[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypoxemic-acute-respiratory-failure\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypoxemic-acute-respiratory-failure":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,67,93],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100605875","comparison-of-two-spo2-targets-with-two-different-oximeters---impact-on-fio2-during-nasal-high-flow-oxygen-therapy-100605875",false,"NCT07168213","Comparison of Two SpO2 Targets With Two Different Oximeters - Impact on FiO2 During Nasal High Flow Oxygen Therapy","Inclusion Criteria:\n\n* ≥ 18 years of age\n* Admiitted in intensive care unit\n* Presence of an arterial catheter\n* Ongoing on high flow nasal oxygen therapy with SpO2 between 88 and 100% with a FiO2 between 40 and 80% with the usual oximeter .\n\nExclusion Criteria:\n\n* No SpO2 signal with oximeter in use\n* False nails or nail polish\n* Methemoglobinemia \\>0.015 on last available arterial gas\n* Patient in isolation (multi-resistant bacteria, C-Difficile, SARS-CoV-2 ...)\n* Expected to use another respiratory support within two hour of inclusion (NIV or mechanical ventilation)","ALL","18 Years",{"count":18,"type":19},30,"ESTIMATED","INTERVENTIONAL",[22],"NA","Several factors can influence oxygenation monitoring and respiratory support through oxygen therapy: the type of oximeter used, skin pigmentation, and the oxygenation target. It is essential to have an accurate measurement of SpO2 in order to optimize the flow of oxygen or FiO2 administered to patients. The question arises as to the impact of these confounding factors on the FiO2 set during high-flow nasal oxygen therapy. The aim of the study is to evaluate the impact of the oxygenation target and the oximeter used on FiO2 in patients receiving high-flow nasal oxygen therapy.",[25,26,27,28],"Oxygen Delivery","Acute Respiratory Failure","High Flow Oxygen Therapy","Hypoxemic Acute Respiratory Failure","RECRUITING","2026-03-05",{"date":32,"type":33},"2026-03-09","ACTUAL",{"date":35,"type":33},"2025-10-21",{"date":37,"type":19},"2027-12",{"name":39,"class":40},"Laval University","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":51,"phases":4,"briefSummary":52,"conditions":53,"keywords":54,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":41},"100549766","effects-of-nasal-ventilation-on-cerebral-and-pulmonary-function-in-orally-intubated-patients-100549766","NCT06438302","Effects of Nasal Ventilation on Cerebral and Pulmonary Function in Orally Intubated Patients","VENTINA","Inclusion Criteria:\n\n1. Age ≥ 18 years old\n2. Hypoxemic acute respiratory failure\n3. Intubation and mechanical ventilation since less than 4 days\n4. PaO2\u002FFiO2 ratio less than 200\n5. RASS\\\u003C-4\n6. Consent obtained from next of kin\n7. Patient with health insurance\n\nExclusion Criteria:\n\n1. Central nervous system diseases (stroke, MS, epilepsy)\n2. Psychiatric illnesses (psychosis, depression) (indicated on patient's medical record)\n3. Hemodynamic instability (noradrenalin\\>2mg\u002Fh)\n4. Patient on AME\n5. Patients under legal protection (guardianship\u002Fcurators)\n6. Pregnant or breast-feeding women",{"count":50,"type":19},22,"OBSERVATIONAL","The passage of air through the nasal cavity generates rhythmic oscillations transmitted by the olfactory bulb to the brain, which induces cerebral activation in functional areas and is associated with better cognitive performance compared to oral breathing. Consequently, the abolition of nasal ventilation in patients intubated via the orotracheal route could have deleterious effects on brain activity. Besides the loss of olfaction, the abolition of nasal ventilation could affect brain activity and respiratory control, consequently altering regional pulmonary ventilation.\n\nThe hypothesis of the study is that nasal ventilation through the passage of humidified nasal airflow in patients intubated via the orotracheal route would be associated with modulation of cerebral electrical activity and tissue oxygenation and a modification of regional pulmonary ventilation.",[28],[55,56,57],"nasal ventilation","orotracheal intubation","brain activity","2025-12-02",{"date":60,"type":33},"2025-12-03",{"date":62,"type":33},"2025-01-31",{"date":64,"type":19},"2028-02-01",{"name":66,"class":40},"Assistance Publique - Hôpitaux de Paris",{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":72,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":74,"targetDuration":4,"studyType":20,"phases":76,"briefSummary":77,"conditions":78,"keywords":79,"overallStatus":83,"whyStopped":4,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":41},"100607498","apneic-oxygenation-with-high-flow-nasal-oxygenation-after-preoxygenation-with-noninvasive-ventilation-before-intubation-in-hypoxemic-patients-in-intensive-care-unit-100607498","NCT07189338","Apneic Oxygenation With High-flow Nasal Oxygenation After Preoxygenation With Noninvasive Ventilation Before Intubation in Hypoxemic Patients in Intensive Care Unit.","APNEIC","Inclusion Criteria:\n\n* Patient admitted in the ICU\n* Indication of orotracheal intubation for Hypoxemic acute respiratory failure defined by:\n\n  * One sign of acute respiratory distress (respiratory rate \\>25\u002Fmin, dyspnea or the use of accessory respiratory muscle)\n  * AND a PaO2\u002FFiO2 ≤ 200 mmHg (measured or calculated FiO2) within 6 hours before the decision of intubation. For the calculation of FiO2, the FiO2 will be estimated by: FiO2 = 0.21 + 0.03 x (flow of oxygen) (Coudroy, Thorax 2020)\n* Informed consent from the patient or relatives. An emergency procedure will be possible when necessary.\n\nExclusion Criteria:\n\n* \\\u003C 18 years old\n\n  * Need for emergent intubation (i.e. cardiac arrest)\n  * Contraindication to non-invasive ventilation for preoxygenation\n  * Known allergy or contraindication to one of the induction drugs\n  * SpO2 device specific for the study not available\n  * Patients without any healthcare insurance scheme or not benefiting from it through a third party,\n  * Persons under law protection, namely minors, pregnant or breastfeeding women, persons deprived of their liberty by a judicial or administrative decision\n  * Previous participation in the study",{"count":75,"type":19},500,[22],"The aim of this clinical study is to assess whether apneic oxygenation with High-Flow Nasal Oxygen (HFNO) would decrease the incidence of severe hypoxemia compared to no apneic oxygenation during the intubation procedure (from the start of laryngoscopy to 5 minutes after successful intubation) in patients with hypoxemic acute respiratory failure.\n\nThe sponsor expects that apneic oxygenation (between the laryngoscopy and the success of intubation) with HFNO compared to no apneic oxygenation could decrease the risk of severe hypoxemia after intubation in hypoxemic critical ill patients.\n\nParticipants will be enrolled according to eligibility criteria and randomized into one of the following groups:\n\nExperimental group : Apneic oxygenation will be used with HFNO between the laryngoscopy and the successful intubation (study intervention).\n\nnon-invasive ventilation (NIV) alone will be used for the preoxygenation and hypoventilation phase until the laryngoscopy. The nasal cannulas of HFNO will be placed on hold beneath the patient's chin (with HFNO on and set with a flow at 60-70L.min-1, FiO2 1.0) pending laryngoscopy began.\n\nAt the time of laryngoscopy: after removing the facemask of NIV, the nasal cannulas for HFNO will be placed in the patient's nares then the laryngoscopy will be performed.\n\nControl group: The control group will receive usual care, i.e., no oxygen during the apneic phase (between the laryngoscopy and the success of the intubation procedure) During the preoxygenation and hypoventilation phase until laryngoscopy, NIV alone will be used as in the experimental group.",[28],[80,81,82],"IUC","Hypoxemic acute respiratory failure","HFNO","NOT_YET_RECRUITING","2025-09-17",{"date":86,"type":33},"2025-09-23",{"date":88,"type":19},"2025-10-30",{"date":90,"type":19},"2028-11-30",{"name":92,"class":40},"University Hospital, Tours",{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":99,"eligibilityCriteria":100,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":101,"targetDuration":4,"studyType":20,"phases":103,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":41},"100579856","closed-loop-oxygen-control-in-intubated-critically-ill-patients-100579856","NCT06829732","Closed Loop Oxygen Control in INtubated Critically Ill Patients","Closed Loop Oxygen Control in INtubated Critically Ill Patients - CLOC-IN","CLOC-IN","Inclusion Criteria:\n\n* Patients admitted to the ICU who are expected to require invasive mechanical ventilation for at least 8 hours and are expected to stay respiratory stable´ in the upcoming 8 hours.\n* Acute respiratory failure with PaO2\u002FFiO2 \\\u003C300 with FiO2 ≥ 0.4 at inclusion\n* Age older than 18 years old.\n* Written informed consent signed and dated by the patient or one relative in case that the patient is unable to consent, after full explanation of the study by the investigator and prior to study participation.\n\nExclusion Criteria:\n\n* Low quality on the SpO2 measurement using finger and ear sensor (quality index \\\u003C60%).\n* Hemodynamic instability defined as a need of continuous infusion of epinephrine or norepinephrine \\> 1 mg\u002Fh.\n* Severe acidosis (pH ≤ 7.30).\n* Chronic or acute dyshemoglobinemia: methemoglobin, CO poisoning, sickle cell disease.\n* Patient under guardianship or deprived of liberties.\n* Impossibility to give informed consent by both patient and family (i.e. language barrier).\n* Patient included in another interventional research study under consent with similar outcome.",{"count":102,"type":19},46,[22],"The deleterious effects of alveolar hyperoxia and (severe) hyperoxaemia are well described. Achieving safe and efficient oxygenation may be challenging. The hypothesis of the present study is that closed-loop oxygen control in intubated and mechanically ventilated critically ill patients improves oxygen administration compared with standard manual oxygen titrations. A single-blind, randomised crossover clinical trial assessing the efficacy and safety of the use of a closed-loop oxygen control versus manual oxygen titration in patients receiving mechanical ventilation has been designed. Patients will be randomised to receive first either closed-loop oxygen control (CLOC) or manual oxygen titration (MOT). The percentage of time spent in optimal and sub-optimal SpO2 (oxygen saturation by pulse oximetry) ranges will be calculated for each period.",[28],"2025-02-11",{"date":108,"type":33},"2025-02-17",{"date":110,"type":33},"2023-04-01",{"date":112,"type":19},"2025-03",{"name":114,"class":40},"Parc Taulí Hospital Universitari"]