[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypoxic-ischemic-brain-injury\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypoxic-ischemic-brain-injury":110},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,43,80,99,122],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100629955","molecular-insights-into-post-cardiac-arrest-brain-injury-via-csf-multi-omics-100629955",false,"NCT07481396","Molecular Insights Into Post-Cardiac Arrest Brain Injury Via CSF Multi-Omics","Identification of Novel Molecular Pathophysiological Mechanisms of Secondary Brain Injury in Post-cardiac Arrest Syndrome Patients Using Cerebrospinal Fluid Multi-omics Analysis","PCABI-OMICS","Inclusion Criteria:\n\n* Patients receiving post-resuscitation care after out-of-hospital cardiac arrest for secondary brain injury treatment.\n* Patients without contraindications for lumbar puncture catheter insertion for cerebrospinal fluid (CSF) collection. This includes the absence of:\n* Uncontrolled diabetes.Coagulation disorders.\n* Thrombocytopenia (platelet count $\\\u003C 100,000).\n* A history of cirrhosis diagnosis.\n* Current receipt of low molecular weight heparin.\n* Current use of platelet inhibitors.\n* A history of posterior spinal fusion that may interfere with catheter insertion.\n* Local skin infection or rash at the puncture site.\n* Signs of systemic infection or sepsis.\n* A history of lumbar puncture within the past 6 hours.\n\nExclusion Criteria:\n\n* Cerebral Edema: Patients with evidence of cerebral edema on a brain computed tomography (CT) scan performed immediately after spontaneous circulation recovery.\n* Patients who underwent extracorporeal membrane oxygenation (ECMO).\n* Patients who could not maintain integrated therapy for more than 24 hours after cardiac arrest.\n* Patients with a history of acute or chronic brain disease.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","3 Months","OBSERVATIONAL","The goal of this study is to uncover the molecular mechanisms responsible for secondary brain injury in patients with post-cardiac arrest syndrome by analyzing cerebrospinal fluid (CSF) using multi-omics techniques.\n\nThe main question this study aims to answer is:\n\nWhich genome-, transcriptome-, proteome-, and metabolome-level changes in CSF are associated with secondary brain injury after cardiac arrest?\n\nTo address this question, CSF samples collected from post-cardiac arrest patients will undergo multi-omics analyses. Identified molecular pathways will be used to screen existing drug databases and generate new therapeutic candidates through computational modeling and compound synthesis. These findings will provide the scientific foundation needed to design and implement future preclinical experiments using cardiac arrest animal models.",[26,27,28,29],"Cardiac Arrest (CA)","Cerebrospinal Fluid","Multiomics","Hypoxic-Ischemic Brain Injury","RECRUITING","2026-03-16",{"date":33,"type":34},"2026-03-18","ACTUAL",{"date":36,"type":34},"2025-12-01",{"date":38,"type":21},"2028-02-28",{"name":40,"class":41},"Chungnam National University Hospital","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":52,"conditions":53,"keywords":59,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":42},"100598144","regional-ventilation-evaluation-during-neuro-injury-weaning-study-100598144","NCT07067671","Regional Ventilation Evaluation During Neuro-injury Weaning Study","Evaluation of Regional Ventilation in Neuro-injured Patients Undergoing Weaning From Mechanical Ventilation","ReVENtS","Inclusion Criteria:\n\n* Age 18 or older\n* Hospitalized in intensive care for an acute brain injury.\n* Mechanical ventilation for more than 48 hours.\n* Ventilator withdrawal planned in the next few days\n* Social security coverage\n\nExclusion Criteria:\n\n* Pregnancy\n* Moribund patient \u002F decision to stop treatment\n* Patient under state medical aid",{"count":20,"type":21},"This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury. It aims to identify predictive EIT patterns related to extubation outcomes.",[54,55,56,57,29,58],"Acute Brain Injury","Mechanical Ventilation","Prolonged Weaning","Traumatic Brain Injury","Intracerebral Hemorrhage",[60,61,62,63,64,65,66,67,68,69],"Electrical Impedance Tomography","Ventilator Weaning","Neurocritical Care","ICU Monitoring","Spontaneous Breathing Trial","Extubation Failure","Respiratory Mechanics","PulmoVista","EIT","Brain-Injured Patients","NOT_YET_RECRUITING","2026-02-18",{"date":73,"type":34},"2026-02-19",{"date":75,"type":21},"2026-03",{"date":77,"type":21},"2028-03",{"name":79,"class":41},"Assistance Publique - Hôpitaux de Paris",{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":87,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":42},"100608158","identification-of-brain-injury-using-portable-mri-100608158","NCT07197918","Identification of Brain Injury Using Portable MRI","Prospective Identification of Hypoxic Ischemic Brain Injury Using Portable Magnetic Resonance Imaging","Inclusion Criteria:\n\n* Unresponsive immediately after ROSC from IHCA or OHCA\n* Age ≥ 18 years of age\n* Conventional MRI is clinically indicated\n* Treatment with temperature control\n\nExclusion Criteria:\n\n* MRI contraindication according to the American Heart Association guidelines\n* Inability to tolerate supine positioning for 30 minutes\n* Diffuse loss of grey-white differentiation and sulcal effacement on head computed tomography within 6 hours of ROSC",{"count":20,"type":21},"The goal of this study is to look for brain injury in patients who had a cardiac arrest, using portable brain imaging. The portable nature of this test will also allow for serial imaging so the investigators can understand how brain injury changes over days. The results of this study may allow for bedside imaging to be available at centers without specialized imaging centers and may identify markers of brain injury that help to select the patients most likely to benefit for clinical trials.",[26,29],"2026-01-26",{"date":92,"type":34},"2026-01-27",{"date":94,"type":34},"2025-12-02",{"date":96,"type":21},"2027-04",{"name":98,"class":41},"Yale University",{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":121},"100269979","perinatal-brain-injury-potential-of-innovative-nirs-to-optimize-hypothermia-100269979","NCT02793999","Perinatal Brain Injury: Potential of Innovative NIRS to Optimize Hypothermia","Inclusion criteria:\n\nNeonates must be \\> 33 weeks gestational age (GA) and meet inclusion criteria for one of the two groups:\n\n1. Therapeutic Hypothermia (TH) Group:\n\n   1. Undergo TH as part of their clinical management\n   2. Parents consent to multiple measures in the first week of life.\n2. No Therapeutic Hypothermia (no-TH) Group:\n\n   1. Signs will be defined broadly as any one of the following which can be considered evidence of NE caused by HIE or other etiologies: i) Seizures alone or ii) any of the following: abnormal consciousness, difficulty maintaining respiration, difficulty feeding (presumed central origin), abnormal tone or reflexes.\n   2. Parents consent to multiple measures in the first week of life.\n\nExclusion criteria:\n\nExclusion criteria includes neonates born at GA ≤ 33 weeks or \\\u003C 2.0 kg, with implanted devices or other devices that preclude the use of MRI will be excluded from the follow up MRI session.","2 Years",{"count":107,"type":21},125,"The purpose of this study is to improve the ability of the investigators to monitor brain health in newborn babies at risk of brain injuries. The researchers will be using an investigational system of devices to non-invasively (that, is, without penetrating the skin), measure the amount of oxygen going to and being used by the brain. They will be taking some bedside research measurements during the babies' stay at the hospital. With these measurements, the intention is to study the role of oxygen in brain injury and test the efficacy of the research device and its potential as a permanent bedside diagnostic device.",[110,111],"Hypoxic Ischemic Brain Injury","Neonatal Encephalopathy","2025-12-09",{"date":114,"type":34},"2025-12-10",{"date":116,"type":4},"2015-05",{"date":118,"type":21},"2028-05",{"name":120,"class":41},"Boston Children's Hospital",3,{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":130,"enrollmentInfo":131,"targetDuration":4,"studyType":133,"phases":134,"briefSummary":136,"conditions":137,"keywords":139,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":42},"100591812","phase-2-dexmedetomidine-versus-morphine-during-cooling-therapy-in-neonates-100591812","NCT06985290","Dexmedetomidine Versus Morphine During Cooling Therapy in Neonates","Comparative Efficacy of Dexmedetomidine Versus Morphine in Alleviating Secondary Brain Injury, When Used for Sedation During Hypothermia Therapy in Neonates: A Pilot Randomized Trial","COOL-SED","Inclusion criteria:\n\n1. Gestational age \\>= 35 weeks\n2. Birth weight \\>= 2500g\n3. Sign of perinatal hypoxic event (any of the following): (a) Arterial Cord blood gas or postnatal gas within 1 hour of life pH \\\u003C= 7.00 OR Base Deficit \\>= 16 (b) Arterial Cord blood gas postnatal gas within 1 hour of life pH 7.00 -7.15 AND Acute sentinel intrapartum event\n4. Sign of Neonatal Encephalopathy\n5. Initiation of Therapeutic Hypothermia within 8 hours of life\n\nExclusion criteria:\n\n1. Informed consent not obtained within 20 hours of life\n2. Congenital Brain Malformations (antenatally known)\n3. Major Chromosomal Anomaly (antenatally diagnosed)\n4. Congenital neuromuscular disorder","20 Hours",{"count":132,"type":21},50,"INTERVENTIONAL",[135],"PHASE2","About \\~3\u002F 1000 live-born newborns may suffer from brain injury due to a transient drop in oxygen supply to the brain during the birth process. The degree of brain injury that ensues in the first 72 hours after the injury is directly proportional to the severity of long-term childhood disabilities (e.g., cerebral palsy and developmental delays). Whole-body cooling during the first 3 days of life is proven effective in reducing the severity of brain injury. However, cooling therapy leads to pain, shivering, stress, and discomfort. The best way to alleviate the pain and agitation of cooled newborns is unknown. Standard practice is to provide morphine infusion to reduce pain. Recently, a new drug called \"dexmedetomidine\" has been tested in small studies and has been found to be safe during cooling in newborns. Dexmedetomidine has added beneficial effects such as anti-inflammation, faster recovery, and shorter hospital stays. This study is going to test the feasibility of conducting a future clinical trial to compare the effects of using Dexmedetomidine versus morphine in the management of cooling-related pain\u002Fagitation on the severity of brain injury in the first week of life. The study will also examine the effect of dexmedetomidine compared to morphine on short-term clinical outcomes, parental experiences and developmental outcomes at 1 year.",[110,111,138],"Perinatal Anoxic-ischemic Brain Injury",[140,141,142,143],"sedation","analgesia","dexmedetomidine","morphine","2025-05-14",{"date":146,"type":34},"2025-05-22",{"date":148,"type":21},"2025-07-01",{"date":150,"type":21},"2028-06-30",{"name":152,"class":41},"Ipsita Goswami"]