[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypoxic-ischaemic-encephalopathy-hie\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypoxic-ischaemic-encephalopathy-hie":25},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,42,63,97],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":16,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100565547","healing-tiny-minds-rural-recovery-through-virtual-and-lived-experience-care-100565547",false,"NCT06643598","Healing Tiny Minds: Rural Recovery Through Virtual and Lived Experience Care","Inclusion Criteria:\n\n1. IPNH-NDCP patients, including:\n\n   * Term-born children diagnosed during the neonatal period with hypoxic-ischemic encephalopathy, or\n   * premature children (born at less than 28 weeks gestational age).\n2. Parent or legal guardian will also be enrolled as a participant\n3. Parents must be English-speaking (able to provide consent and complete questionnaires).\n\nExclusion Criteria:\n\n1. Not suitable for study participation due to other reasons at the discretion of the investigator.\n2. Infants with chromosomal abnormalities, genetic syndromes (for example, such as Down Syndrome or Trisomy18) and major congenital malformations will be excluded.\n3. Infants with vision impairment will also be excluded from the study, as our study procedures do require intact vision to be able to complete.\n4. For parents or legal guardians, there are no exclusion criteria.","ALL","5 Years",{"count":18,"type":19},225,"ESTIMATED","INTERVENTIONAL",[22],"NA","The goal of this behavioral-interventional study is to learn if the Abecedarian Approach implemented virtually for children ages 0-5 with a history of Hypoxic Ischaemic Encephalopathy (HIE) and\u002For premature birth produces the same effects as when administered at in-person facilities.",[25,26,27,28],"Hypoxic Ischaemic Encephalopathy (HIE)","Premature Birth","Cerebral Palsy","Neurological Disorder","RECRUITING","2026-03-24",{"date":32,"type":33},"2026-03-27","ACTUAL",{"date":35,"type":33},"2025-06-03",{"date":37,"type":19},"2030-03",{"name":39,"class":40},"University of Wisconsin, Madison","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":48,"targetDuration":4,"studyType":50,"phases":4,"briefSummary":51,"conditions":52,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":54,"lastUpdatePostDateStruct":55,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":41},"100605701","genetics-of-neonatal-encephalopathy-and-related-disorders-100605701","NCT07165938","Genetics of Neonatal Encephalopathy and Related Disorders","Proband Criteria:\n\nInclusion Criteria:\n\n* Diagnosed with neonatal encephalopathy during the neonatal period as documented in the electronic medical record\n* Less than 6 years old at the time of study enrollment\n* Patient at Boston Children's Hospital\n\nExclusion Criteria:\n\n* Genetic cause of NE already identified\n* Deceased prior to enrollment\n\nParent criteria:\n\nInclusion Criteria:\n\n\\- Biological parent of eligible proband (see above)",{"count":49,"type":19},300,"OBSERVATIONAL","Investigators at Boston Children's Hospital are conducting research in order to better understand the genetic factors which may contribute to neonatal encephalopathy (NE) and related disorders. These findings may help explain the broad spectrum of clinical features and outcomes seen in individuals with a history of NE.",[53,25],"Neonatal Encephalopathy","2026-03-09",{"date":56,"type":33},"2026-03-11",{"date":58,"type":33},"2026-02-04",{"date":60,"type":19},"2035-09",{"name":62,"class":40},"Boston Children's Hospital",{"id":64,"slug":65,"hasResults":11,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":4,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":15,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":50,"phases":4,"briefSummary":75,"conditions":76,"keywords":81,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":41},"100620981","measuring-heart-health-in-both-term-preterm-and-unwell-newborn-babies-with-an-advanced-ultrasound-method-speckle-tracking-echocardiography-100620981","NCT07364682","Measuring Heart Health in Both Term, Preterm and Unwell Newborn Babies With an Advanced Ultrasound Method: Speckle Tracking Echocardiography","Assessment of Cardiac Function Using 2D Speckle Tracking Echocardiography (STE) in Neonates.","Inclusion Criteria:\n\n* Neonates who are inpatient at the Birmingham Women's Hospital\n* Confirmed diagnosis of acute pulmonary hypertension, congenital diaphragmatic hernia, hypoxic ischaemic encephalopathy, or bronchopulmonary dysplasia\u002Fchronic lung disease (defined by oxygen\u002Frespiratory support requirement at 36 weeks post menstrual\u002Fcorrected gestational age).\n\nOR\n\n* Health control (\\>36 weeks - well and on the postnatal ward)\n* Well preterm neonate (\\\u003C36 weeks) admitted to the NICU, transitional care or post-natal wards.\n* Informed consent obtained from parent(s) or legal guardian(s)\n\nExclusion Criteria:\n\n* Presence of major congenital heart disease (other than patent foramen ovale or patent ductus arteriosus).\n* Presence of other life-limiting congenital anomalies (other than CDH) or syndromes that could independently affect cardiac function.\n* Inability to obtain adequate echocardiographic images for STE analysis after reasonable attempts.\n* If the neonatal consultant or neonatal nurse caring for the neonate feels that the neonate is too unstable for inclusion in the study or that consent should not be sought from parents.",true,"0 Minutes","8 Weeks",{"count":74,"type":19},190,"This study aims to improve how neonatologists check the heart function of newborn babies, especially those who are sick. While standard heart ultrasound scans are useful, a more advanced and sensitive technique called 2D speckle tracking echocardiography (STE) can detect subtle problems with how the heart muscle squeezes and relaxes. This may allow doctors to spot potential issues earlier.\n\nOur research will take place at Birmingham Women's Hospital. The investigators will perform these advanced, non-invasive heart scans on several groups of babies:\n\n1. Healthy term and premature babies, to establish a \"normal\" range of heart function.\n2. Babies who are unwell with specific conditions, including those with brain injury due to lack of oxygen at birth (HIE), chronic lung disease of prematurity (BPD), a hole in the diaphragm (CDH), or high blood pressure in their lungs (aPHN).\n\nThe heart scan is a standard, painless procedure. Using STE does not require any extra scanning time or cause any additional discomfort to the baby; the special images are taken during the routine scan. For many of the sick babies, these scans are already part of their normal clinical care.\n\nThe main goals of this observational study are to see if STE is a feasible and reliable tool in newborns, to establish normal values for healthy babies, and to track how heart function changes in sick babies during their illness and recovery.\n\nUltimately, the investigators hope this research will provide doctors with a better tool to assess heart health in newborns. This could lead to earlier, more accurate detection of heart problems and help guide treatment decisions to improve outcomes for these vulnerable infants.",[77,78,25,79,80],"Premature Baby","Pulmonary Hypertension of Newborn","Congenital Diaphragmatic Hernia","Chronic Lung DIsease",[82,83,84,85],"Speckle Tracking Echocardiography","STE","Functional echocardiography","Neonatal Performed Echocardiography","NOT_YET_RECRUITING","2026-01-23",{"date":89,"type":33},"2026-01-26",{"date":91,"type":19},"2026-02-01",{"date":93,"type":19},"2028-03-01",{"name":95,"class":96},"Birmingham Women's NHS Foundation Trust","OTHER_GOV",{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":20,"phases":108,"briefSummary":110,"conditions":111,"keywords":117,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":124,"lastUpdatePostDateStruct":125,"startDateStruct":127,"completionDateStruct":129,"leadSponsor":131,"locationsCount":41},"100573513","early-phase-1-feasibility-and-safety-of-intranasally-administered-breast-milk-in-hie-100573513","NCT06747260","Feasibility and Safety of Intranasally Administered Breast Milk in HIE","Feasibility and Safety of Intranasal Breast Milk in Hypoxic-ischaemic Encephalopathy","F-NEO-BRIGHT","Inclusion Criteria:\n\n* Moderate or severe hypoxic- ischaemic encephalopathy, receiving therapeutic hypothermia\n* ≥ 35. gestational week\n* \\\u003C 48 hours of life\n* Hypothermia treatment for 72 hours\n* Parental consent form\n\nExclusion Criteria:\n\n* Congenital malformation\n* Concurrent cerebral lesions\n* ECMO therapy\n* Contraindication of lactation\n* Mother unable or unwilling to provide fresh breast milk\n* Postpartum asphyxia","48 Hours",{"count":107,"type":19},10,[109],"EARLY_PHASE1","This is a prospective intervention single center study to evaluate the feasibility and safety of intranasal breast milk in hypoxic-ischaemic encephalopathic neonates receiving therapeutic hypothermia.",[25,112,53,113,114,115,116],"Hypoxic Ischemic Encephalopathy of Newborn","Neonatal Hypoxic Ischemic Encephalopathy","Brain Injury","Perinatal Asphyxia","Perinatal Asphyxia , Moderate to Severe HIE",[118,119,120,121,122,123],"Hypoxic-ischaemic encephalopathy","Neonatal encephalopathy","Perinatal asphyxia","Breast milk","Breast milk stem cells","Intranasal breast milk","2025-05-19",{"date":126,"type":33},"2025-05-22",{"date":128,"type":33},"2024-11-22",{"date":130,"type":19},"2030-01-01",{"name":132,"class":40},"Semmelweis University"]