[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypoxemia-during-surgery\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypoxemia-during-surgery":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,41,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100644805","effect-of-preoxygenation-position-and-examination-position-on-hypoxemia-during-painless-gastrointestinal-endoscopy-100644805",false,"NCT07673042","Effect of Preoxygenation Position and Examination Position on Hypoxemia During Painless Gastrointestinal Endoscopy","Effect of Preoxygenation Position and Examination Position on Hypoxemia During Painless Gastrointestinal Endoscopy: A 2×2 Factorial Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18 to 75 years, regardless of gender\n* Body mass index (BMI): 18.5 - 35 kg\u002Fm²\n* ASA physical status class I, II or III\n* Scheduled for painless gastroscopy, painless colonoscopy, or combined painless gastroenteroscopy\n* Able to understand the study procedure and provide written informed consent\n\nExclusion Criteria:\n\n* Severe cardiopulmonary diseases, including severe COPD, heart failure, severe arrhythmia and pulmonary hypertension\n* Difficult airway identified before anesthesia\n* Severe obstructive sleep apnea (OSA)\n* Spinal or thoracic deformity\n* Preoperative baseline hypoxemia\n* Known allergy to any anesthetic drugs used in this study\n* Pregnant females\n* Unable to cooperate with required intraoperative body position","ALL","18 Years","75 Years",{"count":20,"type":21},208,"ESTIMATED","INTERVENTIONAL",[24],"NA","To investigate the independent effects and interaction of pre-oxygenation position (left lateral vs left lateral with 30° head-up tilt) and examination position (left lateral vs left lateral with 30° head-up tilt) on hypoxemia during painless gastroscopy and colonoscopy using a 2×2 factorial design.",[27],"Hypoxemia During Surgery","NOT_YET_RECRUITING","2026-06-24",{"date":31,"type":32},"2026-06-29","ACTUAL",{"date":34,"type":21},"2026-06-23",{"date":36,"type":21},"2026-08-31",{"name":38,"class":39},"General Hospital of Ningxia Medical University","OTHER",1,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":40},"100626205","high-flow-nasal-oxygen-vs-face-mask-during-sedoanalgesia-in-non-intubated-thoracoscopic-pericardial-window-surgery-100626205","NCT07432607","High-Flow Nasal Oxygen vs. Face Mask During Sedoanalgesia in Non-Intubated Thoracoscopic Pericardial Window Surgery","Optimizing Oxygen Delivery During Sedoanalgesia for Video-Assisted Thoracoscopic Pericardial Window: High-Flow Nasal Oxygen vs. Face Mask Oxygenation, A Prospective Comparative Study","HIFI-NIVATS","Inclusion Criteria:\n\n* Adults aged 18 to 75 years\n* Scheduled for elective video-assisted thoracoscopic pericardial window procedure under sedoanalgesia\n* ASA Physical Status Classification I-III\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>75 years\n* ASA Physical Status ≥ IV\n* Body Mass Index (BMI) \\> 30 kg\u002Fm²\n* Need for inotropic support at enrollment\n* Preoperative hemodynamic instability\n* Symptomatic respiratory disease (e.g., pneumonia, nasal congestion, asthma attack)\n* Diagnosed neuromuscular disorder\n* Diagnosed tracheal stenosis\n* Local infection at the site of regional block application\n* Coagulopathy or bleeding diathesis\n* Pregnancy\n* Patients refusing sedoanalgesia\n* Patients refusing study participation\n* Conversion to general anesthesia or use of supraglottic airway intraoperatively",{"count":50,"type":21},60,[24],"This is a prospective, randomized, parallel-group clinical trial designed to evaluate the effects of high-flow nasal oxygen therapy (HFNOT) versus conventional oxygen mask (COM) on perioperative hypoxia in patients undergoing video-assisted thoracoscopic (VATS) pericardial window procedures under sedoanalgesia. The pericardial window procedure, indicated for diagnostic and therapeutic drainage of pericardial effusion, is traditionally performed under general anesthesia. However, the use of non-intubated VATS with sedoanalgesia has gained popularity due to reduced morbidity, shorter recovery, and avoidance of complications associated with general anesthesia, especially in elderly and comorbid patients.\n\nDuring non-intubated VATS, the occurrence of hypoxia and hemodynamic instability may be exacerbated by procedural pneumothorax and underlying cardiac pathology. High-flow nasal oxygen therapy may provide physiological benefits in this setting by reducing airway resistance, improving alveolar ventilation, and minimizing dead space.\n\nThe primary outcome of the study is to compare the incidence of perioperative hypoxia between HFNOT and COM groups. Secondary outcomes include patient comfort, intraoperative oxygenation profiles, hemodynamic stability, and recovery parameters. The trial will be conducted at a single academic center with eligible patients randomized into two treatment arms.",[27],[55,56,57],"hypoxemia","High Flow Oxygen Therapy","non-ıntubated VATS","RECRUITING","2026-05-03",{"date":61,"type":32},"2026-05-05",{"date":63,"type":32},"2025-06-01",{"date":65,"type":21},"2027-02",{"name":67,"class":39},"Ebru Girgin Dinc",{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":75,"maxAge":4,"enrollmentInfo":76,"targetDuration":78,"studyType":79,"phases":4,"briefSummary":80,"conditions":81,"keywords":86,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":4},"100621573","association-of-different-tidal-volumes-and-postoperative-pulmonary-complications-100621573","NCT07372378","Association of Different Tidal Volumes and Postoperative Pulmonary Complications","Association of Various Introperative Tidal Volumes and Postoperative Pulmonary Complications After Video-assisted Thoracic Surgery","Inclusion Criteria:\n\n* Age \\> 50 years.\n* ASA physical status I-II.\n* The cardiopulmonary and other vital organ functions are basically normal, and the patient is able to tolerate surgery.\n* Ariscat score \\> 26.\n* Informed consent has been obtained.\n\nExclusion Criteria:\n\n* Patients who refuse to participate in the clinical trial, or have cognitive impairment or impaired ability to understand and express themselves.\n* ASA physical status ≥ III.\n* Patients with congestive heart failure, severe aortic stenosis, or extensive pleural adhesions.\n* Patients with severe psychiatric disorders or allergy to anesthesia-related medications.\n* Patients with severe organ dysfunction such as the liver or kidney dysfunction.","51 Years",{"count":77,"type":21},650,"7 Days","OBSERVATIONAL","The incidence of lung cancer in China is increasing year by year. Currently, the treatment primarily based on video-assisted thoracoscopic surgery (VATS) is still considered the optimal approach for early-stage non-small cell lung cancer. The widespread application of traditional one-lung ventilation (OLV) technology not only achieves effective lung isolation, but also facilitates exposure of the surgical field during thoracoscopic surgery, making it more convenient for surgeons to operate. However, the occurrence of hypoxemia during one-lung ventilation may pose a risk to patient safety.\n\nOne-lung ventilation can lead to increased intrapulmonary shunt, ventilation\u002Fperfusion (V\u002FQ) mismatch, and ischemic-hypoxic lung injury. Hypoxemia is the major problem during one-lung ventilation. Postoperative pulmonary complications (PPCs) are among the major complications following thoracic and general anesthesia surgeries, including atelectasis, pneumonia, and respiratory failure, which significantly prolong hospital stay and increase mortality.\n\nLow tidal volume lung-protective ventilation strategies have been widely implemented. Additionally, permissive hypercapnia, reducing peak airway pressure to minimize barotrauma, and decreasing FiO₂ all help reduce pulmonary complications.Recently, researchers have focused on optimizing ventilation strategies during OLV, such as using PEEP or low VT ventilation alone or in combination, or exploring different combinations of tidal volume and respiratory frequency under consistent minute ventilation (VE), aiming to balance lung protection and oxygenation, reduce complications, and improve patient outcomes.\n\nHowever, to date, there is still no gold standard tidal volume ventilation strategy for reducing pulmonary complications in patients undergoing lung resection.",[82,27,83,84,85],"Pulmonary Complications","Thoracic Surgery, Video Assisted","One Lung Ventillation (OLV)","Lung Cancer (Non-Small Cell)",[87,55,88,89],"pulmonary complications","video-assisted thoracic surgery","one lung ventilation","2026-01-19",{"date":92,"type":32},"2026-01-28",{"date":94,"type":21},"2026-01-20",{"date":96,"type":21},"2029-02-01",{"name":98,"class":39},"First Affiliated Hospital of Zhejiang University"]