[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"icu-patients\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:icu-patients":28},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,41,70,101,132,160],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100608735","eye-tracking-communication-tool-for-non-verbal-icu-patients-100608735",false,"NCT07205419","Eye-Tracking Communication Tool for Non-verbal ICU Patients","Co-design and Pilot Feasibility Evaluation of an Eye-tracking Communication Tool for Conscious Non-verbal ICU Patients: Study Protocol for a Feasibility Randomized Controlled Trial","Inclusion Criteria:\n\n* aged ≥ 18 years\n* ICU stay ≥ 24 hours\n* unable to communicate through normal verbal means due to endotracheal intubation\u002Ftracheotomy, muscle or nerve injury, acute\u002Fchronic spinal cord injury, etc.\n* Richmond Agitation-Sedation Scale (RASS) score ranging from -1 to 1\n* able to comply with simple instructions for study participation\n\nExclusion Criteria:\n\n* blindness or inability to elevate the eyelids that preclude successful participation in eye-tracking interaction tasks\n* cognitive impairment limiting meaningful participation\n* severe psychological distress","ALL","18 Years",{"count":19,"type":20},40,"ESTIMATED","INTERVENTIONAL",[23],"NA","The objectives of this clinical trial are to explore the feasibility of the eye-tracking communication tool in alleviating communication barriers among non-verbal ICU patients. It will also preliminarily investigate the effectiveness of this tool in facilitating communication for these patients.\n\nResearchers will compare the eye-tracking communication tool with conventional techniques (such as body language, writing boards, etc.) to observe the feasibility and preliminary effectiveness of the eye-tracking communication tool in alleviating communication barriers.\n\nParticipants will use an eye-tracking communication tool for augmentative communication for 2 consecutive days.",[26,27,28],"Communication Barriers","Eye-tracking Technology","ICU Patients","NOT_YET_RECRUITING","2026-05-21",{"date":32,"type":33},"2026-05-27","ACTUAL",{"date":35,"type":20},"2026-07-01",{"date":37,"type":20},"2028-06-30",{"name":39,"class":40},"Shanghai Zhongshan Hospital","OTHER",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":4},"100637761","nurse-led-educational-intervention-for-caregivers-of-icu-patients-nurses-for-family---n4f-100637761","NCT07603219","Nurse-Led Educational Intervention for Caregivers of ICU Patients (Nurses For Family - N4F)","Feasibility And Acceptability of a Nurse-Led Educational Intervention for Caregivers of ICU Patients (Nurses For Family - N4F): Pilot Study","N4F","Inclusion Criteria:\n\nPatients:\n\n* Age \\>18 years\n* ICU stay \\> 24h\n\nCaregivers:\n\n* Age \\>18 years\n* consent to participate in the study\n* meeting the definition of a caregiver\n* able to complete questionnaires\n\nExclusion Criteria:\n\nPatients:\n\n* Age \\\u003C 18 years\n* Discharged\u002FDeceased form ICU \\\u003C 24h\n\nCaregivers:\n\n* Age \\\u003C 18 years\n* without cognitive impairment\n* no consent to participate in the study\n* No able to complete questionnaires",true,{"count":51,"type":20},20,[23],"Admission of a loved one to the intensive care unit (ICU) is a highly stressful experience for family members and caregivers. Many caregivers report increased levels of anxiety, stress, and depressive symptoms, often due to uncertainty about the patient's condition and difficulties in understanding medical information. Improving communication and providing clear, structured information may help reduce this psychological burden.\n\nThis study aims to evaluate the feasibility, acceptability, and preliminary effectiveness of a nurse-led educational intervention called \"Nurses for Family\" (N4F), designed to support caregivers of ICU patients.\n\nThe study will include adult caregivers (aged 18 years or older) of patients admitted to the ICU for more than 24 hours. Participants must provide informed consent and be able to complete questionnaires independently. A total of 20 participants will be enrolled and allocated to one of two groups: an intervention group (receiving nurse-led educational support) or a control group (receiving standard care).\n\nData will be collected at two time points during the ICU stay. At baseline (24-48 hours after ICU admission), participants will complete the Hospital Anxiety and Depression Scale (HADS), which measures symptoms of anxiety and depression. At follow-up (7 days later), participants will complete the HADS again, along with the Family Satisfaction in the ICU (FSICU-24) questionnaire. Feasibility will be assessed based on recruitment and retention rates, adherence to the study protocol, and completeness of data collection. Acceptability will be evaluated through interviews conducted with participants from the control group.\n\nThis pilot study is expected to determine whether the N4F intervention is feasible and acceptable in a clinical setting and to provide preliminary evidence regarding its potential to reduce psychological distress and improve satisfaction among caregivers of ICU patients.",[55,28],"Caregiver",[57,58,59,60],"ICU","caregiver","Family-Centered Care","Nurse-Led Interventions","2026-05-19",{"date":63,"type":33},"2026-05-22",{"date":65,"type":20},"2026-09",{"date":67,"type":20},"2027-09",{"name":69,"class":40},"Medical University of Gdansk",{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":21,"phases":79,"briefSummary":80,"conditions":81,"keywords":85,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":100},"100632512","validation-of-a-regional-citrate-anticoagulation-protocol-in-critically-ill-patients-on-continuous-renal-replacement-therapy-100632512","NCT07514650","Validation of a Regional Citrate Anticoagulation Protocol in Critically Ill Patients on Continuous Renal Replacement Therapy","CRRT","Inclusion Criteria\n\n* Age ≥18 years\n* Admission to the intensive care unit (ICU)\n* Diagnosis of acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT)\n* Use of regional citrate anticoagulation during CRRT Exclusion Criteria\n* Known allergy or intolerance to citrate\n* Contraindications to citrate anticoagulation (e.g., severe liver failure or severe metabolic disorders affecting citrate metabolism)\n* Pregnancy or breastfeeding",{"count":78,"type":20},43,[23],"The objective of this study is to evaluate the effectiveness of a modified continuous renal replacement therapy (CRRT) protocol in maintaining electrolyte balance in adult patients with acute kidney injury (AKI) admitted to the intensive care unit (ICU).\n\nThe study assesses whether the use of continuous venovenous hemodiafiltration (CVVHDF) with post-filter replacement under citrate anticoagulation reduces electrolyte losses and the need for electrolyte supplementation compared with standard dialytic CRRT.\n\nParticipants receiving standard CRRT will be compared with those treated with the modified protocol.\n\nThe duration of participation corresponds to the period during which CRRT is required. Data collection will cease once CRRT is discontinued.",[82,28,83,84],"Acute Kidney Injury","Continuous Renal Replacement Therapy (CRRT)","Electrolytes",[86,82,87,88,89,84],"Regional Citrate Anticoagulation","ICU patients","Continuous Renal Replacement Therapy","Diluted citrate","RECRUITING","2026-04-01",{"date":93,"type":33},"2026-04-07",{"date":95,"type":33},"2024-11-24",{"date":97,"type":20},"2026-11",{"name":99,"class":40},"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau",1,{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":21,"phases":110,"briefSummary":111,"conditions":112,"keywords":117,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":4},"100618913","implementation-of-clinical-nutrition-practice-guidelines-in-surgical-icus-100618913","NCT07337798","Implementation of Clinical Nutrition Practice Guidelines in Surgical ICUs","Effects of Implementing Evidence-Based Clinical Nutrition Practice Guidelines in Surgical Intensive Care Units: A Cohort Study","Inclusion Criteria:\n\nFor ICU healthcare professionals:\n\nEmployed at one of the participating study sites (tertiary general hospitals)\n\nHolds a valid Registered Nurse license issued in the People's Republic of China\n\nCurrently working in frontline clinical nursing care in a surgical intensive care unit (ICU) during the study period\n\nAt least 1 year of clinical working experience\n\nAble to understand the study objectives and procedures\n\nWilling to participate and able to provide written informed consent\n\nFor surgical critically ill patients (outcome assessment population):\n\nAged 18 years or older\n\nAdmitted to a surgical ICU due to surgical-related conditions, including trauma, infection, malignancy, or postoperative complications\n\nExpected length of stay in the surgical ICU of at least 48 hours\n\nNo restriction on sex\n\nPatient or legally authorized representative able to provide written informed consent\n\nExclusion Criteria:\n\nFor ICU healthcare professionals:\n\nCurrently pregnant, breastfeeding, or planning pregnancy during the study period\n\nTemporarily assigned, rotating, externally dispatched, on long-term training, or on leave during the study period, making continuous participation impossible\n\nParticipation in other interventional studies that may interfere with the implementation of this study\n\nDetermined by the research team to have cognitive, communication, or other conditions that would make participation inappropriate\n\nFor surgical critically ill patients:\n\nDiagnosed with brain death or awaiting organ donation\n\nPregnant or breastfeeding women\n\nConcurrent participation in other nutrition-related clinical trials",{"count":109,"type":20},200,[23],"The goal of this interventional clinical trial is to evaluate whether the implementation of an evidence-based, context-adapted clinical nutrition practice guideline can improve clinical nutrition management in surgical intensive care units (ICUs) in China. The guideline is selected based on the best available evidence from existing surgical and critical care nutrition guidelines, adapted to the Chinese healthcare context, and implemented using an i-PARIHS-guided translation strategy. The trial involves ICU healthcare professionals working in surgical ICUs of tertiary general hospitals, while assessing nutrition-related clinical outcomes among surgical critically ill patients.\n\nThe main questions it aims to answer are:\n\nDoes guideline implementation improve ICU healthcare professionals' adherence to recommended clinical nutrition practice guidelines?\n\nDoes the implementation of the clinical nutrition practice guideline improve the proportion of surgical critically ill patients who achieve recommended energy and protein intake targets during ICU stay?\n\nResearchers will compare outcomes before and after guideline implementation to determine whether the i-PARIHS-guided guideline translation improves nutrition management processes, healthcare professional performance, and patient-related clinical outcomes.\n\nParticipants will:\n\nComplete baseline and post-implementation assessments related to clinical nutrition knowledge, attitudes, and practices.\n\nParticipate in guideline-based education, training, and implementation activities guided by the i-PARIHS framework.\n\nApply the adapted clinical nutrition practice guideline during routine clinical care in surgical ICUs.\n\nBe evaluated through on-site audits, questionnaires, and clinical data collection during the implementation process.",[28,113,114,115,116],"Surgical","Nutrition Intervention","Enteral Nutrition","Enteral Nutrition Intolerance",[118,119,120,121,122],"Clinical Nutrition","Surgical Intensive Care Units","i-PARIHS Framework","Implementation Science","Clinical practice guideline","2026-01-11",{"date":125,"type":33},"2026-01-13",{"date":127,"type":20},"2025-12-20",{"date":129,"type":20},"2026-12-31",{"name":131,"class":40},"Xuanwu Hospital, Beijing",{"id":133,"slug":134,"hasResults":11,"nctId":135,"briefTitle":136,"officialTitle":137,"acronym":138,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":21,"phases":142,"briefSummary":143,"conditions":144,"keywords":147,"overallStatus":90,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":156,"leadSponsor":158,"locationsCount":100},"100604417","the-effect-of-a-6-month-dietitian-tailored-nutrition-intervention-to-patients-with-critical-illness-detail-100604417","NCT07149246","The Effect of a 6-month Dietitian-tailored Nutrition Intervention to Patients With Critical Illness (DETAIL)","The Effect of a 6-month DiEtitian-TAILored Nutrition Intervention Compared to Usual Care in Patients With Critical Illness. A Single Center Prospective Intervention Study","DETAIL","Inclusion Criteria: Patients in intensive care who gives an informed consent and meet all of the following will be eligible:\n\n1. Admitted to the intensive care unit for \\>48 hours.\n2. At least 18 years of age\n3. Have one or more organ system failure (respiratory,cardiovascular or renal) related to their acute illness defined as:\n\n   a. PaO2\u002FFiO2≤300 mm Hg) b. Currently on one or more continuous inotrope\u002Fvasopressor infusion which were started at least 4 hours ago at a minimum dose of: i. Norepinephrine≥0.1 mcg\u002Fkg\u002Fmin ii. Epinephrine≥0.1 mcg\u002Fkg\u002Fmin iii. Any dose of vasopressin iv. Milrinone\\>0.1 mcg\u002Fkg\u002Fmin) c. Renal dysfunction defined as: i. Serum creatinine 2.0-2.9 times baseline or ii. Urine output 0.5 mL\u002Fkg\u002Fhour for ≥12 hours or iii. Currently receiving renal replacement therapy) d. Currently has an intracranial pressure monitor or ventricular drain in situ\n4. Permanent living address in Norway\n\nExclusion Criteria: Patients will be excluded if:\n\n1. Death is imminent in the next 96 hours or there is a current treatment limitation in place or the patient is unlikely to survive to 180 days due to underlying\u002Fchronic illness\n2. Dialysis dependent chronic renal failure\n3. Suspected or known pregnancy\n4. Wheelchair user\n5. Cognitive impairment in which intervention is considered not appropriate\n6. Eating disorders -",{"count":141,"type":20},300,[23],"This research project aims to study the effect of optimal and individualised nutrition to patients with critical illness during the intensive care unit (ICU) and hospital admission, and until six months after admission. The investigators want to describe and compare the usual care with a dietitian-tailored nutrition care. The hypothesis is that dietitian-tailored nutrition care will result in a higher mean energy intake compared to usual care.",[28,145,146],"Nutrition Intake","Critical Illness",[148,149,150,57,151],"Nutrition","Energy intake","Protein intake","Dietitian","2025-09-01",{"date":154,"type":33},"2025-09-03",{"date":152,"type":33},{"date":157,"type":20},"2028-03-31",{"name":159,"class":40},"University Hospital of North Norway",{"id":161,"slug":162,"hasResults":11,"nctId":163,"briefTitle":164,"officialTitle":165,"acronym":4,"eligibilityCriteria":166,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":167,"enrollmentInfo":168,"targetDuration":4,"studyType":21,"phases":170,"briefSummary":171,"conditions":172,"keywords":174,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":4},"100597713","ultrasound-guided-bcv-and-ijv-in-icu-patients-100597713","NCT07062068","Ultrasound-Guided BCV and IJV in ICU Patients","Comparative Study Between Ultrasound-Guided Brachiocephalic Vein and Internal Jugular Vein Cannulation in Mechanically Ventilated ICU Patients","Inclusion Criteria:\n\n100 patients with age between ( 18 - 50 years old ) ventilated in ICU with need central venous access , with physical status II or III according to ASA classification .\n\nExclusion Criteria:\n\n* refusal of relatives of patients\n* Any contraindication of Central venous line insertion as thrombocytopenia , coagulopathy …. Etc\n* any suspected or documented thrombus inside vein\n* any congenital or acquired musculo-skeletal deformities of neck or clavicle\n* any active infections or signs of inflammation over insertion site\n* any previous procedures performed at the cannulation site","50 Years",{"count":169,"type":20},100,[23],"This is a prospective randomized clinical trial aiming to compare the success rate, complications, and insertion time between ultrasound-guided brachiocephalic vein (BCV) and internal jugular vein (IJV) cannulation in mechanically ventilated patients in the intensive care unit (ICU). The goal is to determine whether BCV access offers a safer or more effective alternative in critically ill patients requiring central venous catheter placement.",[173,28],"Ultrasound-Guided Vascular Access",[165],"2025-07-02",{"date":177,"type":33},"2025-07-14",{"date":179,"type":20},"2025-07",{"date":181,"type":20},"2025-12",{"name":183,"class":40},"Sohag University"]