Foundational Guideline-Directed-Medical Therapies (GDMT), prolong patient life, improve patient-reported symptoms, and reduce hospitalizations for heart failure. A direct effect of most medication classes encompassed within GDMT is the reduction in blood pressure due to their mechanisms of action. In addition, as patients with HFrEF become more advanced in their disease, a significant proportion develop hypotension related to pump failure and autonomic dysfunction, amongst other possible mechanisms. As a result, a significant proportion of HFrEF patients are not optimized on GDMT with hypotension as their limiting barrier that would otherwise have served to improve their heart function, heart failure symptoms, and mortality. Currently, there does not exist any evidence-based strategies to address the problem of hypotension in HFrEF patients who are not optimized on GDMT.\n\nMidodrine is an alpha-adrenergic agonist (α1-AR) that exerts its effects on peripheral venous and arteriolar vasculature to increase blood pressure. This medication has been used off-label by some clinicians in the hypotensive HFrEF population to increase blood pressure and has been reported to have beneficial effects in improving GDMT utilization as well as increasing left ventricular ejection fraction (LVEF) in published case reports\u002Fcase series. There does not exist any randomized prospective data on the use of midodrine in the hypotensive HFrEF population. The investigators' objective is to complete the first open-label, randomized control trial of midodrine in the hypotensive HFrEF population to demonstrate feasibility in performing a trial in this patient population and to show efficacy in increasing blood pressure without associated harm. The results of this trial will be used as the foundation and rationale for future studies assessing the impact of midodrine use on GDMT utilization as well as hard cardiovascular outcomes in the hypotensive HFrEF population, including hospitalizations for heart failure and mortality.",[269,27,270],"Heart Failure With Reduced Ejection Fraction","LV Dysfunction",[272,273,274],"Heart Failure","GDMT","Midodrine","2026-04-29",{"date":277,"type":39},"2026-04-30",{"date":248,"type":23},{"date":280,"type":23},"2028-06-01",{"name":282,"class":46},"Ottawa Heart Institute Research Corporation",{"id":284,"slug":285,"hasResults":12,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":289,"eligibilityCriteria":290,"healthyVolunteers":12,"sex":55,"minAge":19,"maxAge":291,"enrollmentInfo":292,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":294,"conditions":295,"keywords":298,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":87},"100636387","internal-jugular-vein-collapsibility-index-for-predicting-post-induction-hypotension-100636387","NCT07565025","Internal Jugular Vein Collapsibility Index for Predicting Post-Induction Hypotension","The Value of Internal Jugular Vein Collapsibility Index in Predicting Hypotension Following General Anesthesia Induction in Patients Undergoing Elective Laparoscopic Cholecystectomy","IJV-CI","Inclusion Criteria:\n\n* Patients aged 18-65 years.\n* Patients with ASA (American Society of Anesthesiologists) physical status I, II, or III.\n* Patients scheduled to receive general anesthesia.\n* Patients scheduled for elective laparoscopic cholecystectomy.\n\nExclusion Criteria:\n\n* Patients with obesity (Body Mass Index \\> 35 kg\u002Fm²).\n* Patients with Atrial Fibrillation or other serious cardiac arrhythmias.\n* Patients with a history of neck surgery or any pathology preventing Internal Jugular Vein (IJV) measurement.\n* Patients with advanced heart failure (Ejection Fraction \\\u003C 40%).\n* Patients with severe valvular heart disease.\n* Patients with peripheral vascular disease.\n* Patients undergoing emergency surgery.\n* Patients who are unwilling to participate in the study.","65 Years",{"count":293,"type":23},42,"This study aims to investigate whether the Internal Jugular Vein Collapsibility Index (IJV-CI), measured via ultrasonography, can predict hypotension (low blood pressure) that occurs after the induction of general anesthesia. Researchers will measure the diameter of the internal jugular vein in patients before surgery and compare these measurements with the blood pressure changes during the first minutes of anesthesia. The goal is to determine if IJV-CI can be used as a reliable, non-invasive tool to identify patients at higher risk of developing anesthesia-induced hypotension.",[27,296,297],"Anesthesia, General","Cholecystectomy, Laparoscopic",[299,300,289,301,302,133,303,304],"Internal Jugular Vein","Collapsibility Index","Ultrasonography","Post-induction Hypotension","Laparoscopic Cholecystectomy","Fluid Responsiveness","2026-04-27",{"date":307,"type":39},"2026-05-04",{"date":309,"type":23},"2026-05-01",{"date":311,"type":23},"2027-02",{"name":313,"class":46},"University of Gaziantep",{"id":315,"slug":316,"hasResults":12,"nctId":317,"briefTitle":318,"officialTitle":319,"acronym":320,"eligibilityCriteria":321,"healthyVolunteers":12,"sex":55,"minAge":4,"maxAge":322,"enrollmentInfo":323,"targetDuration":4,"studyType":59,"phases":325,"briefSummary":327,"conditions":328,"keywords":332,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":87},"100503542","phase-4-hydrocortisone-therapy-optimization-during-hypothermia-treatment-in-asphyxiated-neonates-100503542","NCT05836610","Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates","Hydrocortisone Therapy Optimization During Hypothermia Treatment in Asphyxiated Neonates - a Pharmacokinetic Study","UniCort","Inclusion Criteria:\n\n* gestational age ≥ 36 weeks\n* provision of whole-body hypothermia treatment (as described by Azzopardi et al.)\n* presence of systemic hypotension (defined as a mean arterial pressure less than the gestational age in weeks)\n* indication for hydrocortisone treatment during hypothermia by the attending physician\n* indwelling arterial catheter to take blood samples without additional painful punctures: umbilical arterial catheter or peripheral arterial catheter\n* written informed parental consent\n\nExclusion Criteria:\n\n* infants who are expected to be \\> 6 hours of age (not suitable for cooling)\n* critical congenital abnormalities\n* genetic disease\n* signed informed consent is unavailable","72 Hours",{"count":324,"type":23},50,[326],"PHASE4","This is a prospective, single center, pharmacokinetic study of intravenous hydrocortisone therapy for systemic low blood pressure during hypothermia treatment in asphyxiated newborns. Patients will be allocated to hydrocortisone supplementation while receiving conventional inotropic therapy as needed.\n\nThe hypothesis is that a detailed study of hydrocortisone pharmacokinetics during therapeutic hypothermia would help to personalize steroid supplementation in asphyxiated neonates. As the overall metabolic rate decreases with lower body temperature, drug metabolism is likely to be reduced as well, and lower doses, or less frequent dosing will be sufficient to achieve the targeted steroid range and biological effects in asphyxiated neonates with relative adrenal insufficiency. Thus, the investigators are planning to measure initial, baseline serum cortisol levels and serial serum cortisol levels after hydrocortisone supplementation in cooled asphyxiated neonates.",[329,330,27,331],"Hypoxic-Ischemic Encephalopathy","Asphyxia","Circulatory Failure Neonatal",[333,334,335,336,329,330],"Hypothermia treatment","Relative adrenal insufficiency","Hydrocortisone supplementation","Hydrocortisone pharmacokinetics","2026-04-23",{"date":339,"type":39},"2026-04-28",{"date":341,"type":39},"2021-09-21",{"date":343,"type":23},"2027-09",{"name":345,"class":46},"Semmelweis University",{"id":347,"slug":348,"hasResults":12,"nctId":349,"briefTitle":350,"officialTitle":350,"acronym":4,"eligibilityCriteria":351,"healthyVolunteers":17,"sex":18,"minAge":95,"maxAge":352,"enrollmentInfo":353,"targetDuration":4,"studyType":59,"phases":355,"briefSummary":356,"conditions":357,"keywords":358,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":87},"100366608","effects-of-ephedrine-phenylephrine-norepinephrine-and-vasopressin-on-contractility-of-human-myometrium-and-umbilical-vessels-an-in-vitro-study-100366608","NCT04053478","Effects of Ephedrine, Phenylephrine, Norepinephrine and Vasopressin on Contractility of Human Myometrium and Umbilical Vessels: An In-vitro Study","Inclusion Criteria:\n\n* Patients who give written consent to participate in this study\n* Patients with gestational age 37-41 weeks\n* Patients of 19-40 years\n* Non-laboring patients, not exposed to exogenous oxytocin\n* Patients requiring elective primary or first repeat caesarean delivery\n* Patients undergoing caesarean delivery under spinal anesthesia\n\nExclusion Criteria:\n\n* Patients who refuse to give written informed consent\n* Patients who require general anesthesia\n* Patients in labor and those receiving oxytocin for induction of labor\n* Emergency caesarean delivery in labor\n* Patients who have had previous uterine surgery or \\>1 previous caesarean delivery\n* Patients with any condition predisposing to uterine atony\n* Patients on medications that could affect myometrial contractility, such as insulin, nifedipine, labetolol or magnesium sulfate.","40 Years",{"count":354,"type":23},144,[61],"Hypotension is one of the most common adverse effects of spinal anesthesia for cesarean deliveries, affecting as many as 55-90% of mothers. Hypotension during cesarean deliveries can have detrimental effects on the mother and neonate. Various vasopressors, such as ephedrine, phenylephrine and more recently norepinephrine, have been used for the prevention and treatment of hypotension at cesarean deliveries.\n\nEphedrine was historically considered as the gold standard vasopressor for the management of hypotension during cesarean deliveries. This was based on studies in animal models that showed preserved uteroplacental circulation with ephedrine and not with phenylephrine. However, multiple studies in the past several decades have shown that phenylephrine compared with ephedrine results in a more favorable fetal acid-base status. Consequently, the use of phenylephrine for blood pressure management during cesarean deliveries increased. Recently, norepinephrine was introduced in the obstetrical practice for the management of hypotension at cesarean deliveries, due to its ability to maintain maternal cardiac output better than phenylephrine.\n\nStudies have also investigated the use of vasopressin to limit hypotension during CD. There have been case reports of successful vasopressin usage to treat post-spinal hypotension after CD in patients with advanced idiopathic pulmonary arterial hypertension as well as severe mitral stenosis with pulmonary hypertension. Its effect was associated with hemodynamic stability without evidence of harm to the mother or child. However, much controversy still exists surrounding the choice of vasopressor in the obstetric population, in large part due to their varying efficacies, and maternal and fetal effects.\n\nVasopressors used for the treatment of hypotension during cesarean deliveries can have significant direct or indirect effects on the perfusion of uteroplacental and umbilical vessels. Reduction of uteroplacental perfusion and constriction of umbilical vessels can result in fetal acidosis, however, the mechanisms for these effects are unclear. The investigators hypothesize that ephedrine, phenylephrine and norepinephrine and vasopressin have variable effects on the contractility of pregnant myometrium and umbilical arteries due to their variable actions on adrenergic alpha (α) and beta (β) receptors, as well as vasopressin1 and vasopressin2 receptors located in these tissues.",[27],[359,360,361,362,363,364,365,366],"vasopressor","ephedrine","phenylephrine","norepinephrine","umbilical arteries","uterine contraction","fetal acidosis","vasopressin","2026-03-31",{"date":369,"type":39},"2026-04-06",{"date":371,"type":39},"2019-07-08",{"date":373,"type":23},"2026-12",{"name":375,"class":46},"Samuel Lunenfeld Research Institute, Mount Sinai Hospital",{"id":377,"slug":378,"hasResults":12,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":382,"eligibilityCriteria":383,"healthyVolunteers":12,"sex":18,"minAge":384,"maxAge":385,"enrollmentInfo":386,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":388,"conditions":389,"keywords":390,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":87},"100631382","predicting-spinal-hypotension-in-cesarean-section-100631382","NCT07499947","Predicting Spinal Hypotension in Cesarean Section","The Value of Waist Circumference, Body Mass Index, and Modified Shock Index in Predicting Spinal Anesthesia-Induced Hypotension During Cesarean Section: A Prospective Observational Study","prediction","Inclusion Criteria:\n\n1. American Society of Anesthesiologists (ASA) Class II\n2. Having regular antenatal visits\n3. Singleton pregnancy at ≥37 weeks of gestation\n4. Pregnant women aged 18-45 -\n\nExclusion Criteria:\n\n1. Those with eclampsia, those with preeclampsia\n2. Undergoing an emergency cesarean section\n3. Those with bleeding diathesis and those receiving anticoagulant therapy\n4. With a history of carotid artery stenosis,\n5. Cardiovascular disease,\n6. Hypertension,\n7. Chronic obstructive pulmonary disease,\n8. Heart rhythm outside of sinus\n9. Patients with a history of cerebrovascular disease\n10. Alcoholism or psychiatric illness\n11. Placenta previa, accreta, and percreta","18 Months","45 Months",{"count":387,"type":23},321,"This prospective observational study investigates the predictive value of anthropometric and hemodynamic indices for spinal anesthesia-induced hypotension (SAIH) during cesarean section. While spinal anesthesia is preferred for its rapid onset, SAIH remains a frequent complication risking maternal and fetal safety. The study enrolled parturients at Erciyes University, excluding those with hypertension or extreme weight\u002Fheight. Preoperative measurements included BMI, waist circumference (WC), body roundness index (BRI), and modified shock index (MSI). Following standardized spinal anesthesia with hyperbaric bupivacaine (Harten's dosage), hemodynamic parameters and sensory block levels were monitored. This research aims to determine whether BRI and WC offer superior predictive utility compared with conventional markers such as BMI and MSI to enhance individualized risk assessment in obstetric anesthesia.",[28,33,27],[391,392,393,27],"Bupivacaine","Cesarean","Spinal anesthesia","2026-03-30",{"date":367,"type":39},{"date":397,"type":39},"2026-03-16",{"date":399,"type":23},"2026-11-30",{"name":401,"class":46},"TC Erciyes University",{"id":403,"slug":404,"hasResults":12,"nctId":405,"briefTitle":406,"officialTitle":407,"acronym":408,"eligibilityCriteria":409,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":410,"targetDuration":4,"studyType":59,"phases":412,"briefSummary":413,"conditions":414,"keywords":416,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":433,"completionDateStruct":435,"leadSponsor":437,"locationsCount":87},"100630998","effect-of-pre-spinal-mindfulness-based-breathing-exercise-on-hemodynamic-response-in-elective-cesarean-section-100630998","NCT07494955","\"Effect of Pre-Spinal Mindfulness-Based Breathing Exercise on Hemodynamic Response in Elective Cesarean Section\"","\"The Effect of a 5-Minute Mindfulness-Based Breathing Exercise Administered Prior to Spinal Anesthesia on Hemodynamic Response in Patients Undergoing Elective Cesarean Section: A Prospective Randomized Controlled Trial\"","BREATHE-CS","Inclusion Criteria:\n\nPregnant women aged 18-45 years Singleton pregnancy Gestational age 37 weeks or greater American Society of Anesthesiologists (ASA) physical status classification II Scheduled for elective cesarean section under spinal anesthesia Body mass index (BMI) 35 kg\u002Fm2 or less Ability to comprehend verbal instructions and perform the breathing exercise Provision of written informed consent\n\nExclusion Criteria:\n\nEmergency cesarean section Hypertensive disorders of pregnancy (gestational hypertension, preeclampsia, eclampsia, HELLP syndrome) Placenta previa, placental abruption, or active antepartum hemorrhage Multiple pregnancy Contraindications to spinal anesthesia Failed spinal anesthesia requiring conversion to general anesthesia Chronic hypertension or chronic hypotension Known cardiac disease (arrhythmia, valvular disease, cardiomyopathy) Diabetes mellitus with autonomic neuropathy Thyroid dysfunction Chronic pulmonary disease potentially affecting respiratory pattern Body mass index greater than 35 kg\u002Fm2 Regular use of beta-blockers, calcium channel blockers, alpha-agonists, or alpha-antagonists Regular use of anxiolytics, antidepressants, sedatives, or chronic opioids Diagnosed anxiety disorder, panic disorder, major depressive disorder, or other psychiatric illness Regular use of psychiatric medications Cognitive impairment or communication difficulties Attention or compliance problems precluding adequate performance of the breathing exercise Prior regular practice of meditation, yoga, or mindfulness-based training",{"count":411,"type":23},150,[61],"Spinal anesthesia-induced hypotension is one of the most frequent and clinically significant complications of obstetric anesthesia, occurring in up to 50-80% of parturients undergoing elective cesarean section. Preoperative anxiety has been shown to potentiate hemodynamic instability through autonomic nervous system activation, thereby increasing susceptibility to spinal hypotension.\n\nThis prospective, randomized, controlled trial aims to evaluate the effect of a standardized 5-minute mindfulness-based breathing exercise administered immediately prior to spinal anesthesia on the hemodynamic response in pregnant women scheduled for elective cesarean section. Eligible participants will be randomized in a 1:1 ratio into two parallel groups: the Mindfulness-Based Breathing Exercise Group and the Control Group receiving standard preoperative care.\n\nThe breathing intervention consists of slow diaphragmatic breathing at a rate of approximately 6 breaths per minute (4-second inhalation through the nose, 6-second exhalation through the mouth), guided by a standardized script delivered by a trained anesthesiologist or nurse. Participants in the intervention group will be instructed to silently repeat the phrase \"My body is relaxing as I exhale\" with each exhalation, incorporating a mindfulness component.\n\nThe primary outcome is the maximum decrease in systolic arterial pressure (SAP) within the first 10 minutes following spinal anesthesia induction. Secondary outcomes include preoperative state anxiety scores (STAI-5), early spinal hypotension incidence, heart rate changes, and vasopressor requirements.\n\nThe study will be conducted at Atatürk University Faculty of Medicine, Department of Anesthesiology and Reanimation, Erzurum, Turkey, in accordance with the Declaration of Helsinki and Good Clinical Practice guidelines.",[27,33,234,415],"Anxiety, Anticipatory",[393,27,417,418,419,420,421,422,423,424,425,426,427,428,429],"Cesarean section","Mindfulness","Breathing exercise","Hemodynamic response","Preoperative anxiety","Autonomic nervous system","Obstetric anesthesia","Vasopressor","Systolic blood pressure","Heart rate variability","Non-pharmacological intervention","Randomized controlled trial","Baroreflex sensitivity","2026-03-27",{"date":432,"type":39},"2026-04-01",{"date":434,"type":39},"2026-03-01",{"date":436,"type":23},"2028-03-01",{"name":438,"class":46},"Aysenur Dostbil",{"id":440,"slug":441,"hasResults":12,"nctId":442,"briefTitle":443,"officialTitle":443,"acronym":4,"eligibilityCriteria":444,"healthyVolunteers":12,"sex":55,"minAge":19,"maxAge":4,"enrollmentInfo":445,"targetDuration":4,"studyType":59,"phases":447,"briefSummary":448,"conditions":449,"keywords":452,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":458,"startDateStruct":459,"completionDateStruct":461,"leadSponsor":463,"locationsCount":87},"100589344","intraoperative-hypotension-in-pancreatoduodenectomy-a-randomized-trial-of-general-versus-combined-anesthesia-100589344","NCT06953193","Intraoperative Hypotension in Pancreatoduodenectomy: A Randomized Trial of General Versus Combined Anesthesia","Inclusion Criteria:\n\n* Signed written informed consent.\n* Patients scheduled for elective pancreatoduodenectomy at National Institute of Medical Sciences and Nutrition Salvador Zubirán.\n* No contraindications for neuroaxial anesthesia (epidural catheter placement), including:\n\n  * Generalized or localized infection at the puncture site.\n  * Thrombocytopenia.\n  * Coagulation disorders.\n  * Intracranial hypertension.\n  * Patient refusal.\n\nExclusion Criteria:\n\n* Age under 18 years.\n* Pregnancy.\n* Inability to randomize the case due to specific circumstances (such as contraindications to epidural use), resulting in non-eligibility based on participation criteria.",{"count":446,"type":23},206,[61],"This randomized clinical trial compares the hemodynamic effects of general anesthesia versus combined general anesthesia (thoracic epidural) in patients undergoing pancreatoduodenectomy. The primary aim is to assess the incidence of intraoperative hypotension and related adverse events. Secondary outcomes includes vasopressor requirements, transfusion needs, postoperative complications, intensive care unit admission, hospital length of stay, and mortality.",[450,27,451],"Pancreatic Neoplasms","Pancreatoduodenectomy",[453,454,455,456,101,457],"Pancreatic Surgery","General Anesthesia","Hemodynamic Changes","Vasopressors","Combined Anesthesia",{"date":432,"type":39},{"date":460,"type":39},"2025-04-07",{"date":462,"type":23},"2030-04-30",{"name":464,"class":46},"Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran",{"id":466,"slug":467,"hasResults":12,"nctId":468,"briefTitle":469,"officialTitle":470,"acronym":4,"eligibilityCriteria":471,"healthyVolunteers":12,"sex":55,"minAge":291,"maxAge":4,"enrollmentInfo":472,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":474,"conditions":475,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":478,"lastUpdatePostDateStruct":479,"startDateStruct":481,"completionDateStruct":483,"leadSponsor":484,"locationsCount":87},"100629990","skin-conductance-for-predicting-spinal-anesthesia-induced-hypotension-in-geriatric-urologic-oncology-patients-100629990","NCT07481851","Skin Conductance for Predicting Spinal Anesthesia-Induced Hypotension in Geriatric Urologic Oncology Patients","Skin Conductance as a Predictor of Spinal Anesthesia-Induced Hypotension in Geriatric Oncology Patients","Inclusion Criteria:\n\n* Patients aged 65 years and older\n* Patients scheduled for elective urologic oncology surgery under spinal anesthesia\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Patients who provide written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Refusal to participate or inability to provide informed consent\n* Contraindication to spinal anesthesia (e.g., infection at puncture site, coagulopathy)\n* Severe cardiac conduction abnormalities or presence of a cardiac pacemaker\n* Severe autonomic dysfunction or known neuropathy affecting autonomic responses\n* Use of medications that significantly affect autonomic nervous system activity\n* Baseline hypotension or hemodynamic instability before spinal anesthesia\n* Inability to obtain reliable skin conductance measurements (e.g., severe skin lesions at electrode placement site)",{"count":473,"type":23},102,"Spinal anesthesia-induced hypotension is a common and clinically significant complication in elderly patients undergoing oncologic surgery. Early identification of patients at risk for hemodynamic instability remains a major challenge in perioperative management. Skin conductance reflects sympathetic nervous system activity and may provide a noninvasive indicator of autonomic responses. This prospective observational study aims to evaluate whether skin conductance measurements can predict the development of hypotension following spinal anesthesia in geriatric oncology patients undergoing urologic surgery. The findings may contribute to improved perioperative monitoring and early risk stratification in this vulnerable patient population.",[27,476,477,28],"Urologic Neoplasms","Aged","2026-03-23",{"date":480,"type":39},"2026-03-25",{"date":482,"type":39},"2025-12-22",{"date":309,"type":23},{"name":485,"class":46},"Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital",{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":491,"acronym":492,"eligibilityCriteria":493,"healthyVolunteers":12,"sex":55,"minAge":19,"maxAge":56,"enrollmentInfo":494,"targetDuration":4,"studyType":59,"phases":496,"briefSummary":497,"conditions":498,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":499,"lastUpdatePostDateStruct":500,"startDateStruct":502,"completionDateStruct":504,"leadSponsor":506,"locationsCount":87},"100522540","phase-2-vasopressor-impact-on-brain-circulation-organ-blood-flow-and-tissue-oxygenation-during-anesthesia-100522540","NCT06083948","Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia","Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia in Neurosurgical Patients","IMPACT","Inclusion Criteria:\n\n1. Clinical diagnosis of supratentorial malignant or non-malignant brain tumors. Preferably 3 cm or larger( measured as the largest diameter in any plane on MRI).\n2. Scheduled for elective supratentorial craniotomy.\n3. Patients aged between 18 and 75 years.\n4. American Society of Anesthesiologists status 1-3\n\nExclusion Criteria:\n\n1. History of allergy or intolerance to one of the study medications.\n2. Active treatment with monoamine oxidase inhibitors.\n3. An American Society of Anesthesiologists (ASA)physical status IV-VI.\n4. Pregnancy or breastfeeding.\n5. Inability to provide written informed consent -",{"count":495,"type":23},32,[265,266],"The optimal vasopressor for ensuring organ blood flow and tissue oxygen delivery during surgery remains undetermined. This study aim to compare the effects of noradrenaline vs. phenylephrine infusion on blood flow and oxygen delivery to the brain and various other organs in anesthetized neurosurgical patients.",[27],"2026-03-18",{"date":501,"type":39},"2026-03-19",{"date":503,"type":39},"2023-12-20",{"date":505,"type":23},"2027-12-31",{"name":507,"class":46},"University of Aarhus",{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":514,"eligibilityCriteria":515,"healthyVolunteers":12,"sex":55,"minAge":291,"maxAge":4,"enrollmentInfo":516,"targetDuration":4,"studyType":59,"phases":518,"briefSummary":519,"conditions":520,"keywords":522,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":527,"startDateStruct":529,"completionDateStruct":530,"leadSponsor":532,"locationsCount":4},"100626252","frequency-of-electrical-acupoint-stimulation-on-hypotension-during-induction-100626252","NCT07433218","Frequency of Electrical Acupoint Stimulation on Hypotension During Induction","The Influence of Electrical Acupoint Stimulation at Different Frequencies on Hemodynamics During Anesthesia Induction","FRESH","Inclusion Criteria:\n\n* aged over 65 yrs old\n* scheduled for surgery under general anesthesia\n\nExclusion Criteria:\n\n* American society of anesthesiologists status over 3\n* severe cardiac or respiratory dysfunction\n* severe cardiac arrhythmia\n* uncontrolled diabetes\n* systolic arterial pressure over 180 mmHg",{"count":517,"type":23},84,[61],"Within 30 minutes before anesthesia, acupoint electrical stimulation at different frequencies were applied at Neiguan and Jian Shi. The changes in blood pressure during the anesthesia induction period were compared between the high-frequency group and the low-frequency group.",[521,27],"Anesthesia",[523,524,525],"transcutaneous electrical acupoint stimulation","frequency","hemodynamic stability","2026-02-20",{"date":528,"type":39},"2026-02-25",{"date":434,"type":23},{"date":531,"type":23},"2026-11-01",{"name":533,"class":46},"Zhihong LU",{"id":535,"slug":536,"hasResults":12,"nctId":537,"briefTitle":538,"officialTitle":539,"acronym":4,"eligibilityCriteria":540,"healthyVolunteers":12,"sex":55,"minAge":19,"maxAge":4,"enrollmentInfo":541,"targetDuration":4,"studyType":59,"phases":543,"briefSummary":544,"conditions":545,"keywords":547,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":550,"lastUpdatePostDateStruct":551,"startDateStruct":553,"completionDateStruct":555,"leadSponsor":557,"locationsCount":87},"100529986","comparing-fluid-responsiveness-assessment-methods-in-patients-with-impaired-consciousness-100529986","NCT06180902","Comparing Fluid Responsiveness Assessment Methods in Patients With Impaired Consciousness","Comparing Fluid Responsiveness Assessment Methods in Patients With Impaired Consciousness: A Comprehensive Crossover Study Examination","Inclusion Criteria:\n\n* Age ≥ 18 years.\n* Hospitalization in an intensive care unit\n* Level of consciousness on the FOUR scale ≤ 12 points\n* Planned infusion therapy\n* Presence of a central venous catheter or direct indication for catheterization\n* The decision of the medical council to include the patient in the study\n\nExclusion Criteria:\n\n* Pulmonary edema\n* Absence of one or both lower extremities\n* Chronic kidney disease according to KDIGO classification ≥ stage 3b\n* Acute kidney injury grade 3\n* Documented or suspected increased intracranial pressure (cerebral edema, brain compression, hydrocephalus, etc.).\n* Presence of mitral valve regurgitation \\> grade 1\n* Presence of aortic valve regurgitation \\> grade 1\n* Patients previously enrolled in the \"COMPASS\" study in the period of 12 preceding hours",{"count":542,"type":23},222,[61],"Hypotension is a significant precursor to unfavorable clinical outcomes. To determine whether infusion therapy can positively impact the management of hypotension, several evaluative tests can be utilized. These include assessing the collapsibility and distensibility indices of the inferior vena cava, conducting a passive leg raising (PLR) test, and performing a fluid challenge (FC).\n\nTechnologically advanced methods leveraging dynamic testing are capable of real-time prediction of a patient's response to infusion therapy. Nonetheless, the use of systolic pressure variability (SPV), pulse pressure variability (PPV), and stroke volume variability (SVV) is often limited by the prohibitive costs of the necessary equipment. In contrast, the PLR test and FC are not subject to this limitation.\n\nDespite being deemed unreliable by numerous clinical protocols, static measurements of central venous pressure (CVP) or pulmonary capillary wedge pressure (PCWP) persist in usage among certain traditionalists within the medical community. It must be noted that the patient's baseline state and the unique clinical context are pivotal in determining the precision of these methodologies. For example, the PLR test may yield limited information in fully conscious patients, and the prognostic value of CVP measurements is significantly diminished in cases of pneumothorax and hydrothorax.\n\nRegrettably, there is a paucity of data on the prognostic utility of these tests in patients with altered levels of consciousness, despite their growing presence in intensive care units. This gap underscores the necessity for comprehensive studies that evaluate the predictive efficacy of infusion therapy responsiveness in patients with concurrent hypotension and impaired consciousness.\n\nPurpose of the study: to investigate the sensitivity and specificity of methods for assessing fluid responsiveness in patients with hypotension and decreased level of consciousness.",[27,546],"Cognitive Impairment",[27,546,304,548,549],"Intensive Care","Fluid Infusion","2026-01-22",{"date":552,"type":39},"2026-01-23",{"date":554,"type":39},"2024-01-16",{"date":556,"type":23},"2026-05-20",{"name":558,"class":46},"Federal Research and Clinical Centre of Intensive Care Medicine and Rehabilitology",{"id":560,"slug":561,"hasResults":12,"nctId":562,"briefTitle":563,"officialTitle":564,"acronym":4,"eligibilityCriteria":565,"healthyVolunteers":12,"sex":55,"minAge":291,"maxAge":4,"enrollmentInfo":566,"targetDuration":4,"studyType":24,"phases":4,"briefSummary":568,"conditions":569,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":572,"startDateStruct":574,"completionDateStruct":576,"leadSponsor":578,"locationsCount":4},"100619971","the-effect-of-frailty-on-hypotension-after-anesthesia-induction-100619971","NCT07351552","The Effect of Frailty on Hypotension After Anesthesia Induction","The Effect of Frailty in Geriatric Patients on Hypotension Observed After Anesthesia Induction","Inclusion Criteria:\n\n* Patients who do not have difficulty communicating,\n* have good cognitive function,\n* scheduled for surgery under general anesthesia\n\nExclusion Criteria:\n\n* Patients admitted for surgery in emergency situations\n* Patients with active malignancy\n* Patients with physical disabilities and impairments (limb amputations, stroke sequelae, unable to speak, hearing problems)\n* Patients with acute infections\n* Patients with acute illnesses (decompensated congestive heart failure, recent myocardial infarction\u002Fstroke, COPD exacerbation)\n* Patients who have been hospitalized or undergone surgery within the last month\n* Patients with advanced dementia\n* Patients who are unable to provide a medical history or cooperate",{"count":567,"type":23},80,"Frailty is defined as a state of weakness resulting from a decrease in physiological reserves due to physiological changes, diseases, and\u002For malnutrition associated with advancing age. Frail older adults face increased mortality, morbidity, and healthcare costs when exposed to stressors, making this issue increasingly important. The FRAIL Scale, developed by Morley et al. , is a 5-item measure that assesses frailty. The FRAIL Scale has been validated in many countries and has been proven to be an effective method for detecting frailty. This scale assesses the patient's fatigue, resistance, mobility, weight loss, and other diseases. In the 5-item FRAIL scale, patients receive 0 or 1 point based on their answers, and a total of 0 points is considered non-frail, 1-2 points is considered pre-frail, and \\>2 points is considered frail.\n\nFrailty is associated with a higher risk of postoperative complications. Rothenberg and colleagues reported in a study involving more than 400,000 patients that frailty doubles the risk of postoperative complications .\n\nHypotension following anesthesia induction is a common complication in geriatric patients. Decreased cardiopulmonary reserve with age leads to an exaggerated drop in blood pressure during induction .\n\nIn this study, the investigators aimed to determine the effect of frailty level in geriatric patients on hypotension observed after anesthesia induction.",[570,27],"Fraility","2026-01-09",{"date":573,"type":39},"2026-01-20",{"date":575,"type":23},"2026-01-15",{"date":577,"type":23},"2026-06-15",{"name":579,"class":46},"Selcuk University",{"id":581,"slug":582,"hasResults":12,"nctId":583,"briefTitle":584,"officialTitle":585,"acronym":4,"eligibilityCriteria":586,"healthyVolunteers":12,"sex":55,"minAge":95,"maxAge":4,"enrollmentInfo":587,"targetDuration":4,"studyType":59,"phases":589,"briefSummary":590,"conditions":591,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":593,"startDateStruct":595,"completionDateStruct":597,"leadSponsor":599,"locationsCount":4},"100619732","clinical-trial-of-digital-therapeutics-onedr-for-suspected-orthostatic-hypotension-patients-100619732","NCT07348445","Clinical Trial of Digital Therapeutics (One.Dr) for Suspected Orthostatic Hypotension Patients","A Single-center, Randomized, Double-blind, Sham-controlled, Confirmatory Clinical Trial to Evaluate the Efficacy and Safety of the Digital Therapeutics (One.Dr) to Improve Blood Pressure Drop When Standing in Patients With Suspected Orthostatic Hypotension","Inclusion Criteria:\n\n1. Adults over 19 years of age suspected of orthostatic hypotension due to symptoms such as dizziness within one year\n2. Participants who are able to walk and conduct this clinical trial or cooperate with their care providers\n\nExclusion Criteria:\n\n1. Participants diagnosed with diseases that cause dizziness other than orthostatic hypotension, such as otolithiasis and stroke, within one year\n2. Severe anemia (Hb \\\u003C8.0 g\u002FdL, based on the latest test results within 12 months)\n3. Participants unable to use smartphones (android phones) and\u002For smart watches\n4. Participants with chronic diseases less than one year of life expectancy, such as malignant tumors\n5. Participants with severe heart valve disease or severe heart failure (LVEF \\\u003C35%) who have been hospitalized for acute exacerbation within the last 3 months\n6. Participants with recent rapid and unintended weight loss (5% or more than 5 kg within 6 months)",{"count":588,"type":23},86,[61],"Participants who meet the inclusion\u002Fexclusion criteria in the Screening visit are randomly assigned 1:1 to the treatment group or the sham control group. The two-week period after Screening is the Run-in period, and the participant performs self-measured blood pressure monitoring, records data using the One.Dr application, and records symptoms and events related to orthostatic hypotension such as dizziness in the application. Only those who have completed the Run-in period will enter the Intervention period (for 6 weeks at 3-8 weeks), and according to each allocation group, non-pharmaceutical treatment education is provided for the treatment group and general health knowledge education is provided for the sham control group.",[27,592],"Orthostasis",{"date":594,"type":39},"2026-01-16",{"date":596,"type":23},"2026-01",{"date":598,"type":23},"2026-04",{"name":600,"class":46},"Yonsei University",{"id":602,"slug":603,"hasResults":12,"nctId":604,"briefTitle":605,"officialTitle":605,"acronym":4,"eligibilityCriteria":606,"healthyVolunteers":17,"sex":55,"minAge":19,"maxAge":607,"enrollmentInfo":608,"targetDuration":4,"studyType":59,"phases":610,"briefSummary":611,"conditions":612,"keywords":4,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":616,"lastUpdatePostDateStruct":617,"startDateStruct":619,"completionDateStruct":621,"leadSponsor":623,"locationsCount":87},"100615283","phase-2-comparative-analysis-of-dexmedetomidine-and-dexamethasone-as-an-adjuvant-to-05ropivacaine-on-onset-of-ultrasound-guided-supraclavicular-brachial-plexus-block-in-patients-undergoing-upper-limb-surgeries-100615283","NCT07290595","Comparative Analysis Of Dexmedetomidine And Dexamethasone As An Adjuvant To 0.5%Ropivacaine On Onset Of Ultrasound Guided Supraclavicular Brachial Plexus Block In Patients Undergoing Upper Limb Surgeries","Inclusion Criteria\n\n* Patients scheduled for upper limb surgery below mid-humerus level\n* Patients aged 18 to 70 years\n* Patients with ASA class I, II and III\n* Male and non-pregnant females Exclusion Criteria\n* Patients refusal\n* Patients with pre-existing peripheral neuropathy of the upper limb\n* Patients with the Infection at block site\n* Patients with history of ischemic heart disease\n* Patients with bleeding disorder or deranged coagulation profile\n* Patients with known history of allergy to local anaesthetic or any other drugs used","70 Years",{"count":609,"type":23},66,[265,266],"To compare the efficacy of dexmedetomidine and dexamethasone as an adjuvant to 0.5%ropivacaine on onset of ultrasound guided supraclavicular brachial plexus block in patients undergoing upper limb surgeries.\n\nRopivacaine hydrochloride, a long acting local anesthetic, is commonly used for supraclavicular block owing to its favorable safety profile especially in terms of minimal cardiotoxicity and less motor block. Dexmedetomidine, a highly selective alpha-2 adrenergic agonist, enhances the quality of supraclavicular block by providing sedation and analgesia while potentially prolonging the duration of block through hyperpolarization of nerve fibers. While, Dexamethasone, a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties, prolongs duration of analgesia by reducing perineural inflammation and inhibiting nociceptive signal transmission. Supraclavicular brachial plexus block offers dense anesthesia for surgical procedures at or distal to the elbow with relatively high success rate, once described as \"spinal of the arm\". Moreover, supraclavicular brachial plexus block is an excellent alternative to general anesthesia in upper limb surgeries.",[613,614,27,615],"Post Operative Analgesia","Bradycardia","Upper Limb Surgeries","2025-12-20",{"date":618,"type":39},"2025-12-23",{"date":620,"type":39},"2025-01-13",{"date":622,"type":23},"2026-03-12",{"name":624,"class":253},"Sahiwal medical college sahiwal",{"id":626,"slug":627,"hasResults":12,"nctId":628,"briefTitle":629,"officialTitle":630,"acronym":4,"eligibilityCriteria":631,"healthyVolunteers":12,"sex":55,"minAge":19,"maxAge":291,"enrollmentInfo":632,"targetDuration":4,"studyType":59,"phases":633,"briefSummary":634,"conditions":635,"keywords":637,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":641,"lastUpdatePostDateStruct":642,"startDateStruct":644,"completionDateStruct":646,"leadSponsor":648,"locationsCount":87},"100611354","efficacy-and-safety-evaluation-of-non-invasive-temporal-interference-stimulation-for-blood-pressure-regulation-100611354","NCT07239492","Efficacy and Safety Evaluation of Non-invasive Temporal Interference Stimulation for Blood Pressure Regulation","Efficacy and Safety Evaluation of Transcranial Non-invasive Temporal Interference Stimulation for Blood Pressure Regulation: A Pilot, Prospective Study","Inclusion Criteria:\n\n1. Age: 18-65 years old, male or female;\n2. Three groups of patients will be enrolled in the study:\n\n   1. Essential Hypertension Grade 1 (Low Risk) - Antihypertensive Medication-Naive Group: No other cardiovascular risk factors or disease history, with systolic blood pressure (SBP) ≥140 mmHg and \\\u003C160 mmHg and\u002For diastolic blood pressure (DBP) ≥90 mmHg and \\\u003C100 mmHg;\n   2. Essential Hypertension - Refractory Hypertension Group: Meeting one of the following conditions after intensive lifestyle intervention plus taking 3 different types of antihypertensive drugs (including thiazide diuretics) for ≥4 weeks, with each drug at the maximum dose or maximum tolerated dose: Clinic blood pressure ≥140\u002F90 mmHg and 24-hour average ambulatory blood pressure ≥130\u002F80 mmHg, or average home blood pressure ≥135\u002F85 mmHg; or blood pressure can only be controlled below 140\u002F90 mmHg with ≥4 types of antihypertensive drugs;\n   3. Neurogenic Orthostatic Hypotension (nOH) Group: A decrease in SBP ≥20 mmHg and\u002For DBP ≥10 mmHg within 3 minutes of the head-up tilt test (HUTT) and\u002For standing activity;\n3. BMI: 18-30;\n4. After being informed of the potential risks, the patient agrees to participate in this study and signs the informed consent form (ICF).\n\nExclusion Criteria:\n\n1. Patients with secondary hypertension;\n2. Patients with intracranial structural lesions (e.g., infarcts, vascular malformations, space-occupying lesions, etc.);\n3. Pregnant women;\n4. Individuals unable to cooperate due to mental illness or other reasons;\n5. Those who have participated in other clinical studies within the past 3 months;\n6. Patients who apply to withdraw from this clinical study for any reason;\n7. Patients with cardiac insufficiency;\n8. Patients excluding those with white coat effect;\n9. Individuals with a high risk of cerebrovascular disease confirmed by transcranial magnetic resonance imaging (MRI).",{"count":7,"type":23},[61],"The primary objective of this research is to study the efficacy and safety of temporal interference stimulation for regulating the blood pressure.",[636,27],"Hypertension",[638,639,640],"hypertension","temporal in terference","hypotension","2025-11-15",{"date":643,"type":39},"2025-11-20",{"date":645,"type":23},"2025-12-01",{"date":647,"type":23},"2027-01-01",{"name":649,"class":46},"Xuanwu Hospital, Beijing",{"id":651,"slug":652,"hasResults":12,"nctId":653,"briefTitle":654,"officialTitle":655,"acronym":4,"eligibilityCriteria":656,"healthyVolunteers":12,"sex":55,"minAge":657,"maxAge":607,"enrollmentInfo":658,"targetDuration":4,"studyType":59,"phases":660,"briefSummary":661,"conditions":662,"keywords":665,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":667,"lastUpdatePostDateStruct":668,"startDateStruct":670,"completionDateStruct":672,"leadSponsor":674,"locationsCount":87},"100559794","phase-2-comparison-of-eosp-between-usg-guided-s-ficb-vs-usg-guided-peng-block-in-pts-undergoing-femur-fracture-surgery-100559794","NCT06568770","Comparison of EOSP Between Usg Guided S-FICB vs USG Guided PENG Block in Pts Undergoing Femur Fracture Surgery","Comparison of Ease of SPINAL Positioning Between USG Guided Supra-inguinal Fascia Iliaca Block vs USG Guided Pericapsular Nerve Group Block in Patients Undergoing Femur Fracture Surgery","Inclusion Criteria:\n\n* 1\\. Both Genders (Male \u002FFemale). 2. Age between 20 years to 70 years. 3. Radiologically confirmed femur fracture. 4. ASA Class I, II, III.\n\nExclusion Criteria:\n\n1. Patient refusal\n2. Other distracting painful pathology\n3. Any contraindication to Spinal Anesthesia or peripheral nerve blocks\n4. Coagulopathic disorders\n5. H\u002FO ischemic heart disease\n6. Patients on opioids for chronic pain\n7. Patients with significant cognitive impairment\n8. Patients with no pain while sitting by themselves without any support.","20 Years",{"count":659,"type":23},70,[265,266],"To compare the immediate and postoperative analgesic efficacy of S-FICB and PENG block will be the objective. The use of ultrasonography in anesthesia has helped the anesthetist to see the nerve, needle and the distribution of the drug, thereby enhancing the chances of a favorable outcome of the nerve block. Grade A recommendation for an ultrasound guided approach to the peripheral nerve blocks is supported by level Ib evidence for a shortened time for the onset of sensory block, decreased performance time and lower drug doses10.\n\nAlthough individually both the blocks have been studied, there are only a handful of studies comparing both techniques under ultrasound guidance for making patient positioning for spinal anesthesia easy. And no local data is available comparing these blocks. So, we want to compare the analgesic efficacy of USG PENG block with USG S-FICB block in patients with fracture femur in reducing pain associated with positioning (sitting) for subarachnoid block, duration of analgesia, opioid sparing effect and complications. So that procedure with better analgesic efficacy and less complications will be included in our local guidelines as a part of multimodal analgesia.",[663,614,27,664],"Post Operative Pain","Femur Fracture",[666],"PENG,S-FICB,ASA,EOSP","2025-10-21",{"date":669,"type":39},"2025-10-23",{"date":671,"type":39},"2024-07-10",{"date":673,"type":23},"2026-01-10",{"name":624,"class":253},{"id":676,"slug":677,"hasResults":12,"nctId":678,"briefTitle":679,"officialTitle":680,"acronym":681,"eligibilityCriteria":682,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":683,"targetDuration":4,"studyType":59,"phases":685,"briefSummary":686,"conditions":687,"keywords":689,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":692,"lastUpdatePostDateStruct":693,"startDateStruct":695,"completionDateStruct":697,"leadSponsor":698,"locationsCount":700},"100535189","phase-4-continuous-infusion-of-norepinephrine-vs-phenylephrine-during-spinal-anesthesia-for-cesarean-section-inpeace-100535189","NCT06248593","Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section (INPEACE)","Manually Controlled Continuous Infusion of Norepinephrine vs Phenylephrine During Spinal Anesthesia for Cesarean Section: A Double-blinded Randomized Controlled Study","INPEACE","Inclusion Criteria:\n\n* Full-term, singleton, pregnant women, nonlaboring.\n* Scheduled for elective cesarean delivery under spinal anesthesia,\n* American Society of Anesthesiologists physical status : 1 or 2\n* Baseline systolic BP between 90 and 140 mm Hg.\n\nExclusion Criteria:\n\n* Known fetal abnormality.\n* Preexisting or pregnancy-induced hypertension, cardiovascular, cerebrovascular or kidney disease.\n* Contraindication to spinal anesthesia.\n* Peripartum hemorrhage.\n* Body mass index above 40 kg\u002Fm2.",{"count":684,"type":23},140,[326],"The goal of this clinical trial is to compare norepinephrine and ephedrine in maintaining blood pressure during spinal anaesthesia for elective cesarean delivery. The main questions it aims to answer are:\n\n* Do phenylephrine and norepinephrine administered as manually controlled continuous infusion during elective cesarean delivery have different effects on neonatal outcome ?\n* Do phenylephrine and norepinephrine administered as manually controlled continuous infusion during elective cesarean delivery have different effects on maternal hemodynamics? Participants will receive either phenylephrine or norepinephrine infusion, at the time of performing spinal anesthesia, the infusion rate will be adjusted manually depending on maternal arterial pressure.",[688,27],"Cesarean Section Complications",[640,362,690,423,393,691],"cesarean delivery","Phenylephrine","2025-09-08",{"date":694,"type":39},"2025-09-09",{"date":696,"type":39},"2025-01-29",{"date":165,"type":23},{"name":699,"class":46},"Hassan II University",2]