[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"conditionNormalized\":\"idiopathic-inflammatory-demyelinating-disorders-of-the-central-nervous-system\",\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:idiopathic-inflammatory-demyelinating-disorders-of-the-central-nervous-system":27},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,45,66,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100599698","assessment-of-transcranial-alternating-current-stimulations-clinical-efficacy-in-treating-cognitive-impairment-of-idiopathic-inflammatory-demyelinating-diseases-100599698",false,"NCT07087873","Assessment of Transcranial Alternating Current Stimulation's Clinical Efficacy in Treating Cognitive Impairment of Idiopathic Inflammatory Demyelinating Diseases","TACS-CI-IIDDs","Inclusion Criteria:\n\n* Age: 18-60 years old.\n* Diagnosis: Patients with neuromyelitis optica spectrum disease, multiple sclerosis and other inflammatory demyelinating diseases of the central nervous system that meet the diagnostic criteria.\n* Medications have been stable for at least three months.\n\nExclusion Criteria:\n\n* Recurrence has been recorded in the past 3 months.\n* Have a pacemaker or other metal implant in the body.\n* Impaired skin integrity at the site of electrode placement.\n* Previous organic brain disease such as epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infection.\n* Combined with severe or unstable organic diseases, such as heart, liver and kidney and other organ dysfunction.\n* Pregnant or lactating women, those who are planning to become pregnant in the near future.\n* Patient compliance is poor.\n* In the opinion of the investigator, there is a situation that is not suitable to participate in this study.","ALL","18 Years","60 Years",{"count":20,"type":21},128,"ESTIMATED","INTERVENTIONAL",[24],"NA","This study aims to explore the imaging and electrophysiological characteristics of idiopathic inflammatory demyelinating diseases (IIDDs), and their correlation with clinical manifestations. It also evaluates the effectiveness of transcranial electrical stimulation in alleviating clinical symptoms of IIDDs patients, and analyzes the key factors affecting the treatment efficacy. By uncovering the overall and individual characteristics of IIDDs, this study seeks to enhance therapeutic outcomes through personalized neuromodulation programs. The findings will provide a basis for applying non-invasive brain stimulation (NIBS) in IIDDs treatment and offer new ideas for future personalized medicine approaches.",[27,28,29,30,31],"Idiopathic Inflammatory Demyelinating Disorders of the Central Nervous System","MS (Multiple Sclerosis)","NMOSD","Acute Disseminated Encephalomyelitis","Transcranial Alternating Current Stimulation","RECRUITING","2025-07-24",{"date":35,"type":36},"2025-07-28","ACTUAL",{"date":38,"type":36},"2025-05-30",{"date":40,"type":21},"2027-10-31",{"name":42,"class":43},"Xuanwu Hospital, Beijing","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":44},"100588531","transcranial-electrical-stimulation-for-treating-chronic-pain-in-inflammatory-demyelinating-diseases-100588531","NCT06942611","Transcranial Electrical Stimulation for Treating Chronic Pain in Inflammatory Demyelinating Diseases","A Study on the Therapeutic Effects of Transcranial Electrical Stimulation Combined on Chronic Pain in Central Nervous System Inflammatory Demyelinating Diseases","Inclusion Criteria:\n\nPatients diagnosed with neuromyelitis optica spectrum disorder, multiple sclerosis, or other central nervous system inflammatory demyelinating diseases that meet the diagnostic criteria;\n\nNumeric Rating Scale (NRS) pain score ≥4;\n\nAge between 18 and 65 years, regardless of gender;\n\nStable dose of immunosuppressive therapy for at least one month;\n\nEDSS score ≤6;\n\nRight-handed;\n\nAgree to participate and sign the informed consent form.\n\nExclusion Criteria:\n\nA history of relapse within the past month;\n\nRecent medication adjustments or treatment with modified electroconvulsive therapy, transcranial magnetic stimulation, or other neurostimulation techniques within the past month;\n\nParticipation in any other clinical trial within the past month or currently participating in another clinical trial;\n\nPresence of cochlear implants, pacemakers, or implanted stimulators in the brain;\n\nSkin integrity at the electrode placement site is compromised, or allergy to electrode gel or adhesive;\n\nA history of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections;\n\nPregnant or breastfeeding women, or those planning to become pregnant in the near future;\n\nA score of ≥3 on item 3 (suicide item) of the HDRS-17, or a history of severe psychiatric disorders;\n\nPresence of severe or unstable organic diseases;\n\nPoor patient compliance preventing cooperation with treatment, follow-up, or clinical, EEG, and imaging data collection;\n\nAny other situation deemed unsuitable for participation in the study by the investigator.","65 Years",{"count":54,"type":21},80,[24],"Non-invasive neurostimulation can effectively improve patients' symptoms and has shown good therapeutic efficacy in alleviating the symptoms of IIDDs (Inflammatory Immune-mediated Demyelinating Diseases). However, some patients have not achieved the desired results, which may be due to individual differences in neural responsiveness . Therefore, this study aims to assess the therapeutic effect of transcranial electrical stimulation on improving symptoms such as painful spasm in IIDDs patients, by considering both the overall characteristics of IIDDs disease symptoms and individual differences in patients. The study will explore the imaging characteristics, electrophysiological features of the disease symptoms, and their relationship with clinical manifestations, while analyzing the key factors that influence treatment efficacy.",[27],"2025-06-26",{"date":60,"type":36},"2025-07-01",{"date":62,"type":36},"2025-05-03",{"date":64,"type":21},"2027-07-31",{"name":42,"class":43},{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":73,"targetDuration":4,"studyType":22,"phases":75,"briefSummary":76,"conditions":77,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":44},"100595202","effects-of-transcranial-electrical-stimulation-on-cognitive-impairment-in-cns-inflammatory-demyelinating-diseases-100595202","NCT07029386","Effects of Transcranial Electrical Stimulation on Cognitive Impairment in CNS Inflammatory Demyelinating Diseases","The Effectiveness of Individualized Transcranial Electrical Stimulation in Improving Cognitive Impairment in Patients With Central Nervous System Inflammatory Demyelinating Diseases","Inclusion Criteria:、\n\n1. Patients with Neuromyelitis Optica Spectrum Disorders (NMOSD), Multiple Sclerosis (MS), and other Central Nervous System Inflammatory Demyelinating Diseases that meet diagnostic criteria;\n2. Patients with SDMT scores \\\u003C55 or subjective cognitive decline;\n3. Age between 18 and 65 years, gender unrestricted;\n4. Hamilton Anxiety and Depression Scale scores \\\u003C7 points for both scales;\n5. No relapse or medication changes in the past month;\n6. EDSS (Expanded Disability Status Scale) score ≤6;\n7. Right-handed, native Chinese speakers with sufficient educational background to understand the test instructions;\n8. Willing to participate and have signed informed consent.-\n\nExclusion Criteria:\n\n1. Relapse record within the past month;\n2. Medication adjustment within the past month or having undergone modified electroconvulsive therapy, transcranial magnetic stimulation, or other neuromodulation techniques;\n3. Participating in any other clinical research within 1 month prior to enrollment or currently;\n4. Presence of cochlear hearing aids, cardiac pacemakers, or implanted brain stimulation devices;\n5. Skin integrity damage at electrode placement sites, or allergy to electrode gel or adhesives;\n6. History of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections;\n7. Pregnant or lactating women, or those planning pregnancy in the near future;\n8. Scoring ≥3 on item 3 (suicide item) of the HDRS-17 or concurrent severe mental illness;\n9. Concurrent severe or unstable organic diseases;\n10. Unable to cooperate with treatment, follow-up, or clinical, EEG, and imaging data collection due to poor patient compliance;\n11. Other situations deemed inappropriate for study participation by the researchers.",{"count":74,"type":21},85,[24],"Background: Central nervous system inflammatory demyelinating diseases often lead to significant cognitive impairment, presenting a critical challenge in patient management.\n\nObjective: To evaluate the effectiveness of individualized transcranial electrical stimulation (tES) in improving cognitive function among patients with inflammatory demyelinating disorders.\n\nMethods: This study will assess cognitive performance through standardized neuropsychological assessments before and after individualized tES intervention, measuring changes in cognitive domains including memory, attention, executive function, and processing speed.\n\nAnticipated Results: the investigators hypothesize that personalized transcranial electrical stimulation will demonstrate significant improvements in cognitive performance, potentially offering a non-invasive therapeutic approach for managing cognitive decline in central nervous system inflammatory demyelinating diseases.\n\nSignificance: This research may provide novel insights into neuromodulation strategies for cognitive rehabilitation in patients with complex neurological conditions.",[27],"2025-06-18",{"date":80,"type":36},"2025-06-19",{"date":82,"type":36},"2024-12-15",{"date":84,"type":21},"2027-10-01",{"name":42,"class":43},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":52,"enrollmentInfo":93,"targetDuration":4,"studyType":22,"phases":95,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":104,"locationsCount":44},"100587834","effectiveness-of-personalized-alternating-current-stimulation-for-treating-emotional-disorders-in-cns-demyelination-patients-100587834","NCT06933537","Effectiveness of Personalized Alternating Current Stimulation for Treating Emotional Disorders in CNS Demyelination Patients","This Study is Designed to Evaluate the Efficacy of Personalized Alternating Current Stimulation in the Treatment of Emotional Disorders in Patients With Inflammatory Demyelination of the Central Nervous System","Inclusion Criteria:\n\n* Patients diagnosed with inflammatory demyelinating diseases of the central nervous system, such as neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS)\n* Hamilton Anxiety Scale (HAM-A) score \\> 14\n* Aged between 18 and 65 years, with no gender restrictions\n* Receiving stable doses of immunosuppressive therapy for at least one month\n* Expanded Disability Status Scale (EDSS) score ≤ 6\n* Right-handed\n* Willing to participate and sign informed consent\n\nExclusion Criteria:\n\n* Recorded relapse within the past month\n* Recent medication adjustments or treatments involving modified electroconvulsive therapy, transcranial magnetic stimulation, or other neuromodulation techniques within the past month\n* Participation in any other clinical study within the past month or currently\n* Presence of cochlear implants, cardiac pacemakers, or implanted stimulators in the brain\n* Impaired skin integrity at the electrode placement site or allergies to electrode gel or adhesives\n* History of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections\n* Pregnant or breastfeeding women, or those planning to conceive in the near future\n* Hamilton Depression Scale suicide item score ≥ 3 or comorbid severe mental disorders\n* Presence of severe or unstable organic diseases\n* Poor compliance preventing cooperation with treatment, follow-up, or clinical, EEG, and imaging data collection\n* Any condition deemed unsuitable for study participation by the investigator",{"count":94,"type":21},65,[24],"This study is designed to evaluate the efficacy of personalized alternating current stimulation in the treatment of emotional disorders in patients with inflammatory demyelination of the central nervous system.",[27],"2025-04-16",{"date":100,"type":36},"2025-04-18",{"date":102,"type":36},"2024-12-29",{"date":84,"type":21},{"name":42,"class":43}]