[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypovitaminosis-d\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypovitaminosis-d":23},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,37,62,90,124,153],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":21,"conditions":22,"keywords":4,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":25,"lastUpdatePostDateStruct":26,"startDateStruct":29,"completionDateStruct":31,"leadSponsor":33,"locationsCount":36},"100553055","prospective-monocentric-registry-of-patients-undergoing-vitamin-d-treatment-at-san-raffaele-hospital-100553055",false,"NCT06481111","Prospective Monocentric Registry of Patients Undergoing Vitamin D Treatment at San Raffaele Hospital","Inclusion Criteria:\n\n* Adult men and women (age ≥ 18 years) regardless of fertility status and pregnancy\u002Fbreastfeeding conditions\n* Vitamin D supplementation, with any formulation and dosage\n* Signing of informed consent\n\nExclusion Criteria:\n\n* Patients unable to understand and sign informed consent.","ALL","18 Years",{"count":18,"type":19},1000,"ESTIMATED","OBSERVATIONAL","The Endocrinology Unit of the IRCCS San Raffaele Hospital is dedicated to establishing a prospective single-center registry with data from patients undergoing vitamin D supplementation, initiating their first visit to the outpatient unit until December 2029. 1000 patients will be enrolled, aligning with the unit's recent patient influx for hypovitaminosis D.\n\nThe registry's goal is to assess the epidemiological trend, identify risk factors, and evaluate the diagnostic and therapeutic clinical management strategies for hypovitaminosis D. It will involve collecting clinical, laboratory, and historical data during outpatient visits, adhering to the standard diagnostic and therapeutic protocols for endocrine-metabolic diseases. This data collection is expected to continue for a duration of ten years.",[23],"Hypovitaminosis D","RECRUITING","2026-04-02",{"date":27,"type":28},"2026-04-08","ACTUAL",{"date":30,"type":28},"2024-07-10",{"date":32,"type":19},"2034-12-01",{"name":34,"class":35},"IRCCS San Raffaele","OTHER",1,{"id":38,"slug":39,"hasResults":11,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":43,"eligibilityCriteria":44,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":45,"enrollmentInfo":46,"targetDuration":4,"studyType":48,"phases":49,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":56,"completionDateStruct":58,"leadSponsor":60,"locationsCount":36},"100526707","cholecalciferol-and-calcifediol-are-both-useful-to-improve-vitamin-d-serum-levels-100526707","NCT06138249","Cholecalciferol and Calcifediol Are Both Useful to Improve Vitamin D Serum Levels","Different Kinds of Vitamin D Intake and Its Metabolites: Blood Levels and Bone Mineral Density. A Randomized Clinical Trial.","VITD","Inclusion Criteria:\n\n* Hypovitaminosis D (\\\u003C20ng\u002FmL)\n\nExclusion Criteria:\n\n* Osteoporosis (T score \\\u003C-2.5SD)\n* Renal or hepatic diseases","80 Years",{"count":47,"type":19},90,"INTERVENTIONAL",[50],"NA","Patients with hypovitaminosis D are randomized into three arms of treatment:\n\nGroup A: Calcifediol 0,266mg each month Group B: Cholecalciferol 25000UI each 15 days Group C: Calcifediol 4 drops per day. Serum levels of vitamin D are dosed after one month of treatment",[23],"2025-11-20",{"date":55,"type":28},"2025-11-25",{"date":57,"type":28},"2023-07-01",{"date":59,"type":19},"2025-12-30",{"name":61,"class":35},"Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari",{"id":63,"slug":64,"hasResults":11,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":69,"sex":15,"minAge":16,"maxAge":70,"enrollmentInfo":71,"targetDuration":4,"studyType":48,"phases":73,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":36},"100608305","evaluating-response-to-vitamin-d3-and-k2-supplementation-in-healthcare-personnel-100608305","NCT07199829","Evaluating Response to Vitamin D3 and K2 Supplementation in Healthcare Personnel","A Double-Blind Randomized Controlled Trial Evaluating Response to Vitamin D3 and K2 Supplementation Through Inflammatory Markers and the Gut Microbiome in Healthcare Personnel","Inclusion Criteria:\n\n* able to read and understand English\n* 25 OHD serum level equal to or less than 30 ng\u002FmL\n* willing to discontinue vitamin D3 and\u002For K2 supplements for 4.5 months\n* military beneficiary (Active Duty, Retired, Dependent)\n* remaining employed at workplace for 6 months\n\nExclusion Criteria:\n\n* Diagnosed medical condition that prevents nutrient absorption from food (e.g. Inflammatory Bowel Disease, Celiac Disease, post-Roux-en-Y\u002FGastric sleeve surgery)\n* Pregnant or breastfeeding\n* Current antibiotic use or within past 3 months\n* Current anticoagulant use or within past 3 months\n* Current weight loss or fat malabsorption medication use (e.g. Glucagon-Like Peptide 1 agonists, Orlistat)\n* Allergies or sensitivities to methylcellulose, vitamin D (D3, D2), or vitamin K (K2, Menaquinone-4, Menaquinone-7)",true,"69 Years",{"count":72,"type":19},96,[50],"The main purpose of this research study is to learn about the effects of supplemental vitamin D3 and vitamin K2 on blood levels and the gut microbial community, called the gut microbiome. There are many influences on blood levels of vitamin D and K to include your dietary intake, lifestyle behaviors (physical activity, sleep), genetic alterations in metabolism of these vitamins, and the gut microbial abundance and diversity. You will be asked to take one capsule containing vitamin D3 (125 mcg), vitamin K2 (180 mcg), a combination of vitamins D3 and K2 (same doses as previous), or a placebo powder for 90 days. You will also be asked to complete questionnaires, undergo body composition and blood pressure measurements, provide blood samples and a stool swab, all on 2 occasions about 3 - 4 months apart. By conducting this study, we aim to identify the frequency of common genetic alterations in vitamins D and K metabolism and establish the impact on the gut microbiome for the first time. Your participation in this study will last about 4 - 6 months and include up to 3 visits.",[23,76],"Hypovitaminosis",[23,78,79],"Hypovitaminosis K","Gut microbiome","2025-09-22",{"date":82,"type":28},"2025-09-30",{"date":84,"type":28},"2025-03-27",{"date":86,"type":19},"2026-03",{"name":88,"class":89},"Madigan Army Medical Center","FED",{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":69,"sex":15,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":123},"100603979","bone-outcomes-obesity-sunlight-and-trauma-in-children-100603979","NCT07143552","Bone Outcomes, Obesity, Sunlight, and Trauma in Children","A Prospective Case-Control Study of Vitamin D Status, Bone Metabolic Markers, and Overweight in Pediatric Low-Energy Fractures","BOOST","Inclusion Criteria:\n\n* 3-15 years;\n* low-energy trauma;\n* cases = radiographic fracture; controls = no fracture.\n\nExclusion Criteria:\n\n* chronic renal\u002Fliver disease;\n* primary hypo-\u002Fhyperparathyroidism;\n* hypophosphatemic rickets;\n* neuromuscular disorders;\n* corticosteroids\u002Fbisphosphonates;\n* unclear diagnosis\u002Ftreatment.","3 Years","15 Years",{"count":101,"type":19},100,"Prospective case-control study of children (3-15 years) after low-energy trauma. We compare serum bone metabolic markers (25OHD, PTH, ALP, calcium, phosphate), BMI\u002Fpercentile, and dietary calcium intake between fracture and non-fracture presentations. Blood is collected within 7 days (non-fasting; samples on ice for PTH). Primary aim: association of ALP and calcium with fracture status; secondary aims: vitamin D status, BMI percentile, and a composite Bone Risk Score (≥3). Analyses: group comparisons, logistic regression, ROC.",[104,23,105],"Pediatric Fractures","Obesity and Overweight",[107,108,109,110,111,112,113],"Vitamin D","Alkaline phosphatase","Calcium","Case-control","bmi","phosphate","Low-energy trauma","2025-08-26",{"date":116,"type":28},"2025-09-03",{"date":118,"type":28},"2024-07-01",{"date":120,"type":19},"2026-09",{"name":122,"class":35},"Paracelsus Medical University",2,{"id":125,"slug":126,"hasResults":11,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":131,"minAge":132,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":48,"phases":136,"briefSummary":137,"conditions":138,"keywords":140,"overallStatus":24,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":36},"100600355","effect-of-vitamin-d3-supplementation-on-brain-waves-in-male-epileptic-patients-with-hypovitaminosis-d-100600355","NCT07096414","Effect of Vitamin D3 Supplementation on Brain Waves in Male Epileptic Patients With Hypovitaminosis D","Effect of Vitamin D3 Supplementation on Brain Waves in Male Epileptic Patients With Hypovitaminosis D: A Quantitative Electroencephalogram Analysis","Inclusion Criteria:\n\n* Diagnosed male patients with Epilepsy by neurologist from the Out Patient Department of Department of Neurology, BMU by taking proper history of at least two unprovoked (or reflex) seizures occurring \\> 24 hours apart, from patients and eye witnesses.\n* Hypovitaminosis D (\\\u003C30 ng\u002Fml)\n* BMI : 20 - 24 kg\u002Fm²\n* On antiepileptic medication for 6 months to 2 years (enzyme inducing AEDs, e.g. Carbamazepine, Phenytoin, Phenobarbital)\n* Without any medication that affect central nervous system other than antiepileptic drugs (Antidepressants, Antipsychotic, Anxiolytic, Anesthetic drugs)\n* Apparently normal physical health\n\nExclusion Criteria:\n\n* Patients suffering from absence seizure\n* Certain AEDs (Sodium valproate, Ethosuximide, Oxcarbazepine, Topiramate, Lamotrigine, Levetiracetam)\n* Smoker\n* Alcoholic\n* Known hypersensitivity to vitamin D3\n* Patients with hypertension\n* Patient with Thyroid disorder\n* Patient with Diabetes mellitus\n* Patient with Renal Disease\n* Patient with liver Disease\n* Patient with hypercalcemia","MALE","20 Years","40 Years",{"count":135,"type":19},15,[50],"This is an experimental study (interventional self-controlled trial, pretest-post test design). The goal of this clinical trial is to evaluate the effect of vitamin D3 supplementation on quantitative EEG in male epileptic patients with hypovitaminosis D.\n\n. The main question it aims to answer is:\n\nVitamin D3 supplementation has effect on brain waves in male epileptic patients with hypovitaminosis D.\n\nResearcher will compare the effect of Vitamin D3 supplementation on brain waves in male epileptic patients with hypovitaminosis D with their pre-intervention (baseline) condition on brain waves to assess whether there will be any improvement of brain electrical activity by quantitative electroencephalogram (QEEG).\n\nParticipants will:\n\nTake Vitamin D3 orally for 8 weeks (50,000IU\u002Fweek) Visit the medical university after 8 weeks for evaluation of serum 25 (OH) D level and quantitative electroencephalogram (QEEG) Must bring the empty strips of Vitamin D supplement with them during their visit",[139,23],"Epilepsy",[139,141,23,142,143],"Vitamin D3","QEEG","Brainwaves","2025-07-24",{"date":146,"type":28},"2025-07-31",{"date":148,"type":28},"2025-07-19",{"date":150,"type":19},"2025-10",{"name":152,"class":35},"Bangladesh Medical University",{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":160,"targetDuration":4,"studyType":20,"phases":4,"briefSummary":162,"conditions":163,"keywords":4,"overallStatus":164,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":171,"locationsCount":4},"100455705","vitamin-d-insufficiency-investigation-among-hospitalized-inpatients-100455705","NCT05214040","Vitamin D Insufficiency inVestigation Among hospitaLizeD Inpatients","VIVALDI","Inclusion Criteria:\n\n* ≥ 18 years old\n* have had a dosage of circulating 25-hydroxyvitamin D (plasma or serum) in a HUGO establishment\n* consultant or hospitalized between 01\u002F01\u002F2015 and 12\u002F31\u002F2019 in one of the participating HUGOs.\n\nExclusion Criteria:\n\n* None",{"count":161,"type":19},300000,"Hypovitaminosis D is common in the adult population, it affects at least 1 billion people worldwide, and in particular 80% of the French population according to the National Institute for Public Health Surveillance. Hypovitaminosis D is accompanied or complicated by deleterious health manifestations such as bone, immune and cancer diseases, neuromuscular disorders and a propensity to fall, for example. Hypovitaminosis D has also been associated with more complicated care pathways (increase in the severity of the reason for hospitalization, length of hospitalization, risk of in-hospital death). Prevention of these clinical events depends on correcting vitamin D status.\n\nIn sick, dependent or fragile adults, natural intakes are generally insufficient. It is indeed accepted that hypovitaminosis D may not be treated effectively by dietary measures or by simple exposure to the sun in French latitudes. Drug supplementation is therefore necessary, with the objective of achieving a target concentration of circulating 25-hydroxyvitamin D (25 (OH) D) of 75 nmol \u002F L (30 ng \u002F mL) in this population.\n\nVitamin D supplementation, when properly conducted, corrects hypovitaminosis D, and has been associated with improved prognosis, especially life-saving, in therapeutic trials versus placebo. Such results lead the investigators to suggest that the identification and correction of hypovitaminosis D in hospitalized patients could represent a simple, effective and inexpensive strategy for improving hospital care pathways. In this perspective, the first step is to determine the prevalence, severity and clinical profile of hospitalized patients with hypovitaminosis D, as well as their course of care. To the investigators knowledge, there are no large-scale studies based on real-life data on this subject.",[23],"NOT_YET_RECRUITING","2022-01-27",{"date":167,"type":28},"2022-01-28",{"date":169,"type":19},"2022-09",{"date":120,"type":19},{"name":172,"class":173},"University Hospital, Angers","OTHER_GOV"]