[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"hypoxic-ischemic-encephalopathy-of-newborn\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:hypoxic-ischemic-encephalopathy-of-newborn":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,46,84,108,137,159],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100574708","the-hienome-study-genome-sequencing-for-perinatal-hie-100574708",false,"NCT06762795","The HIEnome Study: Genome Sequencing for Perinatal HIE","Inclusion Criteria:\n\n* Delivery ≥35w0d gestation\n* Diagnosed with moderate or severe HIE, or HIE with seizures\n* Undergoing total body cooling \u002F therapeutic hypothermia\n* Able to provide blood or buccal samples during birth hospitalization\n* Admitted to Texas Children's Hospital Main, West, or Woodlands NICU\n\nExclusion Criteria:\n\n* Parents\u002Ffamily not willing to allow participation\n* Inability to collect sufficient neonatal blood samples (in some circumstances, a buccal swab may be used as backup)","ALL","0 Days","1 Year",{"count":19,"type":20},25,"ESTIMATED","INTERVENTIONAL",[23],"NA","Perinatal hypoxic-ischemic encephalopathy is a rare severe condition in which neonates present with encephalopathy and a clinical history suggestive of prenatal or perinatal hypoxic-ischemic injury. Emerging evidence suggests that genetic conditions are frequently identified in cases of perinatal HIE; however, it is unclear which neonates with this diagnosis warrant genetic testing. This study will offer clinical genome sequencing to neonates with HIE who are undergoing total body cooling (therapeutic hypothermia) and their parents.",[26,27,28],"Hypoxic Ischemic Encephalopathy of Newborn","Hypoxic Ischemic Encephalopathy","Hypoxic Ischemic Encephalopathy (HIE)",[30,31,32],"Hypoxic-ischemic encephalopathy","Genetic testing","Genome sequencing","RECRUITING","2025-09-25",{"date":36,"type":37},"2025-10-01","ACTUAL",{"date":39,"type":37},"2025-05-15",{"date":41,"type":20},"2027-06-30",{"name":43,"class":44},"Baylor College of Medicine","OTHER",2,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":67,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":83},"100573513","early-phase-1-feasibility-and-safety-of-intranasally-administered-breast-milk-in-hie-100573513","NCT06747260","Feasibility and Safety of Intranasally Administered Breast Milk in HIE","Feasibility and Safety of Intranasal Breast Milk in Hypoxic-ischaemic Encephalopathy","F-NEO-BRIGHT","Inclusion Criteria:\n\n* Moderate or severe hypoxic- ischaemic encephalopathy, receiving therapeutic hypothermia\n* ≥ 35. gestational week\n* \\\u003C 48 hours of life\n* Hypothermia treatment for 72 hours\n* Parental consent form\n\nExclusion Criteria:\n\n* Congenital malformation\n* Concurrent cerebral lesions\n* ECMO therapy\n* Contraindication of lactation\n* Mother unable or unwilling to provide fresh breast milk\n* Postpartum asphyxia","48 Hours",{"count":56,"type":20},10,[58],"EARLY_PHASE1","This is a prospective intervention single center study to evaluate the feasibility and safety of intranasal breast milk in hypoxic-ischaemic encephalopathic neonates receiving therapeutic hypothermia.",[61,26,62,63,64,65,66],"Hypoxic Ischaemic Encephalopathy (HIE)","Neonatal Encephalopathy","Neonatal Hypoxic Ischemic Encephalopathy","Brain Injury","Perinatal Asphyxia","Perinatal Asphyxia , Moderate to Severe HIE",[68,69,70,71,72,73],"Hypoxic-ischaemic encephalopathy","Neonatal encephalopathy","Perinatal asphyxia","Breast milk","Breast milk stem cells","Intranasal breast milk","2025-05-19",{"date":76,"type":37},"2025-05-22",{"date":78,"type":37},"2024-11-22",{"date":80,"type":20},"2030-01-01",{"name":82,"class":44},"Semmelweis University",1,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":11,"sex":15,"minAge":91,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":21,"phases":95,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":4},"100589154","chest-physical-therapy-on-arterial-blood-gases-for-neonates-post-hypoxic-ischemic-encephalopathy-100589154","NCT06950723","Chest Physical Therapy on Arterial Blood Gases for Neonates Post Hypoxic Ischemic Encephalopathy","Efficacy of Chest Physical Therapy on Arterial Blood Gases for Neonates Post Hypoxic Ischemic Encephalopathy in Neonatal Intensive Care Unit: A Clinical Trial Study","Inclusion Criteria:\n\n* Neonates with chest problems post Hypoxic-ischemic encephalopathy\n\nExclusion Criteria:\n\n* Neonates with chest problems due to other Causes except post Hypoxic-ischemic encephalopathy.\n* unstable medical status\n* Neonates with Post-operative s' respiratory problems due to any reasons.","1 Day","10 Days",{"count":94,"type":20},50,[23],"Hypoxic-ischemic encephalopathy (HIE) is a dangerous illness that happens when a newborn's brain does not receive adequate oxygen and blood flow, which can result in serious effects such as cerebral palsy and epilepsy. Infant diagnosed with HIE required ventilator support and subsequently developed pneumonia. They experienced respiratory problems and feeding challenges. Chest Physical Therapy is the best modalities to clear chest and improve ventilation.",[26],"NOT_YET_RECRUITING","2025-04-27",{"date":101,"type":37},"2025-04-30",{"date":103,"type":20},"2025-05-10",{"date":105,"type":20},"2025-07-15",{"name":107,"class":44},"Cairo University",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":15,"minAge":4,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":21,"phases":118,"briefSummary":119,"conditions":120,"keywords":123,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":136},"100559404","continuous-glucose-monitoring-in-hie-100559404","NCT06563687","Continuous Glucose Monitoring in HIE","Real-time Continuous Glucose Monitoring in Infants With Hypoxic-ischaemic Encephalopathy: a Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Birth weight \\>1.8kg\n* Gestation \\>35 weeks\n* Aged \\\u003C6hours\n* Moderate or severe HIE following perinatal asphyxia\n\nExclusion Criteria:\n\n* Major congenital malformations\n* Inborn errors of metabolism,\n* Congenital infections\n* Imminent death","6 Hours",{"count":117,"type":20},70,[23],"The aim of the study is to examine whether the use of continuous glucose monitoring (CGM) to guide the clinical management of glycaemic control will result into an increased time in the target glucose concentration. To further examine the efficacy of using CGM the following secondary outcomes in the two groups were assessed: mean glucose values, glucose variability within individuals, percentage of time that glucose values are in hyperglycaemic or hypoglycaemic ranges.\n\nRandomized controlled trial recruiting neonates (Birth weight \\>1.8kg, Gestation\\>36 weeks) with moderate or severe hypoxic ischemic encephalopathy (HIE) following perinatal asphyxia . Neonates will be randomly assigned (1:1) within 6 hours of birth to receive either the intervention with real-time CGM or standard care for 72 hours.",[26,121,122],"Hyperglycemia","Hypoglycemia",[124,125,126],"Continuous glucose monitoring","Neonatal hypoglycemia","Neonatal hyperglycemia","2024-08-20",{"date":129,"type":37},"2024-08-21",{"date":131,"type":37},"2024-08-01",{"date":133,"type":20},"2026-12-01",{"name":135,"class":44},"University of Campania Luigi Vanvitelli",3,{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":141,"acronym":4,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":15,"minAge":91,"maxAge":143,"enrollmentInfo":144,"targetDuration":4,"studyType":21,"phases":146,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":83},"100556244","phase-1-role-of-citicoline-in-treatment-of-neonates-with-hypoxic-ischemic-encephalopathy-100556244","NCT06522581","Role of Citicoline in Treatment of Neonates With Hypoxic Ischemic Encephalopathy","Inclusion Criteria:\n\n1. all indoor newborn babies with HIE II and III\n2. who have not received therapeutic hypothermia\n\nExclusion Criteria:\n\n1. grade I HIE\n2. Babies on TH\n3. babies whose parents do not give consent for inclusion in study\n4. babies with major congential malformations -","30 Days",{"count":145,"type":20},200,[147],"PHASE1","Hypoxic ischemic encephalopathy is an acute or subacute brain injury, due to asphyxia in neonates, leading to mortality and long-term morbidity. Its prevalence varies across regions, with developed countries reporting rates of 1.5 per 1000 live births, while developing nations experience a wider range from 2.3 to 26.5 per 1000 live births.\n\nInfants afflicted with moderate HIE face a 10% risk of mortality, with surviving individuals encountering a 30% chance of developing disabilities. The prognosis is graver for severe HIE, with a mortality risk of 60%, and nearly all survivors experiencing some form of disability.",[26],"2024-08-12",{"date":152,"type":37},"2024-08-14",{"date":154,"type":37},"2024-01-01",{"date":156,"type":20},"2025-01-01",{"name":158,"class":44},"Armed Forces Hospital, Pakistan",{"id":160,"slug":161,"hasResults":11,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":91,"enrollmentInfo":166,"targetDuration":4,"studyType":21,"phases":168,"briefSummary":169,"conditions":170,"keywords":172,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":178,"lastUpdatePostDateStruct":179,"startDateStruct":181,"completionDateStruct":183,"leadSponsor":185,"locationsCount":83},"100550444","continuous-versus-bolus-feeding-in-neonates-with-hypoxic-ischemic-encephalopathy-100550444","NCT06447155","Continuous Versus Bolus Feeding in Neonates With Hypoxic Ischemic Encephalopathy","The Impact of Continuous Versus Bolus Feeding in Neonates With Hypoxic Ischemic Encephalopathy Undergoing Therapeutic Hypothermia","Inclusion Criteria:\n\n* The neonates with evidence of encephalopathy de¬fined by seizures or abnormalities on a modified Sarnat exam were enrolled. The hypoxic-ischemic injury was defined by 1. a pH of ≤ 7.0 and\u002For 2. base deficit \\>-16 mmol\u002FL recorded in cord blood or blood gas obtained within the first hour postnatally or a pH of 7.0 - 7.15 and\u002For base deficit (-10-15.9) mmol\u002FL with the presence of an acute perinatal event (cord prolapse, placental abruption, heart rate decelerations, severe fetal bradycardia). In cases where criteria 1 or 2 are met, with the presence of seizures or a diagnosis of moderate to severe encephalopathy according to the Sarnat \\& Sarnat classification based on neurological examination were treated with TH.\n\nExclusion Criteria: Infants with congenital malformation or hereditary metabolic diseases, infants whose enteral feeding was initiated before randomization and infants without lack of parental consent were excluded. The maternal and neonatal demographic characteristics and clinical outcomes were collected from medical records.\n\n\\-",{"count":167,"type":20},60,[23],"Therapeutic hypothermia (TH) is accepted worldwide as a standard of care for infants born at or beyond 36 weeks gestational age with moderate-to-severe hypoxic ischaemic encephalopathy (HIE).\n\nWhile central nervous system is the most affected organ system , multiorgan dysfunction including renal, pulmonary, cardiac, and\u002For gastrointestinal (GI) compromise is not infrequent. Although the process of 'cooling' itself is well defined, based on high-quality randomized controlled trials, there are few data to inform the provision of nutrition to infants with HIE during and soon after TH.However, breastfeeding plays a beneficial role in maintaining the structural and functional integrity of the gut. It may help to reduce systemic inflammatory response and positively regulates the microbiota. In many studies it is stated that enteral feeding during TH appears to be safe and feasible. There is insufficient evidence to choose the type of enteral feeding either bolus or continuous during TH.\n\nThe present study aimed to compare the impact of different types of enteral feeding in infants with HIE receiving TH.",[26,171],"Feeding Patterns",[173,174,175,176,177],"Newborn","Hypoxic ischemic encephalopathy","Enteral feeding","Bolus","Continuous","2024-06-03",{"date":180,"type":37},"2024-06-06",{"date":182,"type":20},"2024-06-15",{"date":184,"type":20},"2026-06-15",{"name":186,"class":187},"Istanbul Training and Research Hospital","OTHER_GOV"]