[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"icu-acquired-weakness\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:icu-acquired-weakness":29},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,43,81,108,138,168,193,224,253,282,310,340,366,392],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100053237","icu-connect-study-comparing-emg-in-healthy-volunteers-and-icu-patients-100053237",false,"NCT07699562","ICU CONNECT: Study Comparing EMG in Healthy Volunteers and ICU Patients.","ICU CONNECT Trial: A MultIcenter Comparison Cohort Trial EvalUating the Correlation Between nOn-iNvasive EMG and iNvasive EMG in Healthy Volunteers and Critically Ill PaTients","ICU CONNECT","Inclusion Criteria:\n\n* Cohort 1: Healthy volunteers\n\nInclusion criteria:\n\n* Subjects must be \\> 18 years old and \\\u003C 90 years old.\n* Subjects must consent to participate. Cohort 2: Non-intubated critically ill patients\n\nInclusion criteria:\n\n* Subjects may be male or female.\n* Subjects must be \\> 18 years old and \\\u003C 90 years old.\n* Subjects must have a POA or next of kin who is able to consent (for those in the ICU and who are unable to consent themselves).\n\nCohort 3: Intubated critically ill patients\n\nInclusion criteria:\n\n* Subjects may be male or female.\n* Subjects must be \\> 18 years old and \\\u003C 90 years old.\n* Subjects must have a POA or next of kin who is able to consent (for those in the ICU and who are unable to consent themselves).\n* For the Subjects in the ICU that are intubated, they must be planned to be intubated for at least 24 hours.\n* Subjects must be intubated for no longer than ≥ 72 hours before enrollment.\n\nExclusion Criteria:\n\n* Cohort 1: Healthy volunteers\n\nExclusion criteria:\n\n* Subjects with previous paralysis or neuromuscular disease.\n* Subjects with spinal cord or brain injuries that impact motor function.\n* Subjects with an allergy to clinical adhesive or hydrogel. Cohort 2: Non-intubated critically ill patients\n\nExclusion criteria:\n\n* Subjects with previous paralysis or neuromuscular diseases.\n* Subjects with previous peripheral nerve injuries to the tested limbs.\n* Subjects with spinal cord or brain injuries (including stroke) that impact motor function.\n* Subjects without a POA or next of kin for those patients that are unable to consent themselves.\n* Subjects with an allergy to clinical adhesive or hydrogel. Cohort 3: Intubated critically ill patients\n\nExclusion criteria:\n\n* Subjects with previous paralysis or neuromuscular disease\n* Subjects with previous peripheral nerve injuries to the tested limbs.\n* Subjects with spinal cord or brain injuries that impact motor function.\n* Subjects without a POA or next of kin for those patients that are in the intubated arm.\n* Subjects with intubations expected to last less than 24 hours.\n* Subjects who have already been intubated for \\> 72 hours.\n* Subjects with an allergy to clinical adhesive or hydrogel.",true,"ALL","18 Years","90 Years",{"count":22,"type":23},24,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study is testing whether a non-invasive nerve monitoring device (TetraGraph) can accurately detect early signs of ICU-acquired weakness by comparing readings from the device with standard nerve conduction\u002FEMG tests done by a specialist to see if they match. They will focus on muscle response signals in the hand and leg over about 10 days in three groups: healthy volunteers, ICU patients who are not on ventilators, and ICU patients who are on ventilators.",[29],"ICU Acquired Weakness","RECRUITING","2026-07-07",{"date":33,"type":34},"2026-07-13","ACTUAL",{"date":36,"type":23},"2026-06",{"date":38,"type":23},"2027-09",{"name":40,"class":41},"Endeavor Health","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":24,"phases":54,"briefSummary":55,"conditions":56,"keywords":63,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":80},"100620841","myokine100-system-closed-loop-electrical-muscle-stimulation-to-mitigate-icu-acquired-weakness-in-medical-icu-patients-100620841","NCT07362862","MyokinE100 System: Closed Loop Electrical Muscle Stimulation to Mitigate ICU Acquired Weakness in Medical ICU Patients","Safety and Feasibility of the MyokinE100 System in ICU Settings to Mitigate ICU Acquired Weakness","ICUAW","Inclusion Criteria:\n\n* Admitted to ER or ICU within the previous 48 hours\n* APACHE II score ≥ 13\n* Meets the criteria for sepsis or severe sepsis\n* Baseline Clinical Frailty Scale (CFS) ≤ 4\n\nExclusion Criteria:\n\n* Anticipated transfer to an ICU not participating in this study\n* Expected length of ICU stay \\\u003C 48 hours\n* Myopathies (e.g. congenital)\n* Acquired myopathies with CK levels 5-times above the upper limit of normal\n* Unable to transfer from bed to chair at baseline\n* Moribund\n* Comfort care\n* New onset deep vein thrombosis within the previous 6-months\n* Malignancy in lower limb\n* Technical obstacles - fracture, burns, amputation\n* Open wound or skin abrasion at the garment application site\n* Pregnancy\n* Pacemaker and implantable cardioverter-defibrillator","85 Years",{"count":53,"type":23},50,[26],"The goal of this clinical trial is to learn if a new medical device that sends electrical signals to the thigh muscles is safe and easy to use for people in the ICU (Intensive Care Unit) who are at risk of losing muscle strength. It will also explore whether this treatment can help slow down muscle weakening.\n\nThe main questions this study aims to answer are:\n\n* Do participants develop medical problems when receiving electrical muscle stimulation in the ICU?\n* Is electrical muscle stimulation a practical way to help reduce muscle weakness in critically ill patients?\n\nResearchers will compare the control group (standard of care) to the intervention group (standard of care plus 60-minute sessions of electrical muscle stimulation daily during the ICU stay) to see if the device is safe and easy to use.\n\nParticipants will:\n\n* Receive either standard of care or standard of care plus electrical muscle stimulation of the thigh muscles\n* Have their muscle strength checked during the study\n* Complete a survey three months after ICU discharge to check on their recovery",[57,58,59,60,49,61,62],"Sepsis","Critical Illness","ICU-acquired Muscle Weakness","ICU-acquired Weakness","Sarcopenia","Secondary Sarcopenia",[64,65,66,67,57,68,69],"Electrical muscle stimulation","Electrical Impedance Myography","Bioimpedance","Rehabilitation","Critical illness","ICU-acquired weakness","2026-06-26",{"date":72,"type":34},"2026-06-29",{"date":74,"type":34},"2026-05-05",{"date":76,"type":23},"2027-08-31",{"name":78,"class":79},"Health Discovery Labs","INDUSTRY",3,{"id":82,"slug":83,"hasResults":11,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":89,"minAge":19,"maxAge":4,"enrollmentInfo":90,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":93,"conditions":94,"keywords":97,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":80},"100480539","muscle-recovery-after-critical-illness-100480539","NCT05537298","Muscle Recovery After Critical Illness","Cellular and Physical Function Outcomes Leading to Failed Muscle Recovery After Critical Illness\u002FMuscle and Physical Functional Recovery After Acute Critical Illness","TRACER","Inclusion Criteria:\n\n* adult (\\>18 y\u002Fo)\n* admission for sepsis or acute respiratory failure with at least 72 hour stay in ICU\n\nExclusion Criteria:\n\n* patients who were not ambulatory prior to ICU admission\n* experienced \\>2 ICU admissions in the past year (chronic or recurrent critical illness due to the same or different reason\n* patients not expected to survive \\~6months after admission\n* acute or chronic neurologic condition\n* acute or chronic orthopedic condition preventing strength\u002Ffunctional testing\n* morbid obesity \\>50 kg\u002Fm2 due to distortion of muscle ultrasonography","MALE",{"count":91,"type":23},209,"OBSERVATIONAL","The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which characteristics are associated with sustained physical disability. This proposal will examine muscle pathophysiology carefully aligned with physical function outcomes in order to longitudinally assess the recovery, or failed recovery, of muscle function in participants after critical illness:\n\n1. to examine the recovery of muscle and physical function in ICU survivors through longitudinal assessments\n2. to investigate the underlying cellular markers and mechanisms of muscle recovery in ICU survivors\n3. to determine which cellular markers contribute to physical disability in ICU survivors up to 1 year after hospital admission",[29,95,96,58],"Post Intensive Care Unit Syndrome","Muscle Weakness",[98,99],"skeletal muscle","physical function","2026-06-23",{"date":70,"type":34},{"date":103,"type":34},"2022-10-18",{"date":105,"type":23},"2027-08-01",{"name":107,"class":41},"Esther Dupont-Versteegden",{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":51,"enrollmentInfo":115,"targetDuration":117,"studyType":92,"phases":4,"briefSummary":118,"conditions":119,"keywords":122,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":136,"locationsCount":42},"100642676","shear-wave-elastography-of-peripheral-nerves-for-early-diagnosis-of-icu-acquired-weakness-100642676","NCT07594249","Shear Wave Elastography of Peripheral Nerves for Early Diagnosis of ICU-acquired Weakness","Clinical Value of Shear Wave Elastography of Peripheral Nerves for the Early Diagnosis of ICU-Acquired Weakness: A Prospective Observational Pilot Study","Inclusion Criteria:\n\n1. Age ≥ 18 years;\n2. Newly admitted to ICU with an expected ICU stay \\> 7 days;\n3. Initiated on mechanical ventilation within 24 hours of admission, with an expected ventilation duration \\> 48 hours;\n4. Patient or legally authorized representative provides written informed consent.\n\nExclusion Criteria:\n\n1. Known pre-existing neuromuscular diseases (e.g., myasthenia gravis, Guillain-Barré syndrome, amyotrophic lateral sclerosis);\n2. Pre-existing limb dysfunction that would interfere with muscle strength assessment (e.g., hemiplegia, paraplegia, severe arthritis);\n3. Presence of acute trauma, surgery, skin breakdown, infection, or severe edema at the measurement sites (wrist, elbow, ankle) that would interfere with ultrasound probe placement;\n4. Pregnant or lactating women;\n5. Any other condition that the investigator believes would make the patient unsuitable for the study.",{"count":116,"type":23},98,"28 Days","This study aims to determine whether shear wave elastography (SWE), a non-invasive ultrasound technique that measures nerve stiffness, can help detect ICU-acquired weakness (ICU-AW) early in critically ill patients. Adults receiving mechanical ventilation in the ICU will undergo ultrasound examinations of the median and tibial nerves on Days 1, 4, and 7. The study will evaluate whether early changes in nerve elasticity can predict ICU-AW, which is usually diagnosed later using a muscle strength score that requires patient cooperation.",[60,120,121],"Critical Illness Polyneuropathy","Critical Illness Myopathy",[123,124,125,126,127],"Shear Wave Elastography","Peripheral Nerve","Ultrasonography","Critical Care","Early Diagnosis","NOT_YET_RECRUITING","2026-06-13",{"date":131,"type":34},"2026-06-16",{"date":133,"type":23},"2026-07-01",{"date":135,"type":23},"2027-06-30",{"name":137,"class":41},"First Affiliated Hospital of Wannan Medical College",{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":92,"phases":4,"briefSummary":147,"conditions":148,"keywords":151,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":167},"100530991","icu-combined-assessment-of-cardio-respiratory-exercise-100530991","NCT06193980","ICU Combined Assessment of Cardio-Respiratory Exercise","Exercise Testing in ICU Survivors to Evaluate ICU-acquired Weakness","ICU-CARE","Inclusion Criteria:\n\n* Patients who have received mechanical ventilation for at least 7 days in the intensive care unit (ICU) and have subsequently been discharged from hospital.\n\nExclusion Criteria:\n\n* Unable to provide consent\n* Trajectory of health expected to be significantly limited in the upcoming 12 months\n* those who self-report that they cannot climb at least one flight of stairs due to limited exercise capacity\n* have significant orthopedic or musculoskeletal impairment affecting mobility\n* have a medical history of neuromuscular disease\n* ongoing respiratory limitations (i.e., supplemental oxygen)\n* significant heart disease (i.e. ejection fraction less than 30%, unstable ischemic heart disease, severe valvular heart disease)\n* a body mass index (BMI) of ≥ 40 kg\u002Fm2 (impacting NIRS signal due to adipose tissue thickness)\n* if participant's primary residence is a significant distance from the participating study site",{"count":53,"type":23},"This study aims to investigate how sepsis and critical illness can impair the cardiovascular system and microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle weakness\u002Fdysfunction or ICU-Acquired Weakness (ICU-AW) and exercise limitations.",[29,57,149,58,150],"Shock","Microcirculation",[152,153,150,98,154,155,156,157],"ICU Survivors","Oxygen Delivery","Exercise","near-infrared spectroscopy","cardiopulmonary exercise test","cardiovascular physiology","2026-06-11",{"date":160,"type":34},"2026-06-15",{"date":162,"type":34},"2023-12-15",{"date":164,"type":23},"2029-12",{"name":166,"class":41},"University of Manitoba",2,{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":172,"acronym":173,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":175,"targetDuration":4,"studyType":24,"phases":177,"briefSummary":178,"conditions":179,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":192},"100456016","remotely-monitored-mobile-health-supported-multidomain-rehabilitation-program-with-high-intensity-interval-training-for-covid-19-100456016","NCT05218083","REmotely Monitored, Mobile Health Supported Multidomain Rehabilitation Program With High Intensity Interval Training for COVID-19","REMM-HIIT-CoV","Inclusion Criteria:\n\n* Primary diagnosis of COVID-19 requiring hospital admission\n* Discharged or expected to be discharged directly home from the hospital (not to a skilled nursing facility, inpatient rehabilitation center, or long-term acute care hospital)\n* Able to ambulate with or without a gait aid prior to hospital discharge\n* Age ≥ 18 years\n\nExclusion Criteria:\n\n* Hospital discharge \\> 60 days unless readmitted to hospital in first 30 days, then 60 day window restarts and new exclusion is last hospital discharge \\> 60 days\n* Not ambulating independently prior to COVID-19 illness (use of a gait aid permitted)\n* Functional impairment resulting in inability to exercise at baseline\n* Inability or unwillingness to comply with the study requirements or unable or unwilling to follow coaching via mobile-health iPhone interaction\n* Any absolute contraindications to exercise, including but not limited to:\n\n  * Recent (\\\u003C 5 days) acute primary cardiac event\n  * Unstable Angina\n  * Uncontrolled dysrhythmias causing symptoms or hemodynamic compromise\n  * Uncontrolled hypertension over 255 mmHg Systolic or 155 diastolic blood pressure\n  * Symptomatic aortic stenosis\n  * Uncontrolled symptomatic heart failure\n  * Acute myocarditis or pericarditis\n  * Suspected or known dissecting aneurysm\n* Any adverse changes during GXT (i.e., persistent oxygen saturation drop below 88% while on prescribed oxygen therapy or significant hypotension such as mean arterial blood pressure \\\u003C 60 mmHg on 2 consecutive readings within 1 minute)\n* High risk for non-adherence as determined by screening evaluation\n* Any condition, including cognitive impairment, that, in the judgment of the investigator, precludes participation because it could affect subject safety or ability of subject to complete the study\n* Pregnant",{"count":176,"type":23},120,[26],"Multicenter, prospective, randomized controlled trial providing mobile health supported physical rehabilitation to 120 patients who have been critically ill with COVID-19 and who complete at least one exercise session.",[180,58,29,181,182],"COVID-19","PICS","Cardiorespiratory Fitness","2026-05-27",{"date":185,"type":34},"2026-05-28",{"date":187,"type":34},"2023-02-23",{"date":189,"type":23},"2027-04-01",{"name":191,"class":41},"Duke University",5,{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":18,"minAge":201,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":24,"phases":205,"briefSummary":207,"conditions":208,"keywords":209,"overallStatus":128,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":42},"100464356","early-phase-1-effect-of-protein-mobility-therapy-and-electric-stimulation-on-recovery-in-older-icu-survivors-100464356","NCT05326633","Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older ICU Survivors","Effect of Protein, Mobility Therapy and Electric Stimulation on Recovery in Older Survivors of Critical Illness","ProMoTE","Inclusion Criteria:\n\n1. LTACH admission within 72 hours\n2. Age ≥ 60 years old\n3. Prior ICU stay ≥ 2 weeks\n4. Able to follow commands in English\n5. Pre-ICU Barthel Index ≥ 70\n6. Able to give consent\n7. Able to perform physical therapy\n8. All four limbs intact and mobile prior to LTACH admission\n\nExclusion Criteria:\n\n1. Acute kidney injury with a glomerular filtration rate \\\u003C15 ml\u002Fmin\n2. Diagnosis of severe organ dysfunction including end stage liver disease or cirrhosis\n3. Diagnosis of active cancer\n4. Severe functional impairment or physical impairment to rehabilitation\n5. Liver function tests \\>2.5x normal limits\n6. Chronic dementia or cognitive impairment","60 Years","99 Years",{"count":204,"type":23},78,[206],"EARLY_PHASE1","Older ICU survivors with ICU acquired weakness (ICUAW) are malnourished, sarcopenic, and functionally debilitated as a consequence of the high burden of comorbidities common in the elderly. To address the sequalae of critical illnesses, the investigators will perform a trial incorporating an intervention that combines mobility-based physical rehabilitation (MRP), high protein supplementation (HPRO), and neuromuscular electric stimulation (NMES). The investigators will then assess both clinical and functional outcomes and determine the relationship of disability with systemic inflammation.",[58,61,29],[29,126,210,211,212,213,214],"Long Term Acute Care Hospital","Protein","Neuromuscular electric stimulation","Physical Rehabilitation","Geriatric population","2026-04-30",{"date":217,"type":34},"2026-05-06",{"date":219,"type":23},"2027-03-01",{"date":221,"type":23},"2029-10-30",{"name":223,"class":41},"University of Maryland, Baltimore",{"id":225,"slug":226,"hasResults":11,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":231,"targetDuration":4,"studyType":24,"phases":233,"briefSummary":234,"conditions":235,"keywords":241,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":248,"leadSponsor":250,"locationsCount":252},"100509938","improved-muscle-metabolism-by-combination-of-muscle-activation-and-protein-substitution--imempro--100509938","NCT05919940","Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO )","Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution: a Randomized, Outcome-assessor Blinded, Proof-of-concept Study (IMEMPRO)","Inclusion Criteria:\n\n* critically ill adults (≥ 18 years of age)\n* newly admitted to the ICU (\\\u003C48h)\n* mechanically ventilated, expected to remain for at least 72h\n* enteral nutrition is feasible\n\nExclusion Criteria:\n\n* a BMI \\> 30\n* expected death or withdrawal of life-sustaining treatments\n* prior neuromuscular disease (e.g. paresis, myopathies, neuropathies)\n* injury or disease preventing neuromuscular electrical stimulation or early mobilization (e.g., elevated intracranial pressure, unstable spine)\n* a pacemaker or other electronic implant\n* allergy to components of NMES adhesive\n* have been dependent during activities of daily living prior to the hospital admission\n* a language barrier",{"count":232,"type":23},40,[26],"Intensive Care Unit Acquired Weakness (ICUAW) describes muscle weakness that occurs in around 40% of patients during an intensive care stay. The morbidity and mortality of these patients is significantly increased over a 5-year period. The aim of this study is to investigate the combined effect of early enteral high-protein nutrition and early muscle activation on muscle atrophy in critically ill patients.\n\nThe study will include 40 patients (20 intervention, 20 observation) with requirement for enteral nutrition at time of inclusion. In the intervention group the maximum possible level of mobilization is carried out and muscles are activated twice a day using neuromuscular electrical stimulation (NMES). The nutrition plan of the intervention group is based on the applicable guidelines for intensive care medicine with exception of increased protein intake. The control group receives therapy without deviating from the standard according of the DGEM guideline.\n\nThe study aims to show that the decrease in muscle mass is significantly less than in the control group (primary hypothesis) via ultrasound of the rectus femoris muscle and in case of given consent muscle biopsy. As secondary hypothesis it is examined whether the combination of early high protein intake and muscle activation improves muscle strength and endurance.",[29,236,237,238,239,240],"Muscle Atrophy","Energy Malnutrition Protein","Quality of Life","Morphological and Microscopic Findings","Metabolic Disturbance",[242],"Early Mobilization and high-protein nutrition","2026-02-28",{"date":245,"type":34},"2026-03-03",{"date":247,"type":34},"2023-06-27",{"date":249,"type":23},"2027-01-31",{"name":251,"class":41},"Technical University of Munich",4,{"id":254,"slug":255,"hasResults":11,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":259,"eligibilityCriteria":260,"healthyVolunteers":11,"sex":18,"minAge":261,"maxAge":4,"enrollmentInfo":262,"targetDuration":4,"studyType":24,"phases":264,"briefSummary":265,"conditions":266,"keywords":271,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":80},"100530297","behavioral-economic--staffing-strategies-in-the-icu-100530297","NCT06184945","Behavioral Economic & Staffing Strategies in the ICU","Behavioral Economic and Staffing Strategies To Increase Adoption of an Evidence Based Bundle in the Intensive Care Unit (BEST ICU): A Stepped Wedge Cluster Randomized Controlled Trial","BEST-ICU","Inclusion Criteria:\n\n* Age \\>19 years at time of ICU admission\n* Received invasive mechanical ventilation while in the ICU\n* Admitted to participating cluster ICU\n* ICU length of stay of at least 24 hours\n\nExclusion Criteria:\n\n* Patient who is admitted to the hospital who is already receiving chronic long-term mechanical ventilation from the home, assisted living, or long-term care setting\n* Prisoners","19 Years",{"count":263,"type":23},8100,[26],"The overarching goal of this study is to support the \"real world\" assessment of strategies used to foster adoption of several highly efficacious evidence-based practices in healthcare systems that provide care to critically ill adults with known health disparities. Investigators will specifically evaluate two discrete strategies grounded in behavioral economic and implementation science theory (i.e., real-time audit and feedback and registered nurse implementation facilitation) to increase adoption of the ABCDEF bundle in critically ill adults.",[267,268,58,269,29,270],"Implementation Science","Delirium","Mechanical Ventilation Complication","Pain",[272],"ABCDEF bundle, delirium, intensive care, critical care, mechanical ventilation","2026-02-16",{"date":275,"type":34},"2026-02-19",{"date":277,"type":34},"2024-07-01",{"date":279,"type":23},"2028-04",{"name":281,"class":41},"University of Nebraska",{"id":283,"slug":284,"hasResults":11,"nctId":285,"briefTitle":286,"officialTitle":287,"acronym":288,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":290,"targetDuration":4,"studyType":24,"phases":292,"briefSummary":293,"conditions":294,"keywords":295,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":309},"100590924","effect-of-the-sitting-out-of-bed-in-an-arm-chair-position-in-icu-on-functional-recovery-among-ventilated-patients-100590924","NCT06973746","Effect of the \"Sitting Out of Bed in an Arm-chair Position\" in ICU on Functional Recovery Among Ventilated Patients","Effect of the \"Sitting Out of Bed in an Arm-chair Position\" in ICU on Functional Recovery Among Ventilated Patients: a Prospective Randomized Controlled Trial","STORM","Inclusion Criteria:\n\n1. Patient \\> 18 years old\n2. Patient on invasive mechanical ventilation for more than 24 hours\n3. Patient in recovery phase with a RASS score greater than \"-3\" for more than 12 hours\n4. Stay expected to last 48 hours\n5. Patient has never been placed in a chair during this hospitalization in intensive care.\n6. Fragility score \\\u003C 6, during the month preceding admission to intensive care\n7. Patient (or support person\u002Frelative if patient is unable to participate) who has agreed to take part in the study.\n\nExclusion Criteria:\n\n1. Patient with an absolute and non-resolving contraindication to chair positioning\n\n   1. Fracture or orthopedic disorder contraindicating mobilization out of bed\n   2. Obesity with body mass index greater than 45 kg\u002Fcm2\n   3. Sacral eschar stage greater than 2\n2. Patient using a wheelchair for mobility (i.e. paraplegic patient or patient with progressive neurological pathology).\n3. Patient treated with veno-venous or veno-arterial ECMO at the time of screening.\n4. Moribund patient\n5. Encephalic death\n6. Acute polyradiculoneuritis (Guillain-Barré syndrome)\n7. Myasthenia\n8. Patient treated by continuous hemodialysis or hemofiltration for more than 72 hours following the onset of awakening.\n9. Complete transmetatarsal or higher amputation of one or both lower limbs.\n10. Protected person (under guardianship or curatorship)\n11. Person under court protection\n12. Person not affiliated to a social security scheme\n13. Pregnant or breast-feeding woman\n14. Patient already included in the study\n15. Patient taking part in an interventional clinical study, the aim of which is to show an improvement in functional level on discharge from the intensive care unit or which focuses on the theme of early rehabilitation in the intensive care unit.",{"count":291,"type":23},150,[26],"Chair positioning is one of a series of early mobilization techniques. At present, this technique, which involves moving a patient out of the resuscitation bed, can be performed passively or actively. It does not constitute a rehabilitative act as such, but it is considered in common paradigms as a technique to improve \"the patient's breathing and strength\".\n\nHowever, recommendations issued in 2013 by the Society of intensive care physiotherapy and the society \"Société de réanimation de langue française (SRLF)\", reveal that this chair position cannot be recommended with a high grade.\n\nThe aim of the investigators is therefore to break down this early mobilization process in intensive care, to find out whether the armchair is an indispensable tool for improving functional and muscular processes.\n\nThe research hypothesis is therefore as follows:\n\n\"Early armchairing of the resuscitation patient, improves functional recovery compared to a conservative positioning strategy (sitting in bed).\"",[29],[296,29,297,298,299],"mechanical ventilation","Arm Chair","Sitting","Early mobility","2025-12-18",{"date":302,"type":34},"2025-12-19",{"date":304,"type":34},"2025-07-04",{"date":306,"type":23},"2028-01",{"name":308,"class":41},"Centre Hospitalier Régional d'Orléans",11,{"id":311,"slug":312,"hasResults":11,"nctId":313,"briefTitle":314,"officialTitle":315,"acronym":316,"eligibilityCriteria":317,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":318,"targetDuration":320,"studyType":92,"phases":4,"briefSummary":321,"conditions":322,"keywords":324,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":42},"100605792","predictive-validity-of-the-chelsea-critical-care-physical-assessment-tool-cpax-for-regaining-autonomy-three-months-after-icu-discharge-100605792","NCT07167121","Predictive Validity of the Chelsea Critical Care Physical Assessment Tool (CPAx) for Regaining Autonomy Three Months After ICU Discharge","Etude de validité Predictive du Chelsea Critical Care Physical Assessment Tool (CPAx) Quant au Retour de l'Autonomie à la Marche 3 Mois après la Sortie de réanimation","CPAx-Predict","Inclusion Criteria:\n\n* Patient affiliated with, or entitled to benefit from, a French social security system.\n* Patient who has received clear and comprehensive information about the study and has signed the informed consent form together with the investigator.\n* Age ≥ 18 years.\n* Having received at least 48 hours of invasive mechanical ventilation.\n* Previous hospitalization in the intensive care unit (ICU) at CHI Elbeuf-Louviers-Val-de-Reuil.\n* Prescription of physiotherapy during the ICU stay.\n* Eligible for the 3-month post-ICU follow-up in the day hospital based on at least one of the following criteria:\n\n  * Mechanical ventilation or catecholamine treatment (norepinephrine) for ≥ 5 days;\n  * Weight loss ≥ 5% during hospitalization (criterion for malnutrition);\n  * Significant muscle weakness (MRC score \\\u003C 28\u002F60);\n  * Presence of post-traumatic stress symptoms related to ICU stay (evaluated by the psychologist).\n* Ability to walk (with or without assistive devices) prior to ICU admission.\n\nExclusion Criteria:\n\n* Patient not affiliated with the French national health insurance system.\n* Documented pre-existing cognitive impairment likely to limit understanding of instructions and participation in functional assessments (e.g., dementia, intellectual disability, severe uncontrolled psychiatric disorder).\n* History of disabling chronic neuromuscular disease (e.g., amyotrophic lateral sclerosis, myopathy, progressive chronic polyneuropathy).\n* History of major pre-existing locomotor impairment preventing autonomous walking (e.g., paraplegia, uncompensated disabling arthropathy).\n* Refusal to participate in the study or withdrawal of consent at any time.\n* Person under legal guardianship, curatorship, or any other legal protection measure.\n* Simultaneous participation in another interventional study likely to interfere with the evaluation criteria of the present study.\n* Medical contraindication to performing the 6-minute walk test at 3 months (e.g., cardiovascular decompensation, acute pulmonary disease, persistent hemodynamic instability).",{"count":319,"type":23},25,"1 Year","This single-center observational study aims to explore the relationship between the CPAx score (Chelsea Critical Care Physical Assessment Tool), measured at ICU discharge, and the 6-minute walk test (6MWT) distance performed 3 months after discharge. The study targets patients who experienced prolonged mechanical ventilation and were admitted to the ICU at CHI Elbeuf-Louviers-Val-de-Reuil. Eligible participants must show signs of malnutrition, muscular weakness, or post-traumatic stress symptoms. Data collection includes the CPAx score, 6MWT distance, MRC score, and relevant clinical and demographic information. The primary objective is to determine whether the CPAx score can predict long-term functional recovery and guide post-ICU rehabilitation strategies. Participants will be evaluated during routine follow-up in the day hospital. This non-interventional study poses minimal risk to participants.",[29,323],"Intensive Care Neuropathy",[325,326,29,327,328,329],"ICU","Physiotherapy","CPAx","Predictive Validity","Test","2025-09-25",{"date":332,"type":34},"2025-09-30",{"date":334,"type":34},"2025-09-01",{"date":336,"type":23},"2026-09-01",{"name":338,"class":339},"Centre Hospitalier Intercommunal Elbeuf-Louviers-Val de Reuil","OTHER_GOV",{"id":341,"slug":342,"hasResults":11,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":347,"targetDuration":4,"studyType":24,"phases":348,"briefSummary":349,"conditions":350,"keywords":351,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":357,"lastUpdatePostDateStruct":358,"startDateStruct":360,"completionDateStruct":362,"leadSponsor":364,"locationsCount":42},"100605471","icu-recover-box-20-smart-technology-for-home-monitoring-of-icu-patients-100605471","NCT07162948","ICU-Recover Box 2.0, Smart Technology for Home Monitoring of ICU Patients","The ICU-Recover Box: Using Smart Technology for Monitoring Health Status After ICU Admission Pilot Study 2.0","Inclusion Criteria:\n\n* Patient has been admitted to the ICU of the LUMC for \\> 24 hours.\n* Patient has received mechanical ventilation.\n* Patient masters the English or Dutch language.\n* Patient is able to use smart technology at home. (i.e. Wi-Fi available, sufficient comprehension of smart technology).\n* Patient can be contacted and informed about the ICU-Recover box on one of the clinical wards of the LUMC.\n* Patient is discharged from a ward within the LUMC to home or an extra-hospital facility.\n\nExclusion Criteria:\n\n* Patient is \\\u003C 18 years old.\n* Patient is pregnant.\n* Patient breastfeeds during the course of the study.\n* Patient is discharged for palliative care.\n* Patient is considered an incapacitated adult.\n* Patient is unwilling to sign the informed consent form.\n* Patient is discharged to another hospital.",{"count":53,"type":23},[26],"Smart technology could improve quality of care in patients who have been admitted to the ICU and have been discharged from ICU and hospital, by early diagnosis of complications and early (ambulatory) treatment.\n\nWith the ICU-Recover Box and its smart technology the investigators see new opportunities to improve patient health and to recognize early if escalation of medical care is needed.\n\nThe primary objective of the pilot study is to assess the feasibility of the use of smart technology by persons that have been discharged from the ICU in the twelve months following ICU discharge.",[29],[352,353,354,355,356],"smart technology","post-ICU recovery","post intensive care syndrome","health care utilization","health related quality of life","2025-09-23",{"date":359,"type":34},"2025-09-29",{"date":361,"type":34},"2025-07-01",{"date":363,"type":23},"2026-12-01",{"name":365,"class":41},"Leiden University Medical Center",{"id":367,"slug":368,"hasResults":11,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":372,"eligibilityCriteria":373,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":374,"targetDuration":4,"studyType":24,"phases":376,"briefSummary":377,"conditions":378,"keywords":380,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":387,"completionDateStruct":389,"leadSponsor":390,"locationsCount":42},"100505740","optimised-nutritional-therapy-and-early-physiotherapy-in-long-term-icu-patients-nutriphyt-trial-100505740","NCT05865314","Optimised Nutritional Therapy and Early Physiotherapy in Long Term ICU Patients (NutriPhyT Trial)","Optimised Nutritional Therapy and Early Physiotherapy in Long Term ICU Patients: a Randomized Controlled Study (NutriPhyT Trial)","NutriPhyT","Inclusion Criteria:\n\nAny patient admitted to the adult ICU :\n\n* ≥18 years old\n* On mechanical ventilation with an expected length of stay ≥ 7 days\n* Requiring artificial nutrition (enteral and\u002For parenteral nutrition)\n\nExclusion Criteria:\n\nTherapeutic withdrawal Pregnant or breastfeeding patients\n\nNeurological disorders with motor deficits:\n\n* New or pre-existing neuromuscular or nervous system disease\n* Spinal cord injury Severe polytrauma of the lower limbs (amputation etc.) Non-independent ambulation (including walking aids) before ICU admission\n\nFor organizational reasons not allowing follow-up :\n\n* Transfer to another ICU\n* Patient living abroad from Switzerland\n* Patient living in nursing homes preceding to ICU admission\n* Incarcerated patients\n* Intellectual\u002Fcognitive disabilities or language barrier, limiting ability to follow the instructions",{"count":375,"type":23},164,[26],"Due to medical advances and quality of care, mortality in adult intensive care units (ICUs) has decreased significantly in recent years, leading to a significant increase in the number of patients with high rehabilitation needs on discharge from the ICU.\n\nA specific management by a multidisciplinary team has been set up since 2017 at the Geneva-ICU for long-stay patients (hospitalised ≥ 7 days).\n\nThis study aim to assess whether an optimization of the nutritional therapy coupled with an early mobility during and after the ICU stay allows an improvement in the muscle function at hospital discharge compared to patients receiving the standard care.",[58,29,379],"Malnutrition",[381,382,383,326],"Early nutrition therapy","Early mobilisation","Long stay ICU patient","2025-08-07",{"date":386,"type":34},"2025-08-12",{"date":388,"type":34},"2023-05-01",{"date":336,"type":23},{"name":391,"class":41},"HEIDEGGER CP",{"id":393,"slug":394,"hasResults":11,"nctId":395,"briefTitle":396,"officialTitle":397,"acronym":398,"eligibilityCriteria":399,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":400,"targetDuration":4,"studyType":24,"phases":402,"briefSummary":403,"conditions":404,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":42},"100544780","hand-and-arm-rehabilitation-using-vr-100544780","NCT06373341","Hand and Arm Rehabilitation Using VR","Rehabilitation of HAND and Arm Function Using a Meta QUEST-based Virtual Reality Game in ICU Patients","HANDQUEST","Inclusion Criteria:\n\n* Length of stay ICU ≥48 hours\n* Lives in catchment area of one of the Frisian hospitals\n* Understands the Dutch language\n* Intact motor skills of at least one upper extremity\n\nExclusion Criteria:\n\n* Active delirium (CAM-ICU ≥1)\n* Severe cognitive dysfunction\n* Internal cardiac defibrillator",{"count":401,"type":23},108,[26],"Patients admitted to the ICU due to critical illness often experience physical, mental, cognitive, or social issues. Research indicates that inadequate physical recovery is associated with lower handgrip strength, and hand function in ICU patients is lower compared to healthy individuals. To address this, a Virtual Reality (VR) exergame was developed to aid rehabilitation. This study aims to investigate the effect of a 4-week VR-exergame intervention on handgrip strength, hand and arm functionality, balance, mobility, and support needs in ICU patients staying for 48 hours or longer. It is a multicenter mixed-methods randomized controlled trial involving adult ICU patients. The intervention involves a 4-week VR-exergame program. Main study parameters include handgrip strength, hand and arm functionality, range of motion, balance, mobility, and support needs. The burden and risks associated with participation are minimal, as VR-based exercises are deemed safe and voluntary. Overall, the study aims to assess the effect of incorporating VR-based rehabilitation into standard care for ICU patients.",[405,29],"Post-Intensive Care Syndrome","2024-04-15",{"date":408,"type":34},"2024-04-18",{"date":410,"type":34},"2024-01-15",{"date":412,"type":23},"2027-01",{"name":414,"class":41},"Frisius Medisch Centrum"]