[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypothalamic-amenorrhea-functional\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypothalamic-amenorrhea-functional":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,78],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100622638","health-and-lifestyle-support-for-functional-hypothalamic-amenorrhea-100622638",false,"NCT07386223","Health and Lifestyle Support for Functional Hypothalamic Amenorrhea","HEAL-FHA: Health and Lifestyle Support for Functional Hypothalamic Amenorrhea","HEAL-FHA","Inclusion Criteria\n\n* female\n* aged 18-42 years\n* fulfill criteria for diagnosis of functional hypothalamic amenorrhea (hypogonadotropic hypogonadism)\n* basic proficiency in Swedish\n* access to a computer.\n\nExclusion Criteria:\n\n* Lack of proficiency in language\n* evere psychiatric co-morbidity e.g. psychosis or active eating disorders (anorexia nervosa).","FEMALE","18 Years","42 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trial is to learn whether a 10-week psychoeducational health and lifestyle intervention can help women with Functional Hypothalamic Amenorrhea (FHA) restore their endocrine balance and menstrual cycles.\n\nThe main questions the study aims to answer are:\n\nDoes the intervention lead to the return of regular menstrual bleeding? Does it improve hormonal markers associated with FHA recovery? To answer these questions, researchers will compare the 10-week psychoeducational intervention with treatment as usual (TAU). This comparison will help determine whether the structured program leads to faster or more reliable recovery of menstrual and endocrine function than the care women typically receive today.\n\nParticipants will:\n\nTake part in a 10-week psychoeducational program focusing on health behaviors important for FHA recovery (intervention group) or receive treatment as usual (comparison group) Complete questionnaires and health assessments Provide blood samples to measure hormone levels Take part in a gynecological exam to monitor ovary activity and endometrial thickness Be followed for 9 months after the program to track progress This study builds on a previous feasibility study and will help determine whether the intervention is effective and should be used more widely to support women with FHA.",[28],"Hypothalamic Amenorrhea, Functional",[30,31,32,33],"psychoeduction","lifestyle change","menstrual restoration","amenorrhea","NOT_YET_RECRUITING","2026-01-27",{"date":37,"type":38},"2026-02-04","ACTUAL",{"date":40,"type":22},"2026-02-01",{"date":42,"type":22},"2028-12-31",{"name":44,"class":45},"Karolinska Institutet","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":54,"enrollmentInfo":55,"targetDuration":57,"studyType":58,"phases":4,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":77},"100560919","the-registry-of-very-early-estrogen-and-anovulation-100560919","NCT06583408","The REgistry of Very Early Estrogen and AnovuLation","REVEAL","Inclusion Criteria:\n\n* 3 or more months of consecutive amenorrhea with a diagnosis of functional hypothalamic amenorrhea or screening hormones consistent with functional hypothalamic amenorrhea including but not limited to:\n\n  * Estradiol: \\\u003C 50pg\u002FmL\n  * LH: \\\u003C 10 IU\u002FmL\n  * FSH: \\\u003C 10 IU\n  * Testosterone: 2 - 45 ng\u002FdL\n  * Free Testosterone: 0.1 - 6.4 pg\u002FmL\n  * FT4: 0.93 - 1.70 ng\u002FdL\n  * Prolactin: \\\u003C 20 ng\u002FmL\n  * AMH: \\> 1 ng\u002FmL\n  * Urine or serum human chorionic gonadotropin: Negative\n* LH:FSH Ratio \\\u003C1\n* No signs of male-like hair growth on the upper lip, chin, chest, abdomen, buttocks, or back\n* Does not have a diagnosis for secondary amenorrhea, including prolactinoma, PCOS, premature ovarian insufficiency, pituitary surgery, infection, or infarction\n* Premenopausal status determined by WISE criteria\n* Able to give informed consent\n* Able to read English\n\nExclusion Criteria:\n\n* Parturition\u002Flactating in the last 6-12 months\n* Lack of consent","40 Years",{"count":56,"type":22},100000,"5 Years","OBSERVATIONAL","The purpose of this study is to to build a registry of women with early estrogen loss due to Functional Hypothalamic Amenorrhea (FHA) to understand the prevalence, racial and ethnic diversity of this condition.",[28,61,62],"Hypothalamic Amenorrhea","Functional Hypogonadotropic Hypogonadism",[64,65,66],"Anovulation","Estrogen Loss","Hypoestrogenemia","RECRUITING","2025-11-18",{"date":70,"type":38},"2025-11-21",{"date":72,"type":38},"2024-07-01",{"date":74,"type":22},"2029-08-01",{"name":76,"class":45},"Mayo Clinic",2,{"id":79,"slug":80,"hasResults":11,"nctId":81,"briefTitle":82,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":84,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":58,"phases":4,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":46},"100587861","assessment-of-nutritional-knowledge-habits-and-eating-behavior-in-athletic-women-to-evaluate-the-possible-impact-on-their-menstrual-function-100587861","NCT06933888","Assessment of Nutritional Knowledge, Habits, and Eating Behavior in Athletic Women to Evaluate the Possible Impact on Their Menstrual Function","Inclusion Criteria:\n\n* Female sex\n* Age 16-30 years\n* Physical activity \\> 2 days per week\n* Informed consent from the patient and\u002For an authorized legal representative\n\nExclusion Criteria:\n\n* Menstrual disorders of organic cause (ovarian cysts, uterine fibroids, polyps, etc.)\n* Concomitant non-reproductive organic diseases (hypertension, diabetes, etc.)\n* Use of psychopharmacological therapies\n* Language barrier","16 Years","30 Years",{"count":87,"type":22},102,"The present study aims to investigate the degree of knowledge about nutrition and dietary habits in athletic women through validated questionnaires and to evaluate a possible impact on their menstrual function, including women with a diagnosis of functional hypothalamic amenorrhea (FHA) and women who present with a different menstrual dysfunction (oligomenorrhea or polymenorrhea in absence of organic causes).",[28],[91,92],"Functional Hypothalamic Amenorrhea","Eating disorders","2025-04-10",{"date":95,"type":38},"2025-04-18",{"date":97,"type":38},"2021-09-13",{"date":99,"type":22},"2026-01",{"name":101,"class":45},"Fondazione IRCCS Policlinico San Matteo di Pavia"]