[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypothyroidism-primary\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypothyroidism-primary":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,70],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100625557","phase-2-t4t3-therapy-in-hypothyroidism-100625557",false,"NCT07424183","T4\u002FT3 Therapy in Hypothyroidism","Inclusion Criteria:\n\n1. Male or female, aged 18-70 years\n2. Hypothyroidism due to either thyroid failure or total thyroidectomy for structural thyroid disease (nodules, benign goiter, or thyroid cancer) for at least 6 months\n3. Taking 75-150 mcg per day LT4 and a minimum of 1.2 mcg\u002Fkg\u002Fday, with stable dose of LT4 for at least 3 months prior to enrollment\n4. TSH of 0.5 to 4.0 mU\u002FL within 2 months of enrollment\n5. Persistent symptoms for at least 2 months, and a TSQ score of ≥ 5\n6. For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation and for an additional 4 weeks after the end of study intervention.\n\nExclusion Criteria:\n\n1. Current use of LT3, thyroid extracts, Tirosint liquid or capsules, amiodarone, lithium, methimazole, propylthiouracil, supraphysiologic doses of corticosteroids, immunotherapy, tyrosine kinase inhibitors, interferon, or biotin supplements\n2. Diseases of the pituitary or hypothalamus\n3. History of thyroid cancer requiring suppression of TSH secretion\n4. Unstable cardiac conditions, including uncontrolled hypertension (current blood pressure greater than 160\u002F100), arrhythmia, or angina\n5. Uncontrolled psychiatric disorders\n6. Pregnancy or lactation, or planned pregnancy within the next 7 months\n7. History of food dye allergies\n8. GFR \\\u003C30 ml\u002Fmin\u002F1.73 m2\n9. Other conditions which, in the opinion of the investigators, would prevent them from participating in the full duration of the study (for example, end-stage cancer)","ALL","18 Years","70 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"PHASE2","This study will test whether 6 months of combination therapy with levothyroxine (LT4) plus liothyronine (LT3) is superior to LT4 plus placebo in participants with hypothyroidism who have residual symptoms of hypothyroidism with TSH levels within the reference range.",[26],"Hypothyroidism Primary",[28,29,30],"Hypothyroidism","levothyroxine","liothyronine","NOT_YET_RECRUITING","2026-04-16",{"date":34,"type":35},"2026-04-21","ACTUAL",{"date":37,"type":20},"2026-06",{"date":39,"type":20},"2027-06",{"name":41,"class":42},"University of Pennsylvania","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":51,"minAge":16,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":54,"phases":4,"briefSummary":55,"conditions":56,"keywords":57,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":66,"leadSponsor":68,"locationsCount":43},"100624371","physical-activity-fatigue-social-support-and-psychological-well-being-in-women-with-primary-hypothyroidism-100624371","NCT07408765","Physical Activity, Fatigue, Social Support, and Psychological Well-Being in Women With Primary Hypothyroidism","Physical Activity, Fatigue, Social Support, and Psychological Well-Being in Women With Primary Hypothyroidism: A Multicenter Observational Cohort Study","Inclusion Criteria:\n\n* Have a diagnosis of primary hypothyroidism (clinical or subclinical), established by a specialist in Endocrinology or Internal Medicine based on TSH and FT4 levels.\n* Female.\n* Are aged ≥18 years at the time of inclusion.\n* Have stable treatment for thyroid dysfunction (levothyroxine dose or other replacement regimen without relevant modifications) for at least the previous 3 months, or a stable clinical condition if treatment is not required.\n* Are able to ambulate independently in the community (with or without usual assistive devices), allowing participation in light to moderate physical activity.\n* Are able to understand and complete the questionnaires independently.\n* Have provided written informed consent\n\nExclusion Criteria:\n\n* Have a diagnosis of severe medical conditions that predominantly limit the ability to perform physical activity independently of hypothyroidism (e.g., advanced heart failure, severe chronic respiratory disease).\n* Have severe psychiatric disorders or significant cognitive impairment that hinder understanding of the information or reliable completion of the questionnaires.\n* Have undergone major surgery, severe trauma, or an acute medical condition that has substantially limited physical activity in the three months prior to assessment.\n* Are pregnant or in the immediate postpartum period, due to potential hormonal and functional interference with the study variables.\n* Are concurrently participating in a clinical trial or a structured physical exercise program.","FEMALE",{"count":53,"type":20},96,"OBSERVATIONAL","Background. Primary hypothyroidism, both clinical and subclinical, is frequently associated with persistent fatigue, reduced psychological well-being, and lower levels of physical activity in adult women. However, evidence integrating these psychosocial factors remains limited and methodologically heterogeneous.\n\nObjective. To analyze the association between physical activity and fatigue, social support, and psychological well-being in women with primary hypothyroidism; to compare these profiles between clinical and subclinical hypothyroidism; and to explore the moderating effect of social support and psychological well-being on the relationship between fatigue and physical activity.\n\nMethods. An observational, analytical, multicenter cohort study will be conducted including 96 adult women with primary hypothyroidism from the Principality of Asturias. Physical activity levels will be assessed using the International Physical Activity Questionnaire-Short Form (IPAQ-SF), while fatigue, social support, and psychological well-being will be measured using the Fatigue Severity Scale (FSS), the Medical Outcomes Study Social Support Survey (MOS-SSS), and the WHO-5 Well-Being Index, respectively. Confounding variables will include age, body mass index, type of hypothyroidism (clinical or subclinical), and time since diagnosis. Descriptive analyses, comparisons between clinical and subclinical groups, and multiple linear regression models will be performed.\n\nExpected results. The study is expected to identify physical activity levels within the sample and determine which psychosocial factors are independently associated with physical activity. Additionally, fatigue is anticipated to be negatively associated with physical activity, whereas social support and psychological well-being are expected to show positive associations and potential moderating effects.",[26],[58,28,59,60],"Female","Physical activity","Physiotherapy","RECRUITING","2026-02-16",{"date":64,"type":35},"2026-02-19",{"date":62,"type":35},{"date":67,"type":20},"2026-05-15",{"name":69,"class":42},"University of Oviedo",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":76,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":78,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":83,"conditions":84,"keywords":85,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":98},"100617829","ayurvedic-diet-in-myxedema-100617829","NCT07323706","Ayurvedic Diet in Myxedema","Ayurvedic Diet as a Supplement to Levothyroxine Treatment of Myxedema","AYUS-MYX","Inclusion Criteria:\n\n* diagnosed with primary hypothyroidism\n* primary digestive type Vishamagni\n* under medical treatment for hypothyroidism\n* unchanged medication for the past 6 months\n\nExclusion Criteria:\n\n* previous Ayurvedic treatment\n* prescription drugs other than medication for hypothyroidism\n* pregnancy\n* lactating women.","90 Years",{"count":80,"type":20},88,[82],"NA","Primary hypothyroidism is diagnosed by elevated thyroid stimulating hormone (TSH) level and a reduced thyroxine (T4) level in plasma. Some of the most common symptoms of hypothyroidism are fatigue, weight gain and reduced cognition and is associated with reduced quality of life and increased days of sick leave. Levothyroxine, a synthetic form of T4, is clinically recommended as first-line treatment for hypothyroidism. When normalizing TSH\u002FT4 with levothyroxine, the prevalence of persistent symptoms is present in 15% of patients. The composition of our gut bacteria, the microbiome, plays a significant role for a healthy thyroid gland and metabolism and is influenced by our diet. The Indian medical system, Ayurveda, is based on generations of experience and knowledge in disease prevention and treatment, including various diet plans, exercise and lifestyles that are put into context for physical and mental health. Ayurveda works with four different types of digestion and is based on a vegetarian diet. The purpose of this study is to investigate the effect of an Ayurvedic diet plan, as a supplement to medical treatment, among people with hypothyroidism.",[26],[86,87,88],"hypothyroidism","Vegetarian diet","Ayurveda","2025-12-31",{"date":91,"type":35},"2026-01-07",{"date":93,"type":35},"2024-10-01",{"date":95,"type":20},"2029-12-31",{"name":97,"class":42},"University of Copenhagen",2]