[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"icu\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:icu":26},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,42,76,101,130,162,184,206,230,252,279,304,330,358,384,407],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100054105","phase-4-effects-of-melatonin-on-sleep-architecture-of-critically-ill-patients-in-the-icu-100054105",false,"NCT07691996","Effects of Melatonin on Sleep Architecture of Critically Ill Patients in the ICU","Inclusion Criteria:\n\n* 18 years or older, admitted to the ICU\n* Expected length of stay of at least 48 hours\n* Not mechanically ventilated\n* Able to take oral medications.\n* Hemodynamically stable as determined by the treating ICU physician\n* Able to provide informed consent or have consent provided by a legally -authorized representative.\n\nExclusion Criteria:\n\n* Mechanically ventilated\n* Currently using melatonin prior to ICU admission,\n* Have neurological conditions that may significantly alter sleep architecture, such as traumatic brain injury, stroke, or severe dementia.\n* Pregnant or lactating individuals\n* Those individuals with a comfort measures-only status","ALL","18 Years",{"count":18,"type":19},30,"ESTIMATED","INTERVENTIONAL",[22],"PHASE4","This is a pilot study to examine the effects of melatonin on the sleep patterns of critically ill patients. Patients will have their sleep patterns measured with a device attached to their head with a headband then be given a dose of melatonin. Their participation in the study will last two days.",[25,26,27,28,29],"Critical Illness","ICU","ICU Hospitalization","Melatonin","Sleep","NOT_YET_RECRUITING","2026-07-09",{"date":33,"type":34},"2026-07-13","ACTUAL",{"date":36,"type":19},"2026-09-01",{"date":38,"type":19},"2028-01",{"name":40,"class":41},"Rutgers, The State University of New Jersey","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":20,"phases":53,"briefSummary":55,"conditions":56,"keywords":63,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100644682","burn-asv-trial-adaptive-support-ventilation-in-severe-burn-injury-100644682","NCT07674563","BURN-ASV Trial: Adaptive Support Ventilation in Severe Burn Injury","Adaptive Support Ventilation Versus Conventional Lung-Protective Ventilation in Severe Burn Injury Including Thermobaric and Drone-Related Burns: The BURN-ASV Randomized Controlled Trial","BURN-ASV","Inclusion Criteria:\n\n* Age 18 years or older.\n* Thermal burn injury involving ≥20% total body surface area (TBSA).\n* Requirement for invasive mechanical ventilation expected to exceed 24 hours.\n* Admission to a participating intensive care unit within 48 hours of injury.\n* Burn injury resulting from conventional flame burns, explosion-related burns, drone-related burns, or thermobaric blast burns.\n* Written informed consent provided by the patient or a legally authorized representative.\n\nExclusion Criteria:\n\n* Age younger than 18 years.\n* Pregnancy or breastfeeding.\n* Pre-existing chronic respiratory failure requiring home oxygen therapy or long-term mechanical ventilation.\n* Severe chronic obstructive pulmonary disease (COPD GOLD IV) or other end-stage pulmonary disease.\n* Extracorporeal membrane oxygenation (ECMO) at the time of enrollment.\n* Severe traumatic brain injury requiring controlled hyperventilation.\n* Expected death within 24 hours of ICU admission.\n* Do-not-resuscitate (DNR) order or limitations of life-sustaining treatment.\n* Previous enrollment in the current study.\n* Participation in another interventional trial that may interfere with study outcomes.","50 Years",{"count":52,"type":19},100,[54],"NA","Severe burn injury frequently requires prolonged mechanical ventilation because of inhalation injury, respiratory failure, systemic inflammation, and repeated surgical procedures. Patients with extensive burns are at high risk of ventilator-associated complications, prolonged intensive care unit (ICU) stay, and death.\n\nAdaptive Support Ventilation (ASV) is an automated mode of mechanical ventilation that continuously adjusts breathing support according to the patient's respiratory needs and lung mechanics. Although ASV has shown potential benefits in general ICU populations, its effectiveness in patients with severe burn injuries has not been adequately studied.\n\nThe purpose of this randomized controlled trial is to compare Adaptive Support Ventilation with conventional lung-protective mechanical ventilation in critically ill adult burn patients, including those with inhalation injury, drone-related burns, and thermobaric blast burns. Participants will be randomly assigned to receive either ASV or conventional ventilation. The study will evaluate whether ASV improves ventilator-free days, reduces duration of mechanical ventilation, decreases ventilator-associated complications, and improves clinical outcomes.\n\nThe results of this study may help identify optimal ventilation strategies for patients with severe burn injuries and improve critical care management in both civilian and military burn centers.",[57,58,59,26,27,60,61,62],"Burn","Mechanical Ventilation","Mechanical Ventilation Complication","Critical Care, Intensive Care","Military Activity","Combat-Related Burn Injury",[64,62,65,66],"burn","adaptive support mechanical ventilation","mechanical ventilation","2026-06-24",{"date":69,"type":34},"2026-06-29",{"date":71,"type":19},"2026-09-23",{"date":73,"type":19},"2026-11-23",{"name":75,"class":41},"Ukrainian Society of Regional Anesthesia and Pain Therapy",{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":15,"minAge":82,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":20,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":98,"locationsCount":100},"100608689","functional-inspiratory-versus-expiratory-muscle-electrical-stimulation-on-weaning-outcomes-in-mechanically-ventilated-patients-100608689","NCT07204821","Functional Inspiratory Versus Expiratory Muscle Electrical Stimulation on Weaning Outcomes in Mechanically Ventilated Patients","Inclusion Criteria:\n\n* All mechanically ventilated patients will be:\n* Their ages range from 45 to 65 years.\n* Their BMI is from 25-29.9kg\u002Fm2.\n* Mechanically ventilated for at least 24 hours.\n* They all have hypoxemic respiratory failure\n* Glasgow coma score (GCS) ranged from 6 to 12.\n* Richmond Agitation-Sedation Scale score: -2 to +2\n* Patients and their relatives had written informed consent.\n\nExclusion Criteria:\n\n* Hemodynamically unstable patients.\n* Patients with rib fractures.\n* Patients with implanted pacemaker.\n* Obese (BMI greater than 30 kgm2).\n* Tachycardia.\n* Uncontrolled hypertension.\n* History of neuromuscular disease at admission.\n* Spinal injuries.\n* Inability to trigger mechanical ventilation\n* Pregnancy\n* An anticipated stay on the ventilator \\\u003C72 h at the time of study\n* Patients who cannot attach electrodes due to local skin damage or infection\n* Patients with Severe intestinal gas accumulation, structural abnormalities, and other reasons that prevent ultrasound detection of diaphragm movement.\n* Congenital myopathies or neuropathies, and contraindications for expiratory muscle FES (cardiac pacemaker, refractory epilepsy, recent (\\\u003C 4 weeks) abdominal surgery).\n* Patients with unrelieved pneumothorax and restricted diaphragm movement disorders.\n* Chest or diaphragm malformation","45 Years","65 Years",{"count":85,"type":19},48,[54],"The Goal of This Clinical Trail is\n\n* To find out the difference in the effect of inspiratory muscle functional electrical stimulation and expiratory muscle functional electrical stimulation on weaning outcomes mechanically ventilated patients.\n* To investigate the effect of inspiratory muscle functional electrical stimulation and expiratory muscle functional electrical stimulation on Laboratory investigation (Arterial Blood Gases).\n* To investigate the effect of inspiratory muscle functional electrical stimulation and expiratory muscle functional electrical stimulation on Sonar parameters (Diaphragmatic excursion, Diaphragmatic muscle fractional thickness in the end of inspiration and the end of expiration and abdominal muscles wall thickness). To evaluate the effect of inspiratory muscle functional electrical stimulation and expiratory muscle functional electrical stimulation on (ICU length of stay and Spontaneous Breathing Trail (SBT)).",[89],"Icu",[91],"Functional Inspiratory Muscle Electrical Stimulation, Functional Expiratory Muscle Electrical Stimulation, Weaning Outcomes in Mechanically Ventilated Patients.","2026-06-02",{"date":94,"type":34},"2026-06-03",{"date":96,"type":19},"2026-06-15",{"date":36,"type":19},{"name":99,"class":41},"Beni-Suef University",1,{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":20,"phases":111,"briefSummary":112,"conditions":113,"keywords":114,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":129},"100619347","trial-on-the-impact-of-indirect-calorimetry-guided-nutritional-support-on-patient-centered-outcomes-in-critically-ill-patients---the-optical-study-100619347","NCT07343440","Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study","A Randomized Controlled Trial on the Impact of Indirect Calorimetry-Guided Nutritional Support on Patient-Centered Outcomes in Critically Ill Patients - The OPTICal Study","OPTICal","Inclusion Criteria:\n\nAll patients admitted to the ICU with the following criteria:\n\n* ≥18 years old\n* On Mechanical Ventilation\n* Expected ICU length of stay \\>72 hours\n\nExclusion Criteria:\n\n* Refusal of the family or patient\n* Patient transferred from another ICU\n* Pregnant patient\n* Patient is planned for a withdrawal of care or is actively dying\n* Cognitive disorder before ICU\n* Patient is in jail\n* Patients already enrolled in the ongoing NutriPhyT trial",{"count":110,"type":19},356,[54],"This multicentric randomized controlled trial aims to evaluate whether indirect calorimetry (IC)-guided nutritional support improves patient-centered outcomes in critically ill adult patients compared to standard formula-based nutritional strategies. The study includes mechanically ventilated patients expected to remain in the ICU for more than 72 hours. The intervention group will receive nutritional targets based on measured resting energy expenditure using the QNRG+ device, with a gradual escalation of energy delivery following current ESPEN guidelines. The primary outcome is quality of life at 3 months post-ICU admission, assessed using the EQ-5D-5L. Secondary outcomes include functional recovery, muscle preservation, infection rates, and rehospitalization. This study is the first to assess the long-term impact of IC-guided nutrition on recovery and quality of life using a patient-centered approach.",[25,26],[115,116,117,118],"Nutrition","Indirect calorimetry","Nutrition therapy","Predictive formula","RECRUITING","2026-05-15",{"date":122,"type":34},"2026-05-19",{"date":124,"type":34},"2026-01-01",{"date":126,"type":19},"2027-09-01",{"name":128,"class":41},"HEIDEGGER CP",3,{"id":131,"slug":132,"hasResults":11,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":4,"eligibilityCriteria":136,"healthyVolunteers":137,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":138,"targetDuration":4,"studyType":20,"phases":140,"briefSummary":141,"conditions":142,"keywords":147,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":100},"100639824","case-based-learning-for-bedside-lung-ultrasound-teaching-in-icu-100639824","NCT07594470","Case-Based Learning for Bedside Lung Ultrasound Teaching in ICU","CBL Mode in Clinical Teaching of Bedside Lung Ultrasound in Intensive Care Unit: A Randomized Controlled Study","Inclusion Criteria:\n\n* Standardized residency trainees currently rotating in the Intensive Care Unit (ICU), specializing in Internal Medicine, Surgery, Emergency Medicine, Anesthesiology, or General Practice.\n* Have completed institutional basic ultrasound theory training or possess preliminary ultrasound knowledge.\n* Voluntarily participate and provide written informed consent.\n* Able to complete the entire teaching and evaluation schedule (including written test and OSCE).\n\nExclusion Criteria:\n\n* Prior formal training or certification in lung\u002Fcritical care ultrasound.\n* Unable to complete the study period due to rotation scheduling or absence.\n* Decline or withdraw informed consent.",true,{"count":139,"type":19},106,[54],"This single-center randomized controlled study aims to evaluate the effectiveness of Case-Based Learning (CBL) compared with traditional teaching in clinical training of bedside lung ultrasound (BLUE) for emergency medicine residents and medical students. The hypothesis is that CBL improves theoretical understanding, practical ultrasound skills, and clinical reasoning in emergency settings.",[143,26,144,145,146],"Medical Education","Emergency Medicine","Lung Ultrasound","Case-based Learning",[148,149,150,144,151,152],"Case-based learning","Bedside Lung Ultrasound (BLUE)","Case-Based Learning (CBL)","Critical ultrasonography","Intensive Care Unit","2026-05-14",{"date":155,"type":34},"2026-05-18",{"date":157,"type":19},"2026-07-01",{"date":159,"type":19},"2027-06-30",{"name":161,"class":41},"First Affiliated Hospital of Wannan Medical College",{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":15,"minAge":169,"maxAge":16,"enrollmentInfo":170,"targetDuration":4,"studyType":171,"phases":4,"briefSummary":172,"conditions":173,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":182,"locationsCount":4},"100632765","what-are-the-predictors-of-acute-kidney-injury-in-children-admitted-to-pediatrics-intensive-care-unit-at-assiut-university-children-hospital-100632765","NCT07517939","What Are the Predictors of Acute Kidney Injury in Children Admitted to Pediatrics Intensive Care Unit at Assiut University Children Hospital?","Predictors of Acute Kidneyinjury in Children Admitted to Pediatrics Intensive Care Unit at Assiut University ChildrenHospital","Inclusion Criteria:\n\n* All cases of acute kidney injury in pediatrics from 1 month to 18years who admitted to PICU Assiut University Children Hospital according to (KDIGO) AKI Staging criteria during the duration of the study.\n\nExclusion Criteria:\n\n* Neonates\n* patients above 18 years of age\n* patients with chronic kidney disease\n* patients with renal malformations","1 Month",{"count":52,"type":19},"OBSERVATIONAL","Identify the Predictors of Acute Kidney Injury in critically ill children admitted to PICU during one year",[174,26],"AKI","2026-04-02",{"date":177,"type":34},"2026-04-08",{"date":179,"type":19},"2026-05-01",{"date":181,"type":19},"2027-08-01",{"name":183,"class":41},"Assiut University",{"id":185,"slug":186,"hasResults":11,"nctId":187,"briefTitle":188,"officialTitle":189,"acronym":4,"eligibilityCriteria":190,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":191,"targetDuration":4,"studyType":171,"phases":4,"briefSummary":193,"conditions":194,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":203,"leadSponsor":204,"locationsCount":4},"100627163","machine-learning-prediction-of-mortality-after-prone-positioning-in-ards-100627163","NCT07445061","Machine Learning Prediction of Mortality After Prone Positioning in ARDS","A Machine Learning Model to Predict Mortality in Patients With Acute Respiratory Distress Syndrome After Prone Positioning","Inclusion Criteria:\n\n* Diagnosis of ARDS according to the Berlin definition \\[15\\];\n* Receipt of at least one session of prone position ventilation (PPV) during hospitalization;\n* Requirement for mechanical ventilation.\n\nExclusion Criteria:\n\n* Age \\\u003C18 years;\n* PPV duration \\\u003C6 hours;\n* ICU length of stay \\\u003C24 hours;\n* Pregnancy;\n* Missing key clinical data.",{"count":192,"type":19},377,"Acute respiratory distress syndrome (ARDS) is a life-threatening condition with high mortality. Prone position ventilation (PPV) is an evidence-based therapy that improves oxygenation and survival in patients with moderate to severe ARDS; however, outcomes remain heterogeneous. Early identification of patients at high risk of mortality after PPV may improve clinical decision-making and individualized management.\n\nThis retrospective observational study aims to develop and validate a machine learning model to predict intensive care unit (ICU) mortality in ARDS patients receiving prone position ventilation. Clinical, laboratory, and treatment variables collected from ICU electronic medical records will be used to construct prediction models using multiple machine learning algorithms. The performance of these models will be evaluated and compared to identify the optimal model for mortality prediction.",[195,196,197,26,198],"Acute Respiratory Distress Syndrome (ARDS)","Prone Position Ventilation","Machine Learning","ARDS","2026-03-01",{"date":201,"type":34},"2026-03-03",{"date":199,"type":19},{"date":179,"type":19},{"name":205,"class":41},"Shanghai Zhongshan Hospital",{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":210,"acronym":211,"eligibilityCriteria":212,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":213,"targetDuration":4,"studyType":171,"phases":4,"briefSummary":215,"conditions":216,"keywords":4,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":229},"100584918","the-high-fidelity-hydraulic-coupling-upper-arm-cuff-assessment-of-limits-safety-and-effectiveness-hipulse-trial-cardiac-output-study-100584918","NCT06895603","The HIgh-fidelity Hydraulic couPling Upper-arm Cuff Assessment of Limits, Safety, and Effectiveness (HIPULSE) Trial (Cardiac Output Study)","CO","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Indication for PAC (Swan-Ganz)\n* Indication for radial arterial line\n* Subject or legal authorized representative is able to understand and speak the local language (also Spanish is also accepted for US sites) to provide voluntary written informed consent prior to study procedures\n\nExclusion Criteria:\n\n* Emergency surgery\n* ICU or surgical positioning where both arms are tucked\n* Inability to place the Philips AMC appropriately due to subject anatomy or condition\n* Known pregnancy or lactating women (self-report)\n* Patients treated with an intra-aortic balloon pump\n* Measurements taken in the lateral position\n* Currently participating in an investigational drug or another device study that clinically interferes with the study endpoints\n* Upper arm circumference \\\u003C 19 cm or \\> 43 cm\n* BMI \\> 45\n* At the PI's discretion, subject does not qualify to participate in the study for any reasons that are not mentioned above",{"count":214,"type":19},75,"The purpose of this study is to compare cardiac output (CO), fluid responsiveness, and related measurements between the Philips AMC and PAC (Swan-Ganz) in ICU or surgical patients.",[26,217,218],"Pulmonary Artery Catheter (PAC)","Swan-Ganz Catheter","2026-02-24",{"date":221,"type":34},"2026-02-27",{"date":223,"type":34},"2025-10-28",{"date":225,"type":19},"2026-06",{"name":227,"class":228},"Philips Clinical & Medical Affairs Global","INDUSTRY",2,{"id":231,"slug":232,"hasResults":11,"nctId":233,"briefTitle":234,"officialTitle":235,"acronym":4,"eligibilityCriteria":236,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":237,"targetDuration":4,"studyType":20,"phases":239,"briefSummary":240,"conditions":241,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":4},"100625981","eye-tracking-interactive-agent-in-non-verbal-icu-patients-100625981","NCT07429695","Eye-Tracking Interactive Agent in Non-verbal ICU Patients","Eye-Tracking Interactive Agent in Non-verbal ICU Patients: A Study Protocol of a Randomized Controlled Trial With an Embedded Qualitative Study","Inclusion Criteria:\n\n* Aged ≥ 18 years\n* Patients in the ICU who are unable to communicate through normal verbal means due to endotracheal intubation\u002Ftracheotomy, muscle or nerve injury, acute\u002Fchronic spinal cord injury, etc.\n* Richmond Agitation-Sedation Scale (RASS) score of -1 to 1\n* Primary caregivers are adults\n* Able to read Chinese characters and follow simple commands\n* Willing to participate in this study.\n\nExclusion Criteria:\n\n* Diseases associated with cognitive impairment, such as pulmonary encephalopathy, hepatic encephalopathy, diabetic hyperosmolar coma, and coma of unknown cause\n* A history of mental disorders, dementia or pre-dementia, or intellectual disability\n* Conditions precluding cooperation with eye-tracking interaction, such as blindness or inability to elevate the eyelids.",{"count":238,"type":19},54,[54],"The goal of this clinical trial is to determine whether an eye-tracking interactive agent can ameliorate communication impairments and reduce the incidence of complications among non-verbal patients in the intensive care unit (ICU). The main questions it aims to answer are:\n\nDoes the eye tracking interactive agent alleviate communication impairments among non-verbal patients in the ICU? Does the eye tracking interactive agent improve communication efficiency among non-verbal patients in the ICU? Does the eye tracking interactive agent m reduce the incidence of negative emotions among non-verbal patients in the ICU? Does the eye tracking interactive agent shorten the ICU length of stay for non-verbal patients in the ICU? Does the eye tracking interactive agent reduce the dosage of analgesic and sedative medications for non-verbal patients in the ICU? Does the eye tracking interactive agent improve family satisfaction for non-verbal patients in the ICU? Does the eye tracking interactive agent alleviate nurses' communication burden among non-verbal patients in the ICU? Researchers will compare eye tracking interactive agent to conventional techniques to see if e eye tracking interactive agent works to alleviate communication impairments.\n\nParticipants will:\n\nUse an eye tracking interactive agent for augmentative communication for 2 consecutive days Document each communication's details, ICU LOS, and analgesic-sedative dosages; assess communication difficulty severity, delirium, anxiety, family satisfaction and nurses' communication burden with validated scales.",[242,26,243,244],"Eye Tracking","Communication Barriers","Non-Verbal Communication","2026-02-22",{"date":219,"type":34},{"date":248,"type":19},"2026-04-01",{"date":250,"type":19},"2027-12-31",{"name":205,"class":41},{"id":253,"slug":254,"hasResults":11,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":258,"eligibilityCriteria":259,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":260,"targetDuration":262,"studyType":171,"phases":4,"briefSummary":263,"conditions":264,"keywords":266,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":270,"lastUpdatePostDateStruct":271,"startDateStruct":273,"completionDateStruct":275,"leadSponsor":277,"locationsCount":4},"100624786","association-between-dynamic-prealbumin-trajectories-and-prognosis-in-critically-ill-patients-100624786","NCT07414160","Association Between Dynamic Prealbumin Trajectories and Prognosis in Critically Ill Patients","Association Between Dynamic Prealbumin Trajectories and Prognosis in Critically Ill Patients: A Prospective Observational Study","PAB-TRACK","Inclusion Criteria:\n\n1. age \\> 18 years,\n2. SOFA score ≥ 2\n3. at least three prealbumin data points within the previous 14 days.\n\nExclusion Criteria:\n\n1. patients with liver failure\n2. patients with kidney failure,\n3. hereditary amyloidosis and Alzheimer's disease\n4. long-term use of hormones or NSAIDs. -",{"count":261,"type":19},500,"28 Days","Nutritional support therapy is a crucial part of ICU patient care, as both malnutrition and overnutrition can lead to adverse clinical outcomes. Meticulous monitoring of nutritional support is essential. Unfortunately, to date, there are no biomarkers available to assess the appropriateness of nutritional support in the ICU setting. However, mounting evidence suggests that phenotypic analysis of patients using nutritional biomarkers or risk screening scores for adaptation may enhance our ability to characterize patients in terms of prognosis and likelihood of treatment response.\n\nThis study aims to identify the trajectory patterns of prealbumin changes based on dynamic monitoring data of prealbumin during hospitalization of critically ill patients, and to analyze the Association between different trajectory groups and patient prognosis. In addition, this study will further analyze its Association with nutritional intake and nutritional indicators, thereby assessing the potential value of prealbumin change trajectories in terms of the adequacy and effectiveness of nutritional support for critically ill patients.",[26,25,265],"Adult",[267,268,269],"prealbumin","Critically Ill Patients","Prognosis","2026-02-10",{"date":272,"type":34},"2026-02-17",{"date":274,"type":19},"2026-03-15",{"date":276,"type":19},"2027-04-15",{"name":278,"class":41},"The First Hospital of Jilin University",{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":4,"eligibilityCriteria":285,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":286,"targetDuration":4,"studyType":171,"phases":4,"briefSummary":288,"conditions":289,"keywords":292,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":302,"locationsCount":100},"100605342","retrospective-cohort-study-of-low-flow-extracorporeal-carbon-dioxide-removal-ecco2r-system-evaluating-ecco2rs-efficacy-and-safety-in-participants-with-respiratory-failure-100605342","NCT07161271","Retrospective Cohort Study of Low-Flow Extracorporeal Carbon Dioxide Removal (ECCO2R) System: Evaluating ECCO2R's Efficacy and Safety in Participants With Respiratory Failure","Retrospective Cohort Study of Low-Flow Extracorporeal Carbon Dioxide Removal (ECCO2R) System: Evaluating Efficacy and Safety","Inclusion Criteria:\n\n* Patients supported with ECCO2R in one of the designated study sites\n* Admitted to the ICU between 1 Jan 2022 and 30 June 2024\n\nExclusion Criteria:\n\n* Patients younger than 18 years old",{"count":287,"type":19},59,"This is an observational study performed by retrospective review of data routinely collected for patients receiving low-flow extracorporeal carbon dioxide removal (ECCO2R) therapy in intensive care units (ICUs). Our aim is to firstly, describe the local practice in terms of patient selection and technical details of clinical management related to the use of low-flow ECCO2R system, and secondly, the clinical results in terms of patient outcomes and adverse events. These findings may allow clinicians to improve the quality and safety of ECCO2R therapy provision in the ICU.",[290,26,291,198],"Respiratory Failure","Asthma (Diagnosis)",[293,26,294,198,295],"ECCO2R","Asthma","Respiratory failure","2025-12-22",{"date":298,"type":34},"2025-12-23",{"date":300,"type":34},"2024-11-01",{"date":159,"type":19},{"name":303,"class":41},"Hong Kong University",{"id":305,"slug":306,"hasResults":11,"nctId":307,"briefTitle":308,"officialTitle":309,"acronym":4,"eligibilityCriteria":310,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":311,"targetDuration":4,"studyType":171,"phases":4,"briefSummary":312,"conditions":313,"keywords":316,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":327,"locationsCount":100},"100602220","ppi-in-weaning-prediction-100602220","NCT07120672","PPI in Weaning Prediction","The Role of Peripheral Perfusion Index as a Predictive Factor During Weaning Process","Inclusion Criteria:\n\n* Patients who have been on mechanical ventilation for at least 48 hours\n* Patients over 18 years of age who are planned to undergo extubation following a spontaneous breathing trial (SBT)\n* Patients or their legal representatives who provide informed consent to participate in the study\n\nExclusion Criteria:\n\n* Patients for whom extubation is not planned due to hemodynamic instability\n* Patients with peripheral vascular disease or a history of hand surgery\n* Patients who die or cannot be followed up during the study period",{"count":52,"type":19},"The aim of this study is to evaluate the predictive role of the Peripheral Perfusion Index (PPI) in forecasting extubation success during the weaning process in intensive care unit (ICU) patients. The study will investigate the ability of PPI to predict extubation failure by comparing it with traditional weaning criteria, including the Rapid Shallow Breathing Index (RSBI), PaO₂\u002FFiO₂ ratio, and respiratory rate.",[314,315,26],"Perfusion Index","Weaning of Mechanical Ventilation",[317,318,319],"perfusion index","weaning","ıcu","2025-08-06",{"date":322,"type":34},"2025-08-13",{"date":324,"type":34},"2025-05-08",{"date":326,"type":19},"2025-08-30",{"name":328,"class":329},"Gaziosmanpasa Research and Education Hospital","OTHER_GOV",{"id":331,"slug":332,"hasResults":11,"nctId":333,"briefTitle":334,"officialTitle":335,"acronym":336,"eligibilityCriteria":337,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":338,"targetDuration":4,"studyType":20,"phases":340,"briefSummary":341,"conditions":342,"keywords":344,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":350,"lastUpdatePostDateStruct":351,"startDateStruct":353,"completionDateStruct":355,"leadSponsor":357,"locationsCount":229},"100579667","mneed-a-multicentre-cluster-randomized-controlled-trial-100579667","NCT06827275","mNEED: a Multicentre, Cluster-randomized, Controlled Trial","Modifying Feeding Protocols for Critically Ill Patients (mNEED) Based on a Predictive Model of Feeding Intolerance in Critically Ill Patients: a Multicentre, Cohorts Randomized, Controlled Trial","mNEED","Inclusion Criteria:\n\nAge 18 or older Failure of one or more organ systems within 24 hours of admission to the ICU (SOFA score ≥2) Expected to stay in ICU for more than 48 hours Inability to eat orally No EN taboo\n\nICU Selection Criteria:\n\nICU in Grade 2 or above hospitals ICU with the ability to carry out intensive care and monitor patient FI ICU type: emergency, medical, surgical, neurosurgical, or comprehensive ICU\n\nExclusion Criteria:\n\nPatients who have received EN treatment in the past three days AGI Level IV patients Receiving palliative care and expected to die within 48 hours Pregnancy Long-term use of steroids or other immunosuppressants Patients undergoing radiotherapy or chemotherapy for malignant diseases Participation in other clinical studies\n\nICU Exclusion Criteria:\n\nICU that refuses to participate in the study ICU that has not passed the ethical review Pediatric ICU",{"count":339,"type":19},2250,[54],"Project Name: Improved Feeding Regimen for Critically Ill Patients (mNEED) Based on Feeding Intolerance Prediction Model Solution version number and version date: Version 5.0; 2024.12.16 Informed consent version number and version date: Version 1.0; 2023.10.19\n\nDear Patient, Recently, the department participated in a nationwide study to develop nutrition protocols for critically ill patients. Participation in a \"Modified Feeding Regimen for Critically Ill Patients Based on a Predictive Model of Feeding Intolerance in Critically Ill Patients (mNEED): a multicenter, cohort randomized, controlled trial\" is being invited. Before deciding whether to participate in the study, it is important to read the following information carefully to understand the clinical treatment study, its purpose, procedures, duration, and potential benefits, discomforts, and risks. If desired, the information can be discussed with relatives, friends, or the attending physician to assist in making an informed decision. For any questions, please direct them to the physician in charge of the study.\n\nI. Introduction of Clinical Trials\n\nResearch Background and Purpose Leading international evidence-based guidelines consistently recommend early targeted nutritional therapy for critically ill patients. However, multicenter cluster-randomized controlled trials (cRCTs) evaluating the impact of implementing these guidelines have not demonstrated patient benefit. In 2022, Ke et al. proposed evidence-based Feeding Guidelines for Critically Ill Patients (NEED), which provided a specific feeding regimen for nutritional therapy in critically ill patients. The results suggested that the NEED group initiated enteral nutrition (EN) earlier and reduced the use of overall parenteral nutrition (PN). However, the NEED feeding strategies did not reduce the incidence of feeding intolerance in critically ill patients.\n\nIn previous studies, a predictive model of feeding intolerance (NOFI) in critically ill patients was constructed, demonstrating good predictive power. Therefore, the NEED feeding program will be improved (mNEED) based on NOFI to reduce the occurrence of feeding intolerance (FI) while ensuring the nutritional needs of critically ill patients are met.\n\nResearch Process\n\nResearch Funds: All treatment methods involved in this study follow conventional treatment procedures, without additional interventions or charges.\n\nStudy Content: This study is conducted by the Department of Intensive Care Medicine of the First Hospital of Jilin University, with 2,250 patients expected to be enrolled from ICUs in 90 hospitals nationwide. This study is a multicenter cluster randomized controlled trial, where each center is randomly divided into an experimental group and a control group. Data will be summarized and analyzed statistically.\n\nPossible Risks This study involves an improvement in the feeding strategy for critically ill patients and will not cause additional risks. In the event of serious gastrointestinal adverse events, symptomatic management will be provided promptly.\n\nSubject Benefits All participants in the study will be examined and treated by clinically experienced physicians, who will address questions and provide timely and thoughtful medical services. Participation may lead to improved conditions, and the results of this study may benefit other patients with similar conditions.\n\nVoluntary Participation and Withdrawal Before the trial, a detailed understanding of the clinical trial is encouraged. The hospital and the attending physician are obligated to provide information related to the clinical trial and address any concerns. Participation in the clinical trial treatment is voluntary.\n\nDuty of Confidentiality Medical records (including medical history, physical examination reports, and laboratory results) will be securely stored in the hospital. Access to these records will be limited to physicians (researchers), professional academic committees, ethics committees, and health supervision and management departments. Any public reporting of the study results will not disclose personal identities. Every effort will be made to protect the privacy of personal medical information to the extent permitted by law.",[343,26],"Feeding",[345,346,347,348,349],"Nutritional support","prognosis","Feeding intolerance","Intensive care unit","Enteral nutrition","2025-07-07",{"date":352,"type":34},"2025-07-10",{"date":354,"type":34},"2025-02-25",{"date":356,"type":19},"2026-12-30",{"name":278,"class":41},{"id":359,"slug":360,"hasResults":11,"nctId":361,"briefTitle":362,"officialTitle":363,"acronym":364,"eligibilityCriteria":365,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":366,"targetDuration":4,"studyType":171,"phases":4,"briefSummary":368,"conditions":369,"keywords":372,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":376,"startDateStruct":378,"completionDateStruct":380,"leadSponsor":382,"locationsCount":100},"100596705","episodes-of-disconnected-consciousness-in-icu-survivors-100596705","NCT07048951","Episodes of (Dis)Connected Consciousness in ICU Survivors","Episodes of (Dis)Connected Consciousness Among Patients Who Survived a Critical Illness","CONSCIOUS-ICU","Inclusion Criteria:\n\n* Adult patients who survived a ≥7 days stay in the intensive care unit\n* Experienced a pharmacological or non-pharmacological episode of loss of consciousness\n* French speaking\n\nExclusion Criteria:\n\n* Refusal\n* Chronic disorder of consciousness\n* Confusion or delirium\n* Deafness\n* Blindness\n* Aphasia",{"count":367,"type":19},200,"This single-center observational study aims to describe the incidence of episodes of connected consciousness and disconnected consciousness (including near-death experience (NDE) and out-of-body experiences) in patients who survived a prolonged stay of at least 7 days in the intensive care unit (ICU) and who had at least one episode of pharmacological or non-pharmacological coma. The investigators are also investigating the risk factors related to these episodes of consciousness. A follow-up at six months aims to explore the long-term psychological implications of these episodes.",[370,371,26,25],"Consciousness","Near Death Experience",[373,374],"near-death experience","out-of-body experience","2025-06-24",{"date":377,"type":34},"2025-07-03",{"date":379,"type":34},"2025-04-01",{"date":381,"type":19},"2027-04",{"name":383,"class":41},"University of Liege",{"id":385,"slug":386,"hasResults":11,"nctId":387,"briefTitle":388,"officialTitle":389,"acronym":390,"eligibilityCriteria":391,"healthyVolunteers":11,"sex":15,"minAge":392,"maxAge":16,"enrollmentInfo":393,"targetDuration":4,"studyType":171,"phases":4,"briefSummary":394,"conditions":395,"keywords":4,"overallStatus":119,"whyStopped":4,"lastUpdateSubmitDate":397,"lastUpdatePostDateStruct":398,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":406},"100569502","nutrition-in-paediatric-critical-care-100569502","NCT06695078","Nutrition in Paediatric Critical Care","Nutrition in Paediatric Critical Care: a Bi-national Prospective Cohort Study","ePICUre","Inclusion Criteria:\n\n1. All patients \\\u003C\u002F=18 years of age\n2. Admitted to the PICU after 00:00 on the day of the study period commencement\n3. Admitted to the PICU for \\>72 hours\n\nExclusion Criteria:\n\n1. Those previously enrolled during the study period (i.e. those re-admitted to PICU)\n2. Those for end of life care only\n3. Those admitted for organ donation","0 Years",{"count":367,"type":19},"This is a multi-centre prospective cohort study of nutrition in paediatric critical care in Australia and New Zealand. The study is planned to run in parallel with the adult ICU cohort study, NUTRIENT. Two study periods are proposed with the first in late 2024 and the second in 2026. This observational study seeks to determine the following (although not limited to) descriptive outcomes of interest:\n\n1. Nutritional outcomes, including route of nutrition support (oral, enteral and\u002For parenteral), energy and protein prescription and provision, and anthropometric measures\n2. Patient-centred outcomes, including duration of invasive respiratory support and hospitalisation, and mortality\n3. Nutrition service delivery in the PICU and ward settings",[26,115,396],"Paediatric","2024-11-17",{"date":399,"type":34},"2024-11-19",{"date":401,"type":34},"2021-06-07",{"date":403,"type":19},"2027-12",{"name":405,"class":41},"Australian and New Zealand Intensive Care Research Centre",11,{"id":408,"slug":409,"hasResults":11,"nctId":410,"briefTitle":411,"officialTitle":412,"acronym":4,"eligibilityCriteria":413,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":4,"enrollmentInfo":414,"targetDuration":4,"studyType":20,"phases":415,"briefSummary":416,"conditions":417,"keywords":421,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":425,"lastUpdatePostDateStruct":426,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":432,"locationsCount":4},"100548799","work-package-3-education-for-icu-clinicians-in-basic-palliative-care-100548799","NCT06425692","Work Package 3 Education for ICU Clinicians in Basic Palliative Care","Enhancing Palliative Care in ICU (EPIC) - Work Package 3","Inclusion Criteria:\n\n* ≥18 years\n* ICU staff and participants of the EPIC intervention study (physician, nurse)\n* participants of patients and family workshops\n* agreement to participate in the study\n\nExclusion Criteria:\n\n* \\<18 years\n* rejection of study participation.",{"count":261,"type":19},[54],"The EPIC project aims at sustainably improving palliative care for seriously ill patients and their families in ICUs. To this aim, an interdisciplinary consortium is working together to provide a new practical palliative care model using telemedicine. The project is the first European intervention study on palliative care in the ICU using a systems- based approach with proactive patient identification, checklist and blended learning designed to meet the specific needs of ICU staff.\n\nEPIC's vision is to contribute to a change in awareness from a narrow focus on prolonging life to a more holistic approach to care.\n\nThe development of blended learning for intensive care staff is the task of Work Package (WP) 3. The aim is to improve the attitude, understanding and self-confidence of ICU staff. Blended learning is to be developed and implemented for this purpose. The aim is to teach the basics of palliative care on a cognitive, affective and psychomotor level.\n\nDue to the international character of the project, it is to be developed in English with subtitles in the local languages. In addition a workshop with patient and family advisors will be conducted.",[26,418,419,420],"Staff Attitude","Learning","Palliative Care, Patient Care",[422,423,424],"multi-center study","ICU staff","EU-Horizon","2024-05-21",{"date":427,"type":34},"2024-05-22",{"date":429,"type":19},"2024-09-01",{"date":431,"type":19},"2029-01-01",{"name":433,"class":41},"Heinrich-Heine University, Duesseldorf"]